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143 results on '"Seifi, Morteza"'

4. 52. ClinGen Pediatric Cancer Taskforce initiatives to advance pediatric clinical interpretations through expert curation

Author

Saliba, Jason, primary, Corson, Laura B., additional, Lever, Jake, additional, Golem, Shivani, additional, Satgunaseelan, Laveniya, additional, Meredith, David M., additional, Grisdale, Cameron J., additional, Krysiak, Kilannin, additional, Evans, Mark G., additional, Luo, Minjie, additional, Sukhanova, Madina, additional, Mathew, Mariam T., additional, Seifi, Morteza, additional, Williams, Heather E., additional, Yap, Kai Lee, additional, Akesson, Lauren, additional, Kanagal-Shamanna, Rashmi, additional, Ji, Jianling, additional, Fakim, Yasmina Jaufeerally, additional, Danos, Arpad, additional, Akkari, Yassmine, additional, Parsons, D. Williams, additional, Schriml, Lynn, additional, Wagner, Alex H., additional, Griffith, Obi L., additional, Griffith, Malachi, additional, Roy, Angshumoy, additional, and Raca, Gordana, additional

Published
2023
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5. 16. ClinGen Cancer Variant Interpretation (CVI) Committee: Pilot guidance for somatic cancer variant curation expert panels

Author

Ritter, Deborah, primary, Duncavage, Eric, additional, Elvin, Julia, additional, Frampton, Garrett, additional, Pavlick, Dean, additional, Griffith, Obi, additional, Griffith, Malachi, additional, Janeway, Katherine, additional, Lively, Tracy, additional, Macconaill, Laura, additional, McCoy, Matthew, additional, Meric-Bernstam, Funda, additional, Merker, Jason, additional, Mullighan, Charles G., additional, Parsons, Donald (Will), additional, Patel, Keyur, additional, Raca, Gordana, additional, Ramos, Erin, additional, Rosenbaum, Jason, additional, Roy, Somak, additional, Roy, Angshumoy, additional, Seifi, Morteza, additional, Sonkin, Dmitriy, additional, Wagner, Alex, additional, Warner, Jeremy, additional, Plon, Sharon, additional, Li, Marilyn, additional, and Kulkarni, Shashikant, additional

Published
2023
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11. Bioengineering of fibroblast‐conditioned polycaprolactone/gelatin electrospun scaffold for skin tissue engineering

Author

Yazdanpanah, Ayna, primary, Madjd, Zahra, additional, Pezeshki‐Modaress, Mohamad, additional, Khosrowpour, Zahra, additional, Farshi, Paniz, additional, Eini, Leila, additional, Kiani, Jafar, additional, Seifi, Morteza, additional, Kundu, Subhas C., additional, Ghods, Roya, additional, and Gholipourmalekabadi, Mazaher, additional

Published
2022
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14. Overview of Real-Time PCR Principles

Author

Seifi, Morteza, primary, Ghasemi, Asghar, additional, Heidarzadeh, Siamak, additional, Khosravi, Mahmood, additional, Namipashaki, Atefeh, additional, Mehri, Vahid, additional, Alizadeh, Ali, additional, and Danaei, Nasim, additional

Published
2012
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20. Exposure to ambient air pollution and risk of childhood cancers: A population-based study in Tehran, Iran

Author

Seifi, Morteza, Niaziesfyani, Sadegh, Johnson, Graham, Nodehi, Vahideh, Yunesian, Masud, Seifi, Morteza, Niaziesfyani, Sadegh, Johnson, Graham, Nodehi, Vahideh, and Yunesian, Masud

Abstract

The relationship between air pollution and childhood cancer is inconclusive. We investigated the associations between exposure to ambient air pollution and childhood cancers in Tehran, Iran. This project included children between 1 and 15 years-of-age with a cancer diagnosis by the Center for the Control of Non Communicable Disease (n = 161) during 2007 to 2009. Controls were selected randomly within the city using a Geographic Information System (GIS) (n = 761). The cases were geocoded based on exact home addresses. Air pollution exposure of cases and random controls were estimated by a previously developed Land Use Regression (LUR) model for the 2010 calendar year. The annual mean concentrations of Particulate Matter ≤ 10 μm (PM10), nitrogen dioxide (NO2) and sulfur dioxide (SO2) in the locations of cancer cases were 101.97 μg/m3, 49.42 ppb and 38.92 ppb respectively, while in the random control group, respective mean exposures were 98.63 μg/m3, 45.98 ppb and 38.95 ppb. A logistic regression model was used to find the probability of childhood cancer per unit increase in PM10, NO2 and SO2. We observed a positive association between exposures to PM10 with childhood cancers. We did, however, observe a positive, but not statistically significant association between NO2 exposure and childhood cancer. Our study is the first to highlight an association between air pollution exposure and childhood cancer risk in Iran, however these findings require replication through future studies.

