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295 results on '"Seneviratne, Suranjith L."'

1. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Author

McDonnell, John, Cousins, Kimberley, Younger, M. Elizabeth M., Lane, Adam, Abolhassani, Hassan, Abraham, Roshini S., Al-Tamemi, Salem, Aldave-Becerra, Juan Carlos, Al-Faris, Eman Hesham, Alfaro-Murillo, Alberto, AlKhater, Suzan A., Alsaati, Nouf, Doss, Alexa Michelle Altman, Anderson, Melissa, Angarola, Ernestina, Ariue, Barbara, Arnold, Danielle E., Assa’ad, Amal H., Aytekin, Caner, Bank, Meaghan, Bergerson, Jenna R. E., Bleesing, Jack, Boesing, John, Bouso, Carolina, Brodszki, Nicholas, Cabanillas, Diana, Cady, Carol, Callahan, Meghan A., Caorsi, Roberta, Carbone, Javier, Carrabba, Maria, Castagnoli, Riccardo, Catanzaro, Jason R., Chan, Samantha, Chandra, Sharat, Chapdelaine, Hugo, Chavoshzadeh, Zahra, Chong, Hey Jin, Connors, Lori, Consonni, Filippo, Correa-Jimenez, Oscar, Cunningham-Rundles, Charlotte, D’Astous-Gauthier, Katherine, Delmonte, Ottavia Maria, Demirdag, Yesim Yilmaz, Deshpande, Deepti R., Diaz-Cabrera, Natalie M., Dimitriades, Victoria R., El-Owaidy, Rasha, ElGhazali, Gehad, Al-Hammadi, Suleiman, Fabio, Giovanna, Faure, Astrid Schellnast, Feng, Jin, Fernandez, James M., Fill, Lauren, Franco, Guacira R., Frenck, Robert W., Fuleihan, Ramsay L., Giardino, Giuliana, Galant-Swafford, Jessica, Gambineri, Eleonora, Garabedian, Elizabeth K., Geerlinks, Ashley V., Goudouris, Ekaterini, Grecco, Octavio, Pan-Hammarström, Qiang, Khani, Hedieh Haji Khodaverdi, Hammarström, Lennart, Hartog, Nicholas L., Heimall, Jennifer, Hernandez-Molina, Gabriela, Horner, Caroline C., Hostoffer, Robert W., Hristova, Nataliya, Hsiao, Kuang-Chih, Ivankovich-Escoto, Gabriela, Jaber, Faris, Jalil, Maaz, Jamee, Mahnaz, Jean, Tiffany, Jeong, Stephanie, Jhaveri, Devi, Jordan, Michael B., Joshi, Avni Y., Kalkat, Amanpreet, Kanarek, Henry J., Kellner, Erinn S., Khojah, Amer, Khoury, Ruby, Kokron, Cristina M., Kumar, Ashish, Lecerf, Kelsey, Lehman, Heather K., Leiding, Jennifer W., Lesmana, Harry, Lim, Xin Rong, Lopes, Joao Pedro, López, Ana Laura, Tarquini, Lucia, Lundgren, Ingrid S., Magnusson, Julieann, Marinho, Ana Karolina B. B., Marseglia, Gian Luigi, Martone, Giulia M., Mechtler, Annamaria G., Mendonca, Leonardo, Milner, Joshua D., Mustillo, Peter J., Naderi, Asal Gharib, Naviglio, Samuele, Nell, Jeremy, Niebur, Hana B., Notarangelo, Luigi, Oleastro, Matias, Ortega-López, María Claudia, Patel, Neil R., Petrovic, Gordana, Pignata, Claudio, Porras, Oscar, Prince, Benjamin T., Puck, Jennifer M., Qamar, Nashmia, Rabusin, Marco, Raje, Nikita, Regairaz, Lorena, Risma, Kimberly A., Ristagno, Elizabeth H., Routes, John, Roxo-Junior, Persio, Salemi, Negin, Scalchunes, Christopher, Schuval, Susan J., Seneviratne, Suranjith L., Shankar, Ashwin, Sherkat, Roya, Shin, Junghee Jenny, Siddiqi, Abeer, Signa, Sara, Sobh, Ali, Lima, Fabiana Mascarenhas Souza, Stenehjem, Kristen K., Tam, Jonathan S., Tang, Monica, Barros, Myrthes Toledo, Verbsky, James, Vergadi, Eleni, Voelker, Dayne H., Volpi, Stefano, Wall, Luke A., Wang, Christine, Williams, Kelli W., Wu, Eveline Y., Wu, Shan Shan, Zhou, Jessie J., Cook, Alexandria, Sullivan, Kathleen E., and Marsh, Rebecca

Published
2024
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4. Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications.

