27 results on '"Seers, T."'
Search Results
2. Analytical Pore Network Approach (APNA) for Rapid Estimation of Capillary Pressure Behaviour in Rock Samples
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Rabbani, H., primary, Guerillot, D., additional, and Seers, T., additional
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- 2020
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3. Non-Monotonic Behavior of Capillary Pressure at the Entrance of Intermediate-Wet Pore
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Rabbani, H., primary and Daniel Seers, T., additional
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- 2019
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4. CD4:CD8 ratio in children with perinatally acquired HIV-1 infection
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Seers, T, primary, Vassallo, P, additional, Pollock, K, additional, Thornhill, JP, additional, Fidler, S, additional, and Foster, C, additional
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- 2018
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5. Sandstone intrusions along different types of faults and their effect on fluid flow in siliciclastic reservoirs
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Palladino, G., Alsop, G. Ian, Grippa, A., Seers, T., and Hurst, A.
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The principle aim of this paper is to document well-preserved field examples of sandstone-filled faults in order to raise awareness of these poorly understood structures, and discuss their potential as fault seals within injection-prone, multilayered siliciclastic reservoirs. To achieve this goal, we have undertaken a detailed field survey in the Panoche and Tumey hills in Central California, which allowed us to recognize numerous faults filled with injected sand. In particular, sandstone-filled extensional, contractional and strike-slip faults are observed cutting the sandstone/mudstone successions. Sandstone-filled faults commonly display small offsets and apertures ranging from a few centimetres to some decimetres. Evidence of tectonic deformation is usually lacking, meaning that sand injection supported by overpressured fluids propped open the fault walls. In this paper we also describe the main mechanism leading to the emplacement of sand along a fault plane, and propose a predictive model of sandstone-filled fault distributions in different structural environments. Finally, we discuss the role of sandstone-filled faults, that although relatively small and not adding significant volume to the reservoirs, can markedly increase fluid transmissibility and thereby promote better reservoir connectivity.
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- 2021
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6. High Performance Visualisation of Multiscale Geological Outcrop Data in Single Software Environment
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Hodgetts, D., primary, Seers, T., additional, Head, W., additional, and Burnham, B.S., additional
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- 2015
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7. Smartphone assisted fieldwork: Towards the digital transition of geoscience fieldwork using LiDAR-equipped iPhones
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Stefano Tavani, Andrea Billi, Amerigo Corradetti, Marco Mercuri, Alessandro Bosman, Marco Cuffaro, Thomas Seers, Eugenio Carminati, Tavani, S., Billi, A., Corradetti, A., Mercuri, M., Bosman, A., Cuffaro, M., Seers, T., and Carminati, E.
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Virtual outcrop models ,Mapping ,Digital transition ,Education ,Fieldwork ,Smartphone ,General Earth and Planetary Sciences - Abstract
Major advances in smartphones and tablets in terms of their built-in sensors (esp. cameras), available computational power and on-board memory are transforming the role of such devices into the key digital platform around which geological fieldwork is redesigning itself. This digital transition is changing how geoscientists collect and share multimodal-multidimensional field datasets, which can now be readily distributed via standardized exchange formats and online data repositories. The increased accessibility of digital field datasets means that such data products are no longer the sole preserve of geospatial/geoscience specialists, but also students, stakeholders and the general public alike, providing great opportunities for knowledge transfer over the entirety of the research value chain. In the wake of this digital transition, the geological community has welcomed with enthusiasm and curiosity the introduction during 2020 of a native LiDAR scanner equipped on both the iPad Pro and the iPhone 12 Pro. This scanner offers a potential paradigm shift in digital geological fieldwork and puts these devices at the forefront of smartphone assisted fieldwork. In this work, we review progress in smartphone/tablet assisted geological fieldwork and test the iPhone 12 Pro's effectiveness as a replacement for conventional geological field tools. Specifically, we evaluate the geo-location accuracy of the iPhone's Global Navigation Satellite System (GNSS) receiver, the effectiveness of its inertial measurement unit (IMU) and magnetometer for orientation data collection, its photo-video imaging capabilities, and the performance of the device's newly equipped LiDAR in the field. We demonstrate that the performance of the iPhone for orientation and raster image data capture is high, being comparable to analog compass-clinometers and reflex/mirrorless cameras. Whilst location error is within the order of a few meters, the level of accuracy and the fast stabilization of the signal means that, beyond survey grade applications, the iPhone's geo-location capabilities are acceptable for most field cases. With regards to the iPhone's built-in LiDAR scanner, it is an excellent tool for depth assisted camera focusing and for casual 3D outcrop sharing, especially for ‘soft’ applications such as geo-heritage documentation and the production of teaching materials (here we also propose a simple mode of uploading outcrops models in Google Maps). However, the generated 3D models in some cases may be considered overly crude for detailed interrogation, particularly where the fidelity of the surface reconstruction is critical to the analysis (e.g. mesh facet orientation estimation). Based on our review of the evolution of digital field acquisition technologies and on our extensive field testing of the sensor suite integrated within the iPhone 12 Pro, it is clear that the digital transition of geological fieldwork is already mature, whereby smartphone devices have become as indispensable in the field as the geologists' traditional hammer and hand lens.
