113 results on '"Sekhri, N."'
Search Results
2. Genotype influences end-stage heart failure occurrence in dilated cardiomyopathy
- Author
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Cannie, D, primary, Bakalakos, A, additional, Protonotarios, A, additional, Syrris, P, additional, Lorenzini, M, additional, Guttmann, O, additional, O'mahony, C, additional, Savvatis, K, additional, Lopes, L, additional, Sekhri, N, additional, Mohiddin, S, additional, and Elliott, P, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Percutaneous extraction of an embolized progesterone contraceptive implant from the pulmonary artery
- Author
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Akhtar MM, Bhan A, Lim ZY, Akhtar MA, Sekhri N, Bharadwaj P, and Mullen M
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Nexplanon ,Pulmonary Artery ,Embolization ,Extraction ,Snare ,Gynecology and obstetrics ,RG1-991 - Abstract
Mohammed Majid Akhtar,1,2 Amit Bhan,2 Zhan Yun Lim,2 Mohammed Abid Akhtar,3 Neha Sekhri,2 Preeti Bharadwaj,4 Michael Mullen2 1Institute of Cardiovascular Sciences, University College London, London, UK; 2Department of Cardiology, Barts Heart Centre, St Bartholomew’s Hospital, London, UK; 3Department of Cardiology and Cardiac Transplantation, Harefield Hospital, Royal Brompton & Harefield NHS Trust, London, UK; 4Community Gynaecology and Sexual & Reproductive Health Department, Waltham Forest, North East London Foundation Trust, London, UK Abstract: The Nexplanon® implant is a commonly used radiopaque contraceptive device that contains progestogen associated with an ethylene vinyl-acetate copolymer resulting in a slow release of the active hormonal ingredient. It is inserted into the subdermal connective tissue and provides contraceptive efficacy for up to 3 years. Device removal for clinical, personal or device “end-of-life span” reasons is straightforward. In rare cases, implant migration can occur locally within centimeters of the insertion site. Distant device embolization is extremely rare and can result in complications including chest pain, dyspnoea, pneumothorax and thrombosis or prevent conception until the active ingredient is depleted. We present one such case, where a Nexplanon® implant embolized into the pulmonary artery of a young female patient. We describe the initial “missed” diagnosis of embolized device on a chest radiograph and subsequent successful percutaneous removal once distant embolization was diagnosed. Keywords: Nexplanon®, pulmonary artery, embolization, extraction, snare
- Published
- 2018
4. Exploring the phenotypic spectrum of desmoplakin cardiomyopathy
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Protonotarios, A, primary, Cannie, D, additional, Akhtar, M, additional, Savvatis, K, additional, Sekhri, N, additional, Mohiddin, S, additional, Lopes, L, additional, Syrris, P, additional, and Elliott, P.M, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Case fatality rates for South Asian and Caucasian patients show no difference 2.5 years after percutaneous coronary intervention
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Jones, D A, Rathod, K S, Sekhri, N, Junghans, C, Gallagher, S, Rothman, M T, Mohiddin, S, Kapur, A, Knight, C, Archbold, A, Jain, A K, Mills, P G, Uppal, R, Mathur, A, Timmis, A D, and Wragg, A
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- 2012
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6. 1174Characterization of disease hot-phases using 18f-fluorodeoxyglucose positron emission tomography in arrhythmogenic cardiomyopathy caused by desmosomal gene mutations
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Protonotarios, A, primary, Wicks, E C, additional, Guttmann, O, additional, Sekhri, N, additional, O'mahony, C, additional, Savvatis, K, additional, Lopes, L R, additional, Barnes, A, additional, Mohiddin, S A, additional, Syrris, P, additional, Menezes, L, additional, and Elliott, P M, additional
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- 2019
- Full Text
- View/download PDF
7. Integrating Transfusion Medicine (TM) into the Anesthesiology Residency Curriculum: A Single Center Experience: AP78
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Padmanabhan, A, Sekhri, N, Kim, R B, Jones, D, and Schwartz, J
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- 2009
8. How effective are rapid access chest pain clinics? Prognosis of incident angina and non-cardiac chest pain in 8762 consecutive patients
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Sekhri, N, Feder, G S, Junghans, C, Hemingway, H, and Timmis, A D
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- 2007
9. Rapid-access chest pain clinics and the traditional cardiology out-patient clinic
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Sekhri, N., Feder, G.S., Junghans, C., Hemingway, H., and Timmis, A.D.
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- 2006
10. The effect of diabetes on heart rate and other determinants of myocardial oxygen demand in acute coronary syndromes
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Foo, K., Sekhri, N., Knight, C., Deaner, A., Cooper, J., Ranjadayalan, K., Suliman, A., and Timmis, A. D.
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- 2004
11. Effect of diabetes on serum potassium concentrations in acute coronary syndromes
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Foo, K, Sekhri, N, Deaner, A, Knight, C, Suliman, A, Ranjadayalan, K, and Timmis, A D
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- 2003
12. Interaction between arrival time and thrombolytic treatment in determining early outcome of acute myocardial infarction
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Wilkinson, J, Foo, K, Sekhri, N, Cooper, J, Suliman, A, Ranjadayalan, K, and Timmis, A D
- Published
- 2002
13. P57615 minutes after Gadolinium two diagnoses appear
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Stephenson, E, primary, Sekhri, N, additional, Guttmann, O P, additional, Savvatis, K, additional, O"mahony, C, additional, Herrey, A S, additional, and Mohiddin, S A, additional
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- 2019
- Full Text
- View/download PDF
14. P379The value of T1 mapping in the presentation of chest pain with left ventricular hypertrophy
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Stephenson, E, primary, Sekhri, N, additional, Sengupta, A, additional, Gkosios, T, additional, Lorenzini, M, additional, and Mohiddin, S A, additional
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- 2019
- Full Text
- View/download PDF
15. P593Hypereosinophilic carditis (HEC): a cmr-based case series from a quaternary cardiology centre
- Author
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Akhtar, A M A, primary, Patel, K, additional, Chahal, A, additional, Akhtar, M, additional, Nay, A, additional, Fung, K, additional, Sekhri, N, additional, Treibel, T, additional, Westwood, M, additional, Davies, C, additional, Khanji, M, additional, Manisty, C, additional, Lorenzini, M, additional, Moon, J, additional, and Petersen, S E, additional
