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173 results on '"Selgrad M"'

6. Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction

Author

Bornschein, J, Wernisch, L, Secrier, M, Miremadi, A, Perner, J, MacRae, S, O'Donovan, M, Newton, R, Menon, S, Bower, L, Eldridge, MD, Devonshire, G, Cheah, C, Turkington, R, Hardwick, RH, Selgrad, M, Venerito, M, Malfertheiner, P, Fitzgerald, RC, Noorani, A, Elliott, RF, Edwards, PAW, Grehan, N, Nutzinger, B, Crawte, J, Chettouh, H, Contino, G, Li, X, Gregson, E, Zeki, S, De la Rue, R, Malhotra, S, Tavare, S, Lynch, AG, Smith, ML, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Noble, F, Owsley, J, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, and Grabowska, A

Subjects
Oncology, Cancer Research, Esophageal Neoplasms, esophageal adenocarcinoma, gastroesophageal junction, SUBTYPES, Transcriptome, Molecular Cancer Biology, 0302 clinical medicine, Gene expression, Prospective Studies, BILE-ACIDS, SIGNATURE, Prognosis, Immunohistochemistry, Phenotype, medicine.anatomical_structure, 030220 oncology & carcinogenesis, OCCAMS Consortium, Adenocarcinoma, Esophagogastric Junction, Life Sciences & Biomedicine, EXPRESSION, medicine.medical_specialty, Biology, CLASSIFICATION, Siewert classification, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Stomach Neoplasms, Internal medicine, gene expression profiling, medicine, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Esophagus, Science & Technology, Anatomical location, IDENTIFICATION, Gene Expression Profiling, gastric cancer, PATHWAYS, medicine.disease, Gene expression profiling, ESOPHAGUS, GASTRIC-CANCER
Abstract

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The gene expression profiles of 107 treatment‐naïve, intestinal type, gastroesophageal adenocarcinomas were assessed by the Illumina‐HTv4.0 beadchip. Differential gene expression (limma), unsupervised subgroup assignment (mclust) and pathway analysis (gage) were undertaken in R statistical computing and results were related to demographic and clinical parameters. Unsupervised assignment of the gene expression profiles revealed three distinct molecular subgroups, which were not associated with anatomical location, tumor stage or grade (p > 0.05). Group 1 was enriched for pathways involved in cell turnover, Group 2 was enriched for metabolic processes and Group 3 for immune‐response pathways. Patients in group 1 showed the worst overall survival (p = 0.019). Key genes for the three subtypes were confirmed by immunohistochemistry. The newly defined intrinsic subtypes were analyzed in four independent datasets of gastric and esophageal adenocarcinomas with transcriptomic data available (RNAseq data: OCCAMS cohort, n = 158; gene expression arrays: Belfast, n = 63; Singapore, n = 191; Asian Cancer Research Group, n = 300). The subgroups were represented in the independent cohorts and pooled analysis confirmed the prognostic effect of the new subtypes. In conclusion, adenocarcinomas at the GEJ comprise three distinct molecular phenotypes which do not reflect anatomical location but rather inform our understanding of the key pathways expressed., What's new? Adenocarcinomas that arise at the junction between the esophagus and the stomach are currently classified based on location. Here, the authors looked at patterns of gene expression of these cancers. They found that gastro‐esophageal junction adenocarcinomas can be sorted into three biological subtypes, independent of location, based on gene expression. Group 1 cancers have boosted stomach‐specific genes that combat the effects of acid reflux. Group 2 tumors express genes characteristic to the intestinal tract, and the genes active in Group 3 relate to inflammation. The differences in biological pathway expression means that these differences could be used to improve treatment.

Published
2019

8. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction

Author

Selgrad, M., De Giorgio, R., Fini, L., Cogliandro, R.F., Williams, S., Stanghellini, V., Barbara, G., Tonini, M., Corinaldesi, R., Genta, R.M., Domiati-Saad, R., Meyer, R., Goel, A., Boland, C.R., and Ricciardiello, L.

