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5. Incidence and Remission of Post‐Surgical Cystoid Macular Edema Following Cataract Surgery in Eyes With Intraocular Inflammation

Author

Gangaputra, Sapna, Newcomb, Craig, Ying, Gui-Shuang, Groth, Sylvia, Fitzgerald, Tonetta D., Artornsombudh, Pichaporn, Kothari, Srishti, Pujari, Siddharth S., Jabs, Douglas A., Levy-Clarke, Grace A., Nussenblatt, Robert B., Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Dreger, Kurt A., Buchanich, Jeanine M., and Kempen, John H.

Published
2024
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6. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2—global current practice patterns for the management of Cytomegalovirus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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7. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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9. Posterior capsular opacification and YAG laser capsulotomy in uveitis patients following cataract surgery

Author

Levy-Clarke, Grace A., Newcomb, Craig W., Ying, Gui-Shuang, Groth, Sylvia L., Kothari, Srishti, Payal, Abhishek, Begum, Hosne, Liesegang, Teresa L., Foster, C. Stephen, Jabs, Douglas A., Nussenblatt, Robert, Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Dreger, Kurt A., Buchanich, Jeanine M., Kempen, John H., and Gangaputra, Sapna

Published
2024
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10. Immune function in X-linked retinoschisis subjects in an AAV8-RS1 phase I/IIa gene therapy trial

Author

Mishra, Alaknanda, Vijayasarathy, Camasamudram, Cukras, Catherine A, Wiley, Henry E, Sen, H Nida, Zeng, Yong, Wei, Lisa L, and Sieving, Paul A

Subjects
Clinical Research, Genetics, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Cytokines, Dependovirus, Disease Management, Eye Proteins, Genetic Diseases, X-Linked, Genetic Predisposition to Disease, Genetic Therapy, Genetic Vectors, Humans, Immunity, Immunity, Cellular, Retinoschisis, T-Lymphocyte Subsets, Treatment Outcome, AAV8 vector, T cells, X-linked retinoschisis, cytokines, gene therapy clinical trial, immune function, ocular inflammation, retinoschisin, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology
Abstract

This study explored systemic immune changes in 11 subjects with X-linked retinoschisis (XLRS) in a phase I/IIa adeno-associated virus 8 (AAV8)-RS1 gene therapy trial (ClinicalTrials.gov: NCT02317887). Immune cell proportions and serum analytes were compared to 12 healthy male controls. At pre-dosing baseline the mean CD4/CD8 ratio of XLRS subjects was elevated. CD11c+ myeloid dendritic cells (DCs) and the serum epidermal growth factor (EGF) level were decreased, while CD123+ plasmacytoid DCs and serum interferon (IFN)-γ and tumor necrosis factor (TNF)-α were increased, indicating that the XLRS baseline immune status differs from that of controls. XLRS samples 14 days after AAV8-RS1 administration were compared with the XLRS baseline. Frequency of CD11b+CD11c+ DCc was decreased in 8 of 11 XLRS subjects across all vector doses (1e9-3e11 vector genomes [vg]/eye). CD8+human leukocyte antigen-DR isotype (HLA-DR)+ cytotoxic T cells and CD68+CD80+ macrophages were upregulated in 10 of 11 XLRS subjects, along with increased serum granzyme B in 8 of 11 XLRS subjects and elevated IFN-γ in 9 of 11 XLRS subjects. The six XLRS subjects with ocular inflammation after vector application gave a modestly positive correlation of inflammation score to their respective baseline CD4/CD8 ratios. This exploratory study indicates that XLRS subjects may exhibit a proinflammatory, baseline immune phenotype, and that intravitreal dosing with AAV8-RS1 leads to systemic immune activation with an increase of activated lymphocytes, macrophages, and proinflammatory cytokines.

Published
2021

11. Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality

Author

Kempen, John H., Newcomb, Craig W., Washington, Terri L., Foster, C. Stephen, Sobrin, Lucia, Thorne, Jennifer E., Jabs, Douglas A., Suhler, Eric B., Rosenbaum, James T., Sen, H. Nida, Levy-Clarke, Grace A., Nussenblatt, Robert B., Bhatt, Nirali P., Lowder, Careen Y., Goldstein, Debra A., Leiderman, Yannek I., Acharya, Nisha R., Holland, Gary N., Read, Russell W., Dunn, James P., Dreger, Kurt A., Artornsombudh, Pichaporn, Begum, Hosne A., Fitzgerald, Tonetta D., Kothari, Srishti, Payal, Abhishek R., Daniel, Ebenezer, Gangaputra, Sapna S., Kaçmaz, R. Oktay, Liesegang, Teresa L., Pujari, Siddharth S., Khachatryan, Naira, Maghsoudlou, Armin, Suga, Hilkiah K., Pak, Clara M., Helzlsouer, Kathy J., and Buchanich, Jeanine M.