- Published
- 2019
- Full Text
- View/download PDF
16. European Cardiomyopathy Pilot Registry : EURObservational Research Programme of the European Society of Cardiology
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Elliott P., Charron P., Blanes J. R. G., Tavazzi L., Tendera M., Konte M., Laroche C., Maggioni A. P., Anastasakis A., Arbustini E., Asselbergs F. W., Axelsson A., Brito D., Caforio A. L. P., Carr-White G., Czekaj A., Damy T., Devoto E., Favalli V., Findlay I., Garcia-Pavia P., Hagege A., Helio T., Iliceto S., Isnard R., Jansweijer J. A., Limongelli G., Linhart A., Cuenca D. L., Mansencal N., McKeown P., Mogensen J., Mohiddin S. A., Monserrat L., Olivotto I., Rapezzi C., Rigopoulos A. G., Rosmini S., Pfeiffer B., Wicks E., Podzimkova J., Kuchynka P., Palecek T., Bundgaard H., Thune J. J., Kumme A., Due Vestergaard L., Hey T., Ollila L., Kaartinen M., Dubourg O., Arslan M., Siam Tsieu M., Guellich A., Tissot C. -M., Guendouz S., Thevenin S., Cheikh Khelifa R., Gandjbakhch E., Komajda M., Neugebauer A., Steriotis A., Ritsatos K., Vlagkouli V., Biagini E., Gentile N., Longhi S., Arretini A., Fornaro A., Cecchi F., Spirito P., Formisano F., Masarone D., Valente F., Pacileo G., Schiavo A., Testolina M., Serio A., Grasso M., Wilde A., Pinto Y., Klopping C., Van Der Heijden J. F., De Jonge N., Sikora-Puz A., Wybraniec M., Francisco A. R., Madeira H., Ortiz-Genga M., Barriales-Villa R., Fernandez X., Lopez-Cuenca D., Gomez-Milanes I., Lopez-Ayala J. M., Guzzo-Merello G., Gallego-Delgado M., Muir A., McOsker J., Jardine T., Iqbal H., Sekhri N., Rajani R., Bueser T., Watkinson O., Cardiology, ACS - Amsterdam Cardiovascular Sciences, ACS - Heart failure & arrhythmias, Perry Elliott, Philippe Charron, Juan Ramon Gimeno Blane, Luigi Tavazzi, Michal Tendera, Marème Konté, Cécile Laroche, Aldo P. Maggioni, the EORP Cardiomyopathy Registry Pilot Investigators: [Aris Anastasaki, Eloisa Arbustini, Folkert W. Asselberg, Anna Axelsson, Dulce Brito, Alida L.P. Caforio, Gerald Carr-White, Agata Czekaj, Thibaud Damy, Emmanuela Devoto, Valentina Favalli, Iain Findlay, Pablo Garcia-Pavia, Albert Hagège, Tiina Heliö, Sabino Iliceto, Richard Isnard, Joeri A. Jansweijer, Giuseppe Limongelli, Ales Linhart, David López Cuenca, Nicolas Mansencal, Pascal McKeown, Jens Mogensen, Saidi A. Mohiddin, Lorenzo Monserrat, Iacopo Olivotto, Claudio Rapezzi, A.G. Rigopoulo, Stefania Rosmini, Barbara Pfeiffer, Eleanor Wicks], Elliott, P., Charron, P., Blanes, J. R. G., Tavazzi, L., Tendera, M., Konte, M., Laroche, C., Maggioni, A. P., Anastasakis, A., Arbustini, E., Asselbergs, F. W., Axelsson, A., Brito, D., Caforio, A. L. P., Carr-White, G., Czekaj, A., Damy, T., Devoto, E., Favalli, V., Findlay, I., Garcia-Pavia, P., Hagege, A., Helio, T., Iliceto, S., Isnard, R., Jansweijer, J. A., Limongelli, G., Linhart, A., Cuenca, D. L., Mansencal, N., Mckeown, P., Mogensen, J., Mohiddin, S. A., Monserrat, L., Olivotto, I., Rapezzi, C., Rigopoulos, A. G., Rosmini, S., Pfeiffer, B., Wicks, E., Podzimkova, J., Kuchynka, P., Palecek, T., Bundgaard, H., Thune, J. J., Kumme, A., Due Vestergaard, L., Hey, T., Ollila, L., Kaartinen, M., Dubourg, O., Arslan, M., Siam Tsieu, M., Guellich, A., Tissot, C. -M., Guendouz, S., Thevenin, S., Cheikh Khelifa, R., Gandjbakhch, E., Komajda, M., Neugebauer, A., Steriotis, A., Ritsatos, K., Vlagkouli, V., Biagini, E., Gentile, N., Longhi, S., Arretini, A., Fornaro, A., Cecchi, F., Spirito, P., Formisano, F., Masarone, D., Valente, F., Pacileo, G., Schiavo, A., Testolina, M., Serio, A., Grasso, M., Wilde, A., Pinto, Y., Klopping, C., Van Der Heijden, J. F., De Jonge, N., Sikora-Puz, A., Wybraniec, M., Francisco, A. R., Madeira, H., Ortiz-Genga, M., Barriales-Villa, R., Fernandez, X., Lopez-Cuenca, D., Gomez-Milanes, I., Lopez-Ayala, J. M., Guzzo-Merello, G., Gallego-Delgado, M., Muir, A., Mcosker, J., Jardine, T., Iqbal, H., Sekhri, N., Rajani, R., Bueser, T., and Watkinson, O.
- Subjects
Registrie ,Male ,Pacemaker, Artificial ,Cardiomyopathy ,Pilot Projects ,030204 cardiovascular system & hematology ,Defibrillator ,0302 clinical medicine ,Interquartile range ,Residence Characteristics ,Dilated ,Medicine ,030212 general & internal medicine ,Registries ,Age of Onset ,Non-U.S. Gov't ,Research Support, Non-U.S. Gov't ,Hypertrophic cardiomyopathy ,Dilated cardiomyopathy ,Middle Aged ,Arrhythmogenic right ventricular dysplasia ,Europe ,Multicenter Study ,cardiovascular system ,Cardiology ,Arrhythmogenic right ventricular ,Female ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies ,Human ,Adult ,medicine.medical_specialty ,Registry ,Cardiotonic Agents ,Restrictive ,Observational Study ,Research Support ,Right ventricular cardiomyopathy ,NO ,03 medical and health sciences ,Age Distribution ,Internal medicine ,Journal Article ,Humans ,Cardiotonic Agent ,Pilot Project ,cardiovascular diseases ,Sex Distribution ,Cardiomyopathie ,business.industry ,Restrictive cardiomyopathy ,Hypertrophic ,medicine.disease ,Death, Sudden, Cardiac ,Residence Characteristic ,Heart failure ,business ,Defibrillators - Abstract
AIMS: Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. METHODS AND RESULTS: Between 1 December 2012 and 30 November 2013, four cardiomyopathy phenotypes were studied: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). Twenty-seven centres in 12 countries participated; 1115 patients were enrolled. The commonest cardiomyopathy was HCM (n = 681), followed by DCM (n = 346), ARVC (n = 59), and RCM (n = 29); 423 patients (46.4% of those reported) had familial disease; and 56 (5.0%) had rare disease phenocopies. Median age at enrolment and diagnosis was 54 [interquartile range (IQR), 42-64] and 46 years (IQR, 32-58), respectively; fewer patients with ARVC and more with RCM were diagnosed in the upper age quartile (P < 0.0001). There was a male predominance for all cardiomyopathies except RCM (P = 0.0023). Most patients were in New York Heart Association functional class I (n = 813) at enrolment; 139 (12.5%) reported syncope, most frequently in ARVC (P = 0.0009). Five hundred and seven (45.5%) patients underwent cardiac magnetic resonance imaging, 117 (10.6%) endomyocardial biopsy, and 462 (41.4%) genetic testing with a causative mutation reported in 236 individuals (51.1%). 1026 patients (92.0%) were receiving drug therapy; 316 (28.3%) had received an implantable cardioverter defibrillator (highest proportion in ARVC, P < 0.0001). CONCLUSION: This pilot study shows that services for patients with cardiomyopathy are complex, requiring access to a large range of invasive and non-invasive investigations and involvement of multidisciplinary teams. Treatment regimens are equally multifaceted and show that patients are likely to need long-term follow-up in close liaison with expert centres.