Author

Cherie, Tan Jiao Jie, Choong, Clarice Shi Hui, Abid, Muhammad Bilal, Weber, Matthew W., Yap, Eng Soo, Seneviratne, Suranjith L., Abeysuriya, Visula, and de Mel, Sanjay

Subjects
AEDES aegypti, DENGUE viruses, PATIENT experience, AEDES albopictus, DENGUE
Abstract

Dengue infection is caused by the dengue virus (DENV) and is transmitted to humans by infected female Aedes aegypti and Aedes albopictus mosquitoes. There are nearly 100 million new dengue cases yearly in more than 120 countries, with a five-fold increase in incidence over the past four decades. While many patients experience a mild illness, a subset suffer from severe disease, which can be fatal. Dysregulated immune responses are central to the pathogenesis of dengue, and haematologic manifestations are a prominent feature of severe disease. While thrombocytopaenia and coagulopathy are major causes of bleeding in severe dengue, leucocyte abnormalities are emerging as important markers of prognosis. In this review, we provide our perspective on the clinical aspects and pathophysiology of haematologic manifestations in dengue. We also discuss the key gaps in our current practice and areas to be addressed by future research. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity

Author

Lyons, Sarah A., Datema, Mareen R., Le, Thuy-My, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Fritsche, Philipp, Gislason, David, Hoffmann-Sommergruber, Karin, Jedrzejczak-Czechowicz, Monika, Jongejan, Laurian, Kowalski, Marek L., Kralimarkova, Tanya Z., Lidholm, Jonas, Papadopoulos, Nikolaos G., Pontoppidan, Bo, Popov, Todor A., Prado, Nayade del, Purohit, Ashok, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Vassilopoulou, Emilia, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Welsing, Paco M.J., Mills, E.N. Clare, Ballmer-Weber, Barbara K., Knulst, André C., Fernández-Rivas, Montserrat, and Van Ree, Ronald

Published
2021
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6. Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation.

Author

de la Morena, M Teresa, Leonard, David, Torgerson, Troy R, Cabral-Marques, Otavio, Slatter, Mary, Aghamohammadi, Asghar, Chandra, Sharat, Murguia-Favela, Luis, Bonilla, Francisco A, Kanariou, Maria, Damrongwatanasuk, Rongras, Kuo, Caroline Y, Dvorak, Christopher C, Meyts, Isabelle, Chen, Karin, Kobrynski, Lisa, Kapoor, Neena, Richter, Darko, DiGiovanni, Daniela, Dhalla, Fatima, Farmaki, Evangelia, Speckmann, Carsten, Español, Teresa, Shcherbina, Anna, Hanson, Imelda Celine, Litzman, Jiri, Routes, John M, Wong, Melanie, Fuleihan, Ramsay, Seneviratne, Suranjith L, Small, Trudy N, Janda, Ales, Bezrodnik, Liliana, Seger, Reinhard, Raccio, Andrea Gomez, Edgar, J David M, Chou, Janet, Abbott, Jordan K, van Montfrans, Joris, González-Granado, Luis Ignacio, Bunin, Nancy, Kutukculer, Necil, Gray, Paul, Seminario, Gisela, Pasic, Srdjan, Aquino, Victor, Wysocki, Christian, Abolhassani, Hassan, Dorsey, Morna, Cunningham-Rundles, Charlotte, Knutsen, Alan P, Sleasman, John, Costa Carvalho, Beatriz Tavares, Condino-Neto, Antonio, Grunebaum, Eyal, Chapel, Helen, Ochs, Hans D, Filipovich, Alexandra, Cowan, Mort, Gennery, Andrew, Cant, Andrew, Notarangelo, Luigi D, and Roifman, Chaim M

