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Herein, poly(caprolactone)/poly (glycerol sebacate) (PCL/PGS) fibrous structures incorporating hydroxyapatite (HA) and graphene oxide (GO) nanofillers were prepared through two procedures, including electrospinning and simultaneous electrospinning/electrospray procedures. Accordingly, introducing nanofillers into the structures through the simultaneous method led to improving the mechanical strength from 3.69 to 4.95 MPa. The electrospray nanofillers caused improvement of the amorphous regions (up to 83.4%) and increased the degradation rate. Furthermore, the filler-filled electrospun/electrospray sample illustrated the highest cell viability of 94.81 ± 0.5%. The results implied that the simultaneous procedure is promising for fabricating filler-loaded membranes as bone tissue scaffolds. [ABSTRACT FROM AUTHOR]

The purpose of this research is to introduce and design scaffolds composed of polycaprolactone(PCL) and gelatine nanofibers containing both hydroxyapatite and graphene nanoparticles at the same time for using in bone tissue engineering. At first, optimal conditions for the production of PCL/gelatine nanofibrous webs were investigated. In the following step, hydroxyapatite and graphene nanoparticles incorporated into PCL/gelatine nanofibrous webs for comparison with PCL/gelatine nanofibrous webs without adding any particles. Morphological, mechanical and biological tests were done to analyse fabricated structures. 50%PCL/50%gelatin sample has the less fiber diameter in both group with or without adding nanoparticles of hydroxyapatite and graphene. The FTIR analyses revealed characteristic absorption bands for PCL/gelatin/hydroxyapatite/graphene nanofibrous scaffolds is still similar to that of PCL/gelatin sample. Also, blending of PCL with gelatin decreased tensile strength and increased the tensile strain. As the final result, the addition of hydroxyapatite and graphene reduces diameter of nanofiber and improves the biological and mechanical properties and has a good potential using in bone tissue engineering. [ABSTRACT FROM AUTHOR]

The drug release systems are useful in controlling efficacy, improvement of function and reduction of side effects of drugs. Herein, Poly (ε-caprolactone) (PCL)/Poly (N-vinyl-2-pyrrolidone) (PVP) core-shell nanofibers loaded by multi-walled carbon nanotubes (MWCNTs) were produced. The surfaces of nanofibers were coated by polypyrrole (PPy) via vapor phase and chemical method. The chemical method was desirable according to SEM images and electrical conductivity of about 502.89 ± 45.25 S/m. Electrical stimulation was performed in the coated sample and the release of 5-fluorouracil (5FU) was investigated. Drug release of non-coated and coated samples without/with field application was investigated. The results exhibited the electric signal could be considered as a drug release control factor for coated samples with electrical field application. [ABSTRACT FROM AUTHOR]

In this study, composites of knitted fabric made from side-by-side multiple glass and polypropylene yarns have been investigated. These composites have been produced by a new manufacturing method – the hot press method. By using various knitted fabrics made from different components of glass and polypropylene yarns, several types of knitted structures and yarn components were investigated: rib 1-1, full Milano and full cardigan. The mechanical properties of composites were measured in three directions. The results showed that hot-pressed knitted composites of glass and polypropylene yarns have high strength, impact resistance, work-to-break and elongation, simultaneously. The highest bending resistance and maximum stiffness are achieved for rib-knitted composites consisting of 8 wt% glass and 92 wt% polypropylene yarns. The highest impact energy absorption was obtained with 18 wt% glass content and 82 wt% polypropylene matrix.