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- 2022
8. Virtual outcrops in a pocket: Smartphone as a fully equipped photogrammetric data acquisition tool
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Thomas Seers, Andrea Billi, Amerigo Corradetti, Stefano Tavani, Corradetti, A., Seers, T. D., Billi, A., Tavani, S., Corradetti, Amerigo, Seers, Thomas D., Billi, Andrea, and Tavani, Stefano
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Photogrammetry ,Data acquisition ,Virtual outcrops ,Outcrop ,Computer graphics (images) ,Geology - Abstract
Since the advent of affordable consumer-grade cameras over a century ago, photographic images have been the standard medium for capturing and visualizing outcrop-scale geological features. Despite the ubiquity of raster image data capture in routine fieldwork, the development of close-range 3D remote-sensing techniques has led to a paradigm shift in the representation and analysis of rock exposures from two- to three-dimensional forms. The use of geological 3D surface reconstructions in routine fieldwork has, however, been limited by the portability, associated learning curve, and/ or expense of tools required for data capture, visualization, and analysis. Smartphones are rapidly becoming a viable alternative to conventional 3D close-range remote-sensing data capture and visualization platforms, providing a catalyst for the general uptake of 3D outcrop technologies by the geological community, which were up until relatively recently the purview of a relatively small number of geospatial specialists. Indeed, the continuous improvement of smartphone cameras, coupled with their integration with global navigation satellite system (GNSS) and inertial sensors provides 3D reconstructions with comparable accuracy to survey-grade systems. These developments have already led many field geologists to replace reflex cameras, as well as dedicated handheld GNSS receivers and compass clinometers, with smartphones, which offer the equivalent functionality within a single compact platform. Here we demonstrate that through the use of a smartphone and a portable gimbal stabilizer, we can readily generate and register high-quality 3D scans of outcropping geological structures, with the workflow exemplified using a mirror of a seismically active fault. The scan is conducted with minimal effort over the course of a few minutes with limited equipment, thus being representative of a routine situation for a field geologist.
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- 2021
9. Photogrammetric 3D Model via Smartphone GNSS Sensor: Workflow, Error Estimate, and Best Practices
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Marco Mercuri, Thomas Seers, Luca Smeraglia, Terry Pavlis, Stefano Tavani, Umberto Riccardi, Amerigo Corradetti, Antonio Pignalosa, Andrea Billi, Tavani, S., Pignalosa, A., Corradetti, A., Mercuri, M., Smeraglia, L., Riccardi, U., Seers, T., Pavlis, T., and Billi, A.
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010504 meteorology & atmospheric sciences ,Computer science ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Terrain ,Satellite system ,GCPs alternative ,010502 geochemistry & geophysics ,Accelerometer ,01 natural sciences ,law.invention ,law ,Computer vision ,SfM-MVS photogrammetry ,3D model registration ,GNSS-Smartphone ,lcsh:Science ,0105 earth and related environmental sciences ,Iterative and incremental development ,business.industry ,Orientation (computer vision) ,Gyroscope ,Photogrammetry ,GNSS applications ,General Earth and Planetary Sciences ,lcsh:Q ,Artificial intelligence ,business - Abstract
Geotagged smartphone photos can be employed to build digital terrain models using structure from motion-multiview stereo (SfM-MVS) photogrammetry. Accelerometer, magnetometer, and gyroscope sensors integrated within consumer-grade smartphones can be used to record the orientation of images, which can be combined with location information provided by inbuilt global navigation satellite system (GNSS) sensors to geo-register the SfM-MVS model. The accuracy of these sensors is, however, highly variable. In this work, we use a 200 m-wide natural rocky cliff as a test case to evaluate the impact of consumer-grade smartphone GNSS sensor accuracy on the registration of SfM-MVS models. We built a high-resolution 3D model of the cliff, using an unmanned aerial vehicle (UAV) for image acquisition and ground control points (GCPs) located using a differential GNSS survey for georeferencing. This 3D model provides the benchmark against which terrestrial SfM-MVS photogrammetry models, built using smartphone images and registered using built-in accelerometer/gyroscope and GNSS sensors, are compared. Results show that satisfactory post-processing registrations of the smartphone models can be attained, requiring: (1) wide acquisition areas (scaling with GNSS error) and (2) the progressive removal of misaligned images, via an iterative process of model building and error estimation.
