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1. The MOST Hosts Survey: spectroscopic observation of the host galaxies of ~40,000 transients using DESI

Author

Soumagnac, Maayane T., Nugent, Peter, Knop, Robert A., Ho, Anna Y. Q., Hohensee, William, Awbrey, Autumn, Andersen, Alexis, Aldering, Greg, Ventura, Matan, Aguilar, Jessica N., Ahlen, Steven, Benzvi, Segev Y., Brooks, David, Brout, Dillon, Claybaugh, Todd, Davis, Tamara M., Dawson, Kyle, de la Macorra, Axel, Dey, Arjun, Dey, Biprateep, Doel, Peter, Douglass, Kelly A., Forero-Romero, Jaime E., Gaztanaga, Enrique, Gontcho, Satya Gontcho A, Graur, Or, Guy, Julien, Hahn, ChangHoon, Honscheid, Klaus, Howlett, Cullan, Kim, Alex G., Kisner, Theodore, Kremin, Anthony, Lambert, Andrew, Landriau, Martin, Lang, Dustin, Guillou, Laurent Le, Manera, Marc, Meisner, Aaron, Miquel, Ramon, Moustakas, John, Myers, Adam D., Nie, Jundan, Palmese, Antonella, Parkinson, David, Poppett, Claire, Prada, Francisco, Qin, Fei, Rezaie, Mehdi, Rossi, Graziano, Sanchez, Eusebio, Schlegel, David D., Schubnell, Michael, Silber, Joseph H., Tarle, Gregory, Weaver, Benjamin A., and Zhou, Zhimin

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present the MOST Hosts survey (Multi-Object Spectroscopy of Transient Hosts). The survey is planned to run throughout the five years of operation of the Dark Energy Spectroscopic Instrument (DESI) and will generate a spectroscopic catalog of the hosts of most transients observed to date, in particular all the supernovae observed by most public, untargeted, wide-field, optical surveys (PTF/iPTF, SDSS II, ZTF, DECAT, DESIRT). Scientific questions for which the MOST Hosts survey will be useful include Type Ia supernova cosmology, fundamental plane and peculiar velocity measurements, and the understanding of the correlations between transients and their host galaxy properties. Here, we present the first release of the MOST Hosts survey: 21,931 hosts of 20,235 transients. These numbers represent 36% of the final MOST Hosts sample, consisting of 60,212 potential host galaxies of 38,603 transients (a transient can be assigned multiple potential hosts). Of these galaxies, 40% do not appear in the DESI primary target list and therefore require a specific program like MOST Hosts. Of all the transients in the MOST Hosts list, only 26.7% have existing classifications, and so the survey will provide redshifts (and luminosities) for nearly 30,000 transients. A preliminary Hubble diagram and a transient luminosity-duration diagram are shown as examples of future potential uses of the MOST Hosts survey. The survey will also provide a training sample of spectroscopically observed transients for photometry-only classifiers, as we enter an era when most newly observed transients will lack spectroscopic classification. The MOST Hosts DESI survey data will be released through the Wiserep platform on a rolling cadence and updated to match the DESI releases. Dates of future releases and updates are available through the https://mosthosts.desi.lbl.gov website., Comment: Submitted to ApJS

Published
2024

2. Overall survival in patients with endometrial cancer treated with dostarlimab plus carboplatin–paclitaxel in the randomized ENGOT-EN6/GOG-3031/RUBY trial

Author

Powell, M.A., Bjørge, L., Willmott, L., Novák, Z., Black, D., Gilbert, L., Sharma, S., Valabrega, G., Landrum, L.M., Gropp-Meier, M., Stuckey, A., Boere, I., Gold, M.A., Segev, Y., Gill, S.E., Gennigens, C., Sebastianelli, A., Shahin, M.S., Pothuri, B., Monk, B.J., Buscema, J., Coleman, R.L., Slomovitz, B.M., Ring, K.L., Herzog, T.J., Balas, M.M., Grimshaw, M., Stevens, S., Lai, D.W., McCourt, C., and Mirza, M.R.

Published
2024
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5. Overview of the DESI Legacy Imaging Surveys

