11 results on '"Segetova, M"'
Search Results
2. Concealed cardiomyopathy as a frequent cause of idiopathic ventricular fibrillation in a representative Czech cohort of survivors of sudden cardiac arrest (SCA)
- Author
-
Krebsova, A, primary, Votypka, P, additional, Peldova, P, additional, Haskova, J, additional, Tavacova, T, additional, Peichl, P, additional, Segetova, M, additional, Roubicek, T, additional, Vancura, V, additional, Kubus, P, additional, Sramko, M, additional, Macek Jr, M, additional, Zoubkova, V, additional, Janousek, J, additional, and Kautzner, J, additional
- Published
- 2021
- Full Text
- View/download PDF
3. Poster session: Dobutamine stress echo
- Author
-
Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, Sikula, V, Segetova, M, and Kautzner, J
- Published
- 2012
4. Prevention of life threating arrythmias in relatives of cardiac arrest survivors; results of family cascade screening in a representative cohort in Czech Republic
- Author
-
Krebsova, A, Kutilkova, E, Votypka, P, Peldova, P, Haskova, J, Segetova, M, Peichl, P, Adamova, M, Tavacova, T, Macek, M, Janousek, J, and Kautzner, J
- Published
- 2024
- Full Text
- View/download PDF
5. P4231Diagnostic yield of longer-term non-invasive trans-telephonic ECG monitoring: results of a 6-year study in 12.789 patients
- Author
-
Sobotkova, S, primary, Dlugosova, V, additional, Kovarikova, D, additional, Gandalovicova, J, additional, Brada, J, additional, Palanova, A, additional, Ondraskova, L, additional, Lanikova, P, additional, Blaschova, E, additional, Kvasnickova, D, additional, Wunschova, H, additional, Segetova, M, additional, Cernosek, M, additional, Fiala, M, additional, and Bulkova, V, additional
- Published
- 2018
- Full Text
- View/download PDF
6. The effect of metformin on energetic metabolism in patients with type 2 diabetes/prediabetes and chronic heart failure
- Author
-
Stolarikova, E., primary, Kopecky, J., additional, Velebova, K., additional, Veleba, J., additional, Belinova, L., additional, Malinska, H., additional, Segetova, M., additional, Melenovsky, V., additional, and Pelikanova, T., additional
- Published
- 2018
- Full Text
- View/download PDF
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1.
- Author
-
Tayal, Upasana, primary, Kallifatidis, Alexandros, primary, Garg, P., primary, Beitzke, D., primary, Funk, Stephanie, primary, Kolker, Shimon, primary, Rutz, Tobias, primary, Safdar, Komal S, primary, Valente, F., primary, Murdoch, R., primary, Macaione, F., primary, Dastidar, Amardeep Ghosh, primary, Pontone, Gianluca, primary, Grigoratos, Chrysanthos, primary, Meloni, Antonella, primary, Pedrotti, Patrizia, primary, De Garate, Estefania, primary, Careri, Giulia, primary, Kockova, R., primary, Oebel, S., primary, Nazir, Sheraz A., primary, Barison, A, primary, Swoboda, Peter P, primary, Bulluck, Heerajnarain, primary, Broncano, J., primary, Desroche, L.M., primary, Bermejo, Zorba Blázquez, primary, Kozor, Rebecca, primary, Scott, Andrew D, additional, Wage, Rick, additional, Ferreira, Pedro, additional, Pennell, Dudley, additional, Zhong, Xiaodong, additional, Epstein, Fred, additional, Firmin, David, additional, Prasad, Sanjay, additional, Prousalis, Anastasios, additional, Mouratoglou, Sophia-Anastasia, additional, Giannakoulas, George, additional, Deligianni, Xenia, additional, Bakaloudis, Michail, additional, Magganaris, Nikolaos, additional, Sianos, George, additional, Karvounis, Haralampos, additional, Santini, Francesco, additional, Aziz, R., additional, Foley, J.R.J., additional, Fent, G., additional, Musa, T.A., additional, Haaf, P., additional, Dobson, L., additional, Swoboda, P.P., additional, Greenwood, J.P., additional, Plein, S., additional, Geest, R.J.V.D., additional, Westenberg, J.J.M., additional, Rasul, S., additional, Wadsak, W., additional, Mitterhauser, M., additional, Nolz, R., additional, Stelzmueller, M., additional, Loewe, C., additional, Hacker, M., additional, Kermer, Josephine, additional, Dogangüzel, Serkan, additional, von Knobelsdorff-Brenkenhoff, Florian, additional, Schulz-Menger, Jeanette, additional, Weisz, Giora, additional, Bogot, Naama, additional, Halpern, Irit Hadas, additional, Wolak, Arik, additional, Ginami, Giulia, additional, Piccini, Davide, additional, Coppo, Simone, additional, Vincenti, Gabriella, additional, Stuber, Matthias, additional, Schwitter, Jürg, additional, Gao, Xuexin, additional, Ambach, Stephanie, additional, Taylor, Michal D, additional, Moore, Ryan, additional, Taylor, Robin J, additional, Toro-Salazar, Olga, additional, Jeffries, John L, additional, Bartone, Cheryl, additional, Raman, Subha V, additional, Mazur, Wojciech, additional, Rodriguez-Palomares, J.F., additional, Gutierrez, L., additional, Pineda, V., additional, Agliano, B., additional, Galian, L., additional, Teixido, G., additional, Gonzalez-Alujas, M.T., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Gandy, S., additional, Nicholas, R., additional, Houston, G., additional, Martin, P., additional, Muir, J., additional, Matthew, S., additional, Ramkumar, P. Guntur-, additional, Cavin, I., additional, Barison, A., additional, Pescetelli, I., additional, Pali, F., additional, Pizzino, F., additional, Terrizzi, A., additional, Di Lisi, D., additional, Novo, G., additional, Todiere, G., additional, Assennato, P., additional, Novo, S., additional, Aquaro, G.D., additional, McAlindon, Elisa, additional, Rodrigues, Jonathan, additional, Baritussio, Anna, additional, Scatteia, Alessandra, additional, De Garate, Estefania, additional, Benny