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3. Longitudinal study of immunity to SARS‐CoV2 in ocrelizumab‐treated MS patients up to 2 years after COVID‐19 vaccination

Author

Kister, Ilya, primary, Curtin, Ryan, additional, Piquet, Amanda L., additional, Borko, Tyler, additional, Pei, Jinglan, additional, Banbury, Barbara L, additional, Bacon, Tamar E., additional, Kim, Angie, additional, Tuen, Michael, additional, Velmurugu, Yogambigai, additional, Nyovanie, Samantha, additional, Selva, Sean, additional, Samanovic, Marie I., additional, Mulligan, Mark J., additional, Patskovsky, Yury, additional, Priest, Jessica, additional, Cabatingan, Mark, additional, Winger, Ryan C., additional, Krogsgaard, Michelle, additional, and Silverman, Gregg J., additional

Published
2024
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6. SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis

Author

Baxter, Ryan M., primary, Cabrera-Martinez, Berenice, additional, Ghosh, Tusharkanti, additional, Rester, Cody, additional, Moreno, Miguel Guerrero, additional, Borko, Tyler L., additional, Selva, Sean, additional, Fleischer, Chelsie L., additional, Haakonsen, Nicola, additional, Mayher, Ariana, additional, Bowhay, Emily, additional, Evans, Courtney, additional, Miller, Todd M., additional, Huey, Leah, additional, McWilliams, Jennifer, additional, van Bokhoven, Adrie, additional, Deane, Kevin D., additional, Knight, Vijaya, additional, Jordan, Kimberly R., additional, Ghosh, Debashis, additional, Klarquist, Jared, additional, Kedl, Ross M., additional, Piquet, Amanda L., additional, and Hsieh, Elena W. Y., additional

Published
2024
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7. SARS-CoV-2 mRNA vaccination induces an antigen-specific T cell response correlating with plasma interferon-gamma in B cell depleted patients

Author

Borko, Tyler L., primary, Baxter, Ryan, additional, Cabrera-Martinez, Berenice, additional, Thiruppathi, Eagappanath, additional, Sabalza, Maite, additional, Venkataraman, Iswariya, additional, Selva, Sean, additional, Rester, Cody, additional, Sillau, Stefan, additional, Pastula, Daniel M., additional, Bennett, Jeffrey L., additional, Alvarez, Enrique, additional, Gross, Robert, additional, Shah, Anna, additional, Kammeyer, Ryan, additional, Corboy, John R., additional, Kedl, Ross M., additional, Hsieh, Elena W.Y., additional, and Piquet, Amanda L., additional

Published
2023
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9. Establishing Demographic and Comorbidity Based Reference Ranges for NfL and GFAP in Healthy Controls (P1-3.005)

Author

Borko, Tyler, primary, Barrera, Britney, additional, Ritchie, Alanna, additional, Selva, Sean, additional, Sillau, Stefan, additional, Engebretson, Eric, additional, Seale, Rebecca, additional, Valdez, Brooke, additional, Alvarez, Enrique, additional, Corboy, John, additional, Shah, Anna, additional, Gross, Robert, additional, Silva, Diego, additional, Owens, Gregory, additional, Piquet, Amanda, additional, Bennett, Jeffrey, additional, Vollmer, Timothy, additional, Chahin, Salim, additional, and Nair, Kavita, additional

Published
2023
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10. Biomarkers of Neuronal and Glial Injury in Leucine-Rich Glioma Inactivated-1 (LGI1) Autoimmune Encephalitis Patients: A Pilot Study (P5-5.013)

Author

Borko, Tyler, primary, Mizenko, Christopher, additional, Kammeyer, Ryan, additional, Ritchie, Alanna, additional, Selva, Sean, additional, Barrera, Britney, additional, Valdez, Brooke, additional, Sillau, Stefan, additional, Owens, Gregory, additional, Vollmer, Timothy, additional, Nair, Kavita, additional, Bennett, Jeffrey, additional, and Piquet, Amanda, additional

Published
2023
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11. An Observational Study on the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis and Other Autoimmune Neurological Disorders Treated With Anti-CD20 Therapies

Author

Borko, Tyler L., primary, Selva, Sean, additional, Baxter, Ryan, additional, Cabrera-Martinez, Berenice, additional, Rester, Cody, additional, Sillau, Stefan, additional, Pastula, Daniel M., additional, Sabalza, Maite, additional, Venkataraman, Iswariya, additional, Thiruppathi, Eagappanath, additional, Bennett, Jeffrey L., additional, Alvarez, Enrique, additional, Gross, Robert, additional, Shah, Anna, additional, Kammeyer, Ryan, additional, Vollmer, Timothy L., additional, Kedl, Ross, additional, Corboy, John R., additional, Hsieh, Elena, additional, and Piquet, Amanda L., additional

