6 results on '"Selma Alagöz"'
Search Results
2. Low-dose valacyclovir use with preemptive monitoring in kidney transplant recipients with intermediate cytomegalovirus infection risk
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Arzu, Velioğlu, Selma, Alagöz, Dilek Ataş, Barutçu, Hakkı, Arıkan, Ebru, Aşıcıoğlu, Burak, Aksu, Nurhan, Seyahi, Serhan, Tuğlular, and VELİOĞLU A., Alagoz S., Atas D. B. , ARIKAN İ. H. , AŞICIOĞLU E., AKSU M. B. , Seyahi N., TUĞLULAR Z. S.
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Temel Tıp Bilimleri ,Cytomegalovirus ,Medicine (miscellaneous) ,Assessment and Diagnosis ,Sağlık Bilimleri ,Temel Bilgi ve Beceriler ,Genel Tıp ,Antiviral Agents ,Fundamental Medical Sciences ,Pathophysiology ,Clinical Medicine (MED) ,DISEASE ,TIP, GENEL & DAHİLİ ,Health Sciences ,Internal Medicine ,Humans ,Klinik Tıp (MED) ,Aile Sağlığı ,MEDICINE, GENERAL & INTERNAL ,Dahiliye ,Patofizyoloji ,Klinik Tıp ,Fundamentals and Skills ,General Medicine ,CLINICAL MEDICINE ,Kidney Transplantation ,Değerlendirme ve Teşhis ,Tıp ,Valacyclovir ,Cytomegalovirus Infections ,General Health Professions ,Medicine ,Tıp (çeşitli) ,Family Practice ,PROPHYLAXISVALGANCICLOVIRVALACICLOVIRPREVENTIONTHERAPYDISEASE ,Genel Sağlık Meslekleri - Abstract
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- 2022
3. Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group
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Abdulmecit Yildiz, Sena Ulu, Aysegul Oruc, Ali Riza Ucar, Savas Ozturk, Selma Alagoz, Necmi Eren, Ismail Kocyigit, Simal Koksal Cevher, Ali Burak Haras, Abdullah Sumnu, Turgay Arinsoy, Garip Sahin, Gultekin Suleymanlar, Caner Cavdar, Gizem Kumru Sahin, Ilhan Kurultak, Abdulkadir Unsal, Gulizar Sahin, Sinan Kazan, Erhan Tatar, Mehmet Dıkec, Belda Dursun, Hayriye Sayarlioglu, Kultigin Turkmen, Ayse Serra Artan, Nimet Aktas, Zulfikar Yilmaz, Ahmet Behlul, Hamad Dheir, Sim Kutlay, and Nurhan Seyahi
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Histopathology ,immunofluorescence ,primary membranous nephropathy ,nephrotic syndrome ,Turkey ,kidney biopsy ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people.Methods This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed.Results A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m2 (IQR, 75.4–116.3), and median proteinuria was 6000 mg/d (IQR, 3656–9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed.Conclusions Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.
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- 2022
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4. The impact of the COVID-19 pandemic on Fabry Disease Patients: an examination of Mood Status, Therapy Adherence, and COVID-19 infection
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Cebrail Karaca, Mevlut Tamer Dincer, Seyda Gul Ozcan, Betul Sarac, Saffa Ahmadzada, Selma Alagoz, Alev Bakir, Ertugrul Kiykim, Sinan Trabulus, and Nurhan Seyahi
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COVID-19 ,Enzyme replacement therapy ,Fabry disease ,Psychological effect ,Medicine - Abstract
Abstract Background Fabry disease (FD) is a rare metabolic disorder, in which a lifelong enzyme replacement therapy (ERT) constitutes the cornerstone of disease-specific therapy. In this study, we examined the effects of the COVID-19 pandemic and lockdown measures on the management of FD patients. Methods We collected data in three main domains; mood status, adherence to ERT, and COVID-19 infection. We used the Hospital Anxiety and Depression Scale (HADS) to evaluate the mood statuses of FD patients and the Morisky Medication Adherence Scale (MMAS) and the Medication Adherence Report Scale (MARS) to assess patients’ adherence to non-disease specific therapy. We also examined a control group to compare the mood status data. Results A total of 67 FD patients (males: 47.8%, mean age: 37.0 years) were recruited to the study, of which 58 were receiving ERT. Both the HADS depression and anxiety scores were higher in the control group compared to FD patients. During the first wave of the pandemic, 25 patients reported to have missed an infusion for a mean of 2.3 ± 1.7 doses and half of the patients had adopted a home-based infusion treatment regimen. COVID-19 infection developed in 25 patients, of which one died. The majority of our patients (71.6%) have had at least one shot of the vaccine. Conclusion We found that FD patients were more resilient to the negative psychological effects of lockdown. Traumatic growth may be an important factor in explaining this finding. Government-supported home therapy programs might be beneficial for FD patients to increase the therapy adherence.