Subjects
Humans, Hematopoietic Stem Cell Transplantation, Proportional Hazards Models, Retrospective Studies, Cohort Studies, Follow-Up Studies, Time, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Hyper-IgM Immunodeficiency Syndrome, Young Adult, Kaplan-Meier Estimate, CD40 ligand, Karnofsky/Lansky scores, X-linked hyper-IgM syndrome, defects in class-switch recombination, hematopoietic cell transplantation, long-term outcomes, primary immunodeficiency, Pediatric, Clinical Research, Transplantation, Inflammatory and immune system, Good Health and Well Being, Immunology, Allergy
Abstract

BackgroundX-linked hyper-IgM syndrome (XHIGM) is a primary immunodeficiency with high morbidity and mortality compared with those seen in healthy subjects. Hematopoietic cell transplantation (HCT) has been considered a curative therapy, but the procedure has inherent complications and might not be available for all patients.ObjectivesWe sought to collect data on the clinical presentation, treatment, and follow-up of a large sample of patients with XHIGM to (1) compare long-term overall survival and general well-being of patients treated with or without HCT along with clinical factors associated with mortality and (2) summarize clinical practice and risk factors in the subgroup of patients treated with HCT.MethodsPhysicians caring for patients with primary immunodeficiency diseases were identified through the Jeffrey Modell Foundation, United States Immunodeficiency Network, Latin American Society for Immunodeficiency, and Primary Immune Deficiency Treatment Consortium. Data were collected with a Research Electronic Data Capture Web application. Survival from time of diagnosis or transplantation was estimated by using the Kaplan-Meier method compared with log-rank tests and modeled by using proportional hazards regression.ResultsTwenty-eight clinical sites provided data on 189 patients given a diagnosis of XHIGM between 1964 and 2013; 176 had valid follow-up and vital status information. Sixty-seven (38%) patients received HCT. The average follow-up time was 8.5 ± 7.2 years (range, 0.1-36.2 years). No difference in overall survival was observed between patients treated with or without HCT (P = .671). However, risk associated with HCT decreased for diagnosis years 1987-1995; the hazard ratio was significantly less than 1 for diagnosis years 1995-1999. Liver disease was a significant predictor of overall survival (hazard ratio, 4.9; 95% confidence limits, 2.2-10.8; P

Published
2017

14. British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders

Author

Hurst, John R., Verma, Nisha, Lowe, David, Baxendale, Helen E., Jolles, Stephen, Kelleher, Peter, Longhurst, Hilary J., Patel, Smita Y., Renzoni, Elisabetta A., Sander, Clare R., Avery, Gerard R., Babar, Judith L., Buckland, Matthew S., Burns, Siobhan, Egner, William, Gompels, Mark M., Gordins, Pavels, Haddock, Jamanda A., Hart, Simon P., Hayman, Grant R., Herriot, Richard, Hoyles, Rachel K., Huissoon, Aarnoud P., Jacob, Joseph, Nicholson, Andrew G., Rassl, Doris M., Sargur, Ravishankar B., Savic, Sinisa, Seneviratne, Suranjith L., Sheaff, Michael, Vaitla, Prashantha M., Walters, Gareth I., Whitehouse, Joanna L., Wright, Penny A., and Condliffe, Alison M.

Published
2017
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19. Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review

Author

Doolan, Brent J, Lavallee, Mark E, Hausser, Ingrid, Schubart, Jane R, Michael Pope, F, Seneviratne, Suranjith L, Winship, Ingrid M, Burrows, Nigel P, and Apollo - University of Cambridge Repository

Subjects
heritable connective tissue disorders (HCTD), joint hypermobility, complications, General Medicine, Ehlers-Danlos syndrome, extracutaneous
Abstract