Lawton, Chris, additional, Erdei, Tamas, additional, Szantho, Gergely, additional, Hamilton, Mark, additional, Bucciarelli-Ducci, Chiara, additional, Andreini, Daniele, additional, Rota, Cristina, additional, Guglielmo, Marco, additional, Mushtaq, Saima, additional, Baggiano, Andrea, additional, Beltrama, Virginia, additional, Solbiati, Anna, additional, Guaricci, Andrea I., additional, Pepi, Mauro, additional, Bratis, Konstantinos, additional, Henningson, Markus, additional, Dell'Omodarme, Matteo, additional, Puntmann, Valentina O., additional, Nagel, Eike, additional, Giunta, Nicola, additional, Giuliano, Pietro, additional, Neri, Maria Giovanna, additional, Restaino, Gennaro, additional, Renne, Stefania, additional, Quota, Alessandra, additional, Positano, Vincenzo, additional, De Marchi, Daniele, additional, Pepe, Alessia, additional, Campadello, Paola, additional, Masciocco, Gabriella, additional, Facchetti, Rita, additional, Milazzo, Angela, additional, Quattrocchi, Giuseppina, additional, Giannattasio, Cristina, additional, Frigerio, Maria, additional, Roghi, Alberto, additional, Rimoldi, Ornella, additional, Ghosh Dastidar, Amardeep, additional, Amadu, Antonio, additional, Venuti, Giuseppe, additional, Rodrigues, Jonathan C., additional, Castelvecchio, Serenella, additional, Camporeale, Antonia, additional, Secchi, Francesco, additional, Menicanti, Lorenzo, additional, Lombardi, Massimo, additional, Sedlacek, K., additional, Wichterle, D., additional, Sikula, V., additional, Tintera, J., additional, Sukupova, L., additional, Kautznerova, D., additional, Segetova, M., additional, Praveckova, A., additional, Langova, R., additional, Kryze, L., additional, El-Husseini, W., additional, Kautzner, J., additional, Dinov, B., additional, Arya, A., additional, Hilbert, S., additional, Sommer, P., additional, Bollmann, A., additional, Hindricks, G., additional, Paetsch, I., additional, Jahnke, C., additional, Greenwood, John P., additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Gershlick, Anthony, additional, McCann, Gerry P., additional, Liga, Riccardo, additional, Bennatti, Elena, additional, Barison, Andrea, additional, Todiere, Giancarlo, additional, Aquaro, Giovanni Donato, additional, Emdin, Michele, additional, Masci, Pier Giorgio, additional, Ortalda, A, additional, Todiere, G, additional, Grigoratos, C, additional, Vergaro, G, additional, Mirizzi, G, additional, Martini, N, additional, De Marchi, D, additional, Keilberg, P, additional, Passino, C, additional, Aquaro, GD, additional, Emdin, M, additional, McDiarmid, Adam K, additional, Erhayiem, Bara, additional, Fent, Graham J, additional, Dobson, Laura E, additional, Garg, Pankaj, additional, Musa, Tarique A, additional, Foley, James R, additional, Page, Stephen P, additional, Greenwood, John P, additional, Plein, Sven, additional, Rosmini, Stefania, additional, Abdel-Gadir, Amna, additional, Bhuva, Anish, additional, Treibel, Thomas A, additional, White, Steven K, additional, Fontana, Marianna, additional, Ramlall, Manish, additional, Hamarneh, Ashraf, additional, Sirker, Alex, additional, Herrey, Anna, additional, Manisty, Charlotte, additional, Yellon, Derek M, additional, Kellman, Peter, additional, Moon, James C, additional, Hausenloy, Derek J, additional, Luna, A., additional, Noguerol, T. Martin –, additional, Caro, P., additional, Toro-Cebada, R., additional, Gonzalez, J. Sanchez –, additional, Milleron, O., additional, Safar, B., additional, Lavie-Badie, Y., additional, Millischer, D., additional, Abtan, J., additional, Jondeau, G., additional, Cuesta, Emilio, additional, Rosillo, Sandra O., additional, Guzmán, Gabriela, additional, Pinilla, Inmaculada, additional, González, Óscar, additional, Caro, Juan, additional, Ponz, Inés, additional, López, Teresa, additional, Refoyo, Elena, additional, Nordin, Sabrina, additional, Castelleti, Silvia, additional, Captur, Gabriella, additional, Steeds, Rick, additional, Baig, Shanat, additional, Grieve, Stuart M, additional, Figtree, Gemma A, additional, Singhal, Priyanka, additional, Strange, Julian, additional, Nightingale, Angus, additional, Baumbach, Andreas, additional, Johnson, Tom, additional, and Delgado, Victoria, additional
- Published
- 2016
- Full Text
- View/download PDF
8. 1030Role of cardiac magnetic resonance and echocardiography prior to cardiac resynchronization therapy
- Author
-
Kockova, R, primary, Tintera, J, additional, Kautznerova, D, additional, Cerna, D, additional, Sedlacek, K, additional, Kryze, L, additional, El-Husseini, W, additional, Sikula, V, additional, Segetova, M, additional, and Kautzner, J, additional
- Published
- 2013
- Full Text
- View/download PDF
9. Abstracts
- Author
-
Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. Sanchez –, Desroche, L.M., Milleron, O., Safar, B., Lavie-Badie, Y., Millischer, D., Abtan, J., Jondeau, G., Bermejo, Zorba Blázquez, Cuesta, Emilio, Rosillo, Sandra O., Guzmán, Gabriela, Pinilla, Inmaculada, González, Óscar, Caro, Juan, Ponz, Inés, López, Teresa, Refoyo, Elena, Kozor, Rebecca, Nordin, Sabrina, Treibel, Thomas A, Rosmini, Stefania, Castelleti, Silvia, Fontana, Marianna, Captur, Gabriella, Steeds, Rick, Baig, Shanat, Manisty, Charlotte, Grieve, Stuart M, Figtree, Gemma A, Moon, James C, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, De Garate, Estefania, Singhal, Priyanka, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, Erdei, Tamas, Strange, Julian, Nightingale, Angus, Baumbach, Andreas, Johnson, Tom, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Lapinskas, Tomas, Bucius, Paulius, Fedaravicius, Augustinas P., Urbonaite, Laura, Stabinskaite, Agnieta, Zaliunas, Remigijus, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Grigoratos, Chrysanthos, Genovesi, Dario, Giorgetti, Assuero, Chiappino, Sara, Barison, Andrea, Vergaro, Giuseppe, Todiere, Giancarlo, Emdin, Michele, Marzullo, Paolo, Aquaro, Giovanni