Published
2019

38. Personalized Gene Expression Analyses of SMAD7 and KLF10 In Breast Cancer

Author

Hosseinzadeh, Ali, primary, Feizi, Mohammad Ali Hosseinpour, additional, Kafil, Hossein Samadi, additional, Pouladi, Nasser, additional, Seifi, Morteza, additional, Gavgani, Reyhaneh Ravanbakhsh, additional, Nadergoli, Omid Kheyri, additional, Rostamizadeh, Leila, additional, Montazeri, Vahid, additional, Fakhrjou, Ashraf, additional, and Sakhinia, Ebrahim, additional

Published
2016
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39. Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy.

Author

Mehrabi, Soraya, Sanadgol, Nima, Barati, Mahmood, Shahbazi, Ali, Vahabzadeh, Gelareh, Barzroudi, Mitra, Seifi, Morteza, Gholipourmalekabadi, Mazaher, and Golab, Fereshteh

Subjects
TEMPORAL lobe epilepsy, KETOGENIC diet, EPILEPSY, CARRIER proteins, JAK-STAT pathway
Abstract

Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy that sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we have investigated the effects of metformin in the rat pilocaroin model of TLE. Male rats were treated with intra peritoneal injection of pilocarpine hydrochloride, in dose of 360 mg/kg to induce status epilepticus (SE). At 45 day after induction of SE, metformin was injected intraperitoneally in dose of 250 mg/kg/day for 5 days. We show that metformin potently reduces the progression of seizures and blocks seizure-induced over-expression of brain-derived neurotropic factor (BDNF) and its receptor, Tropomyosin receptor kinase B (TrkB). We have shown that this reduced expression pattern is mediated by the transcriptional co-repressor CtBP (C-terminal binding protein). Moreover, metformin decreased mechanistic target of rapamycin (mTOR) activation through activation of AMP-activated protein kinase (AMPK) signaling pathway. Our findings have been shown that metformin has anticonvulsant and antiepileptic properties, and suggesting that antiglycolytic compounds such as metformin may represent a new class of drugs for treating epilepsy. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Characteristics, distribution and sources of polychlorinated biphenyls (PCBs) in coastal sediments from the heavily industrialized area of Asalouyeh, Iran.

Author

Dobaradaran, Sina, Arfaeinia, Hossein, Asadgol, Zahra, Seifi, Morteza, Ahmadi, Ehsan, and Moradi, Masoud

Subjects
POLYCHLORINATED biphenyls, MARINE sediments, WATER pollution, INDUSTRIAL waste & the environment
Abstract

In this research, the levels of polychlorinated biphenyls (PCBs) were investigated in the marine sediments of Asaluyeh harbor, in the Persian Gulf. The samples were taken from industrial, semi-industrial and urban regions. The mean concentration levels of total (Σ) 18 detected PCBs were 514.32, 144.67 and 31.6 pg/g dw for the industrial, semi-industrial and urban sampling stations, respectively. Based on a multivariate statistical analysis, it was found that high contamination levels of PCBs in sediments collected along the Persian Gulf were associated with releases from local industries. Total organic carbon (TOC) content was significantly and positively correlated with the concentrations of PCB congeners. World Health Organization toxic equivalents (TEQs) for PCBs ranged from 0.04 to 2.66 pg TEQ/g dry weight (dw) in the coastal sediments. The TEQ values in this study were higher than many reported worldwide in the literature for sediments. This suggests that there are high levels of contamination in the area due to industrial and other human activities. [ABSTRACT FROM AUTHOR]

Published
2017
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45. Long-term air pollution exposure and breast cancer

Author

Niazi, Sadegh, Seifi, Morteza, Nabavi, Samira, Yunesian, Masud, Amini, Hassan, Niazi, Sadegh, Seifi, Morteza, Nabavi, Samira, Yunesian, Masud, and Amini, Hassan

Abstract

Background: Women in urban communities of Iran have the highest incidence rates of breast cancer (BC). The reasons behind this are not fully understood and many of the causes remain unexplained. Aims: The aim of this study was to examine the relationship between exposure of BC cases and exposure of the general population to long-term air pollutants in the Middle Eastern City of Tehran, Iran. Methods: Records of 1534 BC patients were obtained from Non Communicable Disease Center belong to Ministry of Health (with disease onset during 2008 to 2009). Thereafter, they were successfully geo-coded within Tehran megacity by Geographic Information System (GIS) Bureau of Iran’s Post Office based on their postal code. On the other hand, 3008 random cases were created within the city by a GIS. The individual long-term exposure to sulfur dioxide (SO2) and particulate matter ? 10 µm (PM10) air pollutants of all BC and random cases were estimated using land use regression models. Finally, bivariate correlations of the exposure of these groups were calculated. Results: The annual mean concentration of SO2 and PM10 in the BC cases were 62.9 parts per billion (ppb), and 97.6 µg/m3, respectively. While in our random points the mean exposures for mentioned pollutants were 54.1 ppb, and 93 µg/m3, respectively. The correlation of long-term exposure to SO2 between BC and random cases was positive and significant (r = 0.06, p = 0.019). Meanwhile, the correlation of long-term exposure to PM10 between BC and random cases was positive and significant (r = 0.05, p = 0.037).

Published
2013

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