Author

Dey, Arjun, Schlegel, David J., Lang, Dustin, Blum, Robert, Burleigh, Kaylan, Fan, Xiaohui, Findlay, Joseph R., Finkbeiner, Doug, Herrera, David, Juneau, Stephanie, Landriau, Martin, Levi, Michael, McGreer, Ian, Meisner, Aaron, Myers, Adam D., Moustakas, John, Nugent, Peter, Patej, Anna, Schlafly, Edward F., Walker, Alistair R., Valdes, Francisco, Weaver, Benjamin A., Zou, Christophe Yeche Hu, Zhou, Xu, Abareshi, Behzad, Abbott, T. M. C., Abolfathi, Bela, Aguilera, C., Alam, Shadab, Allen, Lori, Alvarez, A., Annis, James, Ansarinejad, Behzad, Aubert, Marie, Beechert, Jacqueline, Bell, Eric F., BenZvi, Segev Y., Beutler, Florian, Bielby, Richard M., Bolton, Adam S., Buckley-Geer, Cesar Briceno Elizabeth J., Butler, Karen, Calamida, Annalisa, Carlberg, Raymond G., Carter, Paul, Casas, Ricard, Castander, Francisco J., Choi, Yumi, Comparat, Johan, Cukanovaite, Elena, Delubac, Timothee, DeVries, Kaitlin, Dey, Sharmila, Dhungana, Govinda, Dickinson, Mark, Ding, Zhejie, Donaldson, John B., Duan, Yutong, Duckworth, Christopher J., Eftekharzadeh, Sarah, Eisenstein, Daniel J., Etourneau, Thomas, Fagrelius, Parker A., Farihi, Jay, Fitzpatrick, Mike, Font-Ribera, Andreu, Fulmer, Leah, Gansicke, Boris T., Gaztanaga, Enrique, George, Koshy, Gerdes, David W., Gontcho, Satya Gontcho A, Gorgoni, Claudio, Green, Gregory, Guy, Julien, Harmer, Diane, Hernandez, M., Honscheid, Klaus, Lijuan, Huang, James, David, Jannuzi, Buell T., Jiang, Linhua, Joyce, Richard, Karcher, Armin, Karkar, Sonia, Kehoe, Robert, Kneib, Jean-Paul, Kueter-Young, Andrea, Lan, Ting-Wen, Lauer, Tod, Guillou, Laurent Le, Van Suu, Auguste Le, Lee, Jae Hyeon, Lesser, Michael, Levasseur, Laurence Perreault, Li, Ting S., Mann, Justin L., Marshall, Bob, Martinez-Vazquez, C. E., Martini, Paul, Bourboux, Helion du Mas des, McManus, Sean, Meier, Tobias Gabriel, Menard, Brice, Metcalfe, Nigel, Munoz-Gutierrez, Andrea, Najita, Joan, Napier, Kevin, Narayan, Gautham, Newman, Jeffrey A., Nie, Jundan, Nord, Brian, Norman, Dara J., Olsen, Knut A. G., Paat, Anthony, Palanque-Delabrouille, Nathalie, Peng, Xiyan, Poppett, Claire L., Poremba, Megan R., Prakash, Abhishek, Rabinowitz, David, Raichoor, Anand, Rezaie, Mehdi, Robertson, A. N., Roe, Natalie A., Ross, Ashley J., Ross, Nicholas P., Rudnick, Gregory, Safonova, Sasha, Saha, Abhijit, Sanchez, F. Javier, Savary, Elodie, Schweiker, Heidi, Scott, Adam, Seo, Hee-Jong, Shan, Huanyuan, Silva, David R., Slepian, Zachary, Soto, Christian, Sprayberry, David, Staten, Ryan, Stillman, Coley M., Stupak, Robert J., Summers, David L., Tie, Suk Sien, Tirado, H., Vargas-Magana, Mariana, Vivas, A. Katherina, Wechsler, Risa H., Williams, Doug, Yang, Jinyi, Yang, Qian, Yapici, Tolga, Zaritsky, Dennis, Zenteno, A., Zhang, Kai, Zhang, Tianmeng, Zhou, Rongpu, and Zhou, Zhimin

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The DESI Legacy Imaging Surveys are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing-Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image approximately 14,000 deg^2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12 and 22 micorons) observed by the Wide-field Infrared Survey Explorer (WISE) satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project., Comment: 47 pages, 18 figures; accepted for publication in the Astronomical Journal

Published
2018
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6. Overview of the DESI Legacy Imaging Surveys

Author

Dey, Arjun, Schlegel, David J, Lang, Dustin, Blum, Robert, Burleigh, Kaylan, Fan, Xiaohui, Findlay, Joseph R, Finkbeiner, Doug, Herrera, David, Juneau, Stéphanie, Landriau, Martin, Levi, Michael, McGreer, Ian, Meisner, Aaron, Myers, Adam D, Moustakas, John, Nugent, Peter, Patej, Anna, Schlafly, Edward F, Walker, Alistair R, Valdes, Francisco, Weaver, Benjamin A, Yèche, Christophe, Zou, Hu, Zhou, Xu, Abareshi, Behzad, Abbott, TMC, Abolfathi, Bela, Aguilera, C, Alam, Shadab, Allen, Lori, Alvarez, A, Annis, James, Ansarinejad, Behzad, Aubert, Marie, Beechert, Jacqueline, Bell, Eric F, BenZvi, Segev Y, Beutler, Florian, Bielby, Richard M, Bolton, Adam S, Briceño, César, Buckley-Geer, Elizabeth J, Butler, Karen, Calamida, Annalisa, Carlberg, Raymond G, Carter, Paul, Casas, Ricard, Castander, Francisco J, Choi, Yumi, Comparat, Johan, Cukanovaite, Elena, Delubac, Timothée, DeVries, Kaitlin, Dey, Sharmila, Dhungana, Govinda, Dickinson, Mark, Ding, Zhejie, Donaldson, John B, Duan, Yutong, Duckworth, Christopher J, Eftekharzadeh, Sarah, Eisenstein, Daniel J, Etourneau, Thomas, Fagrelius, Parker A, Farihi, Jay, Fitzpatrick, Mike, Font-Ribera, Andreu, Fulmer, Leah, Gänsicke, Boris T, Gaztanaga, Enrique, George, Koshy, Gerdes, David W, Gontcho, Satya Gontcho A, Gorgoni, Claudio, Green, Gregory, Guy, Julien, Harmer, Diane, Hernandez, M, Honscheid, Klaus, Huang, Lijuan, James, David J, Jannuzi, Buell T, Jiang, Linhua, Joyce, Richard, Karcher, Armin, Karkar, Sonia, Kehoe, Robert, Jean-Paul, Kneib, Kueter-Young, Andrea, Lan, Ting-Wen, Lauer, Tod R, Le Guillou, Laurent, Le Van Suu, Auguste, Lee, Jae Hyeon, Lesser, Michael, Levasseur, Laurence Perreault, Li, Ting S, Mann, Justin L, and Marshall, Robert