Donato, Ladeiras-Lopes, Ricardo, Turin-Moreira, Henrique, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Sampaio, Francisco, Ambale-Venkatesh, Bharath, Wu, Colin, Liu, Kiang, Bertoni, Alain, Ouyang, Pamela, Bluemke, David, Lima, João, Fent, GJ., Garg, P., Dobson, LE., Musa, TA., Foley, JF., Haaf, P., Greenwood, JP., Plein, S., Swoboda, PP., Abdul Rahman, E., Ismail, JR., Najme Khir, R., Lim, CW., Chua, N., Ibrahim, ZO., Zainal Abidin, HA., Mohd Arshad, MK., Kasim, SS., Rodrigues, Jonathan, Rooms, Ben, Hyde, Katie, Rohan, Stephen, Dastidar, Amardeep Ghosh, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nightingale, Angus, Paton, Julian, Manghat, Nathan, MacIver, David, Gibelli, Giuseppe, Demolli, Walter, Russo, Alessandra, Minoia, Chiara, Biasi, Salvatore, Mkrtchyan, Naira, Eltschkner, Christin, Christian, Meierhofer, Ewert, Peter, Martinoff, Stefan, Stern, Heiko, Fratz, Sohrab, Valinoti, Maddalena, Fabbri, Claudio, Mantovan, Roberto, Severi, Stefano, Corsi, Cristiana, Nyktari, E., Vassiliou, V., Arzanauskaite, M., Izgi, C., Lam, W., Prasad, S., Reindl, Martin, Reinstadler, Sebastian Johannes, Feistritzer, Hans-Josef, Klug, Gert, Mair, Johannes, Mayr, Agnes, Jaschke, Werner, Franz, Wolfgang-Michael, Metzler, Bernhard, Arnhold, K., Muehlberg, F., Fritschi, S., Funk, S., Prothmann, M., von Knobelsdorff-Brenkenhoff, F., Schulz-Menger, J., Lakhani, Zeeshan S. A., Mohan, B., karthik, G A., Raj, Vimal, Weir-McCall, Jonathan, Cassidy, Deirdre B, Belch, Jill JF, Gandy, Stephen J, Houston, Graeme, Lambert, Matthew A, Littleford, Roberta, Rowland, Janice, Struthers, Allan D, Khan, Faisel, Camaioni, Claudia, Salel, Marjorie, Hennig, Alexia, Corneloup, Olivier, Montaudon, Michel, Laurent, Francois, Cochet, Hubert, Kan, Rachel, Erhayiem, Bara, McDiarmid, Adam K., Garg, Pankaj, Dobson, Laura E., Musa, Tarique A., Ripley, David, Ajjan, Ramzi, Greenwood, John P., Plein, Sven, Swoboda, Peter P., Reinstadler, Sebastian J., Fuernau, Georg, Eitel, Charlotte, de Waha, Suzanne, Desch, Steffen, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Klug, Gert, Reindl, Martin, Mair, Johannes, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian Johannes, Reindl, Martin, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Festa, P., Cadoni, A., D'andrea, C., Costa, S., Keilberg, P., Lunardini, A., Ali, L. Ait, Ali, L. Ait, Aquaro, GD., Peritore, G., Ricci, F., De Marchi, D., Passino, C., Festa, P., Martínez, A. Tercero, Cuartero, J. Navarro, Soriano, J.G. Córdoba, Núñez, S. Calero, de Galarreta, T. Cros Ruiz, García, M. Villar, Page, J.C. Gallego, López, J.C. García, Ruiz, M. Barambio, Erdei, Tamas, Rodrigues, Jonathan C., McIntyre, Bethannie, Dastidar, Amardeep Ghosh, Burchell, Amy E., Ratcliffe, Laura, Hart, Emma C., Paton, Julian F., Hamilton, Mark, Nightingale, Angus K., Manghat, Nathan E., Orii, Makoto, Tanimoto, Takashi, Ota, Shingo, Nishiguchi, Tsuyoshi, Tsujioka, Hiroto, Kuroi, Akio, Yamano, Takashi, Matsuo, Yoshiki, Ino, Yasushi, Kitabata, Hironori, Kubo, Takashi, Tanaka, Atsushi, Hozumi, Takeshi, Akasaka, Takashi, Sousa, Alexandra, Pinho, Teresa, Canedo, Paulo, Lopes, Luís, Azevedo, Olga, Madureira, António, Belo, Adriana, Cardoso, José Silva, Machado, José Carlos, Martins, Elisabete, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Brzozowska-Czarnek, Agata, Urbanik, Andrzej, Rakowski, Tomasz, Agudo-Quílez, P., Pozo-Osinalde, E., Viliani, D., Olivera, MJ., Caballero, P., Jiménez-Borreguero, LJ., Alfonso, F., Carrabba, Nazario, Angeloni, Giulia, Migliorini, Angela, Valenti, Renato, Parodi, Guido, Antoniucci, David, Almeida-Morais, Luís, Galrinho, Ana, Moura-Branco, Luísa, Tavares-Jalles, Nuno, António, Marta, Abreu, João, Timóteo, Ana Teresa, Pinto-Teixeira, Pedro, Aguiar-Rosa, Sílvia, Rodrigues, Inês, Modas-Daniel, Pedro, Cruz-Ferreira, Rui, Bica, R., Dobre, D., Stanciu, S., Acatrinei, E., Nour, A., Stefan, L., Calistru, P., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Rajewska-Tabor, J., Pyda, M., Janus, M., Siniawski, A., Shaheen, Sameh Mohamed, Elhammady, Walid Abdel-Azim, Ahmed, Mohamed Ismail, Abdel-Hakim, Ahmed Samir, Allam, Lamyaa Elsayed, Helal, Ayman Mohamed, Inage, Akio, Mizuno, Naokazu, Inage, Akio, Mizuno, Naokazu, TEIS, Albert, JUNCÀ, Gladys, ARCE, Javier, ARMARIO, David, Cescau, Arthur, Logeart, Damien, Gelen, Barnabas, Derumeaux, Genevie`ve, Vicaut, Eric, Mercadier, Jean-Jacques, Sirol, Marc, Cipriani, Alberto, De Lazzari, Manuel, Susana, Angela, Zorzi, Alessandro, Baritussio, Anna, Siciliano, Mariachiara, Marinato, Martina, Prevedello, Francesca, Giorgi, Benedetta, Vezzaro, Roberto, Corrado, Domenico, Marra, Martina Perazzolo, von Roeder, M., Rommel, K.-P., Kowallick, J.T., Blazek, S., Fengler, K., Lotz, J., Hasenfuß, G., Lücke, Ch., Gutberlet, M., Schuler, G., Schuster, A., Lurz, Ph., Mahmoud, Ahmad A., Rifaie, Osama, Samir, Ahmed, Allam, Lamyaa, Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, She, Hoi Lam, Roest, Arno A.W., van den Boogaard, Pieter J., Calkoen, Emmeline E., van der Geest, Rob J., Hazekamp, Mark G., de Roos, Albert, Westenberg, Jos J.M., Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Bainbridge, G., Garg, P., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Charalambos, Max, Rodrigues, Jonathan, Burchell, Amy, Dastidar, Amardeep Ghosh, BSc(Hons), Laura Ratcliffe, Hart, Emma, Hamilton, Mark, Paton, Julian, Nightingale, Angus, Manghat, Nathan, Muñoz, Begoña Igual, Monserrat, Adrian, gonzalez, Alicia Maceira, Tuset, Luis, Miro, Vicente, Hernandiz, Amparo, Fernandez, Rubén, Sauri, Asunción, Sepúlveda, Pilar, Diez, Jose Luis, Montero, Anastasio, Contaldi, Carla, Imbriaco, Massimo, Alcidi, Gianmarco, Ponsiglione, Andrea, Santoro, Ciro, Puglia, Marta, Barbuto, Luigi, Cuocolo, Alberto, Trimarco, Bruno, Galderisi, Maurizio, Muñoz, Begoña