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Frosted branch angiitis (FBA) is a rare type of severe retinal vasculitis characterized with a widespread perivascular translucent sheathing in association with a variable degree of anterior and/or posterior segment inflammation. Secondary type of FBA is the term coined for the patients with various underlying autoimmune diseases or viral infections. We aim to describe the clinical course of a case with a unilateral frosted branch angiitis most likely associated with the hyperhomocysteinemia and methylene tetrahydrofolate reductase mutation who initially presented us with a unilateral central retinal vein occlusion-like appearance. A 37-year-old otherwise healthy woman presented with a left central retinal vein occlusion-like appearance. Extensive systemic and coagulation work up was unremarkable except for the elevated plasma homocysteine level and heterozygous methylene tetrahydrofolate reductase gene mutation. A week later, a full-blown picture of frosted branch angiitis was established. A successful visual and anatomic outcome was achieved with the pulse and then oral steroids, oral azathioprine, and multiple intravitreal aflibercept injections. Two key messages can be considered. First, central retinal vein occlusion-like presentation can be the very early phase of clinical evolution of FBA, and second, patients with FBA should also be evaluated for possible coagulation abnormalities.

A 16-year-old boy with X-linked retinoschisis was examined for the visual decline on his left eye. Upon examination, a vasopermeable elevated mass lesion was determined at the lower temporal retinal periphery associated with surrounding arc-like hard exudates which is consistent with a vasoactive proliferative tumor of the retina. After discussing the therapeutic options with the patient and his parents, 3 successive dexamethasone implants 6 months apart were administered. As no satisfactory regression was noticed, CyberKnife stereotactic radiosurgery (SRS) was performed. Regression of the exudative tumor was obtained in follow-up examinations at 12 and 24 months after the SRS session and the thickness of the lesion was markedly reduced.

Aim To evaluate corneal and crystalline lens densitometry in patients with vernal keratoconjunctivitis (VKC). Methods This is a case-control study. Patients with VKC and age-gender-matched healthy controls underwent a complete ophthalmologic examination with corneal and crystalline lens densitometry measurements. Additionally, the anterior chamber parameters comprise anterior and posterior K-mean and astigmatism, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), pachymeter, and corneal volume (CV). Patients who had clinically grade 0 or grade 1 VKC and with only tarsal conjunctiva involvement during the conductance of the study were included. The variables were compared statistically. Results One hundred and nine eyes were included in the study, in which fifty-one were in the VKC group. There were 25 males in the VKC group (26 female) and 22 males in the control group (36 female). A statistically significant difference was found between the groups in terms of posterior corneal astigmatism (p = 0.02). The mean corneal pachymeter, CV, ACD, ACA, and ACV were similar in both groups (p = 0.63, p = 0.26, p = 0.60, p = 0.41, and p = 0.32, respectively). The total mean corneal densitometry in the zones extending from 6 to 10 mm and 10 to 12 mm was increased in the VKC group compared to the control group (p = 0.04 and p = 0.012, respectively). The mean crystalline lens was found to be denser in the VKC group compared to the control group (8.96 +/- 1.6 vs. 8.5 +/- 0.57, respectively, p = 0.04). Conclusion Posterior corneal astigmatism is increased in VKC cases in comparison with age- and gender-matched controls. The peripheral anterior 6-12 mm annular corneal zone showed increased corneal densitometry in VKC cases compared to the healthy subjects. Additionally, the lens clarity is found to be decreased subclinically in VKC cases compared to control cases.

Wir berichten uber den Fall einer 55-jahrigen Patientin, die sich aufgrund von einer Visusminderung bei bekannter Myopie vorstellte. Die fundoskopische Untersuchung ergab einen hellen Netzhaut-Aderhaut-Reflex an der unteren Grenze der Papille zusatzlich zu einem Staphyloma posticum und schragem Sehnerveneintritt. Koharenztomographisch zeigte sich eine fokale Aderhautkavitation. Die multimodalen Bildgebungseigenschaften dieser Entitat werden in dieser Kasuistik erlautert.

Purpose: To investigate earlier corneal topographical changes and visual acuity after different pterygium surgical techniques using the Pentacam Scheimpflug imaging system.Methods: This study enrolled 98 patients with unilateral primary nasal pterygium. Pterygium surgery with either a conjunctival autograft (group 1) or an anchored conjunctival rotational flap (group 2), with fibrin tissue adhesive was performed under topical anesthesia. Baseline and one-month post-operative best-corrected visual acuity (BCVA) in logarithm of the Minimum Angle of Resolution (logMAR) and anterior corneal astigmatism (ACA), flat keratometry (Kf), steep keratometry (Ks) and posterior corneal astigmatism (PCA) were analyzed.Results: Mean BCVA improved from baseline 0.119±0.113 to 0.082±0.086 logMAR in group 1, and from baseline 0.169±0.128 to 0.120±0.121 logMAR in group 2. There were no statistically significant differences between the two groups in pre-and post-operative ACA, PCA, Kf and Ks. (p=0.686; 0.9020.107; and 0.592, respectively). Intra-group analysis revealed statistically significant differences in both groups: ACA (pConclusions: Significantly improved anterior corneal topographical changes highly associated with conjunctival autografting. However, the conjunctival rotational flap was associated with relatively greater posterior corneal topographical changes.

