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14 results on '"Sengupta, Pracheta"'

1. Contributors

Author

Adhikary, Krishnendu, primary, Affinati, Brenda, additional, Ahmed, Amany M., additional, Al Saadi, Mahmoud, additional, Alkutbi, Alisar, additional, Al-Shar’i, Nizar A., additional, Ansar, Waliza, additional, Arora, Prachi, additional, Bagchi, Debasis, additional, Bagchi, Manashi, additional, Baheti, Akshay M., additional, Baliga, Vineet, additional, Ballambattu, Vishnu Bhat, additional, Banerjee, Pradipta, additional, Banerjee, Priyanka, additional, Banik, Samudra Prosad, additional, Baral, Tejaswini, additional, Bardaweel, Sanaa K., additional, Barros, Nicolas, additional, Basak, Pijush, additional, Becken, III, Bradford A., additional, Bhagyalakshmi, M., additional, Bhattacharya, Joyeeta, additional, Bhattacharya, Mohini, additional, Bhattacharyya, Jhimli, additional, Bhattacharyya, Maitree, additional, Bhattacherjee, Ashmita, additional, Bhavya, Karanam Sai, additional, Bhutia, Rinchen Doma, additional, Birudala, Geetha, additional, Birudala, Ramadevi, additional, Biswas, Ayan, additional, Biswas, Nabendu, additional, Biswas, Sanchita, additional, Biswas, Shaoli, additional, Borah, Pobitra, additional, Bose, Sayantan, additional, Bula Rudas, Fernando J., additional, Chakrabarty, Subhendu, additional, Chakraborti, Modhurima, additional, Chakraborty, Atreyee, additional, Chakraborty, Sanjoy, additional, Chakraborty, Shrabastee, additional, Chakraborty, Sudipta, additional, Chandrasekar, S.B., additional, Chatterjee, Archana, additional, Chatterjee, Aritra, additional, Chatterjee, Gourab, additional, Chatterjee, Rituparna, additional, Chatterjee, Tanima, additional, Chaurasia, Rameshwar Nath, additional, Chen, Bo-Kai, additional, Chettri, Ashna, additional, Chiu, Hui-Fang, additional, Choudhury, Antara, additional, Chowdhury, Sailee, additional, Chowdhury, Sougata Roy, additional, Collins, Courtney, additional, Colomb, Elaine, additional, Cuevas-Galindo, M. Emilio, additional, Das, Amitava, additional, Das, Amlan, additional, Das, Arpita, additional, Das, Dibya, additional, Das, Mousumi, additional, Deb, Pran Kishore, additional, Deb, Sujoy, additional, Debnath, Anirban, additional, Deka, Satyendra, additional, Delair, Shirley F., additional, Delia, Alyssa, additional, Desai, Karishma, additional, Devaraja, S., additional, Dey, Priyankar, additional, Dolma, Karma Gurmey, additional, Downs, Bernard William, additional, Downs, Jaclyn M., additional, Eguiguren, Lourdes, additional, El Masry, Mohamed S., additional, Estevez-Fregoso, Elizabeth, additional, Farfán-García, Eunice D., additional, Ferdous, Zannatul, additional, Ganesan, Ramakrishnan, additional, García-Coronel, Itzel H., additional, García-Machorro, Jazmín, additional, George, Roseline, additional, Ghosh, Nandini, additional, Ghosh, Rituparna, additional, Ghosh, Santanu, additional, Goswami, Arunava, additional, Gourishetti, Karthik, additional, Guith, Tanner, additional, Gurugubelli, Krishna Rao, additional, Hassan, Dania, additional, Hazarika, Sangeeta, additional, Hegde, Vijay, additional, Hossain, Ashfaque, additional, Hossain, Sheikh Shah, additional, Hurst, Amanda L., additional, Jalilvand, Anahita, additional, Jana, Sasmita, additional, Jawed, Junaid Jibran, additional, Jorge, Miguel, additional, Kacar, Sedat, additional, Kansal, Vikash, additional, Kar, Nabanita, additional, Karim, Muhammad Manjurul, additional, Khandelwal, Bidita, additional, Kilic, Ahmet, additional, Koirala, Prakash, additional, Kubal, Chandrashekhar, additional, Kumar, Abhai, additional, Kumar, Umesh, additional, Kumar, V., additional, Kumari, Leena, additional, Kushner, Steve, additional, Lopez, Santiago M.C., additional, Madhu, Maxima, additional, Maitra, Puja, additional, Maji, Himangshu Sekhar, additional, Maji, Sushomasri, additional, Majumder, Rajib, additional, Mandal, Labonya, additional, Mandal, Supriya, additional, McGwire, Bradford S., additional, Mendes, Odete R., additional, Mennuru, Nagendra Babu, additional, Miraj, Sonal Sekhar, additional, Mitra, Sutanuka, additional, Moludi, Jalal, additional, Mukherjee, Sandipan, additional, Munisamy, Murali, additional, Murti, Krishna, additional, NandyMazumdar, Monali, additional, Nateqi, Masoud, additional, Neemann, Kari A., additional, Nguyen, Andrew, additional, Ovung, Aben, additional, Pal, Kunal, additional, Pawar, Anil T., additional, Potty, Prakash Narayanan Vasudevan, additional, Rana, Megha, additional, Rao, Mahadev, additional, Ray, Sayantan, additional, Ray Dutta, Jayati, additional, Rokop, Zachary P., additional, Roy, Sashwati, additional, Rubio-Velazquez, Brenda A., additional, Saha, Abinit, additional, Saha, Rudra P., additional, Saha, Tiyas, additional, Samanta, Saptadip, additional, Sanyal, Saptarshi, additional, Sarkar, Dipayan, additional, Sarkar, Dipika, additional, Sarkar, Riya, additional, Sato, Alice I., additional, Satoskar, Abhay R., additional, Sen, Abhishek Kumar, additional, Sen, Chandan K., additional, Sengupta, Pracheta, additional, Shah, Aditi, additional, Sharma, Dikshya, additional, Shinu, Pottathil, additional, Shivaprasad, H.N., additional, Shrikar Reddy, B., additional, Sil, Moumita, additional, Singh, Abhilasha, additional, Singh, Kanhaiya, additional, Singh, Manoj Kumar, additional, Singh, Smita, additional, Singh, Varun Kumar, additional, Sirisha Mulukuri, N.V.L., additional, Smith, Jessica, additional, Soriano-Ursúa, Marvin A., additional, Srinivas, Shruthi, additional, Sultana, Shahnaz, additional, Talukdar, Arindam, additional, Tata, Pranathi, additional, Thomas, Levin, additional, Trujillo-Ferrara, Jose G., additional, Uddin, Md. Hafiz, additional, Varma, Muralidhar, additional, Varman, Meera, additional, Venugopala, Katharigatta N., additional, Verma, Priyanka, additional, Vishwanath, Shashidhar, additional, Vyas, Navya, additional, Wang, Chin-Kun, additional, Wisler, Jon, additional, and Yadav, Nilesh, additional