Igual, Sanchez, Elena, Plaza, Diego, sanchis, Pilar Sepúlveda, Gonzalez, Alicia Maceira, Hernandiz, Amparo, Miro, Vicente, vazquez, Alex, Diez, Jose Luis, Martinez, Luis, Montero, Anastasio, Muñoz, B. Igual, Alfredo, Hernandez Caballero, Diana, Domingo Valero, Alicia, Maceira Gonzalez, Jordi, Estornell Erill, Jose, Valera martinez Francisco, Alejandro, Vazquez Sanchez, Anastasio, Montero Argudo, Mochula, O.V., Shelkovnikova, T.A., Popov, S.V., Lukyanenok, P.I., Shelupanov, A.A., Oferkin, A.I., Bakhmet'eva, T.A., Ussov, W.Yu., van den Bosch, Harrie CM., Westenberg, Jos JM., Setz-Pels, Wikke, Kersten, Erik, Tielbeek, Alexander, Duijm, Lucien EM., Post, Johannes, Teijink, Joep A.W., de Roos, Albert, Frick, M., Kirschfink, A., Mühler, E., Marx, N., Hövels-Gürich, H., Gert, Klug, Hans-Josef, Feistritzer, Sebastian, Reinstadler, Martin, Reindl, Benjamin, Seidner, Agnes, Mayr, Sylvana, Müller, Bernhard, Metzler, Fawal, aSara E., Zidan, aMamdouh, Webb, Jessica, Holub, Ondrej, Clough, Rachel, Carr-White, Gerald, Razavi, Reza, Sinkus, Ralph, Maksimova, A.S., Bobrikova, E.E., Bukhovets, I.L., Plotnikov, M.P., Rogovskaya, Yu.V., Rebenkova, M.S., Usov, W.Yu., Mayr, Agnes, Klug, Gert, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Reindl, Martin, Metzler, Bernhard, Kremser, Christian, Schocke, Michael, Winter, M.M., Pluchinotta, F.R., Giusti, G., Secchi, F., Piazza, L., Carminati, M., Chessa, M., Bokma, J.P., Bouma, B.J., Mulder, B.J., Lombardi, M., Katia, Menacho, Thomas, Treibel, Rebecca, Kozor, Heeraj, Bulluck, James, Moon, Charlotte, Manisty, Sztajzel, Juan, Bertron, Fabienne, Papavassiliu, Theano, Oezkan, Sueheyla, Lossnitzer, Dirk, Schoenberg, Stefan O., Borggrefe, Martin, Doesch, Christina, Baig, S., Edwards, NC., Liu, B., Hayer, MK., Dawson, CH., Geberhiwot, T., Steeds, RP., Shehu, N., Stern, H., Mkrtchyan, N., Meierhofer, C., Martinoff, S., Ewert, P., Fratz, S., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, Aguiar, José, Vinco, Giulia, Fischer, Kady, Labelle, Chantal, Gelineau, Sylvie, Farkas, Sandra, Lebel, Julie, Friedrich, Matthias G., Webb, Jessica, Villa, Adriana, Bekri, Imane, Shome, Joy, Teall, Tom, Di Giovine, Gabriella, Sammut, Eva, Carr-White, Gerald, Al-Fakih, Khaled, Chiribiri, Amedeo, Kamphuis, Vivian P., Roest, Arno AW., Kroft, Lucia JM., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos JM., Elbaz, Mohammed SM., Bensaoud, M., Soufiani, A., Barahioui, H., Bayi, A., Fellat, N., Benjelloun, H., Tazi, Z., Abawi, Masieh, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Musa, TA., Uddin, A., Dobson, LE., Swoboa, PP., Garg, P., Fent, GJ., Foley, JRJ., Malkin, CJ., Plein, S., Blackman, DJ., Greenwood, JP., Yun, Chun-Ho, Bezerra, Hiram G., Richmond, C., Dobson, LE., Swoboda, PP., Musa, TA., Foley, JF., Garg, P., Haaf, P., Fent, GJ., Plein, S., Greenwood, JP., Meloni, Antonella, Gamberini, Maria Rita, Neri, Maria Giovanna, Cuccia, Liana, D'Ascola, Domenico Giuseppe, Tudisca, Chiara, Vinci, Valentina, Positano, Vincenzo, Pepe, Alessia, Meloni, Antonella, Borgna-Pignatti, Caterina, Del Vecchio, Giovanni Carlo, Romeo, Maria Antonietta, Gamberini, Maria Rita, Bonetti, Federico, Neri, Maria Giovanna, Missere, Massimiliano, Salvatori, Cristina, Pepe, Alessia, Dobson, LE., Musa, TA., Uddin, A., Fairbairn, TA., Bebb, OJ., Swoboda, PP., Haaf, P., Foley, J., Garg, P., Fent, GJ., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Schneeweis, C., Eckert, J., Tröbs, M., Magedanz, A., Schmidt, M., Voigtländer, T., Schmermund, A., Achenbach, S., Foley, JRJ., Dobson, LE., Musa, TA., Swoboda, PP., Garg, P., Fent, GF., Haaf, P., Malkin, CJ., Blackman, DJ., Plein, S., Greenwood, JP., Matthew, S., McCall, J. Weir, Gandy, S.J., Milne, W.G., Houston, J.G, Meloni, A., Ricchi, P., Spasiano, A., Neri, MG., Vallone, A., Resta, MC., Righi, R., Keilberg, P., Santamaria, V., Positano, V., Pepe, A., Henein, Michael Y., Bengrid, Tarek, Nicoll, Rachel, Zhao, Ying, Johansson, Bengt, Schmermund, Axel, Barbanti, Marco, Cascone, Irene, Miccichè, Eligio, Buccheri, Sergio, Immè, Sebastiano, Pilato, Gerlando, Tamburino, Claudia, Patanè, Martina, Gulino, Simona, Todaro, Denise, Salerno, Tatiana, Garretto, Valeria, Privitera, Gianbattista, Capodanno, Davide, Tamburino, Corrado, Manna, Alessio La, Vincenti, Gabriella, Masci, Pier-Giorgio, Rutz, Tobias, De Blois, Jonathan, Schwitter, Juerg, Monney, Pierre, Paelinck, Bernard P., Vandendriessche, Tom, De Bock, Dina, Parizel, Paul M., Rodrigus, Inez E., Claeys, Marc J., Leone, D., Tosello, F., Bruno, G., Avenatti, E., Faletti, R., Ravera, A, Veglio, F., Milan, A., Meloni, A., Maggio, A., Leto, F., Pitrolo, L., De Marchi, D., Positano, V., Neri, MG., Pepe, A., Pizzino, F., Meloni, A., Terrizzi, A., Aquaro, GD., Neri, MG., Spasiano, A., Serra, M., Allò, M., Keilberg, P., Positano, V., Di Bella, G., Zito, C., Pepe, A., Saunders, Laura, Stewart, Neil J., Hammerton, Charlotte, Capener, David, Puntmann, Valentina O, Graves, Martin J., Kiely, David G., Wild, Jim M., Swift, Andrew J., Macaione, F., Meloni, A., Barison, A., Neri, MG., Positano, V., Salvatore, N., Assennato, P., Pepe, A., Kammerlander, Andreas A., Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Duca, Franz, Knechtelsdorfer, Klaus, Wiesinger, Matthias, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Haberka, Maciej, Sosnowski, Maciej, Gasior, Zbigniew, Aslam, Sajid, El-Hamamsy, Ismail, SM, Francois-Pierre Mongeon, Bethke, Anne, Eritsland, Jan, Shanmuganathan, Limalanathan, Abdelnoor, Mikael, Andersen, Geir Øystein, Kløw, Nils Einar, Hoffmann, Pavel, Bouhzam, Najime, Caudron, Jérôme, Tron, Christophe, Camacho, Carlos Rodriguez, Cribier, Alain, Dacher, Jean