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- 2020
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10. Virtual outcrop geology comes of age: The application of consumer-grade virtual reality hardware and software to digital outcrop data analysis
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Stefano Tavani, Ali Sheharyar, Amerigo Corradetti, Thomas Seers, Seers, T. D., Sheharyar, A., Tavani, S., and Corradetti, A.
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Viewport ,Pixel ,Digital outcrop ,Orientation (computer vision) ,Computer science ,business.industry ,Outcrop ,computer.file_format ,Remote sensing ,Virtual reality ,Fracture analysis ,MATLAB language ,Data acquisition ,Software ,Computers in Earth Sciences ,Raster graphics ,business ,computer ,Fracture analysi ,Computer hardware ,ComputingMethodologies_COMPUTERGRAPHICS ,Information Systems - Abstract
In this work, the application of consumer-grade virtual reality (VR) hardware and software to the analysis of digital outcrop data is explored. Here, we utilize a widely available VR hardware platform (HTC Vive) and VR based freeform 3D visual arts software package (Google Tilt Brush), to digitize fault traces from photo-textured digital outcrop models of exposures of the Penrith Sandstone Formation (Lacy's Caves), in northwest England. Using MATLAB routines provided herein, triangular meshes output from Tilt Brush are used as the basis for 3D fracture trace map extraction, which in turn, are used to generate fracture properties (trace length, orientation, areal fracture intensity). We compare the results of this analysis to two equivalent datasets obtained from the Lacy's Caves model using digital outcrop analysis deployed via a conventional flat panel display: namely (1) a 3D trace map extracted using optical ray tracing from manually interpreted calibrated images and (2) 3D traces fitted directly the Lacy's Caves textured mesh using manual polyline interpretation within an established digital outcrop analysis software platform (OpenPlot). Fault statistics obtained using VR based analysis are broadly equivalent to those acquired from 3D trace maps extracted using the flat panel display deployed analyses presented herein. In this case study, it was found that VR based digital outcrop analysis provided faster data acquisition than the comparative pixel-based approach, which requires linkage and merging of traces mapped from multiple contiguous images. Manual raster analysis and optical ray tracing did however provide 3D trace maps with significantly higher areal fault intensity, with VR analysis incurring censoring of finer fault traces, due to the limited resolution of the outcrop model textured mesh. Whilst data acquisition times and resultant fault intensities proved similar between the VR and OpenPlot workflows, it was noted anecdotally, that the VR analysis holds some advantages for the operator when interpreting models exhibiting complex geometries, such as mine workings and caves systems, with the clip point implemented within the viewport of conventional digital outcrop analysis software tools obstructing the user from obtaining an optimum view of the outcrop surface. VR based digital outcrop analysis techniques, such as those presented here, provide an immersive analytical environment to the operator. This allows users to fuse powerful 3D visualizations of photo-realistic outcrop models with geological interpretation and data collection, fulfilling the early promise of ‘virtual outcrops’ as an analytical medium that can emulate traditional fieldwork. It is hoped that this study and its associated code library will facilitate the evaluation of emerging VR technologies for digital outcrop applications, by provided access to VR analytical tools for non-specialists in virtual reality systems. Finally, prospects for the use of VR technology within the field of digital outcrop geology, as well as within the wider geosciences, are also discussed.
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- 2022
11. Terrestrial SfM-MVS photogrammetry from smartphone sensors
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Thomas Seers, Pablo Granado, Stefano Tavani, Umberto Riccardi, Amerigo Corradetti, Tavani, S., Granado, P., Riccardi, U., Seers, T., and Corradetti, A.
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Surveys of cliffs ,010504 meteorology & atmospheric sciences ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Camera sensor ,GCPs alternative ,010502 geochemistry & geophysics ,Accelerometer ,01 natural sciences ,law.invention ,3D model registration ,Camera sensors ,Remote sensing ,law ,Structure from motion ,Computer vision ,Image sensor ,0105 earth and related environmental sciences ,Earth-Surface Processes ,Orientation (computer vision) ,business.industry ,Gyroscope ,Geolocation ,Photogrammetry ,GNSS applications ,Artificial intelligence ,business ,Geology - Abstract
Smartphones can be regarded as cameras, natively equipped with geolocation and orientation sensors, making them powerful, portable, user-friendly and inexpensive tools for terrestrial structure from motion/multiview stereo photogrammetry (SfM-MVS) surveys. Camera extrinsic parameters (i.e. camera position and orientation), required to produce fully georeferenced SfM-MVS 3D models are available for the majority of smartphone images via inbuilt magnetometer, accelerometer/gyroscope, and global navigation satellite system (GNSS) sensors. The precision of these internal sensors is not yet sufficient to directly use them as input to SfM-MVS photogrammetric reconstructions. However, when the reconstructed scene is significantly greater than the positional error, camera extrinsic parameters can be successfully used to register 3D models during post-processing. We present a survey of a 400 m wide vertical cliff to illustrate a workflow that enables the use of smartphone cameras to generate and fully georeference photogrammetric models without employing ground control points. Survey images were acquired at a distance of ~350 m to the mapped scene using a consumer-grade smartphone. This survey image dataset was subsequently used to build an unreferenced 3D model, which was registered during post-processing using orientation and position metadata tagged to each photograph.