Published
2023
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12. Synthesis, molecular modelling, in vitroand in vivoevaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors

Author

S. N. C, Sridhar, Sengupta, Pracheta, Palawat, Saksham, P. S., Dileep, George, Ginson, and Paul, Atish T.

Abstract

AbstractPancreatic lipase is a digestive enzyme involved in the hydrolysis of dietary fats. Orlistat, a potent pancreatic lipase inhibitor, is widely prescribed for long-term obesity treatment. Nevertheless, orlistat is reported for severe adverse effects including hepatotoxicity and pancreatitis. In the present study, a novel series of 11 benzyloxy substituted indole glyoxylamides were designed, synthesized and evaluated for in vitropancreatic lipase inhibitory activity. Three analogues, 10b, 11band 11c, exhibited potent activity (IC50≤ 2.5 µM), with 11bexhibiting a potent IC50of 1.68 µM comparable to orlistat (IC50= 0.99 µM). Further, 11bexhibited reversible competitive inhibition with an inhibitory constant value of 0.98 μM. Molecular docking of these analogues was in agreement with in vitroresults, wherein the MolDock scores exhibited significant correlation with their inhibitory activity (Pearson’s r = 0.7122). A 50 ns molecular dynamics simulation of 11b-pancreatic lipase complex confirmed the role of extended alkyl interactions along with π-π stacking and π-cation interactions, in stabilizing the ligand (Maximum RMSD ≈ 3 Å) in the active site. Gastro-intestinal absorption and toxicity prediction of the three potent analogues highlighted the suitability of 11bfor in vivoexperiments. 11bat a dose of 20 mg/kg exhibited anti-obesity efficacy comparable to orlistat (10 mg/kg), wherein the serum triglycerides were found to be 94.95 and 83.85 mg/dL, respectively. Further, faecal triglyceride quantification indicated 11bto act through pancreatic lipase inhibition similar to orlistat. The present study identified a novel pancreatic lipase inhibitory benzyloxy substituted bis(indolyl) glyoxylamide 11b,with promising anti-obesity activity.Communicated by Ramaswamy H. Sarma

Published
2022
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13. Mechanistically acting anti-obesity compositions/formulations of natural origin: a patent review (2010–2021)

Author

Sengupta, Pracheta, Tiwari, Niyati, Bhatt, Tanya, and Paul, Atish T.

Abstract

ABSTRACTIntroductionCurrent health trends indicate that the rate of incidence of obesity has risen considerably. According to the World Health Organization (WHO) report 2017, the issue of obesity has grown to an epidemic proportion, with over 4 million people dying every year. Orlistat, a potent pancreatic lipase (PL) inhibitor for long-term treatment of obesity has been recently reported to cause hepatic and renal toxicities. Hence, there is a need to develop newer, safer and efficacious therapeutics that targets obesity and its associated disorders.Areas coveredThe present article attempts to review patents on compositions of natural origin that include either combination of two or more lead NPs/whole extract(s)/ mixture of one or more NPs/extracts from various plants and micro-organisms. Patents that were granted during the period 2010 to 2021 have been considered.Expert opinionThe article highlights the recent trends in the rise of the global obesity population. Patents are classified based on the mechanism of action of extracts/NPs. It has been observed that in the years 2013, 2017 and 2019 maximum number of patents from China, South Korea, United States and Japan have been filed for the anti-obesity compositions.

Published
2022
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