Subjects
Space Sciences, Physical Sciences, catalogs, surveys, astro-ph.IM, Astronomical and Space Sciences, Astronomy & Astrophysics, Astronomical sciences, Particle and high energy physics
Abstract

The DESI Legacy Imaging Surveys (http://legacysurvey.org/) are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing-Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image ≈14,000 deg2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12, and 22 μm) observed by the Wide-field Infrared Survey Explorer satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project.

Published
2019

7. Collaborative experience between scientific software projects using Agile Scrum development.

Author

Amanda L. Baxter, Segev Y. BenZvi, Walter Bonivento, Adam Brazier, Michael Clark, Alexis Coleiro, David Collom, Marta Colomer-Molla, Bryce Cousins, Aliwen Delgado Orellana, Damien Dornic, Vladislav Ekimtcov, Shereen ElSayed, Andrea Gallo Rosso, Patrick Godwin, Spencer Griswold, Alec Habig, Remington Hill, Shunsaku Horiuchi, D. Andrew Howell, Margaret W. G. Johnson, Mario Juric, James P. Kneller, Abigail Kopec, Claudio Kopper, Vladimir Kulikovskiy, Mathieu Lamoureux, Rafael F. Lang, Shengchao Li, Massimiliano Lincetto, Lindy Lindstrom, Mark W. Linvill, Curtis McCully, Jost Migenda, Danny Milisavljevic, Spencer Nelson, Rita Novoseltseva, Erin O'Sullivan, Donald Petravick, Barry W. Pointon, Nirmal Raj, Andrew Renshaw, Janet Rumleskie, Tom Sonley, Ron Tapia, Jeffrey C. L. Tseng, Christopher D. Tunnell, Godefroy Vannoye, Carlo F. Vigorito, Clarence J. Virtue, Christopher Weaver, Kathryn E. Weil, Lindley Winslow, Rich Wolski, Xun-Jie Xu, and Yiyang Xu

Published
2022
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8. Miyamoto involutions in axial algebras of Jordan type half

Author

Hall, J. I., Segev, Y., and Shpectorov, S.

Subjects
Mathematics - Group Theory, Mathematics - Rings and Algebras, Primary: 17A99, Secondary: 17C99, 17B69
Abstract

Nonassociative commutative algebras $A$ generated by idempotents $e$ whose adjoint operators ${\rm ad}_e\colon A \rightarrow A$, given by $x \mapsto xe$, are diagonalizable and have few eigenvalues are of recent interest. When certain fusion (multiplication) rules between the associated eigenspaces are imposed, the structure of these algebras remains rich yet rather rigid. For example vertex operator algebras give rise to such algebras. The connection between the Monster algebra and Monster group extends to many axial algebras which then have interesting groups of automorphisms. Axial algebras of Jordan type $\eta$ are commutative algebras generated by idempotents whose adjoint operators have a minimal polynomial dividing $(x-1)x(x-\eta)$, where $\eta \notin \{0,1\}$ is fixed, with well-defined and restrictive fusion rules. The case of $\eta \neq \frac{1}{2}$ was thoroughly analyzed by Hall, Rehren, and Shpectorov in a recent paper, in which axial algebras were introduced. Here we focus on the case where $\eta=\frac{1}{2}$, which is much less understood and is of a different nature., Comment: 40 pages

Published
2016

9. A New Maximum-Likelihood Technique for Reconstructing Cosmic-Ray Anisotropy at All Angular Scales

Author

Ahlers, Markus, BenZvi, Segev Y., Desiati, Paolo, Díaz-Vélez, Juan Carlos, Fiorino, Daniel W., and Westerhoff, Stefan