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- 2020
12. The impact of weathering upon the roughness characteristics of a splay of the active fault system responsible for the massive 2016 seismic sequence of the Central Apennines, Italy
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Thomas Seers, Emanuele Tondi, Stefano Tavani, Miller Zambrano, Amerigo Corradetti, Corradetti, A., Zambrano, M., Tavani, S., Tondi, E., and Seers, T. D.
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Hurst exponent ,Weathering ,Point cloud ,Nucleation ,Singular value decomposition ,Geology ,Slip (materials science) ,Active fault ,Surface finish ,Roughness ,Fractal ,SfM-MVS ,Active faults ,Mount Vettore ,Point clouds ,Seismology - Abstract
Fault roughness constitutes a key element in the understanding of earthquake nucleation, and surficial asperities on the fault plane play a critical role in slip dynamics and frictional behavior during the seismic cycle. Since it is not generally feasible to recover fault roughness profiles or maps directly at the seismogenic sources, faults at the Earth’s surface are typically used as analogues. However, these analogue fault surfaces are often subjected to weathering and erosion, which in turn, reduces their representativeness as seismogenic faults. Rupture along active faults episodically exposes “fresh” fault planes at the Earth’s surface, which represent the best available targets for the evaluation of fault roughness generated at seismogenic depths.Here we present a study conducted on a splay of the Mt. Vettore fault system in the Central Apennines, Italy, along a vertical transect that includes both a weathered and freshly exposed portion of the fault. The latter was exposed after the dramatic Mw 6.5 shock that hit the area on 30 October 2016. We have produced a highly detailed model (i.e., point cloud) of a section of the fault using structure from motion-multiview stereo photogrammetry to assess its roughness parameters (i.e., the Hurst fractal parameter) and to determine the extent to which these parameters are affected by weathering assuming that they had similar fractal characteristics when reaching the surface.Our results show that weathering can modify the value of the fractal parameters. In particular, by independently analyzing different patches of the fault, we have observed that the smoother and recently exposed portions have an average Hurst exponent of 0.52 while the average Hurst exponent of zones with more prolonged exposure times is 0.64. Accordingly, we conclude that by using high-resolution point clouds, it is possible to recognize patches of faults having a similar intensity of deterioration attributable to weathering.
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- 2020
13. Transverse jointing in foreland fold-and-thrust belts: a remote sensing analysis in the eastern Pyrenees
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Thomas Seers, Pablo Granado, Amerigo Corradetti, Josep Maria Casas, Josep Anton Muñoz, Stefano Tavani, Tavani, S., Granado, P., Corradetti, A., Seers, T., Maria Casas, J., and Anton Munoz, J.
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Estratigrafia ,Stratigraphy ,Enginyeria geològica ,Fractures ,Remote sensing ,Soil Science ,Thrust ,Structural basin ,Spatial distribution ,Paleontology ,lcsh:Stratigraphy ,Geochemistry and Petrology ,Perpendicular ,Continuous exposure ,Foreland basin ,lcsh:QE640-699 ,Earth-Surface Processes ,Engineering geology ,lcsh:QE1-996.5 ,Pyrenees ,Geology ,Fold (geology) ,Pirineus ,lcsh:Geology ,Transverse plane ,Fracture ,Geophysics ,Stratigraphic geology - Abstract
Joint systems in the eastern portion of the Ebro Basin of the eastern Pyrenees enjoy near continuous exposure from the frontal portion of the belt up to the external portion of its associated foredeep. Utilizing orthophoto mosaics of these world-class exposures, we have manually digitized over 30 000 joints within a 16 km×50 km study area. The mapped traces exhibit orientations that are dominantly perpendicular to the trend of the belt (transverse) and, subordinately, parallel to the belt (longitudinal). In particular, joints systematically orient perpendicular to the trend of the belt both in the frontal folds and in the inner and central portion of the foredeep basin. Longitudinal joints occur rarely with a disordered spatial distribution, exhibiting null difference in abundance between the belt and the foredeep. Joint orientations in the external portion of the foredeep become less clustered, with adjacent areas dominated by either transverse or oblique joints. Our data indicate that joints in the studied area formed in the foredeep in response to a foredeep-parallel stretching, which becomes progressively less intense within the external portion of the foredeep. There, the minimum stress direction becomes more variable, providing evidence of the poor contribution of the forebulge-perpendicular stretching on stress organization.
