207 results on '"Senff Ribeiro, Andrea"'
Search Results
2. Brown Spider Venom Phospholipase-D Activity upon Different Lipid Substrates
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Chaves-Moreira, Daniele, Gremski, Luiza Helena, de Moraes, Fábio Rogério, Vuitika, Larissa, Wille, Ana Carolina Martins, González, Jorge Enrique Hernández, Chaim, Olga Meiri, Senff-Ribeiro, Andrea, Arni, Raghuvir Krishnaswamy, and Veiga, Silvio Sanches
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Animals ,Sphingomyelins ,Phosphoric Diester Hydrolases ,Phospholipase D ,Spider Venoms ,Phospholipids ,Lysophosphatidylcholines ,Spiders ,brown spider ,Loxosceles intermedia ,venom ,phospholipase-D substrate ,recombinant toxin ,phospholipids ,Biochemistry and Cell Biology ,Pharmacology and pharmaceutical sciences - Abstract
Brown spider envenomation results in dermonecrosis, characterized by an intense inflammatory reaction. The principal toxins of brown spider venoms are phospholipase-D isoforms, which interact with different cellular membrane components, degrade phospholipids, and generate bioactive mediators leading to harmful effects. The Loxosceles intermedia phospholipase D, LiRecDT1, possesses a loop that modulates the accessibility to the active site and plays a crucial role in substrate. In vitro and in silico analyses were performed to determine aspects of this enzyme's substrate preference. Sphingomyelin d18:1/6:0 was the preferred substrate of LiRecDT1 compared to other Sphingomyelins. Lysophosphatidylcholine 16:0/0:0 was preferred among other lysophosphatidylcholines, but much less than Sphingomyelin d18:1/6:0. In contrast, phosphatidylcholine d18:1/16:0 was not cleaved. Thus, the number of carbon atoms in the substrate plays a vital role in determining the optimal activity of this phospholipase-D. The presence of an amide group at C2 plays a key role in recognition and activity. In silico analyses indicated that a subsite containing the aromatic residues Y228 and W230 appears essential for choline recognition by cation-π interactions. These findings may help to explain why different cells, with different phospholipid fatty acid compositions exhibit distinct susceptibilities to brown spider venoms.
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- 2023
3. Novel insights into the application of recombinant mutated phospholipases D as antigens for developing new strategies against Loxoscelism
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Polli, Nayanne Louise Costacurta, Ferreira, Maria Eduarda de Fraga, Schluga, Pedro Henrique Caires, Antunes, Bruno Cesar, Justa, Hanna Câmara da, Theodoro, João Lucas, Zazula, Matheus Felipe, Naliwaiko, Katya, Minozzo, João Carlos, Senff-Ribeiro, Andrea, Wille, Ana Carolina Martins, Veiga, Silvio Sanches, and Gremski, Luiza Helena
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- 2024
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4. Sertraline as a potential cancer therapeutic approach: Biological relevance of TCTP in breast cancer cell lines and tumors
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Baldissera, Antonielle B., Boia-Ferreira, Marianna, Basílio, Alana B.C., Resende, Jean Silva de Souza, Castro, Mauro Antônio Alves, Chaim, Olga M., Gremski, Luiza Helena, Veiga, Silvio S., and Senff-Ribeiro, Andrea
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- 2023
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5. Brown spider venom phospholipases D: From molecular biology and structural analyses to potential vaccine and serum therapy applications
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Polli, Nayanne Louise Costacurta, primary, Baldissera, Antonielle, additional, de Oliveira Leite, Isabel, additional, Gonzalez, Jorge Enrique Hernandez, additional, Gismene, Carolina, additional, Mariutti, Ricardo Barros, additional, Matsubara, Fernando Hitomi, additional, Senff-Ribeiro, Andrea, additional, Arni, Raghuvir Krishnaswamy, additional, Veiga, Silvio Sanches, additional, and Gremski, Luiza Helena, additional
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- 2023
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6. Contributors
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Abbas Bukhari, Syed Nasir, primary, Abhilash, M., additional, Abinaya, K., additional, Adefegha, Stephen A., additional, Adeleke, Oluwakemi V., additional, Aggarwal, Sumit Kumar, additional, Arni, Raghuvir Krishnaswamy, additional, Azam, Mohammad, additional, Baldissera, Antonielle, additional, Bano, Sarika, additional, Bedir, Ipek, additional, Bhatt, Lokesh Kumar, additional, Bhushan, Bharat, additional, Binu, P., additional, Castelli, María Eugenia, additional, Cerminati, Sebastián, additional, Chakraborti, Sajal, additional, Chakraborti, Tapati, additional, Chaudhary, Dharam Paul, additional, Chaurasiya, Shivendra K., additional, Clarke, Christopher J., additional, Correa, Fernando, additional, Dagla, Manesh Chander, additional, De Laurentiis, Andrea, additional, de Oliveira Leite, Isabel, additional, Devadasan, Velmurugan, additional, Dey, Sanjay Kumar, additional, Dhalla, Naranjan S., additional, Ejike, Uju Dorathy Iliemene, additional, Etcheverry, Tomás, additional, Farina, Mariana, additional, Fujita, Masaaki, additional, Ghandour, Botheina, additional, Ghumman, Shazia Akram, additional, Gismene, Carolina, additional, Gonzalez, Jorge Enrique Hernandez, additional, Gremski, Luiza Helena, additional, Hails, Guillermo, additional, Hannun, Yusuf A., additional, Hasan, Sara, additional, Ijaz, Bushra, additional, Jain, Kripa, additional, Jat, Bahadur Singh, additional, Jiang, Xian-Cheng, additional, Jiménez, Jaime Andrés Pereañez, additional, Kumar, Pardeep, additional, Kumar, Satish, additional, Lacava, Franco Emanuel, additional, Liman, Mubarak Labaran, additional, Lo Vasco, Vincenza Rita, additional, Marchisio, Fiorela, additional, Mariutti, Ricardo Barros, additional, Mathew, Bijina J., additional, Matsubara, Fernando Hitomi, additional, Menzella, Hugo Gabriel, additional, Mohammed, Samia, additional, Molehin, Olorunfemi R., additional, Mondal, Kausik, additional, Murakami, Makoto, additional, Muthezhilan, R., additional, Nair, R. Harikumaran, additional, Naz, Anjum, additional, Nezir, Ayca Ece, additional, Noreen, Sobia, additional, Olonishuwa, Paul T., additional, Onal, Meltem Selen, additional, Ozturk, Kaan, additional, Pal, Ajay, additional, Pandey, Amit Kumar, additional, Paoletti, Luciana, additional, Polli, Nayanne Louise Costacurta, additional, Puviarasan, K., additional, Rai, Rupal, additional, Raman, Pachaiappan, additional, Ren, Jihui, additional, Ruwali, Munindra, additional, Senff-Ribeiro, Andrea, additional, Sengupta, Sayan, additional, Singh, Alla, additional, Singh, Amarjeet, additional, Singh, Vinayak, additional, Sonkar, Kamankshi, additional, Takada, Yoko K., additional, Takada, Yoshikazu, additional, Taketomi, Yoshitaka, additional, Tan, Choo Hock, additional, Tan, Kae Yi, additional, Tappia, Paramjit S., additional, Telci, Dilek, additional, Vadak, Namrata, additional, Val, Diego S., additional, Varghese, Mathews V., additional, and Veiga, Silvio Sanches, additional
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- 2023
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7. Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
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Chaves-Moreira, Daniele, Matsubara, Fernando Hitomi, Schemczssen-Graeff, Zelinda, De Bona, Elidiana, Heidemann, Vanessa Ribeiro, Guerra-Duarte, Clara, Gremski, Luiza Helena, Chávez-Olórtegui, Carlos, Senff-Ribeiro, Andrea, Chaim, Olga Meiri, Arni, Raghuvir Krishnaswamy, and Veiga, Silvio Sanches
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Analgesics ,Animals ,Anti-Inflammatory Agents ,Antineoplastic Agents ,Humans ,Immunotherapy ,Insecticides ,Neuroprotective Agents ,Peptides ,Phosphoric Diester Hydrolases ,Recombinant Proteins ,Serine Proteinase Inhibitors ,Spider Venoms ,Tumor Protein ,Translationally-Controlled 1 ,brown spider ,venom ,Loxosceles ,toxins ,biotools ,drug targets ,novel therapeutics ,Biochemistry and Cell Biology ,Pharmacology and pharmaceutical sciences - Abstract
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5-40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action.
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- 2019
8. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism
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Boia-Ferreira, Marianna, Moreno, Kamila G, Basílio, Alana BC, da Silva, Lucas P, Vuitika, Larissa, Soley, Bruna, Wille, Ana Carolina M, Donatti, Lucélia, Barbaro, Katia C, Chaim, Olga M, Gremski, Luiza Helena, Veiga, Silvio S, and Senff-Ribeiro, Andrea
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Biomedical and Clinical Sciences ,Clinical Sciences ,2.1 Biological and endogenous factors ,Aetiology ,Inflammatory and immune system ,Animals ,Biomarkers ,Tumor ,Cimetidine ,Cromolyn Sodium ,Dose-Response Relationship ,Drug ,Hypersensitivity ,Inflammation ,Injections ,Intraperitoneal ,Injections ,Intravenous ,Mast Cells ,Mice ,Phosphoric Diester Hydrolases ,Piperidines ,Promethazine ,Rabbits ,Rats ,Skin Diseases ,Spider Venoms ,Tumor Cells ,Cultured ,Tumor Protein ,Translationally-Controlled 1 ,Loxosceles ,brown spider ,TCTP ,venom ,toxin ,HRF ,Biological sciences ,Biomedical and clinical sciences - Abstract
LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients.
