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1. Activity limitation and social participation restriction among leprosy patients in Boru Meda Hospital, Amhara Region, Ethiopia.

Author

Seid Getahun Abdela, Saskia van Henten, Seid Hassen Abegaz, Fentaw Bialfew Bayuh, Feleke Tilahun Zewdu, Fentaw Tadese Berhe, and Johan van Griensven

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BackgroundAlthough Ethiopia eliminated leprosy as public health problem 20 years ago, still more than 3000 new cases are reported annually. Leprosy related disability affects patients' day to day physical activities and their participation in social activities. Assessing the degree of activity limitation and social participation is recommended to show disability and assess the efficacy of rehabilitation efforts.Methodology and principal findingA hospital based cross sectional study was conducted among a total of 305 leprosy patients. Data were collected by face to face interview using Screening of Activity Limitation and Safety Awareness (SALSA) scale and participation scale. The analysis was done with SPSS version 25. Descriptive statistics was done and then binary logistic regression was used to identify factors associated with activity limitation as well as participation limitation. Most patients (219, 71.8%) had activity limitation; 41 (13.4%) with severe and 25 (8.2%) with extreme limitations. More than half of patients (168, 55.1%) were suffering from participation restriction; with 43 (14.1%) having severe restriction and 30 (9.8%) extreme restriction. Older age, low educational status, distance from treatment center, time of treatment and higher Eye, Hand, Foot disability score were associated with activity limitation. Similarly, older age, low educational status and being unmarried were significantly associated with participation restriction.ConclusionThis study revealed that activity limitation and participation restriction are common among leprosy patients. Earlier diagnosis and improved rehabilitative services may help to decrease activity limitation, whereas community rehabilitation may improve social participation. The old and centralized leprosy rehabilitation services need to be decentralized and backed with modern equipment and trained staffs.

Published
2020
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2. Clinical Profile and Treatment of COVID-19 Patients: Experiences from an Ethiopian Treatment Center

Author

Koku Sisay Tamirat, Seid Hassen Abegaz, Seid Getahun Abdela, Wondmagegn Demsiss, Saskia van Henten, and Johan van Griensven

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Fever, Context (language use), Asymptomatic, Young Adult, Acquired immunodeficiency syndrome (AIDS), Interquartile range, Virology, Internal medicine, Case fatality rate, Medicine, Humans, Retrospective Studies, business.industry, SARS-CoV-2, Medical record, COVID-19, Disease Management, Articles, Middle Aged, medicine.disease, Hospitals, COVID-19 Drug Treatment, Treatment center, Infectious Diseases, Cough, Parasitology, Female, Ethiopia, medicine.symptom, business
Abstract

COVID-19 is not well studied in Africa. Understanding the clinical profile and management of COVID-19 will help to plan better prevention and treatment strategies taking the local context into consideration. In this study, we described the clinical profile, treatment used, and outcomes of COVID-19 patients in one of the COVID-19 treatment centers of Ethiopia, Boru Meda Hospital. An institution-based retrospective cross-sectional study was carried out using medical records of COVID-19 patients who were admitted to Boru Meda Hospital with a positive reverse transcription (RT)-PCR result from May 9, 2020 to September 20, 2020. All patients with a positive RT-PCR were admitted to the hospital, regardless of symptom and severity status. A total of 279 COVID-19 patients were included in the final analysis. The median age of patients was 28 years (interquartile range 23–40). The majority (69.5%) were male. Around a quarter (n = 73; 26.2%) of the patients were symptomatic, of which cough (n = 49; 67.1%) and fever (n = 32; 43.8%) were common symptoms. Among symptomatic patients, 48 (65.8%) were mild, four (5.5%) moderate, 12 (16.4%) severe, and nine (12.3%) were critical. The case fatality rate was 2.1%. Hypertension, age older than 25 years, and HIV/AIDS were significantly associated with symptomatic infection. In this study, most of the COVID-19 patients were asymptomatic. However, the proportion of severe and critical patients among those with symptoms was high. More studies are needed to assess the effect of HIV/AIDS on the severity and mortality of COVID-19.

Published
2020

3. Antibiotic Overuse for COVID-19: Are We Adding Insult to Injury?

Author

Seid Hassen Abegaz, Dereje Bedanie Hundie, Laurens Liesenborghs, Wendemaegn Embiale, Johan van Griensven, Zewdu Hurissa, Etsegenet Arega Asmamaw, Abdene Weya Kaso, Samuel Hunegnaw, Abreham Eshetu Mamo, Seid Getahun Abdela, Gebi Agero, Fentaw Bialfew Bayuh, Saskia van Henten, Tamiru Asefa Mebratie, Fentaw Tadese, and Maraki Assefa Mebrate

Subjects
Adult, Male, medicine.medical_specialty, Microbiological culture, medicine.drug_class, Antibiotics, Cohort Studies, Antimicrobial Stewardship, Interquartile range, Virology, Internal medicine, medicine, Antimicrobial stewardship, Humans, Retrospective Studies, medicine.diagnostic_test, business.industry, SARS-CoV-2, Medical record, Retrospective cohort study, Articles, Bacterial Infections, Middle Aged, Anti-Bacterial Agents, COVID-19 Drug Treatment, Infectious Diseases, Erythrocyte sedimentation rate, Superinfection, Practice Guidelines as Topic, Parasitology, Female, Viral disease, Ethiopia, business
Abstract

In this study, we described the proportion of COVID-19 patients started on antibiotics empirically and the work-ups performed to diagnose bacterial superinfection. We used a retrospective cohort study design involving medical records of symptomatic, hospitalized COVID-19 patients who were admitted to these centers. A total of 481 patients were included, with a median age of 41.0 years (interquartile range, 28-58.5 years). A total of 72.1% (N = 347) of COVID-19 patients received antibiotics, either before or during admission. This is troublesome because none of the patients' bacterial culture or inflammatory markers, such as the erythrocyte sedimentation rate or C-reactive protein, were evaluated, and only 73 (15.2%) underwent radiological investigations. Therefore, national COVID-19 guidelines should emphasize the rational use of antibiotics for the treatment of COVID-19, a primarily viral disease. Integrating antimicrobial stewardship into the COVID-19 response and expanding microbiological capacities in low-income countries are indispensable. Otherwise, we risk one pandemic aggravating another. ispartof: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE vol:105 issue:6 pages:1519-1520 ispartof: location:United States status: published

Published
2021

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