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- 2020
14. Smartphone: An alternative to ground control points for orienting virtual outcrop models and assessing their quality
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Pablo Granado, Marco Snidero, Thomas Seers, Stefano Mazzoli, Amerigo Corradetti, Stefano Tavani, Tavani, S., Corradetti, A., Granado, P., Snidero, M., Seers, T. D., and Mazzoli, S.
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GNSS ,smartphone photogrammetry ,010504 meteorology & atmospheric sciences ,Outcrop ,Stratigraphy ,media_common.quotation_subject ,Control (management) ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Geology ,010502 geochemistry & geophysics ,01 natural sciences ,Human–computer interaction ,Quality (business) ,0105 earth and related environmental sciences ,media_common - Abstract
The application of structure from motion–multiview stereo (SfM-MVS) photogrammetry to map metric- to hectometric-scale exposures facilitates the production of three-dimensional (3-D) surface reconstructions with centimeter resolution and range error. In order to be useful for geospatial data interrogation, models must be correctly located, scaled, and oriented, which typically requires the geolocation of manually positioned ground control points with survey-grade accuracy. The cost and operational complexity of portable tools capable of achieving such positional accuracy and precision is a major obstacle in the routine deployment of SfM-MVS photogrammetry in many fields, including geological fieldwork. Here, we propose a procedure to overcome this limitation and to produce satisfactorily oriented models, which involves the use of photo orientation information recorded by smartphones. Photos captured with smartphones are used to: (1) build test models for evaluating the accuracy of the method, and (2) build smartphone-derived models of outcrops, used to reference higher-resolution models reconstructed from image data collected using digital single-lens reflex (DSLR) and mirrorless cameras. Our results are encouraging and indicate that the proposed workflow can produce registrations with high relative accuracies using consumer-grade smartphones. We also find that comparison between measured and estimated photo orientation can be successfully used to detect errors and distortions within the 3-D models.
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- 2019
15. Geological record of the transition from induced to self-sustained subduction in the Oman Mountains
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Amerigo Corradetti, Stefano Tavani, Monia Sabbatino, Stefano Mazzoli, Thomas Seers, Tavani, Stefano, Corradetti, A, Sabbatino, Monia, Seers, Thoma, Mazzoli, Stefano, Tavani, S., Corradetti, A., Sabbatino, M., Seers, T., and Mazzoli, S.
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Early subduction-related deformation ,Extensional faults ,Oman ,010504 meteorology & atmospheric sciences ,Subduction ,Slab pull ,Extensional fault ,Slab-pull ,010502 geochemistry & geophysics ,Geologic record ,01 natural sciences ,Geophysics ,Lithosphere ,Trench ,Slab ,Convergent boundary ,Foreland basin ,Seismology ,Geology ,0105 earth and related environmental sciences ,Earth-Surface Processes - Abstract
Along convergent plate boundaries, the negative buoyancy of the lithosphere pulls the slab into subduction. Bending and offscraping of the downgoing plate are processes occurring at subduction zones and acting against plate motions. These localised dissipative processes cause extensional deformation in the bulge-foredeep region and thrusting and folding in the thrust wedge respectively. Within this framework, widespread early subduction-related extensional structures affecting pre-orogenic rocks of the downgoing plate of fossil subduction systems, are commonly interpreted as induced by extension occurring in the forebulge-foredeep zone. Slab pull is to date, rarely considered as a potential causative process when interpreting basin-scale pre-shortening extensional structures. The problem of distinguishing slab-pull and foreland flexuring induced extensional structures relates to the fact that for most belts, slab pull and forebulge-foredeep flexuring are expected to produce extension roughly in the same direction (i.e. parallel to the foredeep-belt system) and, when syn-kinematic strata are not available, discriminating between these two processes is arduous. In this work we present a field investigation of basin-scale extensional faults from the downgoing plate of the Oman Mts. fossil subduction system. Syn-kinematic strata indicate that normal fault development largely predated extension in the bulge-foredeep region. Herein, we argue that such faulting occurred during the transition from induced to self-sustained subduction, when the negative buoyancy of the slab started to exceed the resisting forces and the downgoing plate began to be pulled towards the trench. © 2019 Elsevier Ltd
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- 2020
16. Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: Diagnostic Challenges and Determinants of Outcome.
