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O livro'A importância do selênio para a agropecuária e saúde humana'procura apresentar alguns aspectos relacionados às funções que o selênio pode desempenhar em animais e humanos. A obra inicia descrevendo o transporte do elemento a partir dos oceanos para os continentes, a química do microelemento no solo, sua absorção pelas plantas, bem como as funções do selênio nos vegetais. Na sequência, são abordados tópicos relativos aos benefícios que o micronutriente pode trazer aos animais de produção. Os últimos capítulos enfatizam a importância do selênio para a saúde humana, destacando o conceito da prevenção de doenças na população pela suplementação do micronutriente no solo e sua transferência ao longo da cadeia alimentar. Visto que ainda são escassas as publicações em língua portuguesa sobre o assunto, o livro representa uma iniciativa buscando preencher esse espaço. Os textos foram escritos em linguagem simples, acessível, portanto, não só para estudantes de graduação e pós-graduação de diversas áreas, como também para a população leiga.

Selenium (Se) is an essential dietary trace element participating in the regulation of various physiological functions in humans, farm animals and poultry through its incorporation into a range of selenoproteins. Low Se content in main feed ingredients is a common problem worldwide and dietary Se supplementation is a current practise in poultry and farm animal nutrition. Recent research clearly proved that sodium selenite, used for the last 40 years as a feed supplement, is not an optimal form of Se. However, use of organic selenium in animal/poultry diets can help meeting Se requirement and maintain high immunocompetence, productive and reproductive performance. The goal of this book is to provide up to date information about the roles of Se in poultry nutrition and health. A special emphasis is given to the role of selenium as an essential part of the integrated antioxidant system. Se in feed and organic Se are characterised in detail with emphasis to selenomethionine as a storage form of Se in the body. Also specific Se-deficiency related diseases in poultry are described and the importance of Se in growth, development, immunity and reproduction is demonstrated. A link between poultry industry and human health via production of Se-eggs and Se-enriched meat is shown. This book will be of practical importance to poultry producers, to nutritionists and vets as well as for avian/animal scientists, students of agricultural colleges and universities. It will also be of interest for researchers in areas related to ecology, environmental sciences, evolutionary biology, etc.

Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium. - Provides information on cancer research and prevention - Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention - Serves as an indispensable reference for researchers and students alike

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involvingselenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to

Selenium is an important micronutrient in humans and animals, despite its toxicity at high concentrations. This first chapter performs a thorough review of selenium bioavailability in food stuffs and human diet. The second chapter reviews the selenium essentiality and toxicity, the aspects related to the selenium dietary supplementation and its daily consumption. The third chapter describes the status of selenium and their metabolites in an antiretroviral therapy context. The next chapter looks at selenium supplementation and autoimmune thyroid diseases. Next, the authors address the association between diabetes type-2 and its levels in serum related to nutritional habits. Then, the preparation of nanosystems based on zero-valent selenium nanoparticles since this essential trace elements carries unique characteristics is explored. Finally, the prospects of using nanoparticles of elementary selenium as a nutrition source are discussed.

Although toxic in large doses, selenium is an essential trace mineral in the animal diet and in some plants. It has a role in making antioxidant enzymes and a particular role in the functioning of the thyroid gland. This volume examines the chemical activity of selenium and its functional health effects eg towards cancers, in the heart and brain. It also covers other areas such as functional food enrichment, whole body metabolism, and the effects of selenium deficiency on health. Part of The Food and Nutritional Components in Focus series, this edited volume pools knowledge across scientific disciplines in a way that increases its applicability to a wide range of audiences. Victor Preedy's own distinguished career in nutritional science has made him a prolific author of research articles and books in this area, and this project fills a gap in providing comprehensive synopses of food substances. Chemists, analytical scientists, forensic scientists, food scientists, as well as course lecturers will all benefit from this interdisciplinary title written by international experts in this area.

Selenium is one of the most intensively studied of the inorganic components of the diet. Ever since it was recognised in the 1950s that the element, which effects, was also an essential had until then been known only for its toxic nutrient, it has attracted growing interest in both human and agricultural fields of science. The literature on selenium is overwhelming. Possibly 100000 publica­ tions dealing with the element have appeared since it was discovered in 1817. They continue to appear in numbers that make it difficult to keep up with even major aspects of the subject. Selenium specialisations have developed, not simply in agriculture and human studies, but also in molecular biology, metabolism, paediatric, enteral and parenteral nutrition, public health, toxicology and environmental health. All are developing their own literature and often an exclusiveness that results in loss of shared ideas and the fruitfullness of cross-boundary communication. This growth of knowledge and exclusiveness can place many readers at a disadvantage since it limits access to important new information. An appreciation of the role played by selenium in metabolism and health is far more than just an extra item in the intellectual database of modern food and health scientists. An understanding of selenium and its functions can enrich our understanding, not just of a single trace nutrient, but also of the many other food components with which selenium interacts.

Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.

Selenium (Se) is an essential trace element of fundamental importance to health, primarily due to its antioxidant activity. Selenium has chemoprotective, anti-inflammatory, and antiviral properties and is related to enhancing immunity, controlling gastrointestinal, and reducing age-related disorders. In this book, the authors present current research in the study of the sources, functions and health effects of selenium. Topics discussed include selenium biorhythms and hormonal regulation; the physiological role of selenium; selenium supplementation of diet effects on antioxidant activity and protects against antibiotic resistance and avian influenza in poultry; selenium in critical illness and tropical diseases; products of animal origin as a source of Se in the human diet; selenium in food materials and stress signaling and proapoptotic pathways induced by selenite in malignant coloncytes.

Over the past 50 years more than 100,000 scientific papers, not to mention popular articles and books, have been written about Selenium. These publications continue to appear without showing any sign of diminution today. This mass of writing makes it very difficult for anyone, who is not a dedicated and specialized scientist, to get a clear picture of what is now known about the element and its role in human health. The second edition of Selenium in Food and Health takes into account the considerable amount of fresh information that has been published over the past decade, by investigators from a wide range of specialties, not all of which, at first glance, might appear to have much to do with human health. It presents information in an easy-to-follow manner for the general reader who wants to make an informed judgment about the competing claims for and against Selenium's value as a nutritional supplement, and for professionals who want to keep abreast of the latest findings about its potential role in the management of human health.

The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.

Selenium: Geobotany, Biochemistry, Toxicity, and Nutrition focuses on the properties, characteristics, reactions, applications, chemistry, and transformations of selenium. The book first offers information on the geological distribution of selenium, including the formation of seleniferous soils, chemical forms of selenium in soils, selenium in water, selenium on the sea floor and in sea water, and geobotany. The text then takes a look at selenium indicator in plants and accumulation of selenium by plants. Discussions focus on selenium accumulations in indicator plants; selenium accumulation in farm crops and native grasses; factors that influence selenium accumulation in plants; and identification of indicators by germination tests. The manuscript elaborates on selenium poisoning in animals and prevention and control of selenium poisoning. Acute selenium poisoning, chronic selenium poisoning by inorganic selenium, and recognition of poisonous range plants are also discussed. The text also examines selenium in nutrition and the chemistry of selenium. The publication is a valuable source of data for readers interested in the study of selenium.