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- 2022
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5. The Prevalence of Potential Drug-Drug Interactions in CKD-A Retrospective Observational Study of Cerrahpasa Nephrology Unit
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Andleeb Shahzadi, Ikbal Sonmez, Cagla Kose, Burhaneddin Oktan, Selma Alagoz, Haktan Sonmez, Adil Hussain, and Ahmet Gokhan Akkan
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chronic kidney disease ,drug-drug interactions ,polypharmacy ,hypertension ,hypotension ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Chronic kidney disease (CKD) is usually linked with polypharmacy and patients are invariably at risk of complex medication regimens. The present study was designed to estimate the potential drug-drug interactions (pDDIs) through the prescription patterns provided to patients of the Nephrology Transplant Unit of Cerrahpasa Medical Faculty patients. Materials and Methods: 96 patients were included in the study. pDDIs among every combination of the prescribed drug were analyzed using the Thomson Reuters Micromedex. Results: We found 149 pDDIs making 2.16 interactions per prescription with incidence rates of 69.7%. Approximately 4.1% of interactions were of significant severity, 75.1% moderate severity, and 20.8% were classified as minor pDDIs. The most frequent interactions were found between iron and aluminum, calcium or magnesium-containing products (21.37%), calcium channel blockers and beta-blockers (8.96%); and aspirin and aluminum, calcium, or magnesium-containing products (7.58%). We identified 42 drug pairs with probability of clinical significance. The most commonly reported clinical outcomes of the pDDIs were hypo- or hypertension (39.24%), decreased drug efficacy (24.05%), and arrhythmia (9.49%). Aluminum, calcium, or magnesium-containing drug products (33.10%) constituted the primary class of drugs involved in interactions. Conclusions: This study showed pharmacodynamics (49%), pharmacokinetics (42.94%) interactions, polypharmacy and gender as determinant of pDDIs. A comprehensive multicenter research is required to decrease the morbidity and ease the state burden.
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- 2022
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6. Prevalence of anemia in predialysis chronic kidney disease: Is the study center a significant factor?
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Selma Alagoz, Mevlut Tamer Dincer, Necmi Eren, Alev Bakir, Meltem Pekpak, Sinan Trabulus, and Nurhan Seyahi
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Medicine ,Science - Abstract
ObjectivesAnemia is highly prevalent in chronic kidney disease patients; however, its identification and management have been reported to be suboptimal. In this study we aimed to describe the prevalence, severity, risk factors, and treatment of anemia in different nephrology centers, among chronic kidney disease patients who were not given renal replacement therapy.Materials and methodsWe performed a multicenter cross-sectional study in three different nephrology clinics. Adult (>18 years of age) chronic kidney disease patients with an estimated glomerular filtration rate (eGFR) below 60 ml/min, and who were not started dialysis were recruited. Demographic, clinical and laboratory data regarding anemia and its management were collected using a standard data form. Anemia was defined as a hemoglobin level below 12g/dL and severe anemia as a hemoglobin level below 10g/dl.ResultsA total of 1066 patients were enrolled in the study. Anemia and severe anemia were present in 55.9% and 14.9% of the patients, respectively. The mean hemoglobin level for the whole cohort was 11.8±1.8 g/dL. Univariate analyses revealed that the mean hemoglobin level was significantly different among the centers. Moreover, the frequency of the presence of anemia stratified by severity was also significantly different among the centers. According to binary logistic regression analysis, gender, levels of eGFR and iron, ferritin ≥ 100 ng/mL, and the nephrology center were independent determinants of severe anemia.ConclusionsWe found a high prevalence of anemia among chronic kidney disease patients who were not on renal replacement therapy. Each center should determine the treatment strategy according to the patient's characteristics. According to our results, the center-specific management of anemia seems to be important.
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- 2020
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