- Published
- 2016
17. European cardiomyopathy pilot registry: EURObservational research programme of the European society of cardiology
- Author
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Elliott, P. Charron, P. Blanes, J.R.G. Tavazzi, L. Tendera, M. Konté, M. Laroche, C. Maggioni, A.P. Anastasakis, A. Arbustini, E. Asselbergs, F.W. Axelsson, A. Brito, D. Caforio, A.L.P. Carr-White, G. Czekaj, A. Damy, T. Devoto, E. Favalli, V. Findlay, I. Garcia-Pavia, P. Hagège, A. Heliö, T. Iliceto, S. Isnard, R. Jansweijer, J.A. Limongelli, G. Linhart, A. Cuenca, D.L. Mansencal, N. McKeown, P. Mogensen, J. Mohiddin, S.A. Monserrat, L. Olivotto, I. Rapezzi, C. Rigopoulos, A.G. Rosmini, S. Pfeiffer, B. Wicks, E. Podzimkova, J. Kuchynka, P. Palecek, T. Bundgaard, H. Thune, J.J. Kumme, A. Due Vestergaard, L. Hey, T. Ollila, L. Kaartinen, M. Dubourg, O. Arslan, M. Siam Tsieu, M. Guellich, A. Tissot, C.-M. Guendouz, S. Thevenin, S. Cheikh Khelifa, R. Gandjbakhch, E. Komajda, M. Neugebauer, A. Pfeiffer, B. Steriotis, A. Ritsatos, K. Vlagkouli, V. Biagini, E. Gentile, N. Longhi, S. Arretini, A. Fornaro, A. Cecchi, F. Spirito, P. Formisano, F. Masarone, D. Valente, F. Pacileo, G. Schiavo, A. Testolina, M. Serio, A. Grasso, M. Wilde, A. Pinto, Y. Klöpping, C. Van Der Heijden, J.F. De Jonge, N. Sikora-Puz, A. Wybraniec, M. Czekaj, A. Francisco, A.R. Brito, D. Madeira, H. Ortiz-Genga, M. Barriales-Villa, R. Fernandez, X. Lopez-Cuenca, D. Gomez-Milanes, I. Lopez-Ayala, J.M. Guzzo-Merello, G. Gallego-Delgado, M. Muir, A. McOsker, J. Jardine, T. Iqbal, H. Sekhri, N. Rajani, R. Bueser, T. Watkinson, O. on behalf of the EORP Cardiomyopathy Registry Pilot Investigators
- Abstract
Aims: Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. Methods and results: Between 1 December 2012 and 30 November 2013, four cardiomyopathy phenotypes were studied: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). Twenty-seven centres in 12 countries participated; 1115 patients were enrolled. The commonest cardiomyopathy was HCM (n = 681), followed by DCM (n = 346), ARVC (n = 59), and RCM (n = 29); 423 patients (46.4% of those reported) had familial disease; and 56 (5.0%) had rare disease phenocopies. Median age at enrolment and diagnosis was 54 [interquartile range (IQR), 42-64] and 46 years (IQR, 32-58), respectively; fewer patients with ARVC and more with RCM were diagnosed in the upper age quartile (P, 0.0001). There was a male predominance for all cardiomyopathies except RCM (P = 0.0023). Most patients were in New York Heart Association functional class I (n = 813) at enrolment; 139 (12.5%) reported syncope, most frequently in ARVC (P = 0.0009). Five hundred and seven (45.5%) patients underwent cardiac magnetic resonance imaging, 117 (10.6%) endomyocardial biopsy, and 462 (41.4%) genetic testing with a causative mutation reported in 236 individuals (51.1%). 1026 patients (92.0%) were receiving drug therapy; 316 (28.3%) had received an implantable cardioverter defibrillator (highest proportion in ARVC, P, 0.0001). Conclusion: This pilot study shows that services for patients with cardiomyopathy are complex, requiring access to a large range of invasive and non-invasive investigations and involvement of multidisciplinary teams. Treatment regimens are equally multifaceted and show that patients are likely to need long-term follow-up in close liaison with expert centres. © The Author 2015.
- Published
- 2016
18. 4776Prevalence and clinical significance of abnormalities detected on positron emission tomography in patients with clinically suspected myocarditis
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Wicks, E.C., primary, Menezes, L.J., additional, Barnes, A., additional, Mohiddin, S.A., additional, Sekhri, N., additional, Garrett, E.C., additional, Patel, R.S., additional, Pavlou, M., additional, Groves, A.M., additional, and Elliott, P.M., additional
- Published
- 2017
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19. (454) Delayed opioid withdrawal in a patient receiving naloxegol: a case report
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Sekhri, N., primary and Knox, N., additional
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- 2016
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20. Abstract P2-09-24: Information preferences and short-term psychological responses to multiplex genetic testing among individuals at risk for hereditary breast cancer
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Robson, ME, primary, Gaissert, P, additional, Salo-Mullen, EE, additional, Amoroso, K, additional, Sheehan, M, additional, Berliner, JL, additional, Trottier, M, additional, Arnold, AG, additional, Sekhri, N, additional, Marcell, V, additional, Siegel, B, additional, Harlan Fleischut, M, additional, Hay, JL, additional, Walsh, MF, additional, Kauff, ND, additional, Stadler, ZK, additional, Offit, K, additional, and Hamilton, JG, additional
- Published
- 2016
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21. 43 * Anticoagulation strategies in patients with atrial fibrillation does our current practise result in unnecessary delays?
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Honarbakhsh, S., primary, Wakefield, L. A., additional, Sekhri, N., additional, Archbold, A., additional, Dhinoja, M., additional, Weerackody, R., additional, and Ranjadayalan, K., additional
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- 2014
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22. Managed care: the US experience
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Sekhri, N. K.
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Quality Assurance, Health Care ,Managed Care Programs ,Outcome Assessment, Health Care ,Humans ,Program Development ,Sensitivity and Specificity ,United States ,Research Article ,Program Evaluation - Abstract
This article provides an overview of managed health care in the USA--what has been achieved and what has not--and some lessons for policy-makers in other parts of the world. Although the backlash by consumers and providers makes the future of managed care in the USA uncertain, the evidence shows that it has had a positive effect on stemming the rate of growth of health care spending, without a negative effect on quality. More importantly, it has spawned innovative technologies that are not dependent on the US market environment, but can be applied in public and private systems globally. Active purchasing tools that incorporate disease management programmes, performance measurement report cards, and alignment of incentives between purchasers and providers respond to key issues facing health care reform in many countries. Selective adoption of these tools may be even more relevant in single payer systems than in the fragmented, voluntary US insurance market where they can be applied more systematically with lower transaction costs and where their effects can be measured more precisely.
- Published
- 2000
23. Apical hypertrophic cardiomyopathy: chest pain and myocardial perfusion defects result from regional diastolic persistence of hyperdynamic cardiac contractility
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Stephenson, E., primary, Monney, P., additional, Boubertakh, R., additional, Nackvi, J., additional, Sekhri, N., additional, Mills, P., additional, Wragg, A., additional, Mathur, A., additional, Petersen, S., additional, and Mohiddin, S. A., additional
- Published
- 2013
- Full Text
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24. 1071Age and Gender Patterns of Referral for Stress Perfusion MRI. A 5 Year Comparison
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Khanji, M, primary, Newton, T, additional, Westwood, M, additional, Sekhri, N, additional, and Petersen, SE, additional
- Published
- 2013
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25. Case fatality rates for South Asian and Caucasian patients show no difference 2.5 years after percutaneous coronary intervention
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Jones, D A, primary, Rathod, K S, additional, Sekhri, N, additional, Junghans, C, additional, Gallagher, S, additional, Rothman, M T, additional, Mohiddin, S, additional, Kapur, A, additional, Knight, C, additional, Archbold, A, additional, Jain, A K, additional, Mills, P G, additional, Uppal, R, additional, Mathur, A, additional, Timmis, A D, additional, and Wragg, A, additional
- Published
- 2011
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26. Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic resonance in its diagnosis
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Monney, P. A., primary, Sekhri, N., additional, Burchell, T., additional, Knight, C., additional, Davies, C., additional, Deaner, A., additional, Sheaf, M., additional, Baithun, S., additional, Petersen, S., additional, Wragg, A., additional, Jain, A., additional, Westwood, M., additional, Mills, P., additional, Mathur, A., additional, and Mohiddin, S. A., additional
- Published
- 2010
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27. Incremental prognostic value of the exercise electrocardiogram in the initial assessment of patients with suspected angina: cohort study
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Sekhri, N., primary, Feder, G. S, additional, Junghans, C., additional, Eldridge, S., additional, Umaipalan, A., additional, Madhu, R., additional, Hemingway, H., additional, and Timmis, A. D, additional
- Published
- 2008
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28. Presentation of stable angina pectoris among women and South Asian people
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Zaman, M. J., primary, Junghans, C., additional, Sekhri, N., additional, Chen, R., additional, Feder, G. S., additional, Timmis, A. D., additional, and Hemingway, H., additional
- Published
- 2008
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29. P593 Hypereosinophilic carditis (HEC): a cmr-based case series from a quaternary cardiology centre.