Peer reviewed: True, Acknowledgements: We wish to recognize the Ehlers-Danlos Society and the Ehlers-Danlos International Consortium for facilitation of the EDS Skin working group. We would like to thank the authors of published manuscript for providing individual patient data from their studies, with special thanks to Assistant Professor Jennifer Andrews (University of Arizona, USA), Associate Professor Christina Laukaitis (University of Arizona, USA), Professor Benaim Charles (Lausanne University Hospital, Switzerland), Dr. Jessica Eccles (Brighton and Sussex University Hospitals NHS Trust, UK), and Professor Sherene Shalhub (University of Washington, USA)., INTRODUCTION: The Ehlers-Danlos syndromes (EDS) comprise a group of inherited connective tissue disorders presenting with variable fragility to skin, soft tissue, and certain internal organs, which can cause significant complications, particularly arterial rupture, bowel perforation and joint difficulties. Currently, there are 14 proposed subtypes of EDS, with all except one subtype (hypermobile EDS) having an identified genetic etiology. An understanding of the extracutaneous features and complications within each subtype is key to maximizing clinical care and reducing the risk of further complications. METHODS: A systematic review of EDS-related extracutaneous features and complications was undertaken. RESULTS: We identified 839 EDS cases that met the inclusion criteria. We noted a high prevalence of joint hypermobility amongst kyphoscoliotic (39/39, 100%), spondylodysplastic (24/25, 96.0%), and hypermobile (153/160, 95.6%) EDS subtypes. The most common musculoskeletal complications were decreased bone density (39/43, 90.7%), joint pain (217/270, 80.4%), and hypotonia/weakness (79/140, 56.4%). Vascular EDS presented with cerebrovascular events (25/153, 16.3%), aneurysm (77/245, 31.4%), arterial dissection/rupture (89/250, 35.5%), and pneumothorax/hemothorax. Chronic pain was the most common miscellaneous complication, disproportionately affecting hypermobile EDS patients (139/157, 88.5%). Hypermobile EDS cases also presented with chronic fatigue (61/63, 96.8%) and gastrointestinal complications (57/63, 90.5%). Neuropsychiatric complications were noted in almost all subtypes. DISCUSSION: Understanding the extracutaneous features and complications of each EDS subtype may help diagnose and treat EDS prior to the development of substantial comorbidities and/or additional complications. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022308151, identifier CRD42022308151.

Published
2023

21. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author

Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, André C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Náyade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald

Published
2015
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25. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus

Author

Hepburn, Lucy, Prajsnar, Tomasz K., Klapholz, Catherine, Moreno, Pablo, Loynes, Catherine A., Ogryzko, Nikolay V., Brown, Karen, Schiebler, Mark, Hegyi, Krisztina, Antrobus, Robin, Hammond, Katherine L., Connolly, John, Ochoa, Bernardo, Bryant, Clare, Otto, Michael, Surewaard, Bas, Seneviratne, Suranjith L., Grogono, Dorothy M., Cachat, Julien, Ny, Tor, Kaser, Arthur, Török, M. Estée, Peacock, Sharon J., Holden, Matthew, Blundell, Tom, Wang, Lihui, Ligoxygakis, Petros, Minichiello, Liliana, Woods, C. Geoff, Foster, Simon J., Renshaw, Stephen A., and Floto, R. Andres

Published
2014

26. The role of cutaneous manifestations in the diagnosis of the Ehlers-Danlos syndromes

Author

Stembridge, Natasha, Doolan, Brent J, Lavallee, Mark E, Hausser, Ingrid, Pope, F Michael, Seneviratne, Suranjith L, Winship, Ingrid M, Burrows, Nigel P, Doolan, Brent J [0000-0002-9497-0504], Hausser, Ingrid [0000-0002-1095-4962], Winship, Ingrid M [0000-0001-8535-6003], Burrows, Nigel P [0000-0002-1090-8261], and Apollo - University of Cambridge Repository

Subjects
Rare Diseases, FOS: Biological sciences, Genetics, 32 Biomedical and Clinical Sciences, Genetic Testing, 3202 Clinical Sciences, Skin
Abstract

The Ehlers-Danlos syndromes (EDS) comprise a group of inherited connective tissue disorders presenting with features of skin hyperextensibility, joint hypermobility, abnormal scarring and fragility of skin, blood vessels and some organs. The disease is generally diagnosed through the cluster of clinical features, though the addition of genetic analysis is the gold standard for diagnosis of most subtypes. All subtypes display skin manifestations, which are essential to the accurate clinical diagnosis of the condition. Furthermore, cutaneous features can be the first and/or only presenting feature in some cases of EDS and thus understanding these signs is vital for diagnosis. This review focuses on particular cutaneous features of each EDS subtype and their clinical importance. Provision of a specific diagnosis is important for management, prognosis and genetic counselling, often for family members beyond the individual.