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- 2019
9. Insulin inhibits melanoma tumor growth through the expression of activating transcription factor 4, without detectable expression of transcription factor CHOP: an in vivo model
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do Prado, Daniel, primary, Boia-Ferreia, Marianna, additional, da Justa, Hanna Camara, additional, Senff-Ribeiro, Andrea, additional, and Padilha, Sérgio Lunardon, additional
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- 2024
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10. A protective vaccine against the toxic activities following Brown spider accidents based on recombinant mutated phospholipases D as antigens
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Polli, Nayanne Louise Costacurta, Justa, Hanna Camara da, Antunes, Bruno Cesar, Silva, Thais Pereira da, Dittrich, Rosangela Locatelli, de Souza, Giovana Scuissiatto, Wille, Ana Carolina Martins, Matsubara, Fernando Hitomi, Minozzo, João Carlos, Mariutti, Ricardo Barros, Arni, Raghuvir Krishnaswamy, Senff-Ribeiro, Andrea, Veiga, Silvio Sanches, and Gremski, Luiza Helena
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- 2021
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11. Description of a serpin toxin in Loxosceles (Brown spider) venoms: Cloning, expression in baculovirus-infected insect cells and functional characterization
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Schemczssen-Graeff, Zelinda, Justa, Hanna Câmara da, Nowatzki, Jenifer, Baldissera, Antonielle Beatriz, Polli, Nayanne Louise Costacurta, De-Bona, Elidiana, Rossi, Izadora Volpato, Ramirez, Marcel Ivan, Minozzo, João Carlos, Matsubara, Fernando Hitomi, Senff-Ribeiro, Andrea, Gremski, Luiza Helena, and Veiga, Silvio Sanches
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- 2021
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12. Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells
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De-Bona, Elidiana, Chaves-Moreira, Daniele, Batista, Thiago Beltrami Dias, Justa, Hanna Câmara da, Rossi, Gustavo Rodrigues, Antunes, Bruno Cesar, Matsubara, Fernando Hitomi, Minozzo, João Carlos, Wille, Ana Carolina Martins, Veiga, Silvio Sanches, Senff-Ribeiro, Andrea, and Gremski, Luiza Helena
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- 2021
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13. LALLT (Loxosceles Allergen-Like Toxin) from the venom of Loxosceles intermedia: Recombinant expression in insect cells and characterization as a molecule with allergenic properties
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Justa, Hanna Câmara da, Matsubara, Fernando Hitomi, de-Bona, Elidiana, Schemczssen-Graeff, Zelinda, Polli, Nayanne Louise Costacurta, de Mari, Thiago Lopes, Boia-Ferreira, Marianna, Minozzo, João Carlos, Wille, Ana Carolina Martins, Senff-Ribeiro, Andrea, Gremski, Luiza Helena, and Veiga, Silvio Sanches
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- 2020
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14. Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms
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Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta‐Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Fobo, Gisela, Montrone, Corinna, Brauner, Barbara, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Kumar Gupta, Shailendra, Scheel, Julia, Borlinghaus, Hanna, Czauderna, Tobias, Schreiber, Falk, Montagud, Arnau, Ponce de Leon, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G, Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Ackerman, Emily E, Shoemaker, Jason E, Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yağmur, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Eijssen, Lars, Ehrhart, Friederike, Rex, D A B, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Orlic‐Milacic, Marija, Senff‐Ribeiro, Andrea, Rothfels, Karen, Shamovsky, Veronica, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean‐Marie, Fraser, Rupsha, Ortseifen, Vera, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Hu, Xiaoming, Overall, Rupert W, Maier, Dieter, Bauch, Angela, Gyori, Benjamin M, Bachman, John A, Vega, Carlos, Grouès, Valentin, Vazquez, Miguel, Porras, Pablo, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, de Waard, Anita, Turei, Denes, Luna, Augustin, Babur, Ozgun, Soliman, Sylvain, Valdeolivas, Alberto, Esteban‐Medina, Marina, Peña‐Chilet, Maria, Rian, Kinza, Helikar, Tomáš, Puniya, Bhanwar Lal, Modos, Dezso, Treveil, Agatha, Olbei, Marton, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurélien, Naldi, Aurélien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C, Augé, Franck, Beckmann, Jacques S, Hasenauer, Jan, Wolkenhauer, Olaf, Willighagen, Egon L, Pico, Alexander R, Evelo, Chris T, Gillespie, Marc E, Stein, Lincoln D, Hermjakob, Henning, D'Eustachio, Peter, Saez‐Rodriguez, Julio, Dopazo, Joaquin, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, and Schneider, Reinhard
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- 2021
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15. COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
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Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta‐Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Fobo, Gisela, Montrone, Corinna, Brauner, Barbara, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Kumar Gupta, Shailendra, Scheel, Julia, Borlinghaus, Hanna, Czauderna, Tobias, Schreiber, Falk, Montagud, Arnau, Ponce de Leon, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G, Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Ackerman, Emily E, Shoemaker, Jason E, Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yağmur, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Eijssen, Lars, Ehrhart, Friederike, Rex, Devasahayam Arokia Balaya, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Orlic‐Milacic, Marija, Senff-Ribeiro, Andrea, Rothfels, Karen, Shamovsky, Veronica, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean‐Marie, Fraser, Rupsha, Ortseifen, Vera, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Hu, Xiaoming, Overall, Rupert W, Maier, Dieter, Bauch, Angela, Gyori, Benjamin M, Bachman, John A, Vega, Carlos, Grouès, Valentin, Vazquez, Miguel, Porras, Pablo, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, de Waard, Anita, Turei, Denes, Luna, Augustin, Babur, Ozgun, Soliman, Sylvain, Valdeolivas, Alberto, Esteban‐Medina, Marina, Peña‐Chilet, Maria, Rian, Kinza, Helikar, Tomáš, Puniya, Bhanwar Lal, Modos, Dezso, Treveil, Agatha, Olbei, Marton, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurélien, Naldi, Aurélien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C, Augé, Franck, Beckmann, Jacques S, Hasenauer, Jan, Wolkenhauer, Olaf, Willighagen, Egon L, Pico, Alexander R, Evelo, Chris T, Gillespie, Marc E, Stein, Lincoln D, Hermjakob, Henning, D'Eustachio, Peter, Saez‐Rodriguez, Julio, Dopazo, Joaquin, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, and Schneider, Reinhard
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- 2021
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16. Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms
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Senff-Ribeiro, Andrea, Kubiak, Jacek Z., Series editor, Kloc, Malgorzata, Series editor, Telerman, Adam, editor, and Amson, Robert, editor
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- 2017
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17. Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from Three Loxosceles Spider Venoms
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da Justa, Hanna Câmara, primary, Hernández González, Jorge Enrique, additional, Vuitika, Larissa, additional, Mariutti, Ricardo Barros, additional, Magnago, Pedro Augusto Martinho, additional, de Moraes, Fábio Rogério, additional, Senff-Ribeiro, Andrea, additional, Gremski, Luiza Helena, additional, Arni, Raghuvir Krishnaswamy, additional, and Veiga, Silvio Sanches, additional
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- 2023
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18. Acetylation of translationally controlled tumor protein promotes its degradation through chaperone-mediated autophagy
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Bonhoure, Anne, Vallentin, Alice, Martin, Marianne, Senff-Ribeiro, Andrea, Amson, Robert, Telerman, Adam, and Vidal, Michel
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- 2017
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19. Abstract 3814: In CLL the U1 snRNA driver mutation alters splicing in multiple genes and pathways
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Senff-Ribeiro, Andrea, primary, Almodaresi, Fatemeh, additional, Trinh, Quang, additional, Shuai, Shimin, additional, Spaner, David, additional, Puente, Xose S., additional, Campo, Elias, additional, and Stein, Lincoln D., additional
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- 2023
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20. Using the Reactome Database
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Rothfels, Karen, primary, Milacic, Marija, additional, Matthews, Lisa, additional, Haw, Robin, additional, Sevilla, Cristoffer, additional, Gillespie, Marc, additional, Stephan, Ralf, additional, Gong, Chuqiao, additional, Ragueneau, Eliot, additional, May, Bruce, additional, Shamovsky, Veronica, additional, Wright, Adam, additional, Weiser, Joel, additional, Beavers, Deidre, additional, Conley, Patrick, additional, Tiwari, Krishna, additional, Jassal, Bijay, additional, Griss, Johannes, additional, Senff‐Ribeiro, Andrea, additional, Brunson, Timothy, additional, Petryszak, Robert, additional, Hermjakob, Henning, additional, D'Eustachio, Peter, additional, Wu, Guanming, additional, and Stein, Lincoln, additional
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- 2023
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21. Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom
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Morgon, Adriano M., Belisario-Ferrari, Matheus R., Trevisan-Silva, Dilza, Meissner, Gabriel O., Vuitika, Larissa, Marin, Brenda, Tashima, Alexandre K., Gremski, Luiza H., Gremski, Waldemiro, Senff-Ribeiro, Andrea, Veiga, Silvio S., and Chaim, Olga M.