Nicolas, Eltchaninoff, Hélène, Foley, JRJ., Garg, P., Musa, TA., Dobson, LE., Swoboda, PP., Fent, GJ., Haaf, P., Plein, S., Greenwood, JP., Heck, Siri Lagethon, Gulati, Geeta, Von Knobelsdorff-Brenkenhoff, Florian, Storas, Tryggve Holck, Schulz-Menger, Jeanette, Hoffmann, Pavel, Omland, Torbjørn, Kermer, J., Traber, J., Utz, W., Hennig, P., Menza, M., Jung, B., Greiser, A., Kuijer, J., Barckow, P., von Knobelsdorff-Brenkenhoff, F., Töpper, A., Schulz-Menger, J, Malanchini, Giovanni, Moscatelli, Sara, Di Giovine, Gabriella, Balzarini, Luca, Del Corral, Maria Pia, Gasparini, Gabriele, Montini, Orsola, Monti, Lorenzo, Aquaro, Giovanni Donato, Briatico, Alessandra, Toia, Patrizia, Barison, Andrea, Ait-Ali, Lamia, Midiri, Massimo, Cotroneo, Antonio Raffaele, Festa, Pierluigi, Aquaro, G.D., Pizzino, F., Terrizzi, A., Todiere, G., Grigoratos, C., Barison, A., Di Bella, G., Igual-Muñoz, Begoña, de Carranza, María Jose Sancho-Tello, Maceira-Gonzalez, Alicia, Buendía-Fuentes, Francisco, Estornell-Erill, Jordi, Cano-Perez, Oscar, Montero, Anastasio, Igual, Begoña, Sanz, Jorge, Maceira, Alicia, Miro, Vicente, Minguez, Ana Bel, Guillen, Manuel Perez, Lopez, Raquel, Vazquez, Alex, Diez, Jose Luis, rené, Oscar, sepúlveda, Pilar, argudo, Anastasio Montero, Roy, Clotilde, Slimani, Alisson, Amzulescu, Mihaela, de Ravenstein, Christophe de Meester, Pasquet, Agnès, Vancraeyenest, David, Vanoverschelde, Jean-Louis, Gerber, Bernhard, Pouleur, Anne-Catherine, Scatteia, Alessandra, Rodrigues, Jonathan, Lyen, Stephen, De Gerate, Estefania, Baritussio, Anna, Dastidar, Amardeep Ghosh, Maceira, Alicia, Pennell, Dudley, Bucciarelli-Ducci, Chiara, Katulska, Katarzyna, Kociemba, Anna, Rajewska-Tabor, Justyna, Janus, Magdalena, Siniawski, Andrzej, Stajgis, Marek, Pyda, Małgorzata, Brzostowicz, Tomasz, Brzostowicz, Marta, Gibbs, TGJ, Villa, AD, Sammut, E, Mullen, G, Ganeshan, B, Chiribir, A, Singh, Anvesha, McCann, Gerry P, Investigators, the PRIMID-AS, Le, Thu-Thao, Su, Boyang, Cai, Jiasheng, Han, Yiying, Tan, Ru San, Cook, Stuart A, Chin, Calvin WL, Scatteia, Alessandra, Vollema, E. Mara, Leung, Melissa, Marsan, Nina Ajmone, Baritussio, Anna, De Garate, Estefania, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Bax, Jeroen J, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Baritussio, A., De Garate, E., Dastidar, A. Ghosh, Ahmed, N., Scatteia, A., Rodrigues, J., Lawton, C., Thomas, Glyn, Duncan, Edward, Cripps, Tim, Diab, Ihab, Bucciarelli-Ducci, C., Treibel, TA., Fontana, M., Kozor, R., Macrae, R., Malcolmson, JW., Menacho, KD., Scully, PR., Lawrence, DR., Sheikh, AM., Herrey, AS., Manisty, C., Moon, JC., Hinojar, R., Golfin, C. Fernandez, Portugal, JC., Esteban, A., Megias, A., Gomez, A. Gonzalez, Rincon, LM., Nacher, JJ. Jimenez, Zamorano, JL., Valente, F., Gutierrez, L., Maldonado, G., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Allujas, MT., Evangelista, A., Garcia-Dorado, D., Rodriguez-Palomares, JF., Fratz, Sohrab, Belker, Kristina, Naumann, Susanne, Martinoff, Stefan, Stern, Heiko, Shehu, Nerejda, Mkrtchyan, Naira, Meierhofer, Christian, Eicken, Andreas, Ewert, Peter, Hilbert, Sebastian, Weber, Alexander, Oebel, Sabrina, Hindricks, Gerhard, Jahnke, Cosima, Paetsch, Ingo, van der Palen, RLF., Roest, AAW., van den Boogaard, PJ., Blom, NA., de Roos, A., Westenberg, JJM., Piatti, Filippo, Sturla, Francesco, Pirola, Selene, Votta, Emiliano, Nesteruk, Igor, Lombardi, Massimo, Corte, Alessandro Della, Bissell, Malenka, Caiani, Enrico Gianluca, Redaelli, Alberto, Berlot, B., Golfin, C. Fernandez, Hinojar, R., Esteban, A., Mendez, MA Fernandez, Megias, A., Gomez, A. Gonzalez, García, A., Alonso, G., Marco, A., Casas, E., Nacher, JJ. Jimenez, Zamorano, JL., Baggi, Chiara, Piatti, Filippo, Sturla, Francesco, Votta, Emiliano, Pluchinotta, Francesca, Lombardi, Massimo, Redaelli, Alberto, Hinojar, R., Golfin, C. Fernandez, Esteban, A., Mendez, MA Fernandez, Megias, A., Gonzalez Gomez, A., García, A., Alonso, G., Marco, A., Nacher, JJ. Jimenez, Zamorano, JL., McAlindon, Elisa, Dastidar, Amardeep, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Littlejohns, Ben, Suleiman, Saadeh, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, McAlindon, Elisa, Vizzi, Vincenzo, Baumbach, Andreas, Bucciarelli-Ducci, Chiara, Tanaka, Kaoru, Fierens, Yves, Nijs, Jan, De Mey, Johan, Lai, Peng, Raeymaekers, Hubert, Elbaz, Mohammed S.M., Toger, Johannes, Heiberg, Einar, Westenberg, Jos J., Solana, Ana Beatriz, Hafalir, Fatih, Ghedin, Piero, Lai, Peng, Shimakawa, A., Anja, C., Fratz, Sohrab, McGill, Laura-Ann, Ferreira, Pedro, Scott, Andrew D, Nielles-Vallespin, Sonia, Giannakidis, Archontis, J Kilner, Philip, Gatehouse, Peter D, de Silva, Ranil, Firmin, David N, Pennell, Dudley J, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, El-Mawardy, Mohamed, Abdel-Wahab, Mohamed, Richardt, Gert, Merten, Constanze, Beurich, Hans-Wilko, Zachow, Dirk, Abdel-Wahab, Mohamed, El-Mawardy, Mohamed, Tölg, Ralph, Richardt, Gert, De Garate, Estefania, Biglino, Giovanni, Aileen, Wilson, Dodd, James, Bucciarelli-Ducci, Chiara, Salinas, GL. Alonso, Gómez, A. González, Hinojar, R., Golfín, C. Fernández, Esteban, A., del Castillo, A. Marco, Monteagudo, J., Izco, M. Pascual, Megías, A., Martín, A. García, Nacher, JJ. Jiménez, Zamorano, JL, Dastidar, Amardeep Ghosh, Carpenter, Alexander, Rodrigues, Jonathan, Palazzuoli, Alberto, Wilson, Catherine, Kestenbaum, Samantha, Baritussio, Anna, Baumbach, Andreas, Nightingale, Angus, Bucciarelli-Ducci, Chiara, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Szantho, Gergely, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Lawton, Chris Benny, Erdei, Tamas, Manghat, Nathan, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, and Aguiar, José
- Abstract
Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.