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Kurver L, Seers T, van Dorp S, van Crevel R, Pollara G, and van Laarhoven A
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Background: Tuberculosis (TB) can induce secondary hemophagocytic lymphohistiocytosis (HLH), a severe inflammatory syndrome with high mortality. We integrated all published reports of adult HIV-negative TB-associated HLH (TB-HLH) to define clinical characteristics, diagnostic strategies, and therapeutic approaches associated with improved survival., Methods: PubMed, Embase, and Global Index Medicus were searched for eligible records. TB-HLH cases were categorized into (1) patients with a confirmed TB diagnosis receiving antituberculosis treatment while developing HLH and (2) patients presenting with HLH of unknown cause later diagnosed with TB. We used a logistic regression model to define clinical and diagnostic parameters associated with survival., Results: We identified 115 individual cases, 45 (39.1%) from countries with low TB incidence (<10/100 000 per year). When compared with patients with HLH and known TB (n = 21), patients with HLH of unknown cause (n = 94) more often had extrapulmonary TB (66.7% vs 88.3%), while the opposite was true for pulmonary disease (91.5% vs 59.6%). Overall, Mycobacterium tuberculosis was identified in the bone marrow in 78.4% of patients for whom examination was reported (n = 74). Only 10.5% (4/38) of patients tested had a positive result upon a tuberculin skin test or interferon-γ release assay. In-hospital mortality was 28.1% (27/96) in those treated for TB and 100% (18/18) in those who did not receive antituberculosis treatment ( P < .001)., Conclusions: Tuberculosis should be considered a cause of unexplained HLH. TB-HLH is likely underreported, and the diagnostic workup of patients with HLH should include bone marrow investigations for evidence of Mycobacerium tuberculosis . Prompt initiation of antituberculosis treatment likely improves survival in TB-HLH., Competing Interests: Potential conflicts of interest. All authors: No reported conflicts., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
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- 2024
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17. Development and Internal Validation of a Multivariable Prediction Model to Predict Repeat Attendances in the Pediatric Emergency Department: A Retrospective Cohort Study.
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Seers T, Reynard C, Martin GP, and Body R
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- Child, Humans, Aged, Retrospective Studies, Prognosis, Hospitals, Pediatric, Models, Statistical, Emergency Service, Hospital
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Objective: Unplanned reattendances to the pediatric emergency department (PED) occur commonly in clinical practice. Multiple factors influence the decision to return to care, and understanding risk factors may allow for better design of clinical services. We developed a clinical prediction model to predict return to the PED within 72 hours from the index visit., Methods: We retrospectively reviewed all attendances to the PED of Royal Manchester Children's Hospital between 2009 and 2019. Attendances were excluded if they were admitted to hospital, aged older than 16 years or died in the PED. Variables were collected from Electronic Health Records reflecting triage codes. Data were split temporally into a training (80%) set for model development and a test (20%) set for internal validation. We developed the prediction model using LASSO penalized logistic regression., Results: A total of 308,573 attendances were included in the study. There were 14,276 (4.63%) returns within 72 hours of index visit. The final model had an area under the receiver operating characteristic curve of 0.64 (95% confidence interval, 0.63-0.65) on temporal validation. The calibration of the model was good, although with some evidence of miscalibration at the high extremes of the risk distribution. After-visit diagnoses codes reflecting a nonspecific problem ("unwell child") were more common in children who went on to reattend., Conclusions: We developed and internally validated a clinical prediction model for unplanned reattendance to the PED using routinely collected clinical data, including markers of socioeconomic deprivation. This model allows for easy identification of children at the greatest risk of return to PED., Competing Interests: Disclosure: R.B. has received funding personally from Siemens, Roche, Beckman, Singulex, LumiraDx, and Abbott for consulting unrelated to this work. C.R. is employed by Pfizer limited. The work described in this submission was completed before the start of this role. The other authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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18. Zika virus infection in European travellers returning from Thailand in 2022: A GeoSentinel case series.
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Seers T, Rothe C, Hamer DH, Denny S, Spindler R, Schwartz E, and Johnston V
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- Animals, Humans, Thailand epidemiology, Travel, Zika Virus, Zika Virus Infection epidemiology, Epidemics
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Zika virus is a mosquito-borne flavivirus which caused major epidemics in the Pacific and the Americas between 2013 and 2015. International travellers have previously acted as a sentinel population for Zika virus transmission in endemic areas, where local transmission may be incompletely captured by local surveillance systems. We report five recent European travellers returning from Thailand with Zika virus infection, highlighting the risk of ongoing endemic transmission in this popular tourist destination., (© 2023 John Wiley & Sons Ltd.)
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- 2023
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19. Experience of using a regional network of hospitals in the care of older inpatients with COVID-19 in spring 2020.
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Mariam NBG, Dunnett-Kane V, Herdman MT, Seers T, Aldcroft D, Balasegaram S, Davenport R, Redmond A, Ng C, and Wentworth L
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Introduction: Frail, older patients with COVID-19 have an increased risk of hospital admission and death., Methods: We studied a regional model of care used for older patients with COVID-19 in spring 2020 across three settings: an acute teaching hospital, a district general hospital and a temporary emergency hospital. We also studied demographic and outcome data for these patients., Results: Increasing bed capacity in non-acute sites freed up beds in acute hospitals. Strict admission criteria and multidisciplinary team involvement allowed for the safe delivery of care in step-down sites., Conclusion: This model of care allowed for patient flow out of acute sites following the acute stage of their illness allowing for an increase in bed capacity while providing a safe setting for ongoing management., (© Royal College of Physicians 2022. All rights reserved.)