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We present multimodal images of a retinal arterial macroaneurysm in terms of fundus photo, swept source optical coherence tomography, spectral domain optical coherence tomography, fluorescein angiography, and swept source optical coherence tomography angiography.

A 9-year-old otherwise healthy boy was examined due to a 4-day history of visual decline in his right eye. Ophthalmological examination revealed an area of active retinochoroiditis in the right macula. Indocyanine green angiography (ICGA) demonstrated multiple hypocyanescent dots surrounding the active lesion extending 360 degrees towards the equator. Optical coherence tomography angiography (OCTA) exhibited dark dots on the choriocapillaris slab over areas corresponding to the hypocyanescent dots detected with ICGA. Full systemic examination and laboratory investigations were carried out. Toxoplasma gondii serology was positive. The diagnosis of toxoplasmic chorioretinitis with white dot-like choroidal involvement was made. Trimethoprim/sulfamethoxazole, azithromycin, and oral prednisolone were administered orally. On repeated ICGA 2 weeks later, the scattered hypocyanescent dots were significantly fewer in number. A month later, right visual acuity was improved, the macular chorioretinitis focus had become inactive, an epiretinal membrane had formed, and the dark dots on the choriocapillaris slab of OCTA were markedly diminished. ICGA may be helpful to observe possible, subtle choroidal involvement in patients with toxoplasmic chorioretinitis.

Inflammatory choroidal neovascularization (iCNV) is an infrequent but an important cause of visual morbidity in patients with non-infectious uveitis and mostly occurs in intermediate or posterior uveitis. Punctate inner choroiditis, Vogt-Koyanagi-Harada disease and multifocal choroiditis are among the leading causes of uveitis entities resulting in iCNVs. The diagnosis and management of iCNVs still remain a challenge. Use of multimodal imaging techniques such as fluorescein angiography, indocyanine green angiography, optical coherence tomography (OCT) and OCT-angiography may be necessary for the diagnosis of iCNVs. The treatment algorithm is not straightforward for iCNV. While control of the active inflammation with steroids and/or immunosuppressive agents is a key to success, various adjunctive treatment modalities such as thermal laser photocoagulation, photodynamic therapy and surgical membrane removal were also co-administered previously. Nowadays, vascular endothelial growth factor (VEGF) inhibitors have become the most commonly administered adjunctive treatment option as they provide better anatomical and functional outcome and the recurrence rate of CNV is relatively low. We hereby reviewed important clinical studies and case series on anti-VEGF administration in iCNVs and briefly overviewed their results.

© 2020 Gazi Eye Foundation. All rights reserved.Purtscher retinopathy is a rare occlusive retinopathy secondary to trauma. When typical retinal fi ndings occur in the complete absence of trauma, it is termed as Purtscher like retinopathy. Unilateral Purtscher retinopathy was diagnosed in the fi rst case presented with unilateral loss of vision following traffi c accident. We presented multimodal imaging and optical coherence tomography angiography (OCT-A) fi ndings. We also presented multimodal imaging and OCT-A fi ndings in the second case with bilateral Purtscher-like retinopathy secondary to Conn syndrome. It is thought that OCT-A examination in Purtscher retinopathy is valuable as it provides rapid, noninvasive assessment of capillary ischemia in the early period.

Choroidal neovascular membrane (CNV) is a very rare complication in patients with sympathetic ophthalmia. We hereby report a 38-year-old man who developed a type 2 CNV in his only seeing (left) eye while under systemic steroid treatment. Systemic therapy was revised and a total of 5 intravitreal aflibercept injections (2 mg each) were administered over a period of 8 months. Good anatomic and functional outcome was noted at the last visit. Anti-vascular endothelial growth factor injection may be an important adjunct to systemic therapy in eyes with with sympathetic ophthalmia-associated CNV.

This article reports the case of a 55-year-old female patient who presented with visual deterioration and previously known myopia. Funduscopy revealed a tilted optic disc along with a peripapillary staphyloma and a yellowish lesion on the inferior border of the optic disc. Optical coherence tomography showed an intrachoroidal cavitation. Multimodal imaging characteristics of this clinical entity are provided in this case report.

A woman with Bietti’s crystalline dystrophy (BCD) was first examined when she was 27 years of age and has been followed for 10 more years. The disease course was monitored initially with spectral domain-optical coherence tomography and then with swept-source optical coherence tomography angiography (OCTA). OCTA analysis showed that choroidal vessels could be visualized at the outer retinal layer segmentation due to retinal pigment epithelial atrophy and blood flow was reduced at the level of choroidal segmentation. OCTA can play a major role in the follow-up of BCD patients by analyzing changes in choroidal flow.