- Published
- 2016
- Full Text
- View/download PDF
10. Abstracts
- Author
-
Doulaptsis, C, Masci, PG, Goetschalckx, K, Janssens, S, Bogaert, J, Ferreira, VM, Piechnik, SK, DallArmellina, E, Karamitsos, TD, Francis, JM, Ntusi, N, Holloway, C, Choudhury, RP, Kardos, A, Robson, MD, Friedrich, MG, Neubauer, S, Miszalski-Jamka, T, Sokolowska, B, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Malek, L, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Pedrotti, P, Masciocco, G, DAngelo, L, Milazzo, A, Quattrocchi, G, Zanotti, F, Frigerio, M, Roghi, A, Rimoldi, O, Kaasalainen, T, Kivistö, S, Holmström, M, Pakarinen, S, Hänninen, H, Sipilä, O, Lauerma, K, Banypersad, S.M, Fontana, M, Maestrini, V, Sado, D.M, Pinney, J, Wechalekar, A.D, Gillmore, J.D, Lachmann, H, Hawkins, P.N, Moon, J.C, Barone-Rochette, G, Pierard, S, Seldrum, S, de Ravensteen, CM, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Captur, G, Muthurangu, V, Flett, AS, Wilson, R, Barison, A, Anderson, S, Cook, C, Sado, DM, McKenna, WJ, Mohun, TJ, Elliott, PM, Moon, JC, Pepe, A, Meloni, A, Gulino, L, Rossi, G, Paci, C, Spasisno, A, keilberg, P, Restaino, G, Resta, MC, Positano, V, lombardi, M, Reiter, U, Reiter, G, Kovacs, G, Schmidt, A, Olschewski, H, Fuchsjäger, M, Macmillan, A, Dabir, D, Rogers, T, Monaghan, M, Nagel, E, Puntmann, V, Semaan, E, Spottiswoode, B, Freed, B, Carr, M, Wasielewski, M, Fortney-Campione, K, Shah, S, Carr, J, Markl, M, Collins, J, Sung, YM, Hinojar, R, Ucar, EA, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Dabir, D, Rogers, T, Ucar, EA, Kidambi, A, Plein, S, Gebker, R, Schnackenburg, B, Voigt, T, Schaeffter, T, Nagel, E, Puntmann, VO, McAlindon, E, Bucciarelli-Ducci, C, Sado, D, Maestrini, V, Piechnik, S, Porter, J, Yamamura, J, Fischer, R, Moon, J, Symons, R, Doulaptsis, C, Masci, P.G, Goetschalckx, K, Dymarkowski, S, Janssens, S, Bogaert, J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Reinstadler, SJ, Klug, G, Feistritzer, HJ, Mayr, A, Harrasser, B, Krauter, L, Mair, J, Schocke, MF, Pachinger, O, Metzler, B, Rigolli, M, To, A, Edwards, C, Ding, P, Christiansen, J, Rodríguez-Palomares, JF, Ortiz, JT, Bucciarelli, C, Lee, D, Wu, E, Bonow, RO, Karwat, K, Tomala, M, Miszalski-Jamka, K, Licholaj, S, Mazur, W, Kereiakes, DJ, Nessler, J, Zmudka, K, Jazwiec, P, Miszalski-Jamka, T, Peltonen, J, Kaasalainen, T, Kivistö, S, Holmström, M, Lauerma, K, Rutz, T, Meierhofer, C, Martinoff, S, Ewert, P, Hess, J, Stern, H, Fratz, S, Groarke, JD, Waller, AH, Blankstein, R, Kwong, RY, Steigner, M, Alizadeh, Z, Alizadeh, A, Khajali, Z, Mohammadzadeh, A, Kaykhavani, A, Heidarali, M, Singh, A, Bekele, S, Gunarathne, A, Khan, J, Nazir, SN, Steadman, CD, Kanagala, P, Horsfield, MA, McCann, GP, Duncan, RF, Dundon, BK, Nelson, AJ, Williams, K, Carbone, A, Worthley, MI, Zaman, A, Worthley, SG, Monney, P, Piccini, D, Rutz, T, Vincenti, G, Koestner, S, Stuber, M, Schwitter, J, Gripari, P, Maffessanti, F, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Caiani, EG, Pepi, M, El ghannudi, S, Nghiem, A, Germain, P, Jeung, M-J, Roy, C, Gangi, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Pöyhönen, P, Kivistö, S, Holmströn, M, Hänninen, H, Thorning, C, Bickelhaupt, S, Kampmann, C, Wentz, KU, Widmer, U, Juli, CF, Miszalski-Jamka, K, Klys, J, Glowacki, J, Kijas, M, Miszalski-Jamka, T, Adamczyk, T, Kwiecinski, R, Bogucka-Czapska, J, Ozaist, M, Mazur, W, Kluczewska, E, Kalarus, Z, Kukulski, T, Karakus, G, Marzluf, B, Bonderman, D, Tufaro, C, Pfaffenberger, S, Babyev, J, Maurer, G, Mascherbauer, J, Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, El-Husseini, W, Sikula, V, Segetova, M, Kautzner, J, Vasconcelos, M, Lebreiro, A, Martins, E, Cardoso, JS, Madureira, AJ, Ramos, I, Maciel, MJ, Florian, A, Ludwig, A, Rösch, S, Sechtem, U, Yilmaz, A, Monmeneu, J.V, López-Lereu, M.P, Bonanad, C, Sanchis, J, Chaustre, F, Merlos, P, Valero, E, Bodí, V, Chorro, F.J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Klug, G, Reinstadler, SJ, Feistritzer, HJ, Mayr, A, Riegler, N, Schocke, M, Esterhammer, R, Kremser, C, Pachinger, O, Metzler, B, Siddiqi, N, Cameron, D, Neil, C, Jagpal, B, Singh, S, Schwarz, K, Papadopoulou, S, Frenneaux, MP, Dawson, D, Robbers, LFHJ, Eerenberg, ES, Teunissen, PFA, Jansen, MF, Hollander, MR, Horrevoets, AJG, Knaapen, P, Nijveldt, R, Levi, MM, van Rossum, AC, Niessen, HWM, Marcu, CB, Beek, AM, van Royen, N, Everaars, H, Robbers, LFHJ, Nijveldt, R, Beek, AM, Teunissen, PFA, Hirsch, A, van Royen, N, Zijlstra, F, Piek, JJ, van Rossum, AC, Goitein, O, Grupper, A, Hamdan, A, Eshet, Y, Beigel, R, Medvedofsky, D, Herscovici, R, Konen, E, Hod, H, Matetzky, S, Cadenas, R, Iniesta, AM, Refoyo, E, Antorrena, I, Guzman, G, Cuesta, E, Salvador, O, López, T, Moreno, M, López-Sendon, JL, Alam, SR, Spath, N, Richards, J, Dweck, M, Shah, A, Lang, N, Semple, S, MacGillivray, T, Mckillop, G, Mirsadraee, S, Pessotto, R, Zamvar, V, Newby, DE, Henriksen, P, Reiter, G, Reiter, U, Kovacs, G, Olschewski, H, Fuchsjäger, M, Ahmad, S, Raza, U, Malik, A, Sun, JP, Eisner, R, Mazur, W, ODonnell, R, Positano, V, Meloni, A, Santarelli, MF, Landini, L, Tassi, C, Grimaldi, S, Gulino, L, De Marchi, D, Chiodi, E, Renne, S, Lombardi, M, Pepe, A, Wu, L, Germans, T, Güçlü, A, Allaart, CP, van