Published
2023
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12. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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13. Incidence of and Risk Factors for Cataract in Anterior Uveitis

Author

Papaliodis, George N., Rosner, Bernard A., Dreger, Kurt A., Fitzgerald, Tonetta D., Artornsombudh, Pichaporn, Kothari, Srishti, Gangaputra, Sapna S., Levy-Clarke, Grace A., Nussenblatt, Robert B., Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Jabs, Douglas A., Pak, Clara M., Ying, Gui-shuang, and Kempen, John H.

Published
2023
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14. Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB–Mediated Autoinflammatory Disease with Retinal Dystrophy

Author

Huryn, Laryssa A., Kozycki, Christina Torres, Serpen, Jasmine Y., Zein, Wadih M., Ullah, Ehsan, Iannaccone, Alessandro, Williams, Lloyd B., Sobrin, Lucia, Brooks, Brian P., Sen, H. Nida, Hufnagel, Robert B., Kastner, Daniel L., and Kodati, Shilpa

Published
2023
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18. Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors

Author

Roldan, Ana M., Zebardast, Nazlee, Pistilli, Maxwell, Khachatryan, Naira, Payal, Abhishek, Begum, Hosne, Artornsombudh, Pichaporn, Pujari, Siddharth S., Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Jabs, Douglas A., Levy-Clarke, Grace A., Nussenblatt, Robert B., Buchanich, Jeanine M., and Kempen, John H.

Published
2022
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19. Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

Author

Cukras, Catherine, Wiley, Henry E, Jeffrey, Brett G, Sen, H Nida, Turriff, Amy, Zeng, Yong, Vijayasarathy, Camasamudram, Marangoni, Dario, Ziccardi, Lucia, Kjellstrom, Sten, Park, Tae Kwon, Hiriyanna, Suja, Wright, J Fraser, Colosi, Peter, Wu, Zhijian, Bush, Ronald A, Wei, Lisa L, and Sieving, Paul A

Subjects
Biotechnology, Neurosciences, Clinical Research, Gene Therapy, Clinical Trials and Supportive Activities, Eye Disease and Disorders of Vision, Genetics, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Eye, Adult, Aged, Eye Proteins, Female, Genetic Therapy, Humans, Intravitreal Injections, Male, Middle Aged, Mutation, Retina, Retinoschisis, Young Adult, AAV vector, X-linked retinoschisis, clinical trial, gene therapy, ocular disease, retinal disease, Biological Sciences, Technology, Medical and Health Sciences
Abstract

This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait affecting only males, caused by mutations in the RS1 gene. Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfunction, reduced visual acuity, and susceptibility to retinal detachment. This phase I/IIa single-center, prospective, open-label, three-dose-escalation clinical trial administered vector to nine participants with pathogenic RS1 mutations. The eye of each participant with worse acuity (≤63 letters; Snellen 20/63) received the AAV8-RS1 gene vector by intravitreal injection. Three participants were assigned to each of three dosage groups: 1e9 vector genomes (vg)/eye, 1e10 vg/eye, and 1e11 vg/eye. The investigational product was generally well tolerated in all but one individual. Ocular events included dose-related inflammation that resolved with topical and oral corticosteroids. Systemic antibodies against AAV8 increased in a dose-related fashion, but no antibodies against RS1 were observed. Retinal cavities closed transiently in one participant. Additional doses and immunosuppressive regimens are being explored to pursue evidence of safety and efficacy (ClinicalTrials.gov: NCT02317887).

Published
2018

23. Risk of Cataract in Intermediate Uveitis

Author

Minkus, Caroline L., Pistilli, Maxwell, Dreger, Kurt A., Fitzgerald, Tonetta D., Payal, Abhishek R., Begum, Hosne, Kaçmaz, R. Oktay, Jabs, Douglas A., Nussenblatt, Robert B., Rosenbaum, James T., Levy-Clarke, Grace A., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Buchanich, Jeanine M., and Kempen, John H.