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- 2016
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22. Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas
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Morais de Castro, Eduardo, primary, Barbosa, Leonardo Vinícius, additional, Simoneti Fonseca, Aline, additional, Nagashima, Seigo, additional, Busatta Vaz de Paula, Caroline, additional, Zeni, Rafaela, additional, Panini do Carmo, Letícia Arianne, additional, Cavalli, Luciane Regina, additional, Bleggi Torres, Luiz Fernando, additional, Senff Ribeiro, Andrea, additional, de Noronha, Lucia, additional, and Machado-Souza, Cleber, additional
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- 2023
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23. Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity
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Buch, Daniela Regina, Souza, Fernanda Nunes, Meissner, Gabriel Otto, Morgon, Adriano Marcelo, Gremski, Luiza Helena, Ferrer, Valéria Pereira, Trevisan-Silva, Dilza, Matsubara, Fernando Hitomi, Boia-Ferreira, Mariana, Sade, Youssef Bacila, Chaves-Moreira, Daniele, Gremski, Waldemiro, Veiga, Silvio Sanches, Chaim, Olga Meiri, and Senff-Ribeiro, Andrea
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- 2015
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24. sj-docx-2-asn-10.1177_17590914231153481 - Supplemental material for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas
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Morais de Castro, Eduardo, Barbosa, Leonardo Vinícius, Simoneti Fonseca, Aline, Nagashima, Seigo, Busatta Vaz de Paula, Caroline, Zeni, Rafaela, Panini do Carmo, Letícia Arianne, Cavalli, Luciane R, Bleggi Torres, Luiz Fernando, Senff Ribeiro, Andrea, de Noronha, Lucia, and Machado-Souza, Cleber
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FOS: Clinical medicine ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-2-asn-10.1177_17590914231153481 for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas by Eduardo Morais de Castro, Leonardo Vinícius Barbosa, Aline Simoneti Fonseca, Seigo Nagashima, Caroline Busatta Vaz de Paula, Rafaela Zeni, Letícia Arianne Panini do Carmo, Luciane R Cavalli, Luiz Fernando Bleggi Torres, Andrea Senff Ribeiro, Lucia de Noronha and Cleber Machado-Souza in ASN Neuro
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- 2023
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25. sj-docx-3-asn-10.1177_17590914231153481 - Supplemental material for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas
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Morais de Castro, Eduardo, Barbosa, Leonardo Vinícius, Simoneti Fonseca, Aline, Nagashima, Seigo, Busatta Vaz de Paula, Caroline, Zeni, Rafaela, Panini do Carmo, Letícia Arianne, Cavalli, Luciane R, Bleggi Torres, Luiz Fernando, Senff Ribeiro, Andrea, de Noronha, Lucia, and Machado-Souza, Cleber
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FOS: Clinical medicine ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-3-asn-10.1177_17590914231153481 for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas by Eduardo Morais de Castro, Leonardo Vinícius Barbosa, Aline Simoneti Fonseca, Seigo Nagashima, Caroline Busatta Vaz de Paula, Rafaela Zeni, Letícia Arianne Panini do Carmo, Luciane R Cavalli, Luiz Fernando Bleggi Torres, Andrea Senff Ribeiro, Lucia de Noronha and Cleber Machado-Souza in ASN Neuro
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- 2023
- Full Text
- View/download PDF
26. sj-docx-1-asn-10.1177_17590914231153481 - Supplemental material for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas
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Morais de Castro, Eduardo, Barbosa, Leonardo Vinícius, Simoneti Fonseca, Aline, Nagashima, Seigo, Busatta Vaz de Paula, Caroline, Zeni, Rafaela, Panini do Carmo, Letícia Arianne, Cavalli, Luciane R, Bleggi Torres, Luiz Fernando, Senff Ribeiro, Andrea, de Noronha, Lucia, and Machado-Souza, Cleber
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FOS: Clinical medicine ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental material, sj-docx-1-asn-10.1177_17590914231153481 for Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas by Eduardo Morais de Castro, Leonardo Vinícius Barbosa, Aline Simoneti Fonseca, Seigo Nagashima, Caroline Busatta Vaz de Paula, Rafaela Zeni, Letícia Arianne Panini do Carmo, Luciane R Cavalli, Luiz Fernando Bleggi Torres, Andrea Senff Ribeiro, Lucia de Noronha and Cleber Machado-Souza in ASN Neuro
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- 2023
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27. Production and Functional Evaluation of Anti-Loxosceles Sera Raised by Immunizations of Rabbits with Mutated Recombinant Phospholipases-D
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Antunes, Bruno Cesar, primary, Polli, Nayanne Louise Costacurta, additional, Schluga, Pedro Henrique de Caires, additional, Silva, Thais Pereira da, additional, Wille, Ana Carolina Martins, additional, Locatelli-Dittrich, Rosangela, additional, Souza, Giovana Scuissiatto de, additional, Matsubara, Fernando Hitomi, additional, Minozzo, João Carlos, additional, Senff-Ribeiro, Andrea, additional, Gremski, Luiza Helena, additional, and Veiga, Silvio Sanches, additional
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- 2022
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28. Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation
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Gremski, Luiza Helena, primary, da Justa, Hanna Câmara, additional, Polli, Nayanne Louise Costacurta, additional, Schluga, Pedro Henrique de Caires, additional, Theodoro, João Lucas, additional, Wille, Ana Carolina Martins, additional, Senff-Ribeiro, Andrea, additional, and Veiga, Silvio Sanches, additional
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- 2022
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29. Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins
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Gremski, Luiza Helena, Trevisan-Silva, Dilza, Ferrer, Valéria Pereira, Matsubara, Fernando Hitomi, Meissner, Gabriel Otto, Wille, Ana Carolina Martins, Vuitika, Larissa, Dias-Lopes, Camila, Ullah, Anwar, de Moraes, Fábio Rogério, Chávez-Olórtegui, Carlos, Barbaro, Katia Cristina, Murakami, Mario Tyago, Arni, Raghuvir Krishnaswamy, Senff-Ribeiro, Andrea, Chaim, Olga Meiri, and Veiga, Silvio Sanches
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- 2014
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30. Chapter 15 - Brown spider venom phospholipases D: From molecular biology and structural analyses to potential vaccine and serum therapy applications
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Polli, Nayanne Louise Costacurta, Baldissera, Antonielle, de Oliveira Leite, Isabel, Gonzalez, Jorge Enrique Hernandez, Gismene, Carolina, Mariutti, Ricardo Barros, Matsubara, Fernando Hitomi, Senff-Ribeiro, Andrea, Arni, Raghuvir Krishnaswamy, Veiga, Silvio Sanches, and Gremski, Luiza Helena
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- 2023
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31. Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches
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Trevisan-Silva, Dilza, Bednaski, Aline Viana, Gremski, Luiza Helena, Chaim, Olga Meiri, Veiga, Silvio Sanches, and Senff-Ribeiro, Andrea
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- 2013
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32. A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: Cloning, heterologous expression and immunological cross-reactivity approaches
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Matsubara, Fernando Hitomi, Gremski, Luiza Helena, Meissner, Gabriel Otto, Constantino Lopes, Eduardo Soares, Gremski, Waldemiro, Senff-Ribeiro, Andrea, Chaim, Olga Meiri, and Veiga, Silvio Sanches
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- 2013
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33. Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom
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Wille, Ana Carolina Martins, Chaves-Moreira, Daniele, Trevisan-Silva, Dilza, Magnoni, Mariana Gabriel, Boia-Ferreira, Marianna, Gremski, Luiza Helena, Gremski, Waldemiro, Chaim, Olga Meiri, Senff-Ribeiro, Andrea, and Veiga, Silvio Sanches
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- 2013
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34. Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom
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Sade, Youssef B., Bóia-Ferreira, Marianna, Gremski, Luiza H., da Silveira, Rafael B., Gremski, Waldemiro, Senff-Ribeiro, Andrea, Chaim, Olga M., and Veiga, Silvio S.
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- 2012
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35. Correction: Boia-Ferreira et al. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. Cells 2019, 8 , 1489.
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Boia-Ferreira, Marianna, Moreno, Kamila G., Basílio, Alana B. C., da Silva, Lucas P., Vuitika, Larissa, Soley, Bruna, Wille, Ana Carolina M., Donatti, Lucélia, Barbaro, Katia C., Chaim, Olga M., Gremski, Luiza Helena, Veiga, Silvio S., and Senff-Ribeiro, Andrea
- Subjects
SKIN permeability ,VENOM hypersensitivity ,RECOMBINANT proteins ,LOXOSCELES ,MYELOPEROXIDASE ,SPIDER venom - Abstract
This document is a correction notice for an article titled "TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism." The correction addresses a mistake in Figure 6A of the original publication, where an image was unintentionally repeated. The corrected figure has been provided, and the authors state that this correction does not affect the scientific conclusions of the study. The original publication has been updated accordingly. [Extracted from the article]
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- 2024
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36. Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: Endothelial cell membrane phospholipids as targets for toxicity
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Chaim, Olga M., da Silveira, Rafael B., Trevisan-Silva, Dilza, Ferrer, Valéria P., Sade, Youssef B., Bóia-Ferreira, Mariana, Gremski, Luiza H., Gremski, Waldemiro, Senff-Ribeiro, Andrea, Takahashi, Hélio K., Toledo, Marcos S., Nader, Helena B., and Veiga, Silvio S.
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- 2011
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37. Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation.
- Author
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Gremski, Luiza Helena, da Justa, Hanna Câmara, Polli, Nayanne Louise Costacurta, Schluga, Pedro Henrique de Caires, Theodoro, João Lucas, Wille, Ana Carolina Martins, Senff-Ribeiro, Andrea, and Veiga, Silvio Sanches
- Subjects
ACUTE kidney failure ,PHOSPHOLIPASES ,LOXOSCELES ,VENOM ,PATHOLOGICAL physiology ,SYMPTOMS ,SPIDER venom ,SPHINGOMYELINASE - Abstract
Bites of Loxosceles spiders can lead to a set of clinical manifestations called loxoscelism, and are considered a public health problem in many regions. The signs and symptoms of loxoscelism are divided into cutaneous and systemic forms. The former is more frequent and includes signs of envenoming at the bite site or neighboring regions. Systemic loxoscelism, although much less frequent, is associated with complications, and can even lead to death. It may include intravascular hemolysis, acute renal failure, and thrombocytopenia. Loxosceles venoms are enriched with phospholipases D (PLDs), which are a family of isoforms found at intra-species and inter-species levels. Under experimental conditions, these enzymes reproduce the main clinical signs of loxoscelism, including an exacerbated inflammatory response at the bite site and dermonecrosis, as well as thrombocytopenia, intravascular hemolysis, and acute renal failure. The role of PLDs in cutaneous loxoscelism was described over forty years ago, when studies identified and purified toxins featured as sphingomyelinase D. More recently, the production of recombinant PLDs and discoveries about their structure and mechanism has enabled a deeper characterization of these enzymes. In this review, we describe these biochemical and functional features of Loxosceles PLDs that determine their involvement in systemic loxoscelism. [ABSTRACT FROM AUTHOR]
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- 2023
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38. Production and Functional Evaluation of Anti- Loxosceles Sera Raised by Immunizations of Rabbits with Mutated Recombinant Phospholipases-D.