Published
2022
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29. Dengue and COVID-19 co-infections: an important consideration in the tropics.

Author

Dalugama, Chamara and Seneviratne, Suranjith L

Subjects
DENGUE hemorrhagic fever, SARS-CoV-2, COVID-19, MIXED infections, DENGUE
Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected >370 million individuals worldwide. Dengue is endemic in many countries and leads to epidemics at frequent intervals. In the tropics and subtropics, it is possible that individuals may be concurrently infected with both dengue and SARS-CoV-2. Differentiation between the two infections may be difficult from both a clinical and laboratory perspective. We have outlined the currently published findings (as of the end of December 2021) on patients with dengue and SARS-CoV-2 co-infections and have discussed the observed outcomes and management of such patients. Co-infections were more common in males >25 y of age, fever was not universal, 30–50% had medical comorbidities such as diabetes mellitus or hypertension and the case fatality rate was 16–28%. [ABSTRACT FROM AUTHOR]

Published
2023
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31. The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1

Author

Depner, Mark, Fuchs, Sebastian, Raabe, Jan, Frede, Natalie, Glocker, Cristina, Doffinger, Rainer, Gkrania-Klotsas, Effrossyni, Kumararatne, Dinakantha, Atkinson, T. Prescott, Schroeder, Jr., Harry W., Niehues, Tim, Dückers, Gregor, Stray-Pedersen, Asbjørg, Baumann, Ulrich, Schmidt, Reinhold, Franco, Jose L., Orrego, Julio, Ben-Shoshan, Moshe, McCusker, Christine, Jacob, Cristina Miuki Abe, Carneiro-Sampaio, Magda, Devlin, Lisa A., Edgar, J. David M., Henderson, Paul, Russell, Richard K., Skytte, Anne-Bine, Seneviratne, Suranjith L., Wanders, Jennifer, Stauss, Hans, Meyts, Isabelle, Moens, Leen, Jesenak, Milos, Kobbe, Robin, Borte, Stephan, Borte, Michael, Wright, Dowain A., Hagin, David, Torgerson, Troy R., and Grimbacher, Bodo

Published
2016
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32. Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study

Author

Abeysuriya, Visula, primary, Seneviratne, Suranjith L, additional, De Silva, Arjuna P, additional, Mowjood, Riaz, additional, Mowjood, Shazli, additional, de Silva, Thushara, additional, de Mel, Primesh, additional, de Mel, Chandima, additional, Wijesinha, R S, additional, Fernando, Amitha, additional, de Mel, Sanjay, additional, and Chandrasena, Lal, additional

Published
2022
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36. COVID-19 in cancer patients

Author

Seneviratne, Suranjith L, primary, Wijerathne, Widuranga, additional, Yasawardene, Pamodh, additional, and Somawardana, Buddhika, additional

Published
2022
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40. Combination of cycle threshold time, absolute lymphocyte count and neutrophil:lymphocyte ratio is predictive of hypoxia in patients with SARS-CoV-2 infection

Author

Abeysuriya, Visula, primary, Seneviratne, Suranjith L, additional, de Silva, Arjuna P, additional, Mowjood, Riaz, additional, Mowjood, Shazli, additional, de Silva, Thushara, additional, de Mel, Primesh, additional, de Mel, Chandima, additional, Chandrasena, Lal, additional, Wijesinha, R S, additional, Fernando, Amitha, additional, and de Mel, Sanjay, additional

Published
2021
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41. Development and validation of the food allergy severity score