Rossum, AC, Kalisz, K, Lehenbauer, K, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Shah, S, Markl, M, Flukiger, J, Carr, J, Collins, J, Osiak, A, Tyrankiewicz, U, Jablonska, M, Jasinski, K, Jochym, PT, Chlopicki), S, Skorka, T, Kalisz, K, Semaan, E, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, MP, Freed, B, Flukiger, J, Lee, D, Kansal, P, Shah, S, Markl, M, Carr, J, Collins, J, Groarke, JD, Shah, RV, Waller, AH, Abbasi, SA, Kwong, RY, Blankstein, R, Steigner, M, Chin, CWL, Semple, S, Malley, T, White, A, Prasad, S, Newby, DE, Dweck, M, Pepe, A, Meloni, A, Lai, ME, Vaquer, S, Gulino, L, De Marchi, D, Cuccia, L, Midiri, M, Vallone, A, Positano, V, Lombardi, M, Pedrotti, P, Milazzo, A, Quattrocchi, G, Roghi, A, Rimoldi, O, Barison, A, De Marchi, D, Masci, P, Milanesi, M, Aquaro, GD, Keilberg, P, Positano, V, Lombardi, M, Positano, Vincenzo, Barison, Andrea, Pugliese, Nicola Riccardo, Masci, Piergiorgio, Del Franco, Annamaria, Aquaro, Giovanni Donato, Landini, Luigi, Lombardi, Massimo, Dieringer, MA, Deimling, M, Fuchs, K, Winter, L, Kraus, O, Knobelsdorff-Brenkenhoff, FV, Schulz-Menger, J, Niendorf, T, Hinojar, R, Ucar, EA, DCruz, D, Sangle, S, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Sung, YM, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Gripari, P, Cortinovis, S, Loguercio, M, Baggiano, A, Conte, E, Pepi, M, El ghannudi, S, Hop, O, Germain, P, Jeung, M-J, De Cesare, A, Roy, C, Gangi, A, Barone-Rochette, G, Pierard, S, Seldrum, S, De Meester de Ravensteen, C, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Bekele, S, Singh, A, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Singh, A, Steadman, CD, Bekele, S, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Paelinck, BP, Vandendriessche, T, De Bock, D, De Maeyer, C, Parizel, PM, Christiaan, J, Trauzeddel, RF, Gelsinger, C, Butter, C, Barker, A, Markl, M, Schulz-Menger, J, von Knobelsdorff, F, Florian, A, Schäufele, T, Ludwig, A, Rösch, S, Wenzelburger, I, Yilmaz, A, Sechtem, U, López-Lereu, M.P, Bonanad, C, Monmeneu, J.V, Sanchís, J, Estornell, J, Igual, B, Maceira, A, Chorro, F.J, Focardi, M, Cameli, M, Bennati, E, Massoni, A, Solari, M, Carbone, F, Banchi, B, Mondillo, S, Miia, H, Kirsi, L, Helena, H, Tiina, H, Jyri, L, Pauli, P, Sari, K, Schumm, J, Greulich, S, Grün, S, Ong, P, Klingel, K, Kandolf, R, Sechtem, U, Mahrholdt, H, Raimondi, F, Ou, P, Boudjemline, Y, Bajolle, F, Iserin, F, Bonnet, D, Collins, J, Kalisz, K, Benefield, B, Sarnari, R, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Flukiger, J, Kansal, P, Lee, D, Shah, S, Markl, M, Carr, J, Sokolowska, B, Miszalski-Jamka, T, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Silva, G, Almeida, AG, Resende, C, Marques, JS, Silva, D, David, C, Amaro, C, Costa, P, Silva, JAP, Diogo, AN, Tsokolov, AV, Senchilo, VG, Vertelkin, AV, Hoffmann, P, Mykjåland, G, Wangberg, H, Tønnessen, T, Sjaastad, I, Nordsletten, L, Hjørnholm, U, Løset, A, Rostrup, M, Meloni, A, Gulino, L, Keilberg, P, Palazzi, G, Maddaloni, D, Ascioti, C, Missere, M, Salvatori, C, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Filosa, A, Gulino, L, Pulini, S, Salvatori, C, Chiodi, E, Ascioti, C, Keilberg, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Gulino, L, Pietrapertosa, A, Izzi, G, De Marchi, D, Valeri, G, Preziosi, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Ruffo, GB, Keilberg, P, Gulino, L, Gerardi, C, Sallustio, G, Tudisca, C, Positano, V, Lombardi, M, Pepe, A, Greulich, S, Backes, M, Schumm, J, Grün, S, Sechtem, U, Mahrholdt, H, Dorniak, K, MSc, AS, Szurowska, E, Fijalkowski, M, Rawicz-Zegrzda, D, Dudziak, M, Raczak, G, Hamdan, A, Baker, FA, Klein, M, Di Segni, E, Goitein, O, Fibisch, G, Konen, E, Müller-Bierl, B, Tanaka, K, Buls, N, Fierens, Y, van Cauteren, T, Willekens, I, van Laere, S, Luypaert, R, de Mey, J, Muzzarelli, S, Faragasso, E, Pedrazzini, G, Sürder, D, Pasotti, E, Moccetti, T, Faletra, F, Qayyum, AA, Hasbak, P, Larsson, HB, Mathiasen, AB, Vejlstrup, NG, Kjaer, A, Kastrup, J, Moschetti, K, Favre, D, Pinget, C, Pilz, G, Petersen, S, Wagner, A, Wasserfallen, JB, Schwitter, J, Ghosh Dastidar, A, Cengarle, M, McAlindon, E, Augustine, D, Nightingale, AK, Bucciarelli-Ducci, C, Dandekar, VK, Ertel, AW, Dickens, C, Gonzalez, RC, Farzaneh-Far, A, Ripley, DP, Higgins, D, McDiarmid, AK, Bainbridge, GJ, Uddin, A, Kidambi, A, Herzog, B, Greenwood, JP, Plein, S, Khanji, M, Newton, T, Westwood, M, Sekhri, N, and Petersen, SE
- Abstract
Background-Aims: Early post-infarction pericardial injury is a common finding but its diagnosis remains elusive. Though C-reactive protein (CRP) is considered a marker of myocardial damage, reflecting myocardial inflammation at the infarcted area, we sought to assess the relationship between CRP and pericardial injury depicted by cardiovascular magnetic resonance (CMR) imaging in patients with ST elevation myocardial infarction (MI). Methods and results: 181 MI patients (84% male) were studied with CMR in the first week and at 4 months post-infarction to assess infarct characteristics, left ventricular volumes/function and pericardial injury. The latter was defined as pericardial fluid >4mm and/or enhancement on late gadolinium enhancement CMR. The CRP-value at day 2 (according to previous literature) was