- Author
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Antunes, Bruno Cesar, Polli, Nayanne Louise Costacurta, Schluga, Pedro Henrique de Caires, Silva, Thais Pereira da, Wille, Ana Carolina Martins, Locatelli-Dittrich, Rosangela, Souza, Giovana Scuissiatto de, Matsubara, Fernando Hitomi, Minozzo, João Carlos, Senff-Ribeiro, Andrea, Gremski, Luiza Helena, and Veiga, Silvio Sanches
- Subjects
LOXOSCELES ,IMMUNIZATION ,ANTIBODY formation ,RABBITS ,BLOOD proteins - Abstract
Loxoscelism is the clinical condition triggered after the bite of spiders of the genus Loxosceles. The main species involved in accidents in South America are L. intermedia, L. laeta, and L. gaucho. The only specific treatment is the anti-Loxosceles serum produced with crude venoms. As phospholipases D (PLDs) trigger most of the effects observed in accidents, we developed and evaluated second-generation sera using mutated PLDs as antigens. Three isoforms of PLDs with site-directed mutations without biological activities were used for rabbit immunizations: D32A-E34A (L. gaucho), W230A (L. intermedia), and H12A-H47A (L. laeta). Sera were produced using crude venoms of three species of Loxosceles enriched with mutated recombinant PLDs (MIX) or using only mutated PLDs (REC). Immunizations stimulated the immune system from the second immunization with higher antibody production in the REC group. In vivo neutralization assays demonstrated that both sera reduced edema and dermonecrosis caused by Loxosceles intermedia crude venom. Follow-up of animals during the immunization protocols and in the neutralization assays demonstrated that the mutated proteins and the sera are safe. Results demonstrate the potential of using mutated recombinant PLDs in total or partial replacement of Loxosceles venoms in animal immunizations to produce anti-Loxosceles sera for treatments of Loxoscelism. [ABSTRACT FROM AUTHOR]
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- 2023
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39. Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles)
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Trevisan-Silva, Dilza, Gremski, Luiza H., Chaim, Olga M., da Silveira, Rafael B., Meissner, Gabriel O., Mangili, Oldemir C., Barbaro, Katia C., Gremski, Waldemiro, Veiga, Silvio S., and Senff-Ribeiro, Andrea
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- 2010
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40. The reactome pathway knowledgebase 2022
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Gillespie, Marc, primary, Jassal, Bijay, additional, Stephan, Ralf, additional, Milacic, Marija, additional, Rothfels, Karen, additional, Senff-Ribeiro, Andrea, additional, Griss, Johannes, additional, Sevilla, Cristoffer, additional, Matthews, Lisa, additional, Gong, Chuqiao, additional, Deng, Chuan, additional, Varusai, Thawfeek, additional, Ragueneau, Eliot, additional, Haider, Yusra, additional, May, Bruce, additional, Shamovsky, Veronica, additional, Weiser, Joel, additional, Brunson, Timothy, additional, Sanati, Nasim, additional, Beckman, Liam, additional, Shao, Xiang, additional, Fabregat, Antonio, additional, Sidiropoulos, Konstantinos, additional, Murillo, Julieth, additional, Viteri, Guilherme, additional, Cook, Justin, additional, Shorser, Solomon, additional, Bader, Gary, additional, Demir, Emek, additional, Sander, Chris, additional, Haw, Robin, additional, Wu, Guanming, additional, Stein, Lincoln, additional, Hermjakob, Henning, additional, and D’Eustachio, Peter, additional
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- 2021
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41. TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
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Thébault, Stéphanie, Agez, Morgane, Chi, Xiaoke, Stojko, Johann, Cura, Vincent, Telerman, Stéphanie B., Maillet, Laurent, Gautier, Fabien, Billas-Massobrio, Isabelle, Birck, Catherine, Troffer-Charlier, Nathalie, Karafin, Teele, Honoré, Joane, Senff-Ribeiro, Andrea, Montessuit, Sylvie, Johnson, Christopher M., Juin, Philippe, Cianférani, Sarah, Martinou, Jean-Claude, Andrews, David W., Amson, Robert, Telerman, Adam, and Cavarelli, Jean
- Published
- 2016
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42. COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.
- Author
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Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Fonds National de la Recherche - FnR [sponsor], Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta-Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Fobo, Gisela, Montrone, Corinna, Brauner, Barbara, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Kumar Gupta, Shailendra, Scheel, Julia, Borlinghaus, Hanna, Czauderna, Tobias, Schreiber, Falk, Montagud, Arnau, Ponce de Leon, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G., Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Ackerman, Emily E., Shoemaker, Jason E., Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yağmur, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Eijssen, Lars, Ehrhart, Friederike, Rex, Devasahayam Arokia Balaya, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Orlic-Milacic, Marija, Senff Ribeiro, Andrea, Rothfels, Karen, Shamovsky, Veronica, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean-Marie, Fraser, Rupsha, Ortseifen, Vera, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Hu, Xiaoming, Overall, Rupert W., Maier, Dieter, Bauch, Angela, Gyori, Benjamin M., Bachman, John A., Vega, Carlos, Groues, Valentin, Vazquez, Miguel, Porras, Pablo, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, de Waard, Anita, Turei, Denes, Luna, Augustin, Babur, Ozgun, Soliman, Sylvain, Valdeolivas, Alberto, Esteban-Medina, Marina, Peña-Chilet, Maria, Rian, Kinza, Helikar, Tomáš, Puniya, Bhanwar Lal, Modos, Dezso, Treveil, Agatha, Olbei, Marton, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurélien, Naldi, Aurélien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C., Augé, Franck, Beckmann, Jacques S., Hasenauer, Jan, Wolkenhauer, Olaf, Wilighagen, Egon L., Pico, Alexander R., Evelo, Chris T., Gillespie, Marc E., Stein, Lincoln D., Hermjakob, Henning, D'Eustachio, Peter, Saez-Rodriguez, Julio, Dopazo, Joaquin, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, Schneider, Reinhard, Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) [research center], Fonds National de la Recherche - FnR [sponsor], Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta-Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Fobo, Gisela, Montrone, Corinna, Brauner, Barbara, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Kumar Gupta, Shailendra, Scheel, Julia, Borlinghaus, Hanna, Czauderna, Tobias, Schreiber, Falk, Montagud, Arnau, Ponce de Leon, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G., Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Ackerman, Emily E., Shoemaker, Jason E., Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yağmur, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Eijssen, Lars, Ehrhart, Friederike, Rex, Devasahayam Arokia Balaya, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Orlic-Milacic, Marija, Senff Ribeiro, Andrea, Rothfels, Karen, Shamovsky, Veronica, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean-Marie, Fraser, Rupsha, Ortseifen, Vera, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Hu, Xiaoming, Overall, Rupert W., Maier, Dieter, Bauch, Angela, Gyori, Benjamin M., Bachman, John A., Vega, Carlos, Groues, Valentin, Vazquez, Miguel, Porras, Pablo, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, de Waard, Anita, Turei, Denes, Luna, Augustin, Babur, Ozgun, Soliman, Sylvain, Valdeolivas, Alberto, Esteban-Medina, Marina, Peña-Chilet, Maria, Rian, Kinza, Helikar, Tomáš, Puniya, Bhanwar Lal, Modos, Dezso, Treveil, Agatha, Olbei, Marton, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurélien, Naldi, Aurélien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C., Augé, Franck, Beckmann, Jacques S., Hasenauer, Jan, Wolkenhauer, Olaf, Wilighagen, Egon L., Pico, Alexander R., Evelo, Chris T., Gillespie, Marc E., Stein, Lincoln D., Hermjakob, Henning, D'Eustachio, Peter, Saez-Rodriguez, Julio, Dopazo, Joaquin, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, and Schneider, Reinhard
- Abstract
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.