Author

Fernández‐Rivas, Montserrat, primary, Gómez García, Ismael, additional, Gonzalo‐Fernández, Alejandro, additional, Fuentes Ferrer, Manuel, additional, Dölle‐Bierke, Sabine, additional, Marco‐Martín, Guadalupe, additional, Ballmer‐Weber, Barbara K., additional, Asero, Riccardo, additional, Belohlavkova, Simona, additional, Beyer, Kirsten, additional, de Blay, Frédéric, additional, Clausen, Michael, additional, Datema, Mareen R., additional, Dubakiene, Ruta, additional, Grimshaw, Kate E. C., additional, Hoffmann‐Sommergruber, Karin, additional, Hourihane, Jonathan O’B, additional, Jedrzejczak‐Czechowicz, Monika, additional, Knulst, André C., additional, Kralimarkova, Tanya, additional, Le, Thuy‐My, additional, Papadopoulos, Nikolaos G., additional, Popov, Todor A., additional, Poulsen, Lars K., additional, Purohit, Ashok, additional, Seneviratne, Suranjith L., additional, Simpson, Angela, additional, Sinaniotis, Atanasios, additional, Turkalji, Mirjana, additional, Vázquez‐Cortés, Sonia, additional, Vera‐Berrios, Rosialzira N., additional, Muraro, Antonella, additional, Worm, Margitta, additional, Roberts, Graham, additional, van Ree, Ronald, additional, Fernández‐Pérez, Cristina, additional, Turner, Paul J., additional, and Mills, Elizabeth N. Clare, additional

Published
2021
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44. Combination of cycle threshold time, absolute lymphocyte count and neutrophil:lymphocyte ratio is predictive of hypoxia in patients with SARS-CoV-2 infection.

Author

Abeysuriya, Visula, Seneviratne, Suranjith L, Silva, Arjuna P de, Mowjood, Riaz, Mowjood, Shazli, Silva, Thushara de, Mel, Primesh de, Mel, Chandima de, Chandrasena, Lal, Wijesinha, R S, Fernando, Amitha, and Mel, Sanjay de

Subjects
LYMPHOCYTE count, CORONAVIRUS diseases, SARS-CoV-2, HYPOXEMIA, OXYGEN saturation, RECEIVER operating characteristic curves
Abstract

Background There is currently no clinically validated biomarker to predict respiratory compromise in sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cycle threshold time (Ct), absolute lymphocyte count (AL) and neutrophil:lymphocyte ratio (NLR) have been previously evaluated for this purpose. We hypothesized that the combination of these parameters at presentation may be predictive of hypoxia (oxygen saturation <92%). Methods Data were collected on 118 patients with SARS-CoV-2 infection between May 2020 and April 2021. Demographics, clinical parameters and laboratory and radiological investigation results were recorded. Respiratory compromise (RC) was defined based on symptoms and signs, hypoxia and chest X-ray abnormalities. Results RC occurred in 61 (51.7%) of patients. The Ct, AL and NLR at median day 3 of illness were significantly different between patients with and without RC (Ct, RC vs not: 19.46±2.64 vs 22.62±3.37, p=0.0001; AL, RC vs not: 531.49±289.09 vs 764.69±481.79, p=0.0001; NLR, RC vs not: 3.42±0.75 vs 2.59±0.55, p=0.0001). Receiver operating characteristics analysis showed that a Ct <19.9, AL <630.8×103/μL and NLR >3.12 at median day 3 of symptoms was predictive of hypoxia on day 7 of illness (area under the curve 0.805, sensitivity 96.7%, specificity 69.1%). The predictive value for the parameters combined was significantly superior to their individual predictive power. Conclusions Ct, AL and NLR used in combination on day 3 of symptoms are predictive of hypoxia on day 7 of SARS-CoV-2 illness. [ABSTRACT FROM AUTHOR]

Published
2022
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45. INNATE IMMUNITY: A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus

Author

Hepburn, Lucy, Prajsnar, Tomasz K., Klapholz, Catherine, Moreno, Pablo, Loynes, Catherine A., Ogryzko, Nikolay V., Brown, Karen, Schiebler, Mark, Hegyi, Krisztina, Antrobus, Robin, Hammond, Katherine L., Connolly, John, Ochoa, Bernardo, Bryant, Clare, Otto, Michael, Surewaard, Bas, Seneviratne, Suranjith L., Grogono, Dorothy M., Cachat, Julien, Ny, Tor, Kaser, Arthur, Török, Estée M., Peacock, Sharon J., Holden, Matthew, Blundell, Tom, Wang, Lihui, Ligoxygakis, Petros, Minichiello, Liliana, Woods, Geoff C., Foster, Simon J., Renshaw, Stephen A., and Floto, R. Andres

