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7. Efficacy of long‐term treatment with efinaconazole 10% solution in patients with onychomycosis, including severe cases: A multicenter, single‐arm study

Author

Iozumi, Ken, primary, Abe, Masatoshi, additional, Ito, Yoshiko, additional, Uesugi, Takashi, additional, Onoduka, Takashi, additional, Kato, Ichiro, additional, Kato, Fumihiro, additional, Kodama, Kazuo, additional, Takahashi, Hidetoshi, additional, Takeda, Osamu, additional, Tomizawa, Koki, additional, Nomiyama, Tomoko, additional, Fujii, Mizue, additional, Mayama, Jun, additional, Muramoto, Fumio, additional, Yasuda, Hidemi, additional, Yamanaka, Kiyomitsu, additional, Sato, Tomotaka, additional, Oh‐i, Tsunao, additional, Kasai, Hiroko, additional, Tsuboi, Ryoji, additional, Hattori, Naoko, additional, Maruyama, Ryuji, additional, Omi, Tokuya, additional, Shimoyama, Harunari, additional, Sei, Yoshihiro, additional, Nakasu, Ichiro, additional, Nishimoto, Shuhei, additional, Hata, Yasuki, additional, Mochizuki, Takashi, additional, Fukuzawa, Masao, additional, Seishima, Mariko, additional, Sugiura, Kazumitsu, additional, Katayama, Ichiro, additional, Yamamoto, Osamu, additional, Shindo, Masahisa, additional, Kiryu, Hiroe, additional, Kusuhara, Masahiro, additional, Takenaka, Motoi, additional, and Watanabe, Shinichi, additional

Published
2019
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11. National Trends in the Distribution of Candida Species Causing Candidemia in Japan from 2003 to 2014

Author

Kakeya, Hiroshi, primary, Yamada, Koichi, additional, Kaneko, Yukihiro, additional, Yanagihara, Katsunori, additional, Tateda, Kazuhiro, additional, Maesaki, Shigefumi, additional, Takesue, Yoshio, additional, Tomono, Kazunori, additional, Kadota, Jun-ichi, additional, Kaku, Mitsuo, additional, Miyazaki, Yoshitsugu, additional, Kamei, Katsuhiko, additional, Shibuya, Kazutoshi, additional, Niki, Yoshitiho, additional, Yoshida, Minoru, additional, and Sei, Yoshihiro, additional

Published
2018
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12. Epidemiological survey of onychomycosis pathogens in Japan by real-time PCR.

Author

Shimoyama, Harunari, Satoh, Kazuo, Makimura, Koichi, and Sei, Yoshihiro

Abstract

In Japan, an epidemiological survey of onychomycosis pathogens was performed using culture methods; however, the positive culture rate was 40% or less. As part of an epidemiological survey of dermatomycoses in Japan, we overcame this low positive rate by employing a real-time polymerase chain reaction (PCR) assay that allowed rapid and accurate detection and identification. In 2011, nail specimens were collected from patients at nine institutes in various prefectures in Japan and diagnosed as onychomycosis. For the detection and identification of the main pathogens causing onychomycosis, we performed real-time PCR using specific TaqMan® MGB probes and primer sets. Of the 496 onychomycosis samples, real-time PCR detected 382 cases (77.0%) caused by Trichophyton rubrum ; 74 cases (15.0%) caused by Trichophyton interdigitale ; and eight cases (1.6%) caused by Candida albicans. The real-time PCR positive rate was 96.2%. The most frequent pathogen was T. rubrum throughout life, with the number of patients affected peaking in the range of 60 to 69 years of age and no significant differences in the composition of causative pathogens by sex. We were able to detect and identify pathogens from almost all specimens and succeeded in analyzing the pathogens involved in onychomycosis cases in Japan. These data confirmed that our real-time PCR method was effective for detecting and identifying the main fungal pathogens from onychomycosis specimens. [ABSTRACT FROM AUTHOR]

Published
2019
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17. 2011年次皮膚真菌症疫学調査報告.

Author

Sei Yoshihiro

Abstract

An epidemiological survey of dermatomycoses and their causative fungus flora in Japan for 2011 was conducted in accordance with methods and criteria of the past four surveys. The survey covered a total number of 36,052 outpatients who visited 12 dermatological clinics throughout Japan. The results were as follows. 1）Dermatophytosis was the most prevalent cutaneous fungal infection (2,980 cases) seen in these clinics, followed by candidiasis (378 cases) and then Malassezia infections (152 cases). 2）Among dermatophytoses, tinea pedis was the most frequent (1,930 cases : male, 980 ; female, 950), then in decreasing order, tinea unguium (780 cases : male, 409 ; female, 371), tinea corporis (203 cases : male, 132 ; female, 71), tinea cruris (112 cases : male, 86 ; female, 26), tinea manuum (43 cases : male, 25 ; female, 18), and tinea capitis including kerion (16 cases : male, 13 ; female, 3). 3）Tinea pedis and tinea unguium were seen to increase in the summer season and occur mostly among the aged population. Compared to the last survey, by clinical form, there was a marked decrease in dermatophytosis patients. 4）As the causative dermatophyte species, Trichophyton rubrum was the most frequently isolated at about 80 % among all dermatophyte infections excluding tinea capitis. T. mentagrophytes was about 10 %. Microsporum canis was isolated in five cases. M. gypseum was isolated in three cases, and Epidermophyton floccosum was isolated in only one case. T. tonsurans was isolated in 13 cases. 5）Cutaneous candidiasis was seen in 378 cases (305, male ; 537, female). Intertrigo (298 cases) was the most frequent clinical form, followed by diaporcandidiasis (79 cases), erosion interdigitalis (62 cases), genital candidiasis (46 cases). 6）Tinea versicolor was seen in 97 cases. Malassezia folliculitis was isolated in 55 cases. [ABSTRACT FROM AUTHOR]

Published
2015
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42. Comparison of the Nuclear Contour Index (NCI) and T cell Subsets of Erythematous, Plaque and Tumor Lesions in Patients with Mycosis Fungoides (MF)

Author

Hantanyapong, Yaowalak, Iwahara, Kunio, Zhuan, Kung Guo, Yaguchi, Hitoshi, Nakajima, Sumino, Ogawa, Hideoki, Sei, Yoshihiro, and Takiuchi, Iwao

Abstract

Using monoclonal T cell antibodies, we compared T cell subsets of skin infiltrates with the nuclear contour index (NCI) of pan T cells of skin infiltrates from erythematous, plaque and tumor lesions in the same patients with mycosis fungoides (MF). In all lesions, the majority of the skin‐infiltrate population were T cells; helper T cells were especially dominant in the plaque and tumor lesions. The NCI of the T cells in skin infiltrates increased in parallel with advancing stages of the lesions in the same patient. The NCI data for T cell and T cell subsets in different stages of lesions in the same patient were similar to data from different stages of lesions in different patients. Therefore, even in tumor stage patients, topical treatment should be selected in accordance with the cytological stage of their lesions.

Published
1987
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44. IMMUNOLOGICAL STUDIES OF AN EXTRACELLULAR KERATINASE

Author

Takiuchi, Iwao, Higuchi, Dousei, Sei, Yoshihiro, and Koga, Miho

Abstract

The extracellular keratinase from M. caniswas purified using ion exchange chromatography and gel filtration. The purified enzyme showed a single protein band on sodium dodecyl sulfate‐polyacrilamide gel electrophoresis. A molecular weight of approximately 45,000 was determined by SDS‐electrophoresis.

Published
1983
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