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4 results on '"Senfang Sui"'

3. A new approach to the development of quartz crystal sensors distinguishing between mass loading and liquid damping

Author

Fengpin Feng, Chao Zhang, and Senfang Sui

Subjects
Crystal, Resonator, Amplitude, Materials science, Q factor, Electronic engineering, Harmonic number, Fundamental frequency, Quartz crystal microbalance, Electrical and Electronic Engineering, Atomic physics, Instrumentation, Quartz
Abstract

Characteristic damping coefficient K/sub c/ is introduced to distinguish between the effects of mass loading and liquid damping of a quartz resonator vibrating in liquids. When the mass loading of the quartz resonator is constant the value of /spl kappa//sub c/ depends only on the parameters of the resonator itself and not on the properties of the attached mass or liquid. The effect of mass loading can be distinguished from that of liquid damping by measuring the frequency shift and the amplitude of the quartz resonator simultaneously. A series of experiments were carried out to test the value of /spl kappa//sub c/, and the influence of the resonator parameters on /spl kappa//sub c/ was studied, e.g., the electrode area, the harmonic number, and the fundamental frequency.

Published
1998

4. MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX.

Author

Wen Li, Xingli Zhang, Haixia Zhuang, He-ge Chen, Yinqin Chen, Weili Tian, Wenxian Wu, Ying Li, Sijie Wang, Liangqing Zhang, Yusen Chen, Longxuan Li, Bin Zhao, Senfang Sui, Zhe Hu, and Du Feng

Subjects
*MICRORNA, *HYPOXEMIA, *AUTOPHAGY, *GENE targeting, *GENE expression, *MITOCHONDRIAL proteins, *MOLECULAR recognition
Abstract

Background: Mitophagy and microRNA both regulate the occurrence of neurodegenerative diseases and cancers. Results: MicroRNA-137, a hypoxia responsive microRNA, inhibits mitophagy via targeting two mitophagy receptors. Conclusion: A novel link between miR-137 and mitophagy has been revealed. Significance: Understanding mitophagy regulation and microRNA functions may provide new concepts to fight human diseases. Mitophagy receptors mediate the selective recognition and targeting of damaged mitochondria by autophagosomes. The mechanism for the regulation of these receptors remains unknown. Here, we demonstrated that a novel hypoxia-responsive microRNA, microRNA-137 (miR-137), markedly inhibits mitochondrial degradation by autophagy without affecting global autophagy. miR- 137 targets the expression of two mitophagy receptors NIX and FUNDC1. Impaired mitophagy in response to hypoxia caused by miR-137 is reversed by re-expression of FUNDC1 and NIX expression vectors lacking the miR-137 recognition sites at their 3' UTR. Conversely, miR-137 also suppresses the mitophagy induced by fundc1 (CDS'3'UTR) but not fundc1 (CDS) overexpression. Finally, we found that miR-137 inhibits mitophagy by reducing the expression of the mitophagy receptor thereby leads to inadequate interaction between mitophagy receptor and LC3. Our results demonstrated the regulatory role of miRNA to mitophagy receptors and revealed a novel link between miR-137 and mitophagy. [ABSTRACT FROM AUTHOR]

Published
2014
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