Subjects
Polyoma virus -- Identification and classification, Neuroglia -- Diseases, Intestine, Small -- Diseases, Nervous system, Autonomic -- Diseases, Intestines -- Obstructions, Intestines -- Development and progression, Intestines -- Research, Health
Published
2009

18. Das Sheehan Syndrom

Author

Selgrad, C, additional, Kandulski, M, additional, Selgrad, M, additional, Müller, M, additional, and Ortmann, O, additional

Published
2018
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23. Management of helicobacter pylori infection-the Maastricht V/Florence consensus report

Author

Malfertheiner, P., Mégraud, F., O'Morain, C. (C.), Gisbert, J.P. (Javier), Kuipers, E.J. (Ernst), Axon, A.T., Bazzoli, F. (Franco), Gasbarrini, A., Atherton, J., Graham, D.Y. (David Y.), Hunt, R., Moayyedi, P. (Paul), Rokkas, T., Rugge, M. (Massimo), Selgrad, M., Suerbaum, S., Sugano, K. (Kentaro), El-Omar, E., Malfertheiner, P., Mégraud, F., O'Morain, C. (C.), Gisbert, J.P. (Javier), Kuipers, E.J. (Ernst), Axon, A.T., Bazzoli, F. (Franco), Gasbarrini, A., Atherton, J., Graham, D.Y. (David Y.), Hunt, R., Moayyedi, P. (Paul), Rokkas, T., Rugge, M. (Massimo), Selgrad, M., Suerbaum, S., Sugano, K. (Kentaro), and El-Omar, E.

Abstract

Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. Pylori were re-evaluated in 2015. In the Maastricht V/Florence Consensus Conference, 43 experts from 24 countries examined new data related to H. pylori in five subdivided workshops: (1) Indications/ Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) H. pylori and the Gastric Microbiota. The results of the individual workshops were presented to a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in the various clinical scenarios.

Published
2017
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32. Annurca Apple Polyphenol Extracts (APES) reduce polyps formation and growth and increase tumor suppressor genes transcription in APCMIN/+ Mice either fed western or balanced diets

Author

Fini L, Selgrad M, Daoud Y, Garcia M, Fogliano V, Romano M, Genta R, Gasbarrini A, Boland C, PIAZZI, GIULIA, RICCIARDIELLO, LUIGI, Fini L, Selgrad M, Piazzi G, Daoud Y, Garcia M, Fogliano V, Romano M, Genta R, Gasbarrini A, Boland C, and Ricciardiello L

Subjects
POLYPHENOLS, ApcMin/+, apple, COLON CANCER
Published
2009

33. JC Virus Infects the Enteric Glia of Patients with Chronic Idiopathic Intestinal Pseudo-Obstruction

Author

Selgrad M, Fini L, Williams S, Tonini M, Genta RM, Goel A, Boland CR, DE GIORGIO, ROBERTO, COGLIANDRO, ROSANNA FRANCESCA, STANGHELLINI, VINCENZO, BARBARA, GIOVANNI, CORINALDESI, ROBERTO, RICCIARDIELLO, LUIGI, Selgrad M, De Giorgio R, Fini L, Cogliandro R, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Goel A, Boland CR, and Ricciardiello L.

Subjects
COLORECTAL CANCER, LIVER TRANSPLANTATION, jc virus
Published
2008

34. JC virus is present in H. pylori-induced gastritis and gastric cancer

Author

Selgrad M, Wex T, Kuester D, Williams S, Meyer R, Malfertheiner P, Goel A, Boland C., RICCIARDIELLO, LUIGI, Selgrad M, Wex T, Kuester D, Williams S, Meyer R, Ricciardiello L, Malfertheiner P, Goel A, and Boland C.

Subjects
GASTRIC CANCER, jc viru, HELICOBACTER PYLORI
Published
2008

35. Epigenetic Silencing of Dll1 Regulates Notch Activation in Gastric Cancer

Author

Fini L, Garcia M, Selgrad M, Shin SK, Jascur T, Yao Y, Malfertheiner P, Wex T, Genta RM, Goel A, Sepulveda A, Boland CR, RICCIARDIELLO, LUIGI, Fini L, Garcia M, Selgrad M, Shin SK, Jascur T, Yao Y, Malfertheiner P, Wex T, Genta RM, Goel A, Sepulveda A, Boland CR, and Ricciardiello L.

Subjects
NOTCH, COLORECTAL CANCER, DNA METHYLATION
Published
2008

36. The Role of JC Virus in Colorectal Neoplasia Occurring After Liver Transplantation

Author

Selgrad M, Koornstra JJ, Fini L, Haagsma EB, Blom MR, Dijkstra G, Verdonk RC, de Jong S, Williams S, Meyer RL, Goel A, Boland C.R., RICCIARDIELLO, LUIGI, Selgrad M, Koornstra JJ, Fini L, Haagsma EB, Blom MR, Dijkstra G, Verdonk RC, de Jong S, Williams S, Meyer RL, Goel A, Ricciardiello L, and Boland CR.