- Author
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Akhtar, A M A, Patel, K, Chahal, A, Akhtar, M, Nay, A, Fung, K, Sekhri, N, Treibel, T, Westwood, M, Davies, C, Khanji, M, Manisty, C, Lorenzini, M, Moon, J, and Petersen, S E
- Subjects
CONFERENCES & conventions ,HEART ventricles ,MAGNETIC resonance imaging ,CARDIOMYOPATHIES - Published
- 2019
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30. P576 15 minutes after Gadolinium two diagnoses appear.
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Stephenson, E, Sekhri, N, Guttmann, O P, Savvatis, K, O"mahony, C, Herrey, A S, and Mohiddin, S A
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CARDIOMYOPATHIES ,CONFERENCES & conventions ,MAGNETIC resonance imaging ,CONTRAST media ,DIAGNOSIS - Published
- 2019
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31. P379 The value of T1 mapping in the presentation of chest pain with left ventricular hypertrophy.
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Stephenson, E, Sekhri, N, Sengupta, A, Gkosios, T, Lorenzini, M, and Mohiddin, S A
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CHEST pain ,CONFERENCES & conventions ,MAGNETIC resonance imaging ,LEFT ventricular hypertrophy - Published
- 2019
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32. The Safety and Feasibility of Transitioning From Transfemoral to Transradial Access Left Ventricular Endomyocardial Biopsy
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Tyler, Z., Guttmann, O. P., Dhinoja, M., Oro, R., Savvatis, K., Mohiddin, S., Sekhri, N., Lopes, L., Patel, V., Jones, D. A., Bourantas, C. V., Mathur, A., Perry Elliott, and O Mahony, C.
33. Automatic left ventricular analysis with Inline VF performs well compared to manual analysis: results from Barts Cardiovascular Registry
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Mm, Sanghvi, Feuchter P, Zemrak F, Boubertakh R, Suinesiaputra A, Young A, Weerackody R, Sekhri N, As, Herrey, Manisty C, Davies C, Westwood M, Moon J, and Steffen Petersen
34. CMR scanning of MR-conditional pacemakers: a 5-year single centre experience
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Francesco Papalia, Sa, Mohiddin, Davies C, Westwood M, Weerackody R, Whittaker-Axon S, and Sekhri N
35. Clinical utilisation of adenosine stress CMR and its influence on patient management in a tertiary cardiac centre
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Sekhri N, Timmis A, Mahmood A, Ec, Sammut, Ma, Westwood, Davies C, Sa, Mohiddin, Weerackody R, Andrew Wragg, Jones D, Boubertakh R, Se, Petersen, and Mathur A
36. Abstracts
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Doulaptsis, C, Masci, PG, Goetschalckx, K, Janssens, S, Bogaert, J, Ferreira, VM, Piechnik, SK, DallArmellina, E, Karamitsos, TD, Francis, JM, Ntusi, N, Holloway, C, Choudhury, RP, Kardos, A, Robson, MD, Friedrich, MG, Neubauer, S, Miszalski-Jamka, T, Sokolowska, B, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Malek, L, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Pedrotti, P, Masciocco, G, DAngelo, L, Milazzo, A, Quattrocchi, G, Zanotti, F, Frigerio, M, Roghi, A, Rimoldi, O, Kaasalainen, T, Kivistö, S, Holmström, M, Pakarinen, S, Hänninen, H, Sipilä, O, Lauerma, K, Banypersad, S.M, Fontana, M, Maestrini, V, Sado, D.M, Pinney, J, Wechalekar, A.D, Gillmore, J.D, Lachmann, H, Hawkins, P.N, Moon, J.C, Barone-Rochette, G, Pierard, S, Seldrum, S, de Ravensteen, CM, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Captur, G, Muthurangu, V, Flett, AS, Wilson, R, Barison, A, Anderson, S, Cook, C, Sado, DM, McKenna, WJ, Mohun, TJ, Elliott, PM, Moon, JC, Pepe, A, Meloni, A, Gulino, L, Rossi, G, Paci, C, Spasisno, A, keilberg, P, Restaino, G, Resta, MC, Positano, V, lombardi, M, Reiter, U, Reiter, G, Kovacs, G, Schmidt, A, Olschewski, H, Fuchsjäger, M, Macmillan, A, Dabir, D, Rogers, T, Monaghan, M, Nagel, E, Puntmann, V, Semaan, E, Spottiswoode, B, Freed, B, Carr, M, Wasielewski, M, Fortney-Campione, K, Shah, S, Carr, J, Markl, M, Collins, J, Sung, YM, Hinojar, R, Ucar, EA, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Dabir, D, Rogers, T, Ucar, EA, Kidambi, A, Plein, S, Gebker, R, Schnackenburg, B, Voigt, T, Schaeffter, T, Nagel, E, Puntmann, VO, McAlindon, E, Bucciarelli-Ducci, C, Sado, D, Maestrini, V, Piechnik, S, Porter, J, Yamamura, J, Fischer, R, Moon, J, Symons, R, Doulaptsis, C, Masci, P.G, Goetschalckx, K, Dymarkowski, S, Janssens, S, Bogaert, J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Reinstadler, SJ, Klug, G, Feistritzer, HJ, Mayr, A, Harrasser, B, Krauter, L, Mair, J, Schocke, MF, Pachinger, O, Metzler, B, Rigolli, M, To, A, Edwards, C, Ding, P, Christiansen, J, Rodríguez-Palomares, JF, Ortiz, JT, Bucciarelli, C, Lee, D, Wu, E, Bonow, RO, Karwat, K, Tomala, M, Miszalski-Jamka, K, Licholaj, S, Mazur, W, Kereiakes, DJ, Nessler, J, Zmudka, K, Jazwiec, P, Miszalski-Jamka, T, Peltonen, J, Kaasalainen, T, Kivistö, S, Holmström, M, Lauerma, K, Rutz, T, Meierhofer, C, Martinoff, S, Ewert, P, Hess, J, Stern, H, Fratz, S, Groarke, JD, Waller, AH, Blankstein, R, Kwong, RY, Steigner, M, Alizadeh, Z, Alizadeh, A, Khajali, Z, Mohammadzadeh, A, Kaykhavani, A, Heidarali, M, Singh, A, Bekele, S, Gunarathne, A, Khan, J, Nazir, SN, Steadman, CD, Kanagala, P, Horsfield, MA, McCann, GP, Duncan, RF, Dundon, BK, Nelson, AJ, Williams, K, Carbone, A, Worthley, MI, Zaman, A, Worthley, SG, Monney, P, Piccini, D, Rutz, T, Vincenti, G, Koestner, S, Stuber, M, Schwitter, J, Gripari, P, Maffessanti, F, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Caiani, EG, Pepi, M, El