- Published
- 2021
43. COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
- Author
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Fonds National de la Recherche Luxembourg, European Commission, Federal Ministry of Education and Research (Germany), Ministry of Science, Research and Art Baden-Württemberg, German Center for Infection Research, Netherlands Organisation for Health Research and Development, National Institutes of Health (US), European Molecular Biology Laboratory, Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta-Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Schreiber, Falk, Montagud, Arnau, Ponce de León, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G., Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Orlic-Milacic, Marija, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Senff Ribeiro, Andrea, Ackerman, Emily E., Shoemaker, Jason E., Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yagmu, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Rothfels, Karen, Eijssen, Lars, Ehrhart, Friederike, Arokia Balaya Rex, Devasahayam, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Shamovsky, Veronic, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean-Marie, Fraser, Rupsha, Ortseifen, Vera, Soliman, Sylvain, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Valdeolivas, Alberto, Hu, Xiaoming, Overall, Rupert W., Maier, Dieter, Bauch, Angela, Gyori, Benjamin M., Bachman, John A., Vega, Carlos, Groues, Valentin, Vázquez, Miguel, Porras, Pablo, Esteban-Medina, Marina, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, Waard, Anita de, Turei, Denes, Luna, Augustín, Babur, Ozgun, Peña-Chilet, María, Rian, Kinza, Helikar, Tomas, Lal Puniya, Bhanwar, Modos, Dezso, Treveil, Agatha, Olbe, Marton, Fobo, Gisela, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurelien, Naldi, Aurelien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C., Montrone, Corinna, Auge, Franck, Beckmann, Jacques S., Hasenauer, Jan, Wolkenhauer, Olaf, Wilighagen, Egon L ., Pico, Alexander R., Evelo, Chris T., Gillespie, Marc E., Stein, Lincoln D., Hermjakob, Henning, Brauner, Barbara, D’Eustachio, Peter, Sáez-Rodríguez, Julio, Dopazo, Joaquín, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, Schneider, Reinhard, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Gupta, Shailendra Kumar, Scheel, Julia, Borlinghaus, Hanna, Czauderna, Tobias, Fonds National de la Recherche Luxembourg, European Commission, Federal Ministry of Education and Research (Germany), Ministry of Science, Research and Art Baden-Württemberg, German Center for Infection Research, Netherlands Organisation for Health Research and Development, National Institutes of Health (US), European Molecular Biology Laboratory, Ostaszewski, Marek, Niarakis, Anna, Mazein, Alexander, Kuperstein, Inna, Phair, Robert, Orta-Resendiz, Aurelio, Singh, Vidisha, Aghamiri, Sara Sadat, Acencio, Marcio Luis, Glaab, Enrico, Ruepp, Andreas, Schreiber, Falk, Montagud, Arnau, Ponce de León, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G., Dräger, Andreas, Renz, Alina, Naveez, Muhammad, Orlic-Milacic, Marija, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Schmiester, Leonard, Wang, Muying, Senff Ribeiro, Andrea, Ackerman, Emily E., Shoemaker, Jason E., Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yagmu, Hanspers, Kristina, Kutmon, Martina, Coort, Susan, Rothfels, Karen, Eijssen, Lars, Ehrhart, Friederike, Arokia Balaya Rex, Devasahayam, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Matthews, Lisa, Shamovsky, Veronic, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean-Marie, Fraser, Rupsha, Ortseifen, Vera, Soliman, Sylvain, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Goble, Carole, Valdeolivas, Alberto, Hu, Xiaoming, Overall, Rupert W., Maier, Dieter, Bauch, Angela, Gyori, Benjamin M., Bachman, John A., Vega, Carlos, Groues, Valentin, Vázquez, Miguel, Porras, Pablo, Esteban-Medina, Marina, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, Waard, Anita de, Turei, Denes, Luna, Augustín, Babur, Ozgun, Peña-Chilet, María, Rian, Kinza, Helikar, Tomas, Lal Puniya, Bhanwar, Modos, Dezso, Treveil, Agatha, Olbe, Marton, Fobo, Gisela, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurelien, Naldi, Aurelien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C., Montrone, Corinna, Auge, Franck, Beckmann, Jacques S., Hasenauer, Jan, Wolkenhauer, Olaf, Wilighagen, Egon L ., Pico, Alexander R., Evelo, Chris T., Gillespie, Marc E., Stein, Lincoln D., Hermjakob, Henning, Brauner, Barbara, D’Eustachio, Peter, Sáez-Rodríguez, Julio, Dopazo, Joaquín, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, Schneider, Reinhard, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Gupta, Shailendra Kumar, Scheel, Julia, Borlinghaus, Hanna, and Czauderna, Tobias
- Abstract
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective.
- Published
- 2021
44. Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom
- Author
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Appel, Marcia Helena, da Silveira, Rafael Bertoni, Chaim, Olga Meiri, Paludo, Kátia Sabrina, Silva, Dilza Trevisan, Chaves, Daniele M., da Silva, Paulo Henrique, Mangili, Oldemir C., Senff-Ribeiro, Andrea, Gremski, Waldemiro, Nader, Helena B., and Veiga, Silvio Sanches
- Published
- 2008
- Full Text
- View/download PDF
45. Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs
- Author
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Gremski, Luiza Helena, primary, Matsubara, Fernando Hitomi, additional, Polli, Nayanne Louise Costacurta, additional, Antunes, Bruno Cesar, additional, Schluga, Pedro Henrique de Caires, additional, Justa, Hanna Câmara da, additional, Minozzo, João Carlos, additional, Wille, Ana Carolina Martins, additional, Senff-Ribeiro, Andrea, additional, and Veiga, Silvio Sanches, additional
- Published
- 2021
- Full Text
- View/download PDF
46. Loxosceles Astacin-Like Proteases (LALPs)
- Author
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Trevisan-Silva, Dilza, primary, Gremski, Luiza Helena, additional, Chaim, Olga Meiri, additional, Senff-Ribeiro, Andrea, additional, and Veiga, Silvio Sanches, additional
- Published
- 2013
- Full Text
- View/download PDF
47. Contributors
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Abbott, Catherine Anne, primary, Abraham, Carmela R., additional, Adachi, Hideki, additional, Adachi, Osao, additional, Adam, Zach, additional, Adams, Michael W.W., additional, Adang, Michael J., additional, Adham, Ibrahim M., additional, Aducci, Patrizia, additional, Agard, David A., additional, Agranovsky, Alexey A., additional, Akamatsu, Tetsuya, additional, Akiyama, Yoshinori, additional, Albrechtsen, Reidar, additional, Alejo, Alí, additional, Amberg, Sean M., additional, Amerik, Alexander Y., additional, Amparyup, Piti, additional, Andrade, Felipe, additional, Andrés, Germán, additional, Andrews, Daniel M., additional, Andrews, Robert K., additional, Antalis, Toni M., additional, Anthony, Colin S., additional, Aoki, Naoya, additional, Apte, Suneel S., additional, Arima, Kazunari, additional, Arlaud, Gérard, additional, Arni, Raghuvir Krishnaswamy, additional, Arnoux, Pascal, additional, Aronson, Nathan N., additional, Arthur, Michel, additional, Asano, Yasuhisa, additional, Ascenzi, Paolo, additional, Assakura, Marina T., additional, Auld, David S., additional, Ávila, Veridiana de Melo Rodrigues, additional, Avilés, Francesc X., additional, Awad, William M., additional, Bachhawat, Anand K., additional, Bai, Shan, additional, Baird, Teaster T., additional, Bajaj, S. Paul, additional, Baker, Susan C., additional, Banbula, Agnieszka, additional, Barrett, Alan J., additional, Barrowman, Jemima, additional, Bartlett, John D., additional, Bartsch, Jörg W., additional, Baschuk, Nikola, additional, Baskova, Isolda P., additional, Batra, Jyotsna, additional, Bauer, Karl, additional, Baumann, Ulrich, additional, Baumeister, Wolfgang, additional, Bauvois, Cédric, additional, Bayés, Alex, additional, Beauvais, Anne, additional, Becker-Pauly, Christoph, additional, Begley, Tadhg P., additional, Békés, Miklós, additional, Belas, Robert, additional, Beleford, Daniah, additional, Beppu, Teruhiko, additional, Bergmann, Ernst M., additional, Bernard, Bruno A., additional, Bernard, Dominique, additional, Berndt, Michael C., additional, Berruti, Giovanna, additional, Berry, Colin, additional, Bertenshaw, Greg P., additional, Betzel, Christian, additional, Bhaskarla, Chetana, additional, Bhosale, Manoj, additional, Bierbaum, Gabriele, additional, Bjarnason Jón, B., additional, Blaber, Michael, additional, Blackman, Michael J., additional, Blinkovsky, Alexander, additional, Boeke, Jef D., additional, Bogyo, Matthew, additional, Bohn, Stefan, additional, Boileau, Guy, additional, Boland, Mike, additional, Bolken, Tové C., additional, Bond, Judith S., additional, Bondeson, Jan, additional, Bordallo, Javier, additional, Borelli, Claudia, additional, Botelho, Tiago O., additional, Bott, Richard R., additional, Bourne, David G., additional, Bovenschen, Niels, additional, Bradshaw, Ralph A., additional, Breddam, Klaus, additional, Brew, Keith, additional, Brindley, Paul J., additional, Brinkman, Diane L., additional, Britton, Collette, additional, Broadbent, Jeff R., additional, Broadhurst, Anne, additional, Brómme, Dieter, additional, Broom, Murray, additional, Brown, Jeremy