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- 2022
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20. Clinical frailty as a key characteristic of the patient population of the NHS Nightingale North West COVID-19 temporary emergency field hospital: cohort study April to June 2020.
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Trent Herdman M, Seers T, Ng C, Davenport R, Sibley S, Mannion S, Balasegaram S, and Redmond AD
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Objectives: COVID-19 temporary emergency 'field' hospitals have been established in the UK to support the surge capacity of the National Health Service while protecting the community from onward infection. We described the population of one such hospital and investigated the impact of frailty on clinical outcomes., Design: Cohort study., Setting: NHS Nightingale Hospital North West, April-June 2020., Participants: All in-patients with COVID-19., Main Outcome Measures: Mortality and duration of admission., Methods: We analysed factors associated with mortality using logistic regression and admission duration using Cox's regression, and described trends in frailty prevalence over time using linear regression., Results: A total of 104 COVID-19 patients were admitted, 74% with moderate-to-severe frailty (clinical frailty score, CFS > 5). A total of 84 were discharged, 14 transferred to other hospitals, and six died on site. High C-reactive protein (CRP) > 50 mg/dL predicted 30-day mortality (adjusted odds ratio 11.9, 95%CI 3.2-51.5, p < 0.001). Patients with CFS > 5 had a 10-day median admission, versus 7-day for CFS ≤ 5 and half the likelihood of discharge on a given day (adjusted hazard ratio 0.51, 95%CI 0.29-0.92, p = 0.024). CRP > 50 mg/dL and hospital-associated COVID-19 also predicted admission duration. As more frail patients had a lower rate of discharge, prevalence of CFS > 5 increased from 64% initially to 90% in the final week (non-zero slope p < 0.001). Conclusions: The NNW population was characterized by high levels of frailty, which increased over the course of the hospital's operation, with subsequent operational implications. Identifying and responding to the needs of this population, and acknowledging the risks of this unusual clinical context, helped the hospital to keep patients safe., (© 2021 The Author(s).)
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- 2021
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21. Bilateral ocular toxoplasmosis in a returning traveller: age and route of infection as potential risk factors.
- Author
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Seers T, Myneni J, Chaudhry NL, and Ugarte M
- Subjects
- Age Factors, Aged, Anti-Bacterial Agents therapeutic use, Azithromycin therapeutic use, Fundus Oculi, Glucocorticoids therapeutic use, Humans, Male, South America, Tomography, Optical Coherence, Toxoplasmosis, Ocular drug therapy, Toxoplasmosis, Ocular pathology, Toxoplasmosis, Ocular transmission, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, United Kingdom, Toxoplasmosis, Ocular diagnosis, Travel-Related Illness
- Abstract
We report the case of a 69-year-old man, who presented in the UK with a short history of deteriorating vision and clinical features of bilateral atypical retinochoroiditis, after travelling to South America. Vitreous samples demonstrated Toxoplasma gondii DNA by PCR. Serology tests demonstrated recent acquired Toxoplasma gondii infection with IgM antibodies. He responded well to treatment with trimethoprim-sulfamethoxazole, azithromycin and oral steroids.This case is a reminder of the global importance of Toxoplasma related eye disease, and its uncommon bilateral severe presentation in a returning traveller, where the risk factors were age and the route of infection likely to be a virulent parasite oocyst from vegetables or water rather than undercooked meat or direct contact with cats., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2021
- Full Text
- View/download PDF
22. Phosphate metabolism and respiratory alkalosis: a forgotten lesson in COVID-19.
- Author
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Seers T and Davenport R
- Subjects
- Alkalosis, Respiratory etiology, COVID-19, Coronavirus Infections epidemiology, Coronavirus Infections metabolism, Humans, Pandemics, Pneumonia, Viral epidemiology, Pneumonia, Viral metabolism, SARS-CoV-2, Alkalosis, Respiratory metabolism, Betacoronavirus, Coronavirus Infections complications, Phosphates metabolism, Pneumonia, Viral complications