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The arrival directions of TeV-PeV cosmic rays show weak but significant anisotropies with relative intensities at the level of one per mille. Due to the smallness of the anisotropies, quantitative studies require careful disentanglement of detector effects from the observation. We discuss an iterative maximum-likelihood reconstruction that simultaneously fits cosmic ray anisotropies and detector acceptance. The method does not rely on detector simulations and provides an optimal anisotropy reconstruction for ground-based cosmic ray observatories located in the middle latitudes. It is particularly well suited to the recovery of the dipole anisotropy, which is a crucial observable for the study of cosmic ray diffusion in our Galaxy. We also provide general analysis methods for recovering large- and small-scale anisotropies that take into account systematic effects of the observation by ground-based detectors., Comment: version published in The Astrophysical Journal, Volume 823, Number 1

Published
2016
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10. Scanning superconducting quantum interference device on a tip for magnetic imaging of nanoscale phenomena

Author

Finkler, A., Vasyukov, D., Segev, Y., Ne'eman, L., Lachman, E. O., Rappaport, M. L., Myasoedov, Y., Zeldov, E., and Huber, M. E.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We describe a new type of scanning probe microscope based on a superconducting quantum interference device (SQUID) that resides on the apex of a sharp tip. The SQUID-on-tip is glued to a quartz tuning fork which allows scanning at a tip-sample separation of a few nm. The magnetic flux sensitivity of the SQUID is 1.8 {\mu}_0/Hz^{1/2} and the spatial resolution is about 200 nm, which can be further improved. This combination of high sensitivity, spatial resolution, bandwidth, and the very close proximity to the sample provides a powerful tool for study of dynamic magnetic phenomena on the nanoscale. The potential of the SQUID-on-tip microscope is demonstrated by imaging of the vortex lattice and of the local AC magnetic response in superconductors., Comment: 10 figures

Published
2012
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11. Mott insulator phases and first-order melting in BSCCO crystals with periodic surface holes

Author

Goldberg, S., Segev, Y., Myasoedov, Y., Gutman, I., Avraham, N., Rappaport, M., Zeldov, E., Tamegai, T., Hicks, C. W., and Moler, K. A.

Subjects
Condensed Matter - Superconductivity
Abstract

We measured the effects of periodic surface holes, created using a focused ion beam, on the phase diagram of the vortex matter in high-T_c Bi_2Sr_2CaCu_2O_{8+\delta} crystals. Differential magneto-optical measurements show that the irreversibility line is shifted to higher fields and temperatures, with respect to the pristine melting line. The irreversibility line displays weak field dependence between integer matching fields indicating multiple-flux-quanta pinning at holes. We find reduced equilibrium compressibility of the vortex matter at integer matching fields, which is strong evidence for the existence of thermodynamic Mott insulator phases. Shaking with a transverse ac field surprisingly reveals first-order melting that is not shifted with respect to the pristine melting line and that seems to occur within the Mott insulator regions. This melting is understood to be the first-order transition in the bulk of the crystal beneath the surface holes. The transition is visible at the surface, despite the reduced vortex compressibility in the top layer., Comment: 11 pages, 8 figures. To appear in Physical Review B

Published
2009
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12. Agile Scrum Development in an ad hoc Software Collaboration.

Author

Amanda L. Baxter, Segev Y. BenZvi, Walter Bonivento, Adam Brazier, Michael Clark, Alexis Coleiro, David Collom, Marta Colomer-Molla, Bryce Cousins, Aliwen Delgado Orellana, Damien Dornic, Vladislav Ekimtcov, Shereen ElSayed, Andrea Gallo Rosso, Patrick Godwin, Spencer Griswold, Alec Habig, Shunsaku Horiuchi, D. Andrew Howell, Margaret W. G. Johnson, Mario Juric, James P. Kneller, Abigail Kopec, Claudio Kopper, V. Kulikovskiy, Mathieu Lamoureux, Rafael F. Lang, Shengchao Li, Massimiliano Lincetto, W. Lindstrom, Mark W. Linvill, Curtis McCully, Jost Migenda, Danny Milisavljevic, Spencer Nelson, Rita Novoseltseva, Erin O'Sullivan, Donald Petravick, Barry W. Pointon, Nirmal Raj, Andrew Renshaw, Janet Rumleskie, Ron Tapia, Jeffrey C. L. Tseng, Christopher D. Tunnell, Carlo F. Vigorito, Clarence J. Virtue, Christopher Weaver, Lindley Winslow, Richard Wolski, Xun-Jie Xu, and Yiyang Xu