ghannudi, S, Nghiem, A, Germain, P, Jeung, M-J, Roy, C, Gangi, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Pöyhönen, P, Kivistö, S, Holmströn, M, Hänninen, H, Thorning, C, Bickelhaupt, S, Kampmann, C, Wentz, KU, Widmer, U, Juli, CF, Miszalski-Jamka, K, Klys, J, Glowacki, J, Kijas, M, Miszalski-Jamka, T, Adamczyk, T, Kwiecinski, R, Bogucka-Czapska, J, Ozaist, M, Mazur, W, Kluczewska, E, Kalarus, Z, Kukulski, T, Karakus, G, Marzluf, B, Bonderman, D, Tufaro, C, Pfaffenberger, S, Babyev, J, Maurer, G, Mascherbauer, J, Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, El-Husseini, W, Sikula, V, Segetova, M, Kautzner, J, Vasconcelos, M, Lebreiro, A, Martins, E, Cardoso, JS, Madureira, AJ, Ramos, I, Maciel, MJ, Florian, A, Ludwig, A, Rösch, S, Sechtem, U, Yilmaz, A, Monmeneu, J.V, López-Lereu, M.P, Bonanad, C, Sanchis, J, Chaustre, F, Merlos, P, Valero, E, Bodí, V, Chorro, F.J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Klug, G, Reinstadler, SJ, Feistritzer, HJ, Mayr, A, Riegler, N, Schocke, M, Esterhammer, R, Kremser, C, Pachinger, O, Metzler, B, Siddiqi, N, Cameron, D, Neil, C, Jagpal, B, Singh, S, Schwarz, K, Papadopoulou, S, Frenneaux, MP, Dawson, D, Robbers, LFHJ, Eerenberg, ES, Teunissen, PFA, Jansen, MF, Hollander, MR, Horrevoets, AJG, Knaapen, P, Nijveldt, R, Levi, MM, van Rossum, AC, Niessen, HWM, Marcu, CB, Beek, AM, van Royen, N, Everaars, H, Robbers, LFHJ, Nijveldt, R, Beek, AM, Teunissen, PFA, Hirsch, A, van Royen, N, Zijlstra, F, Piek, JJ, van Rossum, AC, Goitein, O, Grupper, A, Hamdan, A, Eshet, Y, Beigel, R, Medvedofsky, D, Herscovici, R, Konen, E, Hod, H, Matetzky, S, Cadenas, R, Iniesta, AM, Refoyo, E, Antorrena, I, Guzman, G, Cuesta, E, Salvador, O, López, T, Moreno, M, López-Sendon, JL, Alam, SR, Spath, N, Richards, J, Dweck, M, Shah, A, Lang, N, Semple, S, MacGillivray, T, Mckillop, G, Mirsadraee, S, Pessotto, R, Zamvar, V, Newby, DE, Henriksen, P, Reiter, G, Reiter, U, Kovacs, G, Olschewski, H, Fuchsjäger, M, Ahmad, S, Raza, U, Malik, A, Sun, JP, Eisner, R, Mazur, W, ODonnell, R, Positano, V, Meloni, A, Santarelli, MF, Landini, L, Tassi, C, Grimaldi, S, Gulino, L, De Marchi, D, Chiodi, E, Renne, S, Lombardi, M, Pepe, A, Wu, L, Germans, T, Güçlü, A, Allaart, CP, van Rossum, AC, Kalisz, K, Lehenbauer, K, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Shah, S, Markl, M, Flukiger, J, Carr, J, Collins, J, Osiak, A, Tyrankiewicz, U, Jablonska, M, Jasinski, K, Jochym, PT, Chlopicki), S, Skorka, T, Kalisz, K, Semaan, E, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, MP, Freed, B, Flukiger, J, Lee, D, Kansal, P, Shah, S, Markl, M, Carr, J, Collins, J, Groarke, JD, Shah, RV, Waller, AH, Abbasi, SA, Kwong, RY, Blankstein, R, Steigner, M, Chin, CWL, Semple, S, Malley, T, White, A, Prasad, S, Newby, DE, Dweck, M, Pepe, A, Meloni, A, Lai, ME, Vaquer, S, Gulino, L, De Marchi, D, Cuccia, L, Midiri, M, Vallone, A, Positano, V, Lombardi, M, Pedrotti, P, Milazzo, A, Quattrocchi, G, Roghi, A, Rimoldi, O, Barison, A, De Marchi, D, Masci, P, Milanesi, M, Aquaro, GD, Keilberg, P, Positano, V, Lombardi, M, Positano, Vincenzo, Barison, Andrea, Pugliese, Nicola Riccardo, Masci, Piergiorgio, Del Franco, Annamaria, Aquaro, Giovanni Donato, Landini, Luigi, Lombardi, Massimo, Dieringer, MA, Deimling, M, Fuchs, K, Winter, L, Kraus, O, Knobelsdorff-Brenkenhoff, FV, Schulz-Menger, J, Niendorf, T, Hinojar, R, Ucar, EA, DCruz, D, Sangle, S, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Sung, YM, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Gripari, P, Cortinovis, S, Loguercio, M, Baggiano, A, Conte, E, Pepi, M, El ghannudi, S, Hop, O, Germain, P, Jeung, M-J, De Cesare, A, Roy, C, Gangi, A, Barone-Rochette, G, Pierard, S, Seldrum, S, De Meester de Ravensteen, C, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Bekele, S, Singh, A, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Singh, A, Steadman, CD, Bekele, S, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Paelinck, BP, Vandendriessche, T, De Bock, D, De Maeyer, C, Parizel, PM, Christiaan, J, Trauzeddel, RF, Gelsinger, C, Butter, C, Barker, A, Markl, M, Schulz-Menger, J, von Knobelsdorff, F, Florian, A, Schäufele, T, Ludwig, A, Rösch, S, Wenzelburger, I, Yilmaz, A, Sechtem, U, López-Lereu, M.P, Bonanad, C, Monmeneu, J.V, Sanchís, J, Estornell, J, Igual, B, Maceira, A, Chorro, F.J, Focardi, M, Cameli, M, Bennati, E, Massoni, A, Solari, M, Carbone, F, Banchi, B, Mondillo, S, Miia, H, Kirsi, L, Helena, H, Tiina, H, Jyri, L, Pauli, P, Sari, K, Schumm, J, Greulich, S, Grün, S, Ong, P, Klingel, K, Kandolf, R, Sechtem, U, Mahrholdt, H, Raimondi, F, Ou, P, Boudjemline, Y, Bajolle, F, Iserin, F, Bonnet, D, Collins, J, Kalisz, K, Benefield, B, Sarnari, R, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Flukiger, J, Kansal, P, Lee, D, Shah, S, Markl, M, Carr, J, Sokolowska, B, Miszalski-Jamka, T, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Silva, G, Almeida, AG, Resende, C, Marques, JS, Silva, D, David, C, Amaro, C, Costa, P, Silva, JAP, Diogo, AN, Tsokolov, AV, Senchilo, VG, Vertelkin, AV, Hoffmann, P, Mykjåland, G, Wangberg, H, Tønnessen, T, Sjaastad, I, Nordsletten, L, Hjørnholm, U, Løset, A, Rostrup, M, Meloni, A, Gulino, L, Keilberg, P, Palazzi, G, Maddaloni, D, Ascioti, C, Missere, M, Salvatori, C, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Filosa, A, Gulino, L, Pulini, S, Salvatori, C, Chiodi, E, Ascioti, C, Keilberg, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Gulino, L, Pietrapertosa, A, Izzi, G, De