- Published
- 2020
- Full Text
- View/download PDF
23. Properties and Microstructure Distribution of High-Performance Thermal Insulation Concrete.
- Author
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Mohammad M, Masad E, Seers T, and Al-Ghamdi SG
- Abstract
The aim of this experimental study is to develop high strength and lightweight concrete mixture suitable for structural applications. This work investigates the effect of replacing normal aggregate either partially or totally with expanded perlite aggregate. This material allows for better thermal insulation properties, thus decreasing the energy usage within the life cycle of the concrete structure. Expanded perlite aggregate was used in concrete by 20%, 40%, 60%, 80%, and 100% in replacement of the natural aggregate. Material characterization tests of compressive strength, flexural strength, and thermal conductivity were carried out for six concrete mixtures. In addition, microstructure analysis was performed with the aid of a micro-computed tomography system to investigate the effects and relation of microstructure quantities on material properties. The proposed concrete mixture, which has 100% of expanded perlite aggregate, has a unit weight of 1703 kg/m
3 and achieved reduction percentage of thermal conductivity around 62% (1.81 to 0.69 W·m-1 ·K-1 ) and a compressive strength of 42 MPa at 28 days; and thus is ideal for structural applications with enhanced properties.- Published
- 2020
- Full Text
- View/download PDF
24. Professionals underestimate patients' pain: a comprehensive review.
- Author
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Seers T, Derry S, Seers K, and Moore RA
- Subjects
- Humans, Pain Measurement, Severity of Illness Index, Health Personnel, Pain diagnosis
- Abstract
Pain assessment by patients is the rule in clinical trials but may not be in clinical practice. We examined studies comparing assessment of pain by patients and professionals in clinical practice using published studies (1990-2016; ≥20 patients), in English, in an institutional setting, comparing pain assessment within 24 hours by patients and health care professionals. A difference of at least 10% of the maximum score was considered significant. We judged quality on sampling method, blinding, and study size. Eighty studies (20,496 patients) provided data from a range of settings and locations; most (51%) used unbiased sampling, and most (68%) were blind or probably blind. Nine studies with ≥500 patients involved 58% of patients; 60 with <200 patients involved 25%. Large studies were more likely to use comprehensive or random sampling and blinding of patients and professionals. Underestimation of pain by professionals compared with patients was reported by 62/80 studies (78%); there was no difference in 17 (21%) and overestimation in 1 (1%). Underestimation was reported in 75% of large studies (>500 patients), 91% of mid-sized studies (200-400), and 78% of small studies (<200). High-quality studies (blind, comprehensive, or random sampling, >200 patients) consistently reported underestimation (10/11; 91%). The extent of underestimation tended to increase with pain severity. Professionals consistently tend to underestimate pain compared with assessment by patients. This tendency is more pronounced with more severe pain, and the extent of underestimation can be large. It is likely that this contributes to undertreatment of pain.
- Published
- 2018
- Full Text
- View/download PDF
25. Shock due to faecal impaction.
- Author
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Baik JS, Seers T, Qureshi S, and Nadel S
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2018
- Full Text
- View/download PDF
26. Hepatocellular Carcinoma in Perinatally Acquired HIV and HBV Coinfection: A Case Report.
- Author
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Seers T, Sarker D, Ross P, Heaton N, Suddle A, Lyall H, Tudor-Williams G, Fidler S, and Foster C
- Subjects
- Adult, Fatal Outcome, Humans, Infectious Disease Transmission, Vertical, Male, Young Adult, Carcinoma, Hepatocellular, Coinfection, HIV Infections, Hepatitis B, Chronic, Liver Neoplasms
- Abstract
This report describes a case of hepatocellular carcinoma in an adolescent with perinatally acquired HIV and hepatitis B virus coinfection, arising despite more than a decade of suppressive antiretroviral therapy for both HIV and hepatitis B virus. This case raises important questions regarding optimal hepatocellular carcinoma screening in this high-risk group and the oncogenic potential of even very well-controlled viral infection.
- Published
- 2017
- Full Text
- View/download PDF
27. Identification of targets of tumor suppressor microRNA-34a using a reporter library system.
- Author
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Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov KD, Boldin MP, and Asahara H
- Subjects
- Breast Neoplasms pathology, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic, Genes, Reporter, Glial Cell Line-Derived Neurotrophic Factor Receptors metabolism, Humans, MicroRNAs metabolism, RNA Helicases genetics, Trans-Activators genetics, Breast Neoplasms genetics, Gene Library, Glial Cell Line-Derived Neurotrophic Factor Receptors genetics, MicroRNAs genetics
- Abstract
miRNAs play critical roles in various biological processes by targeting specific mRNAs. Current approaches to identifying miRNA targets are insufficient for elucidation of a miRNA regulatory network. Here, we created a cell-based screening system using a luciferase reporter library composed of 4,891 full-length cDNAs, each of which was integrated into the 3' UTR of a luciferase gene. Using this reporter library system, we conducted a screening for targets of miR-34a, a tumor-suppressor miRNA. We identified both previously characterized and previously uncharacterized targets. miR-34a overexpression in MDA-MB-231 breast cancer cells repressed the expression of these previously unrecognized targets. Among these targets, GFRA3 is crucial for MDA-MB-231 cell growth, and its expression correlated with the overall survival of patients with breast cancer. Furthermore, GFRA3 was found to be directly regulated by miR-34a via its coding region. These data show that this system is useful for elucidating miRNA functions and networks.
- Published
- 2017
- Full Text
- View/download PDF
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