Published
2021

16. Clear cell carcinoma of the endometrium

Author

Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Enomoto, T, Takehara, K, Denys, H, Lorusso, D, Coleman, R, Vaughan, M, Takano, M, Provencher, D, Sagae, S, Wimberger, P, Poka, R, Segev, Y, Kim, S, Kim, J, Candido dos Reis, F, Mariani, A, Leitao, M, Makker, V, Rustum, N, Vergote, I, Zannoni, G, Tan, D, Mccormack, M, Bini, M, Lopez, S, Raspagliesi, F, Panici, P, di Donato, V, Muzii, L, Colombo, N, Scambia, G, Pignata, S, Monk, B, Bogani G., Ray-Coquard I., Concin N., Ngoi N. Y. L., Morice P., Enomoto T., Takehara K., Denys H., Lorusso D., Coleman R., Vaughan M. M., Takano M., Provencher D., Sagae S., Wimberger P., Poka R., Segev Y., Kim S. I., Kim J. -W., Candido dos Reis F. J., Mariani A., Leitao M. M., Makker V., Rustum N. A., Vergote I., Zannoni G. F., Tan D. S. P., McCormack M., Bini M., Lopez S., Raspagliesi F., Panici P. B., di Donato V., Muzii L., Colombo N., Scambia G., Pignata S., Monk B. J., Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Enomoto, T, Takehara, K, Denys, H, Lorusso, D, Coleman, R, Vaughan, M, Takano, M, Provencher, D, Sagae, S, Wimberger, P, Poka, R, Segev, Y, Kim, S, Kim, J, Candido dos Reis, F, Mariani, A, Leitao, M, Makker, V, Rustum, N, Vergote, I, Zannoni, G, Tan, D, Mccormack, M, Bini, M, Lopez, S, Raspagliesi, F, Panici, P, di Donato, V, Muzii, L, Colombo, N, Scambia, G, Pignata, S, Monk, B, Bogani G., Ray-Coquard I., Concin N., Ngoi N. Y. L., Morice P., Enomoto T., Takehara K., Denys H., Lorusso D., Coleman R., Vaughan M. M., Takano M., Provencher D., Sagae S., Wimberger P., Poka R., Segev Y., Kim S. I., Kim J. -W., Candido dos Reis F. J., Mariani A., Leitao M. M., Makker V., Rustum N. A., Vergote I., Zannoni G. F., Tan D. S. P., McCormack M., Bini M., Lopez S., Raspagliesi F., Panici P. B., di Donato V., Muzii L., Colombo N., Scambia G., Pignata S., and Monk B. J.

Abstract

Clear cell endometrial carcinoma represents an uncommon and poorly understood entity. Data from molecular/genomic profiling highlighted the importance of various signatures in assessing the prognosis of endometrial cancer according to four classes of risk (POLE mutated, MMRd, NSMP, and p53 abnormal). Unfortunately, data specific to clear cell histological subtype endometrial cancer are lacking. More recently, data has emerged to suggest that most of the patients (more than 80%) with clear cell endometrial carcinoma are characterized by p53 abnormality or NSMP type. This classification has important therapeutic implications. Although it is an uncommon entity, clear cell endometrial cancer patients with POLE mutation seem characterized by a good prognosis. Chemotherapy is effective in patients with NSMP (especially in stage III and IV) and patients with p53 abnormal disease (all stages). While, preliminary data suggested that patients with MMRd are less likely to benefit from chemotherapy. The latter group appears to benefit much more from immune checkpoint inhibitors: recent data from clinical trials on pembrolizumab plus lenvatinib and nivolumab plus cabozantinib supported that immunotherapy plus tyrosine kinase inhibitors (TKI) would be the most appropriate treatment for recurrent non-endometrioid endometrial cancer (including clear cell carcinoma) after the failure of platinum-based chemotherapy. Moreover, ongoing clinical trials testing the anti-tumor activity of innovative products will clarify the better strategies for advanced/recurrent clear cell endometrial carcinoma. Further prospective evidence is urgently needed to better characterize clear cell endometrial carcinoma.

Published
2022

17. Endometrial carcinosarcoma

Author

Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Caruso, G, Enomoto, T, Takehara, K, Denys, H, Lorusso, D, Coleman, R, Vaughan, M, Takano, M, Provencher, D, Sagae, S, Wimberger, P, Póka, R, Segev, Y, Kim, S, Kim, J, Candido Dos Reis, F, Ramirez, P, Mariani, A, Leitao, M, Makker, V, Abu-Rustum, N, Vergote, I, Zannoni, G, Tan, D, Mccormack, M, Paolini, B, Bini, M, Raspagliesi, F, Benedetti Panici, P, Di Donato, V, Muzii, L, Colombo, N, Pignata, S, Scambia, G, Monk, B, Bogani, Giorgio, Ray-Coquard, Isabelle, Concin, Nicole, Ngoi, Natalie Yan Li, Morice, Philippe, Caruso, Giuseppe, Enomoto, Takayuki, Takehara, Kazuhiro, Denys, Hannelore, Lorusso, Domenica, Coleman, Robert, Vaughan, Michelle M, Takano, Masashi, Provencher, Diane Michele, Sagae, Satoru, Wimberger, Pauline, Póka, Robert, Segev, Yakir, Kim, Se Ik, Kim, Jae-Weon, Candido Dos Reis, Francisco Jose, Ramirez, Pedro T, Mariani, Andrea, Leitao, Mario, Makker, Vicky, Abu-Rustum, Nadeem R, Vergote, Ignace, Zannoni, Gianfranco, Tan, David, McCormack, Mary, Paolini, Biagio, Bini, Marta, Raspagliesi, Francesco, Benedetti Panici, Pierluigi, Di Donato, Violante, Muzii, Ludovico, Colombo, Nicoletta, Pignata, Sandro, Scambia, Giovanni, Monk, Bradley J, Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Caruso, G, Enomoto, T, Takehara, K, Denys, H, Lorusso, D, Coleman, R, Vaughan, M, Takano, M, Provencher, D, Sagae, S, Wimberger, P, Póka, R, Segev, Y, Kim, S, Kim, J, Candido Dos Reis, F, Ramirez, P, Mariani, A, Leitao, M, Makker, V, Abu-Rustum, N, Vergote, I, Zannoni, G, Tan, D, Mccormack, M, Paolini, B, Bini, M, Raspagliesi, F, Benedetti Panici, P, Di Donato, V, Muzii, L, Colombo, N, Pignata, S, Scambia, G, Monk, B, Bogani, Giorgio, Ray-Coquard, Isabelle, Concin, Nicole, Ngoi, Natalie Yan Li, Morice, Philippe, Caruso, Giuseppe, Enomoto, Takayuki, Takehara, Kazuhiro, Denys, Hannelore, Lorusso, Domenica, Coleman, Robert, Vaughan, Michelle M, Takano, Masashi, Provencher, Diane Michele, Sagae, Satoru, Wimberger, Pauline, Póka, Robert, Segev, Yakir, Kim, Se Ik, Kim, Jae-Weon, Candido Dos Reis, Francisco Jose, Ramirez, Pedro T, Mariani, Andrea, Leitao, Mario, Makker, Vicky, Abu-Rustum, Nadeem R, Vergote, Ignace, Zannoni, Gianfranco, Tan, David, McCormack, Mary, Paolini, Biagio, Bini, Marta, Raspagliesi, Francesco, Benedetti Panici, Pierluigi, Di Donato, Violante, Muzii, Ludovico, Colombo, Nicoletta, Pignata, Sandro, Scambia, Giovanni, and Monk, Bradley J