Marchi, D, Valeri, G, Preziosi, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Ruffo, GB, Keilberg, P, Gulino, L, Gerardi, C, Sallustio, G, Tudisca, C, Positano, V, Lombardi, M, Pepe, A, Greulich, S, Backes, M, Schumm, J, Grün, S, Sechtem, U, Mahrholdt, H, Dorniak, K, MSc, AS, Szurowska, E, Fijalkowski, M, Rawicz-Zegrzda, D, Dudziak, M, Raczak, G, Hamdan, A, Baker, FA, Klein, M, Di Segni, E, Goitein, O, Fibisch, G, Konen, E, Müller-Bierl, B, Tanaka, K, Buls, N, Fierens, Y, van Cauteren, T, Willekens, I, van Laere, S, Luypaert, R, de Mey, J, Muzzarelli, S, Faragasso, E, Pedrazzini, G, Sürder, D, Pasotti, E, Moccetti, T, Faletra, F, Qayyum, AA, Hasbak, P, Larsson, HB, Mathiasen, AB, Vejlstrup, NG, Kjaer, A, Kastrup, J, Moschetti, K, Favre, D, Pinget, C, Pilz, G, Petersen, S, Wagner, A, Wasserfallen, JB, Schwitter, J, Ghosh Dastidar, A, Cengarle, M, McAlindon, E, Augustine, D, Nightingale, AK, Bucciarelli-Ducci, C, Dandekar, VK, Ertel, AW, Dickens, C, Gonzalez, RC, Farzaneh-Far, A, Ripley, DP, Higgins, D, McDiarmid, AK, Bainbridge, GJ, Uddin, A, Kidambi, A, Herzog, B, Greenwood, JP, Plein, S, Khanji, M, Newton, T, Westwood, M, Sekhri, N, and Petersen, SE
- Abstract
Background-Aims: Early post-infarction pericardial injury is a common finding but its diagnosis remains elusive. Though C-reactive protein (CRP) is considered a marker of myocardial damage, reflecting myocardial inflammation at the infarcted area, we sought to assess the relationship between CRP and pericardial injury depicted by cardiovascular magnetic resonance (CMR) imaging in patients with ST elevation myocardial infarction (MI). Methods and results: 181 MI patients (84% male) were studied with CMR in the first week and at 4 months post-infarction to assess infarct characteristics, left ventricular volumes/function and pericardial injury. The latter was defined as pericardial fluid >4mm and/or enhancement on late gadolinium enhancement CMR. The CRP-value at day 2 (according to previous literature) was used for correlation with CMR and clinical parameters. Pericardial injury was noted in 87 patients, i.e. effusion (n = 30), inflammation (n = 46), both (n = 11). Patients with pericardial injury had significantly higher peak values of cardiac biomarkers (p<0.001) and higher peak CRP-values than patients with normal pericardium (median 13 vs 43 mg/dl, p<0.001). A strong correlation was found between peak CRP-values and a) left venticular ejection fraction and infarct size both at 1 week and 4 months, b) myocardial hemorrhage, microvascular obstruction (MVO) and pericardial injury at 1 week, c) cardiac biomarkers values and time to PCI. However in a multiple regression model only pericardial injury (p = 0.003) and less importantly time to PCI (p = 0.022) were the independent predictors of CRP values. Conclusion: Pericardial damage described by cardiac MRI occurs often after acute ST elevation MI. CRP-values at the acute phase of MI reflect not only inflammation at the infarcted area but even more the inflammation of the surrounding pericardial tissue.
Table 1 Comparison of baseline clinical and biochemical parameters of patients with or without evidence of early post-infarct pericardial damage on CMR Normal Group (n = 94) Pericardial injury group (n = 87) p-value Agem, years 59±11 60±12 0.48 Male, n(%) 83 (88) 69 (79) 0.10 Diabets, n(%) 12 (13) 9 (10) 0.61 Smoker, n(%) 52 (55) 44 (51) 0.52 Hyperlipidemia, n(%) 56 (60) 55 (63) 0.62 BSA m2 2.0 ± 0.2 2.0 ± 0.2 0.20 Time to PCI, min 195 (155 − 274) 223 (160 − 335) 0.20 Troponin I, μ/l 44 (19 − 92) 90 (44 − 149) >0.001 CK-MB, U/L 128 (77 − 216) 250 (143 − 443) >0.001 CRP, mg/dL 13 (7 − 28) 43 (16 − 96) >0.001 Day of peak CRP 2 (1 − 3) 2 (1 − 3) 0.39 Table 2 Significant correlations between CRP Values and corresponding CMR measurements, cardic biomarkers and clinical related parameters Varibles Spearmanscorrelations r p-value CMR parameters 1 week LV EF −0.28 >0,001 Infractsize(%ofLV) 0.40 >0,001 Microvasular obstruction 0.27 >0,001 Hemorrhage 0.33 >0,001 Size of area atrisk 0.31 >0,001 Transmurality 0.30 >0,001 Pericaldial damage 0.43 >0,001 CMR parameters 4 months LVEF −0.43 >0,001 Infarctsize(%ofLV) 0.46 >0,001 Cardiac Biomarkers Peak TnI 0.34 >0,001 Peak CK-MB 0.32 >0,001 Other Time to PCI 0,182 0,007 - Published
- 2013
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37. Fibrofatty involution of rhabdomyomas: a longitudinal series of cardiac MRI studies in a patient with possible tuberous sclerosis complex.
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Ferreira J, Velazquez PP, Zaromytidou M, Montrasio G, Mohiddin S, and Sekhri N
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- Humans, Male, Longitudinal Studies, Magnetic Resonance Imaging, Young Adult, Heart Neoplasms diagnostic imaging, Rhabdomyoma diagnostic imaging, Tuberous Sclerosis diagnostic imaging, Tuberous Sclerosis complications
- Abstract
Competing Interests: Declaration of interests We declare no competing interests.
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- 2024
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38. Distal Ventricular Pacing for Drug-Refractory Mid-Cavity Obstructive Hypertrophic Cardiomyopathy: A Randomized, Placebo-Controlled Trial of Personalized Pacing.