Published
2021
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27. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis

Author

Agarwal, Mamta, Agarwal, Manisha, Aggarwal, Ashutosh, Aggarwal, Kanika, Agrawal, Mukesh, Al-Dhibi, Hassan, Androudi, Sofia, Asyari, Fatma, Balasundaram, Manohar Babu, Murthy, Kalpana Babu, Baglivo, Edoardo, Banker, Alay, Bansal, Reema, Basu, Soumyava, Behera, Digamber, Biswas, Jyotirmay, Bodaghi, Bahram, Carreño, Ester, Caspers, Laure, Chee, Soon Phaik, Chhabra, Romi, Cimino, Luca, Concha del Rio, Luz Elena, Cunningham, Emmett T., Land Curi, Andrè Luiz, Das, Dipankar, Davis, Janet, DeSmet, Marc, Denisova, Ekaterina, Denniston, Alastair K., Errera, Marie-Hélène, Fonollosa, Alejandro, George, Amala, Goldstein, Debra A., Crosier, Yan Guex, Gunasekeran, Dinesh Visva, Gurbaxani, Avinash, Invernizzi, Alessandro, Isa, Hazlita M., Islam, Shah Md., Jones, Nicholas, Katoch, Deeksha, Khairallah, Moncef, Khosla, Amit, Kramer, Michal, Kumar, Amitabh, Kumar, Atul, La Distia Nora, Rina, Lee, Richard, Lowder, Careen, Luthra, Saurabh, Mahendradas, Padmamalini, Makhoul, Dorine, Mazumdar, Shahana, McCluskey, Peter, Mehta, Salil, Miserocchi, Elisabetta, Mochizuki, Manabu, Mohamed, Oli S., Muccioli, Cristina, Munk, Marion R., Murthy, Somasheila, Narain, Shishir, Nascimento, Heloisa, Neri, Piergiorgio, Nguyen, Myhanh, Okada, Annabelle A., Ozdal, Pinar, Palestine, Alan, Pichi, Francesco, Raje, Dhananjay, Rathinam, S.R., Rousselot, Andres, Schlaen, Ariel, Sehgal, Shobha, Sen, H. Nida, Sharma, Aman, Sharma, Kusum, Shoughy, Samir S., Singh, Nirbhai, Singh, Ramandeep, Soheilian, Masoud, Sridharan, Sudharshan, Thorne, Jennifer E., Tappeiner, Christoph, Teoh, Stephen, Tognon, Maria Sofia, Tugal-Tutkun, Ilknur, Tyagi, Mudit, Uy, Harvey, Vasconcelos Santos, Daniel Vitor, Valentincic, Natasa Vidovic, Westcott, Mark, Yanai, Ryoji, Alvarez, Bety Yanez, Zahedur, Rahman, Zierhut, Manfred, Agrawal, Rupesh, Testi, Ilaria, Mahajan, Sarakshi, Yuen, Yew Sen, Agarwal, Aniruddha, Kon, Onn Min, Barisani-Asenbauer, Talin, Kempen, John H., Gupta, Amod, Jabs, Douglas A., Smith, Justine R., Nguyen, Quan Dong, Pavesio, Carlos, and Gupta, Vishali

Published
2021
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28. Cancer-Associated Retinopathy

Author

Wei, Maggie M., Armbrust, Karen R., Jeffrey, Brett G., Sen, H. Nida, Gupta, Vishali, editor, Nguyen, Quan Dong, editor, LeHoang, Phuc, editor, and Agarwal, Aniruddha, editor

Published
2020
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29. Autoimmune Retinopathy

Author

Armbrust, Karen R., Wei, Maggie M., Jeffrey, Brett G., Sen, H. Nida, Gupta, Vishali, editor, Nguyen, Quan Dong, editor, LeHoang, Phuc, editor, and Agarwal, Aniruddha, editor

Published
2020
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32. Factors Predictive of Remission of Chronic Anterior Uveitis

Author

Sobrin, Lucia, Pistilli, Maxwell, Dreger, Kurt, Kothari, Srishti, Khachatryan, Naira, Artornsombudh, Pichaporn, Pujari, Siddharth S., Foster, C. Stephen, Jabs, Douglas A., Nussenblatt, Robert B., Rosenbaum, James T., Levy-Clarke, Grace A., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., and Kempen, John H.