Abstract

Endometrial carcinosarcoma is a rare and aggressive high-grade endometrial carcinoma with secondary sarcomatous trans-differentiation (conversion theory). The clinical presentation and diagnostic work-up roughly align with those of the more common endometrioid counterpart, although endometrial carcinosarcoma is more frequently diagnosed at an advanced stage. Endometrial carcinosarcoma is not a single entity but encompasses different histological subtypes, depending on the type of carcinomatous and sarcomatous elements. The majority of endometrial carcinosarcomas are characterized by p53 abnormalities. The proportion of POLE and microsatellite instablity-high (MSI-H) is directly related to the epithelial component, being approximately 25% and 3% in endometrioid and non-endometrioid components.The management of non-metastatic disease is based on a multimodal approach with optimal surgery followed by (concomitant or sequential) chemotherapy and radiotherapy, even for early stages. Palliative chemotherapy is recommended in the metastatic or recurrent setting, with carboplatin/paclitaxel doublet being the first-line regimen. Although the introduction of immunotherapy plus/minus a tyrosine kinase inhibitor shifted the paradigm of treatment of patients with recurrent endometrial cancer, patients with endometrial carcinosarcoma were excluded from most studies evaluating single-agent immunotherapy or the combination. However, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved the use of pembrolizumab and lenvatinib in endometrial cancer (all histotypes) after progression on chemotherapy and single-agent immunotherapy in MSI-H cancers. In the era of precision medicine, emerging knowledge on molecular endometrial carcinosarcoma is opening new promising therapeutic options for more personalized treatment. The present review outlines state-of-the-art knowledge and future directions for patients with endometrial carcinosarcoma.

Published
2023

18. SNEWPY: A Data Pipeline from Supernova Simulations to Neutrino Signals.

Author

Amanda L. Baxter, Segev Y. BenZvi, Joahan Jaimes, Alexis Coleiro, Marta Molla, Damien Dornic, Spencer Griswold, Tomer Goldhagen, Anne Graf, Alec Habig, Remington Hill, Shunsaku Horiuchi, James P. Kneller, Mathieu Lamoureux, Rafael F. Lang, Massimiliano Lincetto, Jost Migenda, McKenzie Myers, Evan O'Connor, Andrew Renshaw, Kate Scholberg, Andrey Sheshukov, Jeff Tseng, Christopher D. Tunnell, Navya Uberoi, and Arkin Worlikar

Published
2021
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20. 731P Post-progression survival outcomes in patients (pts) with primary advanced or recurrent endometrial cancer (pA/rEC) in the ENGOT-EN6-NSGO/GOG-3031/RUBY trial who received follow-up immunotherapy

Author

Mirza, M.R., Mathews, C., Gilbert, L., Bjorge, L., Ring, K., Pishchyk, M.M., Pennington, K., Segev, Y., Powell, M.A., Van Gorp, T., Bender, D., Schneider, K., Miller, R., Armstrong, A., Canturia, G., Gogoi, R., Antony, G., Stevens, S., Valabrega, G., and Landrum, L.M.