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Malcolmson JW, Hughes RK, Husselbury T, Khan K, Learoyd AE, Lees M, Wicks EC, Smith J, Simms AD, Moon JC, Lopes LR, O'Mahony C, Sekhri N, Elliott PM, Petersen SE, Dhinoja MB, and Mohiddin SA
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- Humans, Male, Female, Middle Aged, Treatment Outcome, Aged, Quality of Life, Time Factors, Hemodynamics, Ventricular Outflow Obstruction physiopathology, Ventricular Outflow Obstruction therapy, Ventricular Outflow Obstruction diagnosis, Exercise Tolerance, Ventricular Function, Right, Recovery of Function, Cardiac Pacing, Artificial methods, Cardiomyopathy, Hypertrophic therapy, Cardiomyopathy, Hypertrophic physiopathology, Cardiomyopathy, Hypertrophic diagnosis, Cross-Over Studies, Ventricular Function, Left
- Abstract
Background: Patients with refractory, symptomatic left ventricular (LV) mid-cavity obstructive (LVMCO) hypertrophic cardiomyopathy have few therapeutic options. Right ventricular pacing is associated with modest hemodynamic and symptomatic improvement, and LV pacing pilot data suggest therapeutic potential. We hypothesized that site-specific pacing would reduce LVMCO gradients and improve symptoms., Methods: Patients with symptomatic-drug-refractory LVMCO were recruited for a randomized, blinded trial of personalized prescription of pacing (PPoP). Multiple LV and apical right ventricular pacing sites were assessed during an invasive hemodynamic study of multisite pacing. Patient-specific pacing-site and atrioventricular delays, defining PPoP, were selected on the basis of LVMCO gradient reduction and acceptable pacing parameters. Patients were randomized to 6 months of active PPoP or backup pacing in a crossover design. The primary outcome examined invasive gradient change with best-site pacing. Secondary outcomes assessed quality of life and exercise following randomization to PPoP., Results: A total of 17 patients were recruited; 16 of whom met primary end points. Baseline New York Heart Association was 3±0.6, despite optimal medical therapy. Hemodynamic effects were assessed during pacing at the right ventricular apex and at a mean of 8 LV sites. The gradients in all 16 patients fell with pacing, with maximum gradient reduction achieved via LV pacing in 14 (88%) patients and right ventricular apex in 2. The mean baseline gradient of 80±29 mm Hg fell to 31±21 mm Hg with best-site pacing, a 60% reduction ( P <0.0001). One cardiac vein perforation occurred in 1 case, and 15 subjects entered crossover; 2 withdrawals occurred during crossover. Of the 13 completing crossover, 9 (69%) chose active pacing in PPoP configuration as preferred setting. PPoP was associated with improved 6-minute walking test performance (328.5±99.9 versus 285.8±105.5 m; P =0.018); other outcome measures also indicated benefit with PPoP., Conclusions: In a randomized placebo-controlled trial, PPoP reduces obstruction and improves exercise performance in severely symptomatic patients with LVMCO., Registration: URL: https://clinicaltrials.gov/study; Unique Identifier: NCT03450252., Competing Interests: Prof Petersen provides Consultancy to Circle Cardiovascular Imaging Inc., Calgary, Alberta, Canada. Dr Lopes has received speaker fees from Sanofi, Alnylam, and Bristol Myers Squibb (BMS); and received a grant from BMS.
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- 2024
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39. Peripheral Nerve Stimulation for Treating Acute Pain Following Traumatic Fracture: A Case Report of Rapid-Onset Analgesia Without Motor Blockade.
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Siddiqui A, Sekhri N, Salik I, Yu F, and Xu JL
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Analgesia following acute traumatic fracture remains a clinical challenge. Pain relief via peripheral nerve stimulation (PNS) is a promising treatment modality due to its opioid-sparing effects and rapid, reversible sensory blockade without motor blockade. We present the case of a patient who suffered a traumatic tibial plateau fracture. A popliteal sciatic PNS device was placed on postoperative day 1 following inadequate pain control. The patient reported marked pain relief, a significant reduction in morphine milligram equivalent (MME) utilization, and improved early functional recovery. The PNS lead was removed at the patient's 2-month follow-up visit without any adverse events., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Siddiqui et al.)
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- 2024
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40. Fentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report.
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Siddiqui A, Agrawal S, and Sekhri N
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- Female, Humans, Young Adult, Adult, Fentanyl, Serotonin Agents adverse effects, Seizures, Serotonin Syndrome chemically induced, Serotonin Syndrome drug therapy, Drug Overdose drug therapy
- Abstract
A 21-year-old patient with intellectual disability was admitted for gastroenteritis due to serotonergic medication overdose, and subsequently developed serotonin syndrome. Her symptoms initially improved after the cessation of serotonergic medications, but worsened 5 days later after fentanyl administration during general anesthesia. On emergence, she had convulsions and was nonresponsive. Subsequent imaging and electroencephalography did not demonstrate intracranial pathology or seizure activity. We suspect she had an exacerbation of her serotonin syndrome. She recovered successfully after supportive care. This case demonstrates that common medications used during anesthesia such as fentanyl can provoke serotonin syndrome, even several days after serotonergic drug discontinuation., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 International Anesthesia Research Society.)
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- 2023
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41. Risk Factors for Postoperative Unplanned Reintubation in a Cohort of Patients Undergoing General Anesthesia.
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Sofjan I, Vazquez S, Dominguez J, Sekhri N, Wecksell M, Samuel BM, and Salik I
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Background Unplanned post-operative reintubation (UPR) is a complication of general anesthesia (GA) that can be associated with worsened outcomes. Objective Evaluate characteristics associated with UPR in patients undergoing procedures under GA. Methods Patients over the age of 18 undergoing surgical procedures under GA were extracted from our institution's electronic medical record. Patient baseline, procedural, and anesthesia characteristics were evaluated for associations with UPR. Results In 29,284 surgical procedures undergoing GA, there were 29 (0.1%) patients that required UPR. The most common surgical service with UPR was otolaryngology; the most common surgical positioning was supine. When controlling for operative time and case complexity, UPR was predicted by high-dose opioids, defined as opioid administration greater than the 75th percentile of our institutional cohort. Prolonged operative time, estimated blood loss (EBL), body mass index (BMI), extubation time after reversal, or age were not independently associated with UPR. Conclusion Our analysis revealed that high-dose opioid administration is independently associated with intraoperative UPR. Awareness of patients at the highest risk for UPR along with provider education regarding techniques to avoid respiratory depression in this patient population is essential in reducing patient morbidity and mortality. This knowledge will help guide perioperative physicians in medical optimization, appropriate selection of intraoperative analgesics, and cautious extubation criteria to ensure patient safety., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Sofjan et al.)
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- 2023
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42. Health-related quality of life in cardiac sarcoidosis: a systematic review.
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Quijano-Campos JC, Sekhri N, Thillai M, and Sanders J
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People living with cardiac sarcoidosis (CS) are likely to have worse clinical outcomes and greater impairment on health-related quality of life (HRQoL) than other sarcoidosis manifestations. CS can result in a constellation of intrusive symptoms (such as palpitations, dizziness, syncope/pre-syncope, chest pain, dyspnoea, orthopnoea, or peripheral oedema) and/or life-threatening episodes, requiring consideration of invasive cardiac procedures for diagnosis and for the management of acute events. Additionally, the presence of multisystemic involvement and persistent non-specific sarcoidosis symptoms negatively affect HRQoL. A systematic review was undertaken to explore the impact of CS on HRQoL in adults with CS. Multiple bibliographic databases were searched for studies with HRQoL as primary or secondary outcomes in CS (PROSPERO registration: CRD42019119752). Data extraction and quality assessments were undertaken independently by two authors. From the initial 1609 identified records, only 11 studies included CS patients but none specifically reported HRQoL scores for CS patients. The average representation of CS patients was 14.5% within these cohorts (range 2-22%). The majority (73%) was conducted in single-centre tertiary care settings, and only one study (9%) included longitudinal HRQoL data. CS patients were among those sarcoidosis patients with impaired HRQoL and worse outcomes, requiring higher doses of sarcoidosis-specific therapy which contribute to further deterioration of HRQoL. Sarcoidosis studies do not incorporate stratified HRQoL scores for CS patients. While there is a need for longitudinal and multicentre studies assessing HRQoL outcomes in CS cohorts, the development of CS-specific tools is also needed., Competing Interests: Conflict of interest: J.S. is the primary supervisor for the award NIHR301572 and is supported to attend European Society of Cardiology (ESC) meetings as board member for the Association for Cardiovascular Nursing and Allied Professions (ACNAP). The other authors declare no conflict of interest relevant to this article., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2023
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43. Acute Myocarditis Associated With Desmosomal Gene Variants.