S., additional, Brown, Mark A., additional, Bruchhaus, Iris, additional, Burleigh, Barbara A., additional, Burns, Kristin E., additional, Burrows, James F., additional, Butler, Michael J., additional, Buttle, David J., additional, Byrd, Chelsea M., additional, Byun, Tony, additional, Cadel, Sandrine, additional, Caffrey, Conor R., additional, Cal, Santiago, additional, Caldentey, Javier, additional, Candela, Thomas, additional, Capasso, Clemente, additional, Capriogilio, Daniel R., additional, Carginale, Vincenzo, additional, Carmona, Adriana Karaoglanovic, additional, Carruthers, Vern B., additional, Castellino, Francis J., additional, Catanese, Joseph J., additional, Caterson, Bruce, additional, Caughey, George H., additional, Cawley, Naimh X., additional, Cawston, Tim E., additional, Cazzulo, Juan José, additional, Chai, Jijie, additional, Chai, Karl X., additional, Chaim, Olga Meiri, additional, Chang, L.S., additional, Chao, Julie, additional, Chapot-Chartier, Marie-Pierre, additional, Charli, Jean-Louis, additional, Charlier, Paulette, additional, Chave, Karen J., additional, Chen, Jian-Min, additional, Chen, Jinq-May, additional, Chen, Li-Mei, additional, Chen, Ya-Wen, additional, Chen, Yu-Yen, additional, Chevrier, Bernard, additional, Chich, Jean-François, additional, Chien, Jeremy, additional, Chimalapati, Suneeta, additional, Cho, Ki Joon, additional, Choi, Kwan Yong, additional, Chuang, Woei-Jer, additional, Chung, Chin Ha, additional, Chung, Ivy Yeuk Wah, additional, Clamagirand, Christine, additional, Clark, Ian M., additional, Clarke, Adrian K., additional, Clarke, Nicola E., additional, Clarke, Steven Gerard, additional, Clauziat, Philippe, additional, Clements, Judith A., additional, Coffinier, Catherine, additional, Cohen, Paul, additional, Colige, Alain, additional, Collignon, Anne, additional, Colloms, Sean D., additional, Conzelmann, Andreas, additional, Coombs, Graham H., additional, Cooney, Jakki C., additional, Cooper, Jonathan B., additional, Cooper, Max D., additional, Copeland, Nikki A., additional, Cottrell, Graeme S., additional, Coyle, Joseph T., additional, Craik, Charles S., additional, Creemers, John W.M., additional, Cretu, Daniela, additional, Croce, Jenifer, additional, Cross, Keith J., additional, Cueva, Rosario, additional, Cui, Sheng, additional, Cunha, Luis, additional, Cutting, Simon, additional, d’Enfert, Christophe, additional, D’Orchymont, Hugues, additional, Dahlbäck, Björn, additional, Dai, Shujia, additional, Dalbey, Ross E., additional, Dalton, John P., additional, Dando, Pam M., additional, Daniel, R.M., additional, Danilov, Sergei M., additional, Davies, Donna E., additional, De Araujo, Heloisa S., additional, De los Santos, Teresa, additional, de Luca, Viviana, additional, De Meester, Ingrid, additional, de Oliveira, Ana Karina, additional, de Oliveira, Eduardo Brandt, additional, De Oliveira, Pedro Lagerblad, additional, de Vos, Sarah, additional, Declercq, Jeroen, additional, Declercq, Wim, additional, Deghmane, Ala-Eddine, additional, Dekker, Niek, additional, Del Prete, Sonia, additional, Del Rosal, Marina, additional, Delmas, Bernard, additional, DeLotto, Robert, additional, Demidyuk, Ilya V., additional, Denison, Mark R., additional, Deussing, Jan M., additional, Devi, Lakshmi A., additional, Diamandis, Eleftherios P., additional, Diaz, Isabel, additional, Díaz-Perales, Araceli, additional, Dijkstra, Bauke W., additional, Ding, Yan, additional, Dixon, Jack E., additional, Dodt, Johannes, additional, Dokland, Terje, additional, Dolenc, Iztok, additional, Dong, Ningzheng, additional, Dong, Tran Cat, additional, Dong, Ying, additional, Dongre, Mitesh, additional, Donovan, Mark, additional, Dore, Timothy M., additional, Dorstyn, Loretta, additional, Dou, Hong, additional, Dou, Zhicheng, additional, Dougall, Annette M., additional, Drag, Marcin, additional, Dudley, Edward G., additional, Dunn, Ben M., additional, Dupuy, Bruno, additional, Duque-Magalhāes, Maria Conceicāo, additional, Durá, M. Asunción, additional, Eeckhout, Yves, additional, Eijsink, Vincent, additional, Eisen, Arthur Z., additional, Eissa, Azza, additional, Eklund, Sandra, additional, Eletr, Ziad M., additional, Ellis, Vincent, additional, Engel, Wolfgang, additional, Erdös, Ervin G., additional, Escalante, Teresa, additional, Estell, David A., additional, Etscheid, Michael, additional, Evans, Herbert J., additional, Everett, Roger D., additional, Faesen, Alex C., additional, Fahrenholz, Falk, additional, Fanjul-Fernández, Miriam, additional, Farady, Christopher J., additional, Feller, Georges, additional, Feng, Hong, additional, Fenster, Kurt M., additional, Férec, Claude, additional, Ferrari, Silvia, additional, Fingleton, Barbara, additional, Fisher, Jed F., additional, Fives-Taylor, Paula M., additional, Fong, Loren G., additional, Forneris, F., additional, Forster, Brian M., additional, Forster, Friedrich, additional, Foster, Simon J., additional, Foulon, Thierry, additional, Foundling, Stephen I., additional, Fox, Jay William, additional, Franzetti, Bruno, additional, Frasch, Alejandra P., additional, Freeze, Hudson H., additional, Frère, Jean-Marie, additional, Frey, Teryl K., additional, Fricke, Beate, additional, Fricker, Lloyd D., additional, Fridman, Rafael, additional, Froelich, Christopher J., additional, Fröhlich, Camilla, additional, Fu, Hsueh-Liang, additional, Fuhrmann, Cynthia N., additional, Fujimura, Satoshi, additional, Fujiwara, Hiroshi, additional, Fukushima, Jun, additional, Fukuyama, Keiichi, additional, Fuller, Robert S., additional, Fusek, Martin, additional, Gaboriaud, Christine, additional, Gache, Christian, additional, Gakh, Oleksandr, additional, Gal, Peter, additional, Gao, Junjun, additional, García-Sastre, Adolfo, additional, Gardiner, Donald L., additional, Gatehouse, John A., additional, Gaucher, G.M., additional, Gauthier, Francis, additional, Ghuysen, Jean-Marie, additional, Gibson, Wade, additional, Gillies, Jennifer, additional, Glaser, Elzbieta, additional, Glaser, Fabian, additional, Glickman, Michael H., additional, Goettig, Peter, additional, Goffin, Colette, additional, Gohda, Eiichi, additional, Goldberg, Alfred L., additional, Goldberg, Daniel E., additional, Goldberg, Gregory I., additional, Goldfarb, Nathan E., additional, Gomis-Rüth, F. Xavier, additional, Gopal, B., additional, Gorbalenya, Alexander E., additional, Gordon, Stuart G., additional, Gorrell, Mark D., additional, Götz, Friedrich, additional, Goulas, Theodoros, additional, Gouzy-Darmon, Cécile, additional, Govind, K., additional, Gráf, Lászlo, additional, Granados, Robert R., additional, Gräwert, Melissa Ann, additional, Gray, Douglas A., additional, Graycar, Thomas P., additional, Green, Jonathan A., additional, Gremski, Luiza Helena, additional, Groll, Michael, additional, Gromova, Tania Yu, additional, Gros, P., additional, Grubman, Marvin J., additional, Grunden, Amy M., additional, Gudmundsdóttir, Ágústa, additional, Guinand, Micheline, additional, Gully, Djamel, additional, Gustchina, Alla, additional, Gutiérrez, José María, additional, Ha, Byung Hak, additional, Haeggström, Jesper Z., additional, Hageman, James H., additional, Haiko, Johanna, additional, Hailfinger, Stephan, additional, Haitchi, Hans Michael, additional, Han, Ji Seon, additional, Hanquez, Chantal, additional, Harada, Minoru, additional, Hara-Nishimura, Ikuko, additional, Harboe, Marianne, additional, Härd, Torleif, additional, Harris, David A., additional, Hassiepen, Ulrich, additional, Hata, Shoji, additional, Hattori, Akira, additional, He, Rong-Qiao, additional, Heck, Albert J.R., additional, Hendricks, Dirk F., additional, Henrich, Bernhard, additional, Henriet, Patrick, additional, Hernández-Arana, Andrés, additional, Herrera-Camacho, Irma, additional, Heussipp, Gerhard, additional, Hibino, Toshihiko, additional, Hicks, P.M., additional, Hillman, Bradley I., additional, Hiraoka, B. Yukihiro, additional, Hiratake, Jun, additional, Hizukuri, Yohei, additional, Ho, Heng-Chien, additional, Hoa, Ngo Thi, additional, Hochstrasser, Mark, additional, Hodge, Kathryn M., additional, Hofmann, Theo, additional, Hohn, Thomas, additional, Hoidal, John R., additional, Höltje, Joachim-Volker, additional, Homma, Koichi J., additional, Honek, John F., additional, Hook, Vivian Y.H., additional, Hooper, John D., additional, Hooper, Nigel M., additional, Hosoi, Kazuo, additional, Howe, Christopher J., additional, Hruby, Dennis E., additional, Hseih, James J.