Subjects
COLORECTAL CANCER, POLYOMAVIRUS JC INFECTION, LIVER TRANSPLANTATION
Published
2008

37. Association between JC virus and the development of colorectal neoplasia after liver transplantation

Author

Blom M, Selgrad M, de Jong S, Fini L, Dijkstra G, Verdonk RC, Williams S, Meyer R, Goel A, Kleibeuker JH, Haagsma EB, Boland CR, Koornstra J.J., RICCIARDIELLO, LUIGI, Blom M, Selgrad M, de Jong S, Fini L, Dijkstra G, Verdonk RC, Williams S, Meyer R, Goel A, Kleibeuker JH, Haagsma EB, Ricciardiello L, Boland CR, and Koornstra JJ.

Subjects
COLORECTAL CANCER, jc viru, LIVER TRANSPLANTATION
Published
2008

39. JC virus infection in patients with chronic idiopathic intestinal pseudo obstruction

Author

Selgrad M, Fini L, Williams S, Meyer R, Genta R. M, Goel A, Boland C, Ricciardiello L., DE GIORGIO, ROBERTO, COGLIANDRO, ROSANNA FRANCESCA, STANGHELLINI, VINCENZO, BARBARA, GIOVANNI, TONINI, MARCELLO, CORINALDESI, ROBERTO, BRITISH SOCIETY OF GASTROENTEROLOGY, Selgrad M, De Giorgio R, Fini L, Cogliandro R, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Williams S, Meyer R, Genta R. M, Goel A, Boland C, and Ricciardiello L.

Published
2007

40. Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

Author

Malfertheiner, P, primary, Megraud, F, additional, O'Morain, C A, additional, Gisbert, J P, additional, Kuipers, E J, additional, Axon, A T, additional, Bazzoli, F, additional, Gasbarrini, A, additional, Atherton, J, additional, Graham, D Y, additional, Hunt, R, additional, Moayyedi, P, additional, Rokkas, T, additional, Rugge, M, additional, Selgrad, M, additional, Suerbaum, S, additional, Sugano, K, additional, and El-Omar, E M, additional

Published
2016
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42. S3-Leitlinie 'Magenkarzinom' – Diagnostik und Therapie der Adenokarzinome des Magens und ösophagogastralen Übergangs

Author

Moehler, M., Al-Batran, S. E., Andus, T., Anthuber, M., Arends, J., Arnold, D., Aust, D., Baier, P., Baretton, G., Bernhardt, J., Boeing, H., Böhle, E., Bokemeyer, C., Bornschein, J., Budach, W., Burmester, E., Caca, K., Diemer, W. A., Dietrich, C. F., Ebert, M., Eickhoff, A., Ell, C., Fahlke, J., Feussner, H., Fietkau, R., Fischbach, W., Fleig, W., Flentje, M., Gabbert, H. E., Galle, P. R., Geissler, M., Gockel, I., Graeven, U., Grenacher, L., Gross, S., Hartmann, J. T., Heike, M., Heinemann, V., Herbst, B., Herrmann, T., Höcht, S., Hofheinz, R. D., Höfler, H., Höhler, T., Hölscher, A. H., Horneber, M., Hübner, J., Izbicki, J. R., Jakobs, R., Jenssen, C., Kanzler, S., Keller, M., Kiesslich, R., Klautke, G., Körber, J., Krause, B. J., Kuhn, C., Kullmann, F., Lang, H., Link, H., Lordick, F., Ludwig, K., Lutz, M., Mahlberg, R., Malfertheiner, P., Merkel, S., Messmann, H., Meyer, H. J., Mönig, S., Piso, P., Pistorius, S., Porschen, R., Rabenstein, T., Reichardt, P., Ridwelski, K., Röcken, C., Roetzer, I., Rohr, P., Schepp, W., Schlag, P. M., Schmid, R. M., Schmidberger, H., Schmiegel, W. H., Schmoll, H. J., Schuch, G., Schuhmacher, C., Schütte, K., Schwenk, W., Selgrad, M., Sendler, A., Seraphin, J., Seufferlein, T., Stahl, Michael, Stein, H., Stoll, C., Stuschke, Martin, Tannapfel, A., Tholen, R., Thuss-Patience, P., Treml, K., Vanhoefer, Udo Joachim, Vieth, M., Vogelsang, H., Wagner, D., Wedding, U., Weimann, A., Wilke, Hansjochen, Wittekind, C., AWMF, and Bockisch, Andreas (Beitragende*r)

Subjects
Medizin
Published
2011

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