Published
2024
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21. Uterine serous carcinoma

Author

Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Enomoto, T, Takehara, K, Denys, H, Nout, R, Lorusso, D, Vaughan, M, Bini, M, Takano, M, Provencher, D, Indini, A, Sagae, S, Wimberger, P, Poka, R, Segev, Y, Kim, S, Candido dos Reis, F, Lopez, S, Mariani, A, Leitao, M, Raspagliesi, F, Panici, P, Di Donato, V, Muzii, L, Colombo, N, Scambia, G, Pignata, S, Monk, B, Bogani G., Ray-Coquard I., Concin N., Ngoi N. Y. L., Morice P., Enomoto T., Takehara K., Denys H., Nout R. A., Lorusso D., Vaughan M. M., Bini M., Takano M., Provencher D., Indini A., Sagae S., Wimberger P., Poka R., Segev Y., Kim S. I., Candido dos Reis F. J., Lopez S., Mariani A., Leitao M. M., Raspagliesi F., Panici P. B., Di Donato V., Muzii L., Colombo N., Scambia G., Pignata S., Monk B. J., Bogani, G, Ray-Coquard, I, Concin, N, Ngoi, N, Morice, P, Enomoto, T, Takehara, K, Denys, H, Nout, R, Lorusso, D, Vaughan, M, Bini, M, Takano, M, Provencher, D, Indini, A, Sagae, S, Wimberger, P, Poka, R, Segev, Y, Kim, S, Candido dos Reis, F, Lopez, S, Mariani, A, Leitao, M, Raspagliesi, F, Panici, P, Di Donato, V, Muzii, L, Colombo, N, Scambia, G, Pignata, S, Monk, B, Bogani G., Ray-Coquard I., Concin N., Ngoi N. Y. L., Morice P., Enomoto T., Takehara K., Denys H., Nout R. A., Lorusso D., Vaughan M. M., Bini M., Takano M., Provencher D., Indini A., Sagae S., Wimberger P., Poka R., Segev Y., Kim S. I., Candido dos Reis F. J., Lopez S., Mariani A., Leitao M. M., Raspagliesi F., Panici P. B., Di Donato V., Muzii L., Colombo N., Scambia G., Pignata S., and Monk B. J.

Abstract

Serous endometrial cancer represents a relative rare entity accounting for about 10% of all diagnosed endometrial cancer, but it is responsible for 40% of endometrial cancer-related deaths. Patients with serous endometrial cancer are often diagnosed at earlier disease stage, but remain at higher risk of recurrence and poorer prognosis when compared stage-for-stage with endometrioid subtype endometrial cancer. Serous endometrial cancers are characterized by marked nuclear atypia and abnormal p53 staining in immunohistochemistry. The mainstay of treatment for newly diagnosed serous endometrial cancer includes a multi-modal therapy with surgery, chemotherapy and/or radiotherapy. Unfortunately, despite these efforts, survival outcomes still remain poor. Recently, The Cancer Genome Atlas (TCGA) Research Network classified all endometrial cancer types into four categories, of which, serous endometrial cancer mostly is found within the “copy number high” group. This group is characterized by the increased cell cycle deregulation (e.g., CCNE1, MYC, PPP2R1A, PIKCA, ERBB2 and CDKN2A) and TP53 mutations (90%). To date, the combination of pembrolizumab and lenvatinib is an effective treatment modality in second-line therapy, with a response rate of 50% in advanced/recurrent serous endometrial cancer. Owing to the unfavorable outcomes of serous endometrial cancer, clinical trials are a priority. At present, ongoing studies are testing novel combinations of various targeted and immunotherapeutic agents in newly diagnosed and advanced/recurrent endometrial cancer - an important strategy for serous endometrial cancer, whereby tumors are usually p53+ and pMMR, making response to PD-1 inhibitor monotherapy unlikely. Here, the rare tumor working group (including members from the European Society of Gynecologic Oncology (ESGO), Gynecologic Cancer Intergroup (GCIG), and Japanese Gynecologic Oncology Group (JGOG)), performed a narrative review reporting on the current landscape of serous