-D., additional, Hsu, Chun-Chieh, additional, Huang, Tony T., additional, Huang, Tur-Fu, additional, Huet, Yoann, additional, Hughes, Clare, additional, Hugonnet, Jean-Emmanuel, additional, Huston, Adrienne L., additional, Ibrahim-Granet, Oumaïma, additional, Ichishima, Eiji, additional, Ikehara, Yukio, additional, Inagami, Tadashi, additional, Ingram, Jessica, additional, Isaac, R.E., additional, Isaya, Grazia, additional, Isaza, Clara E., additional, Ishii, Shin-ichi, additional, Isnard, Amandine, additional, Ito, Kiyoshi, additional, Ito, Koreaki, additional, Itoh, Yoshifumi, additional, Iturrioz, Xavier, additional, Iwanaga, Sadaaki, additional, Jack, Ralph W., additional, Jackson, Mel C., additional, James, Michael N.G., additional, Janata, Jiří, additional, Janoir, Claire, additional, Janska, Hanna, additional, Jarrell, Ken F., additional, Jaskolski, Mariusz, additional, Jaswal, Sheila S., additional, Jean, Ying Y., additional, Jenne, Dieter E., additional, Jeon, Young Joo, additional, Jiang, Ping, additional, Johnson, John E., additional, Johnson, Michael D., additional, Johnston, James A., additional, Jones, Amanda, additional, Jones, Elizabeth W., additional, Joudiou, Carine, additional, Juliano, Luiz, additional, Jung, Hea-Jin, additional, Jupp, Ray, additional, Kagawa, Todd F., additional, Kalbacher, Hubert, additional, Kamata, Yayoi, additional, Kaminogawa, Shuichi, additional, Kamio, Yoshiyuki, additional, Kaneda, Makoto, additional, Kang, Sung Gyun, additional, Kang, Sung Hwan, additional, Kania, Mary, additional, Kantyka, Tomasz, additional, Kanzawa, Nobuyuki, additional, Karim, Abdulkarim Y., additional, Kasumi, Takafumi, additional, Kataoka, Hiroaki, additional, Kaur, Hardeep, additional, Kawabata, Shun-Ichiro, additional, Kawaguchi, Mari, additional, Kay, John, additional, Kaynar, Murat, additional, Keiler, Kenneth C., additional, Kelly, R.M., additional, Kenton, Nathaniel T., additional, Kerr, Michael A., additional, Kersse, Kristof, additional, Kervinen, Jukka, additional, Kessler, Benedikt M., additional, Kessler, Efrat, additional, Khoronen, Timo K., additional, Kidd, Simon, additional, Kikkert, Marjolein, additional, Kilian, Mogens, additional, Kim, Do-Hyung, additional, Kim, Doyoun, additional, Kim, Eunice EunKyeong, additional, Kim, In Seop, additional, Kim, Jung-Gun, additional, Kim, Kyeong Kyu, additional, Kim, Kyung Hyun, additional, Kimber, Matthew S., additional, Kimura, Yukio, additional, Kirschke, Heidrun, additional, Kiso, Yoshiaki, additional, Kleanthous, Colin, additional, Klein, Jürgen R., additional, Klemba, Michael, additional, Kmiec, Beata, additional, Kobayashi, Hideyuki, additional, Kodama, Hiroyuki, additional, Koelsch, Gerald, additional, Kok, Jan, additional, Kolattukody, P.E., additional, Kolb, Fabrice A., additional, Kolmar, Harald, additional, Komori, Yumiko, additional, Konvalinka, Jan, additional, Korkmaz, Brice, additional, Kostrov, Sergey V., additional, Kräusslich, Hans-Georg, additional, Krczal, Gabi, additional, Kress, Lawrence F., additional, Kristjánsson, Magnüs Már, additional, Kučera, Tomáš, additional, Kukday, Sayali S., additional, Kumagai, Hidehiko, additional, Kumar, Sharad, additional, Kumarasiri, Malika, additional, Kumazaki, Takashi, additional, Kümmerer, Beate M., additional, Kuno, Kouji, additional, Kurkinen, Markku, additional, Kutejová, Eva, additional, Kveiborg, Marie, additional, Kwarciak, Agnieszka, additional, Laakkonen, Liisa, additional, Labrou, Nikolaos E., additional, Laing, Gavin D., additional, Lamppa, Gayle, additional, Langer, Thomas, additional, Laursen, Richard A., additional, Lawrenson, Richard A., additional, Layne, Matthew D., additional, Le Bonniec, Bernard F., additional, Leal, María C., additional, Lechan, Ronald M., additional, Lee, David H., additional, Lee, Irene, additional, Lee, Jae, additional, Lee, Kye Joon, additional, Lee, Soohee, additional, Lei, Xiaobo, additional, Leis, Jonathan, additional, LeMosy, Ellen K., additional, Lepage, Thierry, additional, Leppla, Stephen H., additional, Lesner, Adam, additional, Lessard, Ivan A.D., additional, Lhomond, Guy, additional, Li, Huilin, additional, Li, Shu-Ming, additional, Li, Weiguo, additional, Liao, Ta-Hsiu, additional, Liddington, Robert C., additional, Lieber, Toby, additional, Lijnen, H.R., additional, Lima, Christopher D., additional, Lin, Chen-Yong, additional, Lin, Gang, additional, Lin, Ming T., additional, Lin, Xinli, additional, Lin, Yee-Shin, additional, Lindsay, L.L., additional, Lipscomb, William N., additional, Little, John W., additional, Liu, Ching-Chuan, additional, Liu, Chuan-ju, additional, Lively, Mark O., additional, Livnat-Levanon, Nurit, additional, Ljungdahl, Per O., additional, Llorens-Cortes, Catherine, additional, Lobel, Peter, additional, Loh, Y. Peng, additional, Lohi, Jouko, additional, Lomonossoff, G.P., additional, Looze, Yvan, additional, López-Otin, Carlos, additional, Lopez-Quezada, Landys, additional, Loukas, Alex, additional, Lu, Long-Sheng, additional, Lundwall, Áke, additional, Luo, Liu-Ying, additional, Lupas, Andrei, additional, Luthe, Dawn S., additional, Lynch, Nicholas J., additional, Lyons, Peter J., additional, MacKay, Vivian L., additional, Macleod, Jesica M. Levingston, additional, Magdolen, Viktor, additional, Mainardi, Jean-Luc, additional, Mäkinen, Kauko K., additional, Mallari, Jeremy P., additional, Manandhar, Surya P., additional, Mandelbaum, Fajga R., additional, Manicone, Anne M., additional, Mansfeld, Johanna, additional, Marcotrigiano, Joseph, additional, Mares, Michael, additional, Marfany, Gemma, additional, Markland, Francis S., additional, Marokházi, Judith, additional, Marquis, Hélène, additional, Marr, Robert A., additional, Martegani, Enzo, additional, Martin, Erik W., additional, Martinez, Manuel, additional, Martins, L. Miguel, additional, Maruyama, Masato, additional, Maruyama, Masugi, additional, Maruyama, Sususmu, additional, Masaki, Takeharu, additional, Massoumi, Ramin, additional, Mathew, Rency T., additional, Matrisian, Lynn M., additional, Matsuda, Yoshihiro, additional, Matsushita, Osamu, additional, Matuschek, Marco, additional, Matušková, Anna, additional, Matúz, Krisztina, additional, Mauch, Cornelia, additional, Maurizi, Michael R., additional, Mayr, Lorenz M., additional, McCafferty, Dewey G., additional, McDonald, J. Ken, additional, McKerrow, James H., additional, McMillan, David, additional, Mecham, Robert P., additional, Mehta, Darshini P., additional, Meisinger, Chris, additional, Mellors, Alan, additional, Melton, Roger G., additional, Melvin, Jeffrey A., additional, Ménard, Robert, additional, Menéndez-Arias, Luis, additional, Menezes, Milene C., additional, Mesecar, Andrew, additional, Mesnage, Stéphane, additional, Meyer, Diane H., additional, Meyers, Gregor, additional, Michaelis, Susan, additional, Michalska, Karolina, additional, Mielicki, Wojciech P., additional, Mierau, Igor, additional, Mikoulinskaia, Galina V., additional, Miller, Charles G., additional, Miller, Lydia K., additional, Mills, John, additional, Mills, Kenneth V., additional, Min, Jinrong, additional, Mistou, Michel-Yves, additional, Misumi, Yoshio, additional, Miyoshi, Shin-ichi, additional, Mizutani, Shigehiko, additional, Mobashery, Shahriar, additional, Mochizuki, Satsuki, additional, Mock, William L., additional, Möhrlen, Frank, additional, Moiré, Nathalie, additional, Monahan, Paul E., additional, Moncada-Pazos, Angela, additional, Monnet, Véronique, additional, Monod, Michel, additional, Montecucco, Cesare, additional, Morelli, Laura, additional, Mori, Sumiko, additional, Morita, Takashi, additional, Morrissey, James H., additional, Morse, Richard J., additional, Mort, John S., additional, Mortensen, Uffe H., additional, Morty, Rory E., additional, Moss, Joel, additional, Motoshima, Hidemasa, additional, Mottram, Jeremy C., additional, Moura-da-Silva, Ana M., additional, Mudgett, Mary Beth, additional, Mundt, Egbert, additional, Murakami, Kazuo, additional, Murakami, Mario Tyago, additional, MurakamiMurofoshi, Kimiko, additional, Murao, Sawao, additional, Murphy, Gillian, additional, Murthy, M.R.N., additional, Muta, Tatsushi, additional, Myburgh, Elmarie, additional, Mzhavia, Nino, additional, Nabi, A.H.M. Nurun, additional, Nagase, Hideaki, additional, Nagle, Michael W., additional, Nägler, Dorit K., additional, Naik, Rajesh R., additional, Nair, Divya B., additional, Nakai, Toshiki, additional, Nakajima, Yoshitaka, additional, Nakamura, Yukio, additional, Nakatogawa, Hitoshi, additional, Nakayama, Toru, additional, Nalivaeva, Natalia N., additional, Nandi, Dipankar, additional, Nascimento-Silva, Maria Clara Leal, additional, Nasmyth, Kim, additional, Nathan, Carl F., additional, Navarro-García, Fernando, additional, Naves, Dayane Lorena, additional, Nedialkova, Danny D., additional, Neuman, Keir C., additional, Nguyen, Jeffrey-Tri, additional, Nguyen, Ky-Anh, additional, Niemirowicz, Gabriela T., additional, Nikai, Toshiaki, additional, Nishi, Eiichiro, additional, Nishii, Wataru, additional, Nishiyama, Makoto, additional, Nishiyama, Yasuhiro, additional, Noda, Masatoshi, additional, Nomura, Seiji, additional, Norioka, Shigemi, additional, Nsangou, Desire M.M., additional, O’Brien, Amornrat, additional, O’Connor, Michael B., additional, Oda, Kohei, additional, Odinokova, Irina V., additional, Oetjen, Joyce, additional, Ogura, Teru, additional, Ohman, Dennis E, additional, Ohsumi, Yoshinori, additional, Ojha, Mukti, additional, Okabe, Akinobu, additional, Okada, Yasunori, additional, Okamoto, Keinosuke, additional, Okuda, Kenji, additional, Okumura, Nobuaki, additional, Okuno, Takashi, additional, Oleson, Kjeld, additional, Oliveira de Giuseppe, Priscila, additional, Olivier, Martin, additional, Ono, Yasuko, additional, Oroszlan, Stephen, additional, Ota, Nobuyuki, additional, Ovadia, Michael, additional, O-Wang, Jiyang, additional, Oxvig, Claus, additional, Packer, Jeremy C.L., additional, Padilla-López, Sergio, additional, Paetzel, Mark, additional, Page, Michael J., additional, Page-McCaw, Andrea, additional, Paine, Mark J.I., additional, Park, Byoung Chul, additional, Park, Eunyong, additional, Park, John E., additional, Park, Pyong Woo, additional, Park, Sung Goo, additional, Parkin, Kirk L., additional, Parks, William C, additional, Paschoalin, Thaysa, additional, Pastore, Annalisa, additional, Patananan, Alexander