Published
2014
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47. Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles

Author

Datema, Mareen R., primary, Lyons, Sarah A., additional, Fernández-Rivas, Montserrat, additional, Ballmer-Weber, Barbara, additional, Knulst, André C., additional, Asero, Riccardo, additional, Barreales, Laura, additional, Belohlavkova, Simona, additional, de Blay, Frédéric, additional, Clausen, Michael, additional, Dubakiene, Ruta, additional, Fernández-Perez, Cristina, additional, Fritsche, Philipp, additional, Gislason, David, additional, Hoffmann-Sommergruber, Karin, additional, Jedrzejczak-Czechowicz, Monika, additional, Jongejan, Laurian, additional, Kowalski, Marek L., additional, Kralimarkova, Tanya Z., additional, Lidholm, Jonas, additional, Papadopoulos, Nikolaos G., additional, Popov, Todor A., additional, Prado, Nayade del, additional, Purohit, Ashok, additional, Reig, Isabel, additional, Seneviratne, Suranjith L., additional, Sinaniotis, Athanassios, additional, Vassilopoulou, Emilia, additional, Versteeg, Serge A., additional, Vieths, Stefan, additional, Welsing, Paco M. J., additional, Mills, E. N. Clare, additional, Le, Thuy-My, additional, Zwinderman, Aeilko H., additional, and van Ree, Ronald, additional

Published
2021
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48. Admission ultrasonography as a predictive tool for thrombocytopenia and disease severity in dengue infection

Author

Donaldson, Callum D, primary, de Mel, Sanjay, additional, Clarice, Choong Shi Hui, additional, Thilakawardana, Basuru Uvindu, additional, de Mel, Primesh, additional, Shalindi, Malka, additional, Samarasinghe, U, additional, de Mel, Chandima, additional, Chandrasena, Lal, additional, Wijesinha, Rasanga S, additional, Wijesinha, A Nirmala I, additional, Yip, Christina, additional, Yap, Eng-Soo, additional, Seneviratne, Suranjith L, additional, and Abeysuriya, Visula, additional

Published
2021
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50. immature platelet fraction, a predictive tool for early recovery from dengue-related thrombocytopenia: a prospective study.

Author

Abeysuriya, Visula, Seneviratne, Suranjith L, Mel, Primesh de, Clarice, Choong Shi Hui, Mel, Chandima de, Chandrasena, Lal, Yip, Christina, Yap, Eng-Soo, and Mel, Sanjay de

Subjects
BLOOD platelets, THROMBOCYTOPENIA, PLATELET count, LONGITUDINAL method, ELECTRONIC health records
Abstract

Background There is a paucity of predictive factors for early recovery from thrombocytopenia related to dengue. The immature platelet fraction (IPF%) is reflective of megakaryopoiesis and may correlate with recovery from dengue-related thrombocytopenia. Our objective was to assess the predictive value of IPF% on days 2 and 3 of illness for recovery from dengue-related thrombocytopenia. Methods A prospective study was conducted among patients with dengue admitted to our institution (Nawaloka Hospital PLC) from December 2019 to October 2020. Dengue was diagnosed based on positive non-structural antigen 1 or IgM. IPF% data were extracted from the Sysmex-XN-1000 automated hematology analyzer. Clinical data were obtained from electronic medical records. Statistical analyses were performed using SPSS version 20. Results We included 240 patients. An IPF% on day 2 of illness of >7.15% had a sensitivity of 80.0% and specificity of 70.4% for prediction of platelet recovery (defined as platelet count ≥60×109/L) on day 7 of illness. An IPF% of >7.25% on day 3 of illness had a sensitivity of 88.9% and specificity of 47.1% for predicting platelet recovery >60×109/L on day 8 of illness. The IPF% was significantly lower in patients with severe dengue. Platelet recovery was observed within 48 h after the peak IPF% was reached, regardless of severity. Conclusion We propose that IPF% values on days 2 and 3 of illness are a promising predictive tool for early recovery from dengue-related thrombocytopenia. [ABSTRACT FROM AUTHOR]

Published
2022
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