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Ammirati E, Raimondi F, Piriou N, Sardo Infirri L, Mohiddin SA, Mazzanti A, Shenoy C, Cavallari UA, Imazio M, Aquaro GD, Olivotto I, Pedrotti P, Sekhri N, Van de Heyning CM, Broeckx G, Peretto G, Guttmann O, Dellegrottaglie S, Scatteia A, Gentile P, Merlo M, Goldberg RI, Reyentovich A, Sciamanna C, Klaassen S, Poller W, Trankle CR, Abbate A, Keren A, Horowitz-Cederboim S, Cadrin-Tourigny J, Tadros R, Annoni GA, Bonoldi E, Toquet C, Marteau L, Probst V, Trochu JN, Kissopoulou A, Grosu A, Kukavica D, Trancuccio A, Gil C, Tini G, Pedrazzini M, Torchio M, Sinagra G, Gimeno JR, Bernasconi D, Valsecchi MG, Klingel K, Adler ED, Camici PG, and Cooper LT Jr
- Subjects
- Gadolinium, Humans, Retrospective Studies, Stroke Volume, Troponin, Ventricular Function, Left, Young Adult, Heart Failure, Myocarditis genetics
- Abstract
Background: The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown., Objectives: The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV., Methods: In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up., Results: In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM., Conclusions: Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk., Competing Interests: Funding Support and Author Disclosures Dr Ammirati has received a grant from the Italian Ministry of Health (GR-2019-12368506) and is a consultant for Kiniksa and Cytokinetics. Dr Adler is a consultant for Abbott, Abiomed, AstraZeneca, Endotronix, Ionis, Medtronic, and Novartis; is on the board of directors of Genstem Therapeutics; and is a shareholder of Rocket Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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44. Systematic assessment in patients with dilated cardiomyopathy phenotype.
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Khanji MY, Archbold RA, Gallagher A, and Sekhri N
- Subjects
- Fibrosis, Phenotype, Cardiomyopathies, Cardiomyopathy, Dilated diagnostic imaging, Cardiomyopathy, Dilated genetics, Citrus sinensis
- Abstract
Competing Interests: Conflict of interest: None declared.
- Published
- 2022
- Full Text
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45. Evidence to support magnetic resonance conditional labelling of all pacemaker and defibrillator leads in patients with cardiac implantable electronic devices.
- Author
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Bhuva AN, Moralee R, Brunker T, Lascelles K, Cash L, Patel KP, Lowe M, Sekhri N, Alpendurada F, Pennell DJ, Schilling R, Lambiase PD, Chow A, Moon JC, Litt H, Baksi AJ, and Manisty CH
- Subjects
- Electronics, Humans, Magnetic Resonance Imaging adverse effects, Magnetic Resonance Spectroscopy, Defibrillators, Implantable, Pacemaker, Artificial
- Abstract
Aims: Many cardiac pacemakers and defibrillators are not approved by regulators for magnetic resonance imaging (MRI). Even following generator exchange to an approved magnetic resonance (MR)-conditional model, many systems remain classified 'non-MR conditional' due to the leads. This classification makes patient access to MRI challenging, but there is no evidence of increased clinical risk. We compared the effect of MRI on non-MR conditional and MR-conditional pacemaker and defibrillator leads., Methods and Results: Patients undergoing clinical 1.5T MRI with pacemakers and defibrillators in three centres over 5 years were included. Magnetic resonance imaging protocols were similar for MR-conditional and non-MR conditional systems. Devices were interrogated pre- and immediately post-scan, and at follow-up, and adverse clinical events recorded. Lead parameter changes peri-scan were stratified by MR-conditional labelling. A total of 1148 MRI examinations were performed in 970 patients (54% non-MR conditional systems, 39% defibrillators, 15% pacing-dependent) with 2268 leads. There were no lead-related adverse clinical events, and no clinically significant immediate or late lead parameter changes following MRI in either MR-conditional or non-MR conditional leads. Small reductions in atrial and right ventricular sensed amplitudes and impedances were similar between groups, with no difference in the proportion of leads with parameter changes greater than pre-defined thresholds (7.1%, 95% confidence interval: 6.1-8.3)., Conclusions: There was no increased risk of MRI in patients with non-MR conditional pacemaker or defibrillator leads when following recommended protocols. Standardizing MR conditions for all leads would significantly improve access to MRI by enabling patients to be scanned in non-specialist centres, with no discernible incremental risk., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2022
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46. Postoperative analgesic technique with the use of thoracolumbar dorsal ramus nerve catheter for adult non-opioid naïve patients after spinal deformity surgery.
- Author
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Ma H, Yu F, Rahimi M, Sekhri N, and Xu JL
- Subjects
- Adult, Analgesics, Catheters, Humans, Lumbar Vertebrae surgery, Postoperative Period, Spinal Fusion, Thoracic Vertebrae surgery
- Published
- 2022
- Full Text
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47. Extensive myocardial scarring in idiopathic dilated cardiomyopathy: implications for management and prognosis.
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Khanji MY, Archbold RA, Gallagher A, and Sekhri N
- Subjects
- Cicatrix diagnostic imaging, Cicatrix pathology, Humans, Myocardium pathology, Prognosis, Cardiomyopathy, Dilated diagnostic imaging, Cardiomyopathy, Dilated pathology, Cardiomyopathy, Dilated therapy
- Published
- 2022
- Full Text
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48. Complete heart block and multisystem sarcoidosis: myocardial inflammation and scar imaging to guide diagnosis and management.
- Author
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Oji O, Sohaib A, Sekhri N, and Khanji MY
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- 2022
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49. Spinal vs. General Anesthesia for Hip-Fracture Surgery.
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Shabsigh M, Sekhri N, and Xu JL
- Subjects
- Anesthesia, General, Humans, Spine, Hip Fractures surgery
- Published
- 2022
- Full Text
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50. Cervical Epidural Injection
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Dydyk AM and Sekhri N
- Abstract
Many patients with symptoms of cervical radiculopathy can benefit from a cervical epidural injection. Before one considers a cervical epidural injection, the patient’s pain must persist for at least six to eight weeks, and the patient has to have failed conservative management. Furthermore, patients must not have progressively worsening neurologic deficits. Cervical radiculopathy affects approximately 83 per 100,000 people per year.[1] Most cases of cervical radiculitis improve with conservative management and do not require a cervical epidural or surgical intervention.[2] Studies are mixed on the efficacy of cervical epidural pain relief, but overall, the injection seems to provide significant pain relief. Patients with chronic recurring neck pain with radicular symptoms can benefit from cervical epidural corticosteroid injections. Significant pain relief is considered 50 percent pain reduction at three months, with 50 percent of patients having significant pain relief after the procedure.[3][4] The typical injection pattern for cervical corticosteroid injections is following the initial injection; one or two repeat injections can occur two to four weeks later.[5] Radicular symptoms can have multiple etiologies ranging from non-degenerative to diabetes to malignancy. Spondylolisthesis and degenerative disc disease can occur and be a common etiology. Nerve root compression from either cervical spinal stenosis or a herniated disc of the cervical vertebra is the most common cause of cervical radiculopathy. The majority of patients with disc herniation or spondylosis do not require cervical epidural injections.[1][6] Cervical radiculopathy can lead to chronic neck pain, and intervention is often needed in refractory cases. Overall complications of the procedure include infection, spinal headache, allergic reaction, nerve damage, paralysis, and death. A transforaminal approach to a cervical epidural injection is a more targeted therapy delivery in comparison to an intralaminar technique but has a higher complication rate.[7], (Copyright © 2022, StatPearls Publishing LLC.)
- Published
- 2022
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