Nikolich, additional, Paul, Sudhir, additional, Paulson, Henry L., additional, Pawel-Rammingen, Ulrich von, additional, Pearce, David A., additional, Pearson, Mark S., additional, Pei, Duanqing, additional, Pejler, Gunnar, additional, Pemberton, Alan D., additional, Peng, Jianhao, additional, Pernier, Julien, additional, Peters, Jan-Michael, additional, Pfirrmann, Thorsten, additional, Pham, Viet-Laï, additional, Pichová, Iva, additional, Pickering, Darren, additional, Piesse, Christophe, additional, Pignol, David, additional, Pike, Robert N., additional, Pinck, Lothaire, additional, Pirkle, Hubert, additional, Pitot, Henry C., additional, Plaut, Andrew G., additional, Ploegh, Hidde, additional, Polgár, László, additional, Porter, Corrine, additional, Postina, Rolf, additional, Potempa, Jan, additional, Poulsen, Knud, additional, Power, Scott D., additional, Pratt, Rex. F., additional, Prehna, Gerd, additional, Prévost, Gilles, additional, Pshezhetsky, Alexey V., additional, Qasim, Mohammad A., additional, Qian, Feng, additional, Qiu, Jiazhou, additional, Quesada, Víctor, additional, Radisky, Evette S., additional, Rader, Stephen D., additional, Raman, Kavita, additional, Ramsay, Andrew J., additional, Rancourt, Derrick E., additional, Ranjit, Najju, additional, Rao, Narayanam V., additional, Ratia, Kiira, additional, Rawlings, Neil D., additional, Rawson, Robert B., additional, Reddy, Vijay, additional, Redman, Colvin M., additional, Regonesi, Maria Elena, additional, Reichert, Andreas S., additional, Reichl, Antonia P., additional, Remaut, Han, additional, Remington, S. James, additional, Renatus, Martin, additional, Reverter, David, additional, Reynolds, Eric C., additional, Rholam, Mohamed, additional, Rice, Charles M., additional, Ridky, Todd W., additional, Riezman, Howard, additional, Rijken, D.C., additional, Rio, Marie-Christine, additional, Ritchie, Alison, additional, Robert-Baudouy, Janine, additional, Robinson, Mark W., additional, Robinson, Michael, additional, Rodriguez-Romero, Adela, additional, Rodriques, Renata Santos, additional, Rogers, John C., additional, Rojas, Camilo, additional, Romesberg, Floyd E., additional, Roper, David J., additional, Rosas-Murrieta, Nora, additional, Rose, A.M., additional, Rosenthal, Philip J., additional, Rosing, J., additional, Rossetto, Ornella, additional, Rossi, Véronique, additional, Roth, Richard A., additional, Rottensteiner, Hanspeter, additional, Rowan, Andrew D., additional, Rozanov, Mikhail, additional, Rucavado, Alexandra, additional, Ruecker, Andrea, additional, Rul, Françoise, additional, Rümenapf, Till, additional, Russo, Ilaria, additional, Ryan, Martin D., additional, Sacco, Elena, additional, Sadler, J. Evan, additional, Saenger, W., additional, Sahl, Hans-Georg, additional, Sajid, Mohammed, additional, Sakaguchi, Masayoshi, additional, Sakiyama, Fumio, additional, Salas, Maria L., additional, Salgado, Maria Cristina O., additional, Salvesen, Guy S., additional, Sánchez, Edith, additional, Sanchez, Eladio F., additional, Sang, Qing-Xiang Amy, additional, Sankaran, Krishnan, additional, Sarkar, Susanta K., additional, Sarras, Michael P., additional, Sasagawa, Yoshikiyo, additional, Satohiko, Araki, additional, Sauvage, Eric, additional, Saveanu, Loredana, additional, Savithri, H.S., additional, Sawada, Hitoshi, additional, Sawers, R. Gary, additional, Scarisbrick, Isobel A., additional, Schaller, Andreas, additional, Scheer, Justin M., additional, Scheiflinger, Friedrich, additional, Schiene-Fischer, Cordelia, additional, Schlomann, Uwe, additional, Schlösser, Manfred, additional, Schmaier, Alvin H., additional, Schmidt, Walter K., additional, Schneemann, Anette, additional, Schnellmann, Rick G., additional, Scholze, Henning, additional, Schomburg, Lutz, additional, Schwaeble, Wilhelm J., additional, Scott, Christopher J., additional, Scudiero, Rosaria, additional, Sehara-Fujisawa, Atsuko, additional, Seidah, Nabil G., additional, Seiki, Motoharu, additional, Sekiguchi, Junichi, additional, Senff-Ribeiro, Andrea, additional, Seong, Ihn Sik, additional, Serpe, Mihaela, additional, Serrano, Solange M.T., additional, Setlow, Peter, additional, Shahian, Tina, additional, Shanks, M., additional, Shao, Feng, additional, Shapiro, Steven D., additional, Sharma, Navneet, additional, Shaw, Lindsey N., additional, Shen, Aimee, additional, Shen, Lei, additional, Sherwood, Roger F., additional, Shi, Yun-Bo, additional, Shimoi, Hitoshi, additional, Shimura, Yoichiro, additional, Shirras, A.D., additional, Shridhar, Viji, additional, Shukla, Jinal K., additional, Siigur, Ene, additional, Siigur, Jüri, additional, Silmon de Monerri, Natalie C., additional, Sim, Robert B., additional, Simmer, James P., additional, Simmons, William H., additional, Singh, Jaspreet, additional, Singleton, Alison, additional, Sirakova, Tatiana D., additional, Sixma, Titia K., additional, Skern, Tim, additional, Skidgel, Randal A., additional, Slack, Jeffrey, additional, Sleat, David E., additional, Slusher, Barbara S., additional, Smith, Janet L., additional, Smith, Matthew A., additional, Smyth, Mark J., additional, Snijder, Erik J., additional, Sobhanifar, Solmaz, additional, Söderhaäll, Kenneth, additional, Sohar, Istvan, additional, Sonderegger, Peter, additional, Sorgine, Marcos Henrique Ferreira, additional, Sorimachi, Hiroyuki, additional, Soukhodolets, Karen E., additional, Souza, Tatiana de Arruda Campos Brasil de, additional, Sperka, Tamás, additional, Sriskandan, Shiranee, additional, St. Geme, Joseph W., additional, St. Leger, Raymond J., additional, Staib, Peter, additional, Steele, James L., additional, Stefansson, Bjarki, additional, Steinkühler, Christian, additional, Stenberg, Leisa M., additional, Stenflo, Johan, additional, Stennicke, Henning R., additional, Stepanov, Valentin M., additional, Stepnaya, Olga A., additional, Steven, Frank, additional, Stevens, Richard L., additional, Stevenson, Kenneth J., additional, St-Louis, Mathieu, additional, Stobart, Christopher C., additional, Stöcker, Walter, additional, Storer, Andrew C., additional, Sträter, Norbert, additional, Strauss, Ellen G., additional, Strauss, James H., additional, Stříšovský, Kvido, additional, Strynadka, Natalie C.J., additional, Sturrock, Edward D., additional, Su, Dan, additional, Su, Xiao-Dong, additional, Suárez-Rendueles, Paz, additional, Sulea, Traian, additional, Sundararajan, Venkatesh, additional, Suno, Ryoji, additional, Suzuki, Carolyn K., additional, Suzuki, Fumiaki, additional, Suzuki, Hideyuki, additional, Suzuki, Nobuhiro, additional, Swenson, Stephen, additional, Szabady, Rose L., additional, Szecsi, Pal Bela, additional, Szilágyi, Lászlo, additional, Taha, Muhamed-Kheir, additional, Takahashi, Eizo, additional, Takahashi, Kenji, additional, Takai, Toshiro, additional, Takeda, Atsushi, additional, Takeda, Soichi, additional, Tame, Jeremy J.R.H., additional, Tamura, Tomohiro, additional, Tan, Fulong, additional, Tanaka, Keiji, additional, Tanase, Carmen, additional, Tang, Jordan, additional, Tanizaki, Martha M., additional, Tannich, Egbert, additional, Tans, Guido, additional, Tarentino, Anthony L., additional, Tassanakajon, Anchalee, additional, Tatsumi, Hiroki, additional, Tautz, Norbert, additional, Taylor, Erin Bassford, additional, Teixeira, Pedro Filipe, additional, 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- Published
- 2013
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48. Biological and structural comparison of recombinant phospholipase D toxins from Loxosceles intermedia (brown spider) venom
- Author
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Ribeiro, Rodrigo Otávio S., Chaim, Olga Meiri, da Silveira, Rafael Bertoni, Gremski, Luiza Helena, Sade, Youssef Bacila, Paludo, Kátia Sabrina, Senff-Ribeiro, Andrea, de Moura, Juliana, Chávez-Olórtegui, Carlos, Gremski, Waldemiro, Nader, Helena B., and Veiga, Silvio Sanches
- Published
- 2007
- Full Text
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49. Brown Spiders’ Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms
- Author
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da Silva, Thaís Pereira, primary, de Castro, Fernando Jacomini, additional, Vuitika, Larissa, additional, Polli, Nayanne Louise Costacurta, additional, Antunes, Bruno César, additional, Bóia-Ferreira, Marianna, additional, Minozzo, João Carlos, additional, Mariutti, Ricardo Barros, additional, Matsubara, Fernando Hitomi, additional, Arni, Raghuvir Krishnaswamy, additional, Wille, Ana Carolina Martins, additional, Senff-Ribeiro, Andrea, additional, Gremski, Luiza Helena, additional, and Veiga, Silvio Sanches, additional
- Published
- 2021
- Full Text
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50. Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?
- Author
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Gremski, Luiza Helena, primary, Matsubara, Fernando Hitomi, additional, Justa, Hanna Câmara da, additional, Schemczssen-Graeff, Zelinda, additional, Baldissera, Antonielle Beatriz, additional, Schluga, Pedro Henrique de Caires, additional, Leite, Isabel de Oliveira, additional, Boia-Ferreira, Marianna, additional, Wille, Ana Carolina Martins, additional, Senff-Ribeiro, Andrea, additional, and Veiga, Silvio Sanches, additional
- Published
- 2021
- Full Text
- View/download PDF
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