used for correlation with CMR and clinical parameters. Pericardial injury was noted in 87 patients, i.e. effusion (n = 30), inflammation (n = 46), both (n = 11). Patients with pericardial injury had significantly higher peak values of cardiac biomarkers (p<0.001) and higher peak CRP-values than patients with normal pericardium (median 13 vs 43 mg/dl, p<0.001). A strong correlation was found between peak CRP-values and a) left venticular ejection fraction and infarct size both at 1 week and 4 months, b) myocardial hemorrhage, microvascular obstruction (MVO) and pericardial injury at 1 week, c) cardiac biomarkers values and time to PCI. However in a multiple regression model only pericardial injury (p = 0.003) and less importantly time to PCI (p = 0.022) were the independent predictors of CRP values. Conclusion: Pericardial damage described by cardiac MRI occurs often after acute ST elevation MI. CRP-values at the acute phase of MI reflect not only inflammation at the infarcted area but even more the inflammation of the surrounding pericardial tissue.
Table 1 Comparison of baseline clinical and biochemical parameters of patients with or without evidence of early post-infarct pericardial damage on CMR Normal Group (n = 94) Pericardial injury group (n = 87) p-value Agem, years 59±11 60±12 0.48 Male, n(%) 83 (88) 69 (79) 0.10 Diabets, n(%) 12 (13) 9 (10) 0.61 Smoker, n(%) 52 (55) 44 (51) 0.52 Hyperlipidemia, n(%) 56 (60) 55 (63) 0.62 BSA m2 2.0 ± 0.2 2.0 ± 0.2 0.20 Time to PCI, min 195 (155 − 274) 223 (160 − 335) 0.20 Troponin I, μ/l 44 (19 − 92) 90 (44 − 149) >0.001 CK-MB, U/L 128 (77 − 216) 250 (143 − 443) >0.001 CRP, mg/dL 13 (7 − 28) 43 (16 − 96) >0.001 Day of peak CRP 2 (1 − 3) 2 (1 − 3) 0.39 Table 2 Significant correlations between CRP Values and corresponding CMR measurements, cardic biomarkers and clinical related parameters Varibles Spearmanscorrelations r p-value CMR parameters 1 week LV EF −0.28 >0,001 Infractsize(%ofLV) 0.40 >0,001 Microvasular obstruction 0.27 >0,001 Hemorrhage 0.33 >0,001 Size of area atrisk 0.31 >0,001 Transmurality 0.30 >0,001 Pericaldial damage 0.43 >0,001 CMR parameters 4 months LVEF −0.43 >0,001 Infarctsize(%ofLV) 0.46 >0,001 Cardiac Biomarkers Peak TnI 0.34 >0,001 Peak CK-MB 0.32 >0,001 Other Time to PCI 0,182 0,007 - Published
- 2013
- Full Text
- View/download PDF
11. Glucose Homeostasis, Pancreatic Endocrine Function, and Outcomes in Advanced Heart Failure.
- Author
-
Melenovsky V, Benes J, Franekova J, Kovar J, Borlaug BA, Segetova M, Tura A, and Pelikanova T
- Subjects
- Aged, Biomarkers blood, Cachexia blood, Cachexia diagnosis, Cachexia physiopathology, Case-Control Studies, Female, Glucose Tolerance Test, Heart Failure diagnosis, Heart Failure physiopathology, Homeostasis, Humans, Insulin blood, Islets of Langerhans physiopathology, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Risk Factors, Severity of Illness Index, Time Factors, Ventricular Dysfunction, Right blood, Ventricular Dysfunction, Right diagnosis, Ventricular Dysfunction, Right physiopathology, Ventricular Function, Right, Blood Glucose metabolism, Glucagon blood, Heart Failure blood, Islets of Langerhans metabolism
- Abstract
Background: The mechanisms and relevance of impaired glucose homeostasis in advanced heart failure (HF) are poorly understood. The study goals were to examine glucose regulation, pancreatic endocrine function, and metabolic factors related to prognosis in patients with nondiabetic advanced HF., Methods and Results: In total, 140 advanced HF patients without known diabetes mellitus and 21 sex-, age-, and body mass index-matched controls underwent body composition assessment, oral glucose tolerance testing, and measurement of glucose-regulating hormones to model pancreatic β-cell secretory response. Compared with controls, HF patients had similar fasting glucose and insulin levels but higher levels after oral glucose tolerance testing. Insulin secretion was not impaired, but with increasing HF severity, there was a reduction in glucose, insulin, and insulin/glucagon ratio-a signature of starvation. The insulin/C-peptide ratio was decreased in HF, indicating enhanced insulin clearance, and this was correlated with lower cardiac output, hepatic insufficiency, right ventricular dysfunction, and body wasting. After a median of 449 days, 41% of patients experienced an adverse event (death, urgent transplant, or assist device). Increased glucagon and, paradoxically, low fasting plasma glucose displayed the strongest relations to outcome ( P =0.01). Patients in the lowest quartile of fasting plasma glucose (3.8-5.1 mmol·L
-1 , 68-101 mg·dL-1 ) had 3-times higher event risk than in the top quartile (6.0-7.9 mmol·L-1 , 108-142 mg·dL-1 ; relative risk: 3.05 [95% confidence interval, 1.46-6.77]; P =0.002)., Conclusions: Low fasting plasma glucose and increased glucagon are robust metabolic predictors of adverse events in advanced HF. Pancreatic insulin secretion is preserved in advanced HF, but levels decrease with increasing HF severity due to enhanced insulin clearance that is coupled with right heart failure and cardiac cachexia., (© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.)- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.