Published
2020
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33. Consensus on the Diagnosis and Management of Nonparaneoplastic Autoimmune Retinopathy Using a Modified Delphi Approach

Author

Fox, Austin R, Gordon, Lynn K, Heckenlively, John R, Davis, Janet L, Goldstein, Debra A, Lowder, Careen Y, Nussenblatt, Robert B, Butler, Nicholas J, Dalal, Monica, Jayasundera, Thiran, Smith, Wendy M, Lee, Richard W, Adamus, Grazyna, Chan, Chi-Chao, Hooks, John J, Morgans, Catherine W, Detrick, Barbara, and Sen, H Nida

Subjects
Clinical Research, Eye Disease and Disorders of Vision, Autoantibodies, Autoantigens, Autoimmune Diseases, Consensus, Delphi Technique, Humans, Paraneoplastic Syndromes, Ocular, Retina, Retinal Diseases, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo develop diagnostic criteria for nonparaneoplastic autoimmune retinopathy (AIR) through expert panel consensus and to examine treatment patterns among clinical experts.DesignModified Delphi process.MethodsA survey of uveitis specialists in the American Uveitis Society, a face-to-face meeting (AIR Workshop) held at the National Eye Institute, and 2 iterations of expert panel surveys were used in a modified Delphi process. The expert panel consisted of 17 experts, including uveitis specialists and researchers with expertise in antiretinal antibody detection. Supermajority consensus was used and defined as 75% of experts in agreement.ResultsThere was unanimous agreement among experts regarding the categorization of autoimmune retinopathies as nonparaneoplastic and paraneoplastic, including cancer-associated retinopathy and melanoma-associated retinopathy. Diagnostic criteria and tests essential to the diagnosis of nonparaneoplastic AIR and multiple supportive criteria reached consensus. For treatment, experts agreed that corticosteroids and conventional immunosuppressives should be used (prescribed) as first- or second-line treatments, though a consensus agreed that biologics and intravenous immunoglobulin were considered appropriate in the treatment of nonparaneoplastic AIR patients regardless of the stage of disease. Experts agreed that more evidence is needed to treat nonparaneoplastic AIR patients with long-term immunomodulatory therapy and that there is enough equipoise to justify randomized, placebo-controlled trials to determine if nonparaneoplastic AIR patients should be treated with long-term immunomodulatory therapy. Regarding antiretinal antibody detection, consensus agreed that a standardized assay system is needed to detect serum antiretinal antibodies. Consensus agreed that an ideal assay should have a 2-tier design and that Western blot and immunohistochemistry should be the methods used to identify antiretinal antibodies.ConclusionsConsensus was achieved using a modified Delphi process to develop diagnostic criteria for nonparaneoplastic AIR. There is enough equipoise to justify randomized, placebo-controlled trials to determine whether patients with nonparaneoplastic AIR should be treated with long-term immunomodulatory therapy. Efforts to develop a standardized 2-tier assay system for the detection of antiretinal antibodies have been initiated as a result of this study.

Published
2016

37. Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy

Author

Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J.W., Sen, H. Nida, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Infection & Immunity, Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J.W., and Sen, H. Nida

Published
2024

38. From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotypes with Supercells

Author

Candia, Julián, Maunu, Ryan, Driscoll, Meghan, Biancotto, Angélique, Dagur, Pradeep, McCoy Jr, J. Philip, Sen, H. Nida, Wei, Lai, Maritan, Amos, Cao, Kan, Nussenblatt, Robert B., Banavar, Jayanth R., and Losert, Wolfgang

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Cell heterogeneity and the inherent complexity due to the interplay of multiple molecular processes within the cell pose difficult challenges for current single-cell biology. We introduce an approach that identifies a disease phenotype from multiparameter single-cell measurements, which is based on the concept of "supercell statistics", a single-cell-based averaging procedure followed by a machine learning classification scheme. We are able to assess the optimal tradeoff between the number of single cells averaged and the number of measurements needed to capture phenotypic differences between healthy and diseased patients, as well as between different diseases that are difficult to diagnose otherwise. We apply our approach to two kinds of single-cell datasets, addressing the diagnosis of a premature aging disorder using images of cell nuclei, as well as the phenotypes of two non-infectious uveitides (the ocular manifestations of Beh\c{c}et's disease and sarcoidosis) based on multicolor flow cytometry. In the former case, one nuclear shape measurement taken over a group of 30 cells is sufficient to classify samples as healthy or diseased, in agreement with usual laboratory practice. In the latter, our method is able to identify a minimal set of 5 markers that accurately predict Beh\c{c}et's disease and sarcoidosis. This is the first time that a quantitative phenotypic distinction between these two diseases has been achieved. To obtain this clear phenotypic signature, about one hundred CD8+ T cells need to be measured. Beyond these specific cases, the approach proposed here is applicable to datasets generated by other kinds of state-of-the-art and forthcoming single-cell technologies, such as multidimensional mass cytometry, single-cell gene expression, and single-cell full genome sequencing techniques., Comment: 22 pages, 4 figures. To appear in PLOS Computational Biology