Published
2021

23. Collaborative experience between scientific software projects using Agile Scrum development

Author

Baxter, Amanda L., BenZvi, Segev Y., Bonivento, Walter, Brazier, Adam, Clark, Michael, Coleiro, Alexis, Collom, David, Colomer-Molla, Marta, Cousins, Bryce, Orellana, Aliwen Delgado, Dornic, Damien, Ekimtcov, Vladislav, ElSayed, Shereen, Rosso, Andrea Gallo, Godwin, Patrick, Griswold, Spencer, Habig, Alec, Hill, Remington, Horiuchi, Shunsaku, Howell, D. Andrew, Johnson, Margaret W. G., Kneller, James P., Kopec, Abigail, Kopper, Claudio, Kulikovskiy, Vladimir, Lamoureux, Mathieu, Lang, Rafael F., Li, Shengchao, Lincetto, Massimiliano, Lindstrom, Lindy, Linvill, Mark W., McCully, Curtis, Migenda, Jost, Milisavljevic, Danny, Nelson, Spencer, Novoseltseva, Rita, O'Sullivan, Erin, Petravick, Donald, Pointon, Barry W., Raj, Nirmal, Renshaw, Andrew, Rumleskie, Janet, Sonley, Tom, Tapia, Ron, Tseng, Jeffrey C. L., Tunnell, Christopher D., Vannoye, Godefroy, Vigorito, Carlo F., Virtue, Clarence J., Weaver, Christopher, Weil, Kathryn E., Winslow, Lindley, Wolski, Rich, Xu, Xun-Jie, Xu, Yiyang, Baxter, Amanda L., BenZvi, Segev Y., Bonivento, Walter, Brazier, Adam, Clark, Michael, Coleiro, Alexis, Collom, David, Colomer-Molla, Marta, Cousins, Bryce, Orellana, Aliwen Delgado, Dornic, Damien, Ekimtcov, Vladislav, ElSayed, Shereen, Rosso, Andrea Gallo, Godwin, Patrick, Griswold, Spencer, Habig, Alec, Hill, Remington, Horiuchi, Shunsaku, Howell, D. Andrew, Johnson, Margaret W. G., Kneller, James P., Kopec, Abigail, Kopper, Claudio, Kulikovskiy, Vladimir, Lamoureux, Mathieu, Lang, Rafael F., Li, Shengchao, Lincetto, Massimiliano, Lindstrom, Lindy, Linvill, Mark W., McCully, Curtis, Migenda, Jost, Milisavljevic, Danny, Nelson, Spencer, Novoseltseva, Rita, O'Sullivan, Erin, Petravick, Donald, Pointon, Barry W., Raj, Nirmal, Renshaw, Andrew, Rumleskie, Janet, Sonley, Tom, Tapia, Ron, Tseng, Jeffrey C. L., Tunnell, Christopher D., Vannoye, Godefroy, Vigorito, Carlo F., Virtue, Clarence J., Weaver, Christopher, Weil, Kathryn E., Winslow, Lindley, Wolski, Rich, Xu, Xun-Jie, and Xu, Yiyang

Abstract

Developing sustainable software for the scientific community requires expertise in software engineering and domain science. This can be challenging due to the unique needs of scientific software, the insufficient resources for software engineering practices in the scientific community, and the complexity of developing for evolving scientific contexts. While open-source software can partially address these concerns, it can introduce complicating dependencies and delay development. These issues can be reduced if scientists and software developers collaborate. We present a case study wherein scientists from the SuperNova Early Warning System collaborated with software developers from the Scalable Cyberinfrastructure for Multi-Messenger Astrophysics project. The collaboration addressed the difficulties of open-source software development, but presented additional risks to each team. For the scientists, there was a concern of relying on external systems and lacking control in the development process. For the developers, there was a risk in supporting a user-group while maintaining core development. These issues were mitigated by creating a second Agile Scrum framework in parallel with the developers' ongoing Agile Scrum process. This Agile collaboration promoted communication, ensured that the scientists had an active role in development, and allowed the developers to evaluate and implement the scientists' software requirements. The collaboration provided benefits for each group: the scientists actuated their development by using an existing platform, and the developers utilized the scientists' use-case to improve their systems. This case study suggests that scientists and software developers can avoid scientific computing issues by collaborating and that Agile Scrum methods can address emergent concerns.

Published
2022
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47. Dielectric Relaxation of Hydration Water in Native Collagen Fibrils

Author

Kurzweil-Segev Y., Popov I., Solomonov I., Sagit I., and Feldman Y.

Abstract

© 2017 American Chemical Society. The dielectric relaxation of hydrated collagen powders was studied over a wide temperature and frequency range. We revealed two mechanisms of dielectric relaxation in hydration water that are driven by the migration of ionic and orientation defects. At high water fractions in powders (h > 0.2), the hydration shell around the collagen triple helixes presents a spatial H-bonded network consisting of structural water bridges and cleft water channels. These two water phases provide the long-range paths for proton hopping and orientation defect migration. At low water fractions (h < 0.2) and in the hydrated collagen samples after the dehydrothermal treatment, the hydration shell presents localized individual water compartments not connected to one another. In these cases, the relaxation mechanism due to proton hopping either disappears or becomes inhibited by the orientation defect migration.

Published
2017

48. Confined water dynamics in a hydrated photosynthetic pigment-protein complex

Author

Kurzweil-Segev Y., Popov I., Eisenberg I., Yochelis S., Keren N., Paltiel Y., and Feldman Y.

Subjects
macromolecular substances
Abstract

© This journal is the Owner Societies. Water is of fundamental importance for life. It plays a critical role in all biological systems. In p hycocyanin, a pigment-protein complex, the hydration level influences its absorption spectrum. However, there is currently a gap in the understanding of how protein interfaces affect water's structure and properties. This work presents combined dielectric and calorimetric measurements of hydrated phycocyanin with different levels of hydration in a broad temperature interval. Based on the dielectric and calorimetric tests, it was shown that two types of water exist in the phycocyanin hydration shell. One is confined water localized inside the phycocyanin ring and the second is the water that is embedded in the protein structure and participates in the protein solvation. The water confined in the phycocyanin ring melts at the temperature 195 ± 3 K and plays a role in the solvation at higher temperatures. Moreover, the dynamics of all types of water was found to be effected by the presence of the ionic buffer.

Published
2017

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