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U radu su analizirani kratkoročni ishodi u kohorti bolesnika s gastroshizom, liječene u KBC-u Zagreb tijekom desetogodišnjeg razdoblja (2007. - 2017. god.) i razlika ishoda s obzirom na pridružene intestinalne anomalije/komplikacije.

Kratkoročni rezultati liječenja u 7 bolesnika nisu pokazali značajne koristi od liječenja. Očekuju se dugoročni rezultati.

Liječenje djece s ekstrahepatalnom atrezijom žučnih vodova

3.5 godišnja djevojčica s Haddadovim sindromom. U dobi od 4.5 godine započela s noćnim strojnim prodisavanjem pozitivnim tlakom na masku pomoću prijenosnog ventilatora. Dijete dobro tjelesno i psihomotorički napreduje i odlično je prilagođena vršnjacima.

U razdoblju od 7 godina 950 pregleda zbog opstipacije. Prva dijagnostička metoda bila je anorektalna manometrija. Opisan naš dijagnostički postupnik.

Pheochromocytoma is a rare tumor of chromaffin tissue of the adrenal gland that synthesizes, stores and releases cathecolamines. In 10% of the patients it arises outside the adrenal gland, and has been called paraganglioma. The following study describes our experience in the diagnostic process and treatment of pheochromocytoma in two children, a 8-year-old boy with the right ureteral paraganglioma, and a 8-year-old girl with pheo- chromocytoma of the leftsuprarenal gland. Characteristic clinical features with predominant signs of hypertension, as well as the diagnostic flow diagram, have been presented. We have analysed recent diagnostic possibilities, sensitivity of diagnostic methods (ultrasonography, CT, selective angiography and J131 MIBG scintigraphy), indications for their use, and the importance of appropriate preoperative management. The major role of the J131-metaiodobenzilguanidine scintigraphy in diagnostic assessment, especially in precise preoperative localization and postoperative verification of tumour removal, has been stressed.

In this paper eight patients with myogenic or neurogenic muscle disorders are presented, in whom cardiomyopathy was also found. From the presentation could be concluded that in neurogenic muscle diseases and progressive muscular dystrophy respectively most frequently dilated cardiomyopathies are usually found in children with mitochondrial disorders.

Acute pancreatitis is a still a medical emergency. unfourtanetley, the medical treatment of acute pancreatitis still remains unsatisfactory and mortality is still high. Therefore, in terms of the suggested organoprotective effect, our newly isolated human gastric juice peptide (M.P), witch we call Body Protection Compound (BPC9 partialy sequenced H2N--Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-COOH ; MW 40, 000) was investigated on models of acute pancreatitis.

In this paper eight patients with myogenic or neurogenic muscle disorders are presented, in whom cardiomiopathy was also found. Six patients developed a dilated cardiomiopathy associated with neurogenic atrophies or progressive muscular dystrophy. In patients with Mb. Friedreich and HSNM type II together with the total dilatation of the septum hypertrophy was observed and in patients with spinal muscular amyotrophy of scapuloperoneal type atriomyopathy dominated. In two patients with mitochondrial disorders a hypertrophic cardiomyopathy was found. One of them had mitochondrial encephalomyoneuropathy and the other mitochondrial encephalopathy with myoclonic epilepsy. In none of them a restrictive cardiomyopathy was found. From the presentation could be concluded that in neurogenic muscle diseases and progressive muscular dystrophy respectively most frequently dilated cardiomyopathies have been developed. Hypertrophic cardiomyopathies are usually found in children with mitochondrial disorders

Unlike previous data on gastric lesions in rats, the influence of somatostatin (0.0001, 0.001, 0.01, 0.1 mg/kg b.w. i.p.) applied just before 3h - water immersion stress (water temperature 26 C) was investigated in mice. In comparison to the controls (saline 4.0 ml/kg b.w. i.p.) the two lowest were ineffective. In contrast, an ulcerogenic effect was obtained with 0.01 mg/kg b.w. of somatostatin.

A novel substance, colled Body Protection Compound (BPC) was testedagainst different models of hepatic lesions. Different standard models Were used: ligation of bile duct and hepatic artery, restraint stress, and carbon tetrachloride (CCl4)poisoning.BPC has a prounonced beneficial effect on a variety of experimentally induced liver lesions in rats. Relative to liver protection achieved by dopamine agonists the new substance BPC shows even better effectiveness. One of the possible mechanisms of action for BPC could be that of natural scavenger. This is supported by its protective effect in CCL4 poisoning effected in much lower doses than that of conventional scavengers (e.g.vit. E)(micrograms of BPC vs. mg of vit. E)