Published
2013
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40. Comparison Between Methotrexate and Mycophenolate Mofetil Monotherapy for the Control of Noninfectious Ocular Inflammatory Diseases

Author

Gangaputra, Sapna S., Newcomb, Craig W., Joffe, Marshall M., Dreger, Kurt, Begum, Hosne, Artornsombudh, Pichaporn, Pujari, Siddharth S., Daniel, Ebenezer, Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Jabs, Douglas A., Nussenblatt, Robert B., Rosenbaum, James T., Levy-Clarke, Grace A., and Kempen, John H.

Published
2019
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42. Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.

Author

Nath, Pulak R., Maclean, Mary, Nagarajan, Vijay, Lee, Jung Wha, Yakin, Mehmet, Kumar, Aman, Nadali, Hadi, Schmidt, Brian, Kaya, Koray D., Kodati, Shilpa, Young, Alice, Caspi, Rachel R., Kuiper, Jonas J. W., and Sen, H. Nida

Subjects
KILLER cells, T cells, CELL receptors, CELLULAR recognition, CELL populations
Abstract

Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with MHC-I allele HLA-A29. The striking association with MHC-I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unstudied. Here we show that HLA-A29-positive birdshot chorioretinopathy patients have a skewed NK cell pool containing expanded CD16 positive NK cells which produce more proinflammatory cytokines. These NK cells contain populations that express CD8A which is involved in MHC-I recognition on target cells, display gene signatures indicative of high cytotoxic activity (GZMB, PRF1 and ISG15), and signaling through NK cell receptor CD244 (SH2D1B). Long-term monitoring of a cohort of birdshot chorioretinopathy patients with active disease identifies a population of CD8bright CD244bright NK cells, which rapidly declines to normal levels upon clinical remission following successful treatment. Collectively, these studies implicate CD8bright CD244bright NK cells in birdshot chorioretinopathy. Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with HLA-A29. Here the authors use a single cell RNA sequencing approach to characterise NK cell involvement in this disease and show that CD8bright CD244bright NK cells are associated with active disease. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Refractory Candida dubliniensis Retinitis in an Immunocompetent Patient.

Author

Murtaza, Fahmeeda, Pereira, Austin, Sen, H. Nida, Wiley, Henry E., and Christakis, Panos G.

Subjects
CANDIDA, OPTICAL coherence tomography, INTRAVITREAL injections, AMPHOTERICIN B, VISUAL acuity
Abstract

Fungal endophthalmitis is an intraocular infection that rarely develops in immunocompetent individuals. A 35-year-old healthy, immunocompetent male presented with a 1-week history of pain and redness in the left eye. Visual acuity was 20/50. Dilated fundus examination revealed focal chorioretinitis in the posterior pole with associated vitritis, suspicious for a fungal etiology. He was started empirically on oral voriconazole and valacyclovir. A comprehensive systemic workup returned negative. Inflammation worsened and a diagnostic vitrectomy was performed which revealed Candida dubliniensis. The dose of oral voriconazole was increased, and intravitreal voriconazole and amphotericin B injections were added for refractory disease. Treatment response was gauged by fungal pillar height on optical coherence tomography. Eight months of oral voriconazole and 68 intravitreal antifungal injections were required to achieve complete regression and a final visual acuity of 20/20. Candida dubliniensis endophthalmitis can affect immunocompetent individuals and require a prolonged treatment course. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Pharmacologic Treatment of Noninfectious Uveitis

Author

Knickelbein, Jared E., Armbrust, Karen R., Kim, Meredith, Sen, H. Nida, Nussenblatt, Robert B., Barrett, James E., Editor-in-chief, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Page, Clive P, Series editor, Rosenthal, Walter, Series editor, Wang, KeWei, Series editor, Whitcup, Scott M., editor, and Azar, Dimitri T., editor

Published
2017
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47. Risk of Ocular Hypertension in Adults with Noninfectious Uveitis

Author

Daniel, Ebenezer, Pistilli, Maxwell, Kothari, Srishti, Khachatryan, Naira, Kaçmaz, R. Oktay, Gangaputra, Sapna S., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Foster, C. Stephen, Jabs, Douglas A., Nussenblatt, Robert B., Rosenbaum, James T., Levy-Clarke, Grace A., Bhatt, Nirali P., and Kempen, John H.

Published
2017
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