Published
2022
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12. Examining the Differences in Biomarkers of Neuronal and Glial Injury Between Autoimmune Neurologic Disease Patients and Healthy Controls

Author

Borko, Tyler L., primary, Barrera, Britney, additional, Mizenko, Christopher, additional, Ledreux, Aurélie, additional, Kammeyer, Ryan, additional, Ritchie, Alanna, additional, Selva, Sean, additional, Sillau, Stefan, additional, Engebretson, Eric, additional, Seale, Rebecca, additional, Valdez, Brooke, additional, Bennett, Jeffrey L., additional, Vollmer, Timothy L., additional, Nair, Kavita, additional, and Piquet, Amanda, additional

Published
2022
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13. sj-docx-1-mso-10.1177_20552173211069359 - Supplemental material for Tolerability and Safety of Switching from Rituximab to Ocrelizumab: Evaluating Factors Associated with Infusion Related Reactions

Author

Alvarez, Enrique, Nair, Kavita V., Sillau, Stefan, Shelton, Ian, Seale, Rebecca, Selva, Sean, Corboy, John, and Vollmer, Timothy L

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173211069359 for Tolerability and Safety of Switching from Rituximab to Ocrelizumab: Evaluating Factors Associated with Infusion Related Reactions by Enrique Alvarez, Kavita V. Nair, Stefan Sillau, Ian Shelton, Rebecca Seale, Sean Selva, John Corboy and Timothy L Vollmer in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2022
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15. Evaluating the Correlation Between Spinal Fluid and Blood Levels of Neurofilament Light, GFAP, Tau, and UCHL1: Do We Need a Correction Factor in Evaluating Blood Levels? (4912)

Author

Alvarez, Enrique, primary, Ritchie, Alanna, additional, Nair, Kavita, additional, Gross, Robert, additional, Piquet, Amanda, additional, Knapp, Courtney, additional, Selva, Sean, additional, Sillau, Stefan, additional, Bennett, Jeffrey L., additional, Owens, Gregory, additional, and Vollmer, Timothy, additional

Published
2020
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22. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype.

Author

Gross PS, Laforet VD, Manavi Z, Zia S, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Schafer DP, and Huang JK

Abstract

The capacity to regenerate myelin in the central nervous system (CNS) diminishes with age. This decline is particularly evident in multiple sclerosis (MS), which has been suggested to exhibit features of accelerated biological aging. Whether cellular senescence, a hallmark of aging, contributes to remyelination impairment remains unknown. Here, we show that senescent cells (SCs) accumulate within demyelinated lesions after injury, and their elimination enhances remyelination in young mice but not in aged mice. In young mice, we observed the upregulation of senescence-associated transcripts primarily in microglia after demyelination, followed by their reduction during remyelination. However, in aged mice, senescence-associated factors persisted within lesions, correlating with inefficient remyelination. We found that SC elimination enhanced remyelination in young mice but was ineffective in aged mice. Proteomic analysis of senescence-associated secretory phenotype (SASP) revealed elevated levels of CCL11/Eotaxin-1 in lesions, which was found to inhibit efficient oligodendrocyte maturation. These results suggest therapeutic targeting of SASP components, such as CCL11, may improve remyelination in aging and MS.

Published
2024
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23. Proinflammatory cytokines and matrix metalloproteinases in CSF of patients with VZV vasculopathy.

Author

Jones D, Alvarez E, Selva S, Gilden D, and Nagel MA

Abstract

Objective: To determine the levels of proinflammatory cytokines and matrix metalloproteinases (MMPs) in the CSF of patients with virologically verified varicella zoster virus (VZV) vasculopathy., Methods: CSF from 30 patients with virologically verified VZV vasculopathy was analyzed for levels of proinflammatory cytokines and MMPs using the Meso Scale Discovery multiplex ELISA platform. Positive CNS inflammatory disease controls were provided by CSF from 30 patients with multiple sclerosis. Negative controls were provided by CSF from 20 healthy controls., Results: Compared to multiple sclerosis CSF and CSF from healthy controls, levels of interleukin (IL)-8, IL-6, and MMP-2 were significantly elevated in VZV vasculopathy CSF., Conclusions: CSF of patients with VZV vasculopathy revealed a unique profile of elevated proinflammatory cytokines, IL-8 and IL-6, along with elevated MMP-2. The relevance of these cytokines to the pathogenesis of VZV vasculopathy requires further study.

Published
2016
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