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3. Elevated aldolase 1A, retrogene 1 expression induces cardiac apoptosis in rat experimental autoimmune myocarditis model

Author

Choi, Seungmin, Chung, Joo Hee, Nam, Myung-Hee, Bang, Eunjung, Hong, Kwan Soo, Kim, Yong-Hwan, Seo, Jong Bok, and Chi, Sung-Gil

Subjects
Cytochrome c -- Genetic aspects -- Health aspects, Dextrose -- Health aspects -- Genetic aspects, Myosin -- Genetic aspects -- Health aspects, Muscle proteins -- Health aspects -- Genetic aspects, Metabolites -- Health aspects -- Genetic aspects, Infection -- Genetic aspects, Lactates -- Health aspects, Glucose -- Health aspects -- Genetic aspects, Triglycerides -- Health aspects -- Genetic aspects, Apoptosis -- Genetic aspects -- Health aspects, Myocarditis -- Genetic aspects, Biological sciences
Abstract

Acute myocarditis is an unpredictable heart disease that is caused by inflammation-associated cell death. Although viral infection and drug exposure are known to induce acute myocarditis, the molecular basis for its development remains undefined. Using proteomics and molecular analyses in myosin-induced rat experimental autoimmune myocarditis (EAM), we identified that elevated expression of aldolase 1A, retrogene 1 (Aldoart1) is critical to induce mitochondrial dysfunction and acute myocarditis development. Here, we demonstrate that cardiac cell death is associated with increased expressions of proapoptotic genes in addition to high levels of glucose, lactate, and triglyceride in metabolite profiling. The functional protein association network analysis also suggests that Aldoart1 upregulation correlates with high levels of dihydroxyacetone kinase and triglyceride. In H9c2 cardiac cells, lipopolysaccharides (LPS) or high glucose exposure significantly increases the cytochrome c release and the conversion of pro-caspase 3 into the cleaved form of caspase 3. We also found that LPS- or glucose-induced toxicities are almost completely reversed by siRNA-mediated knockdown of Aldoartl, which consequently increases cell viability. Together, our study strongly suggests that Aldoart1 may be involved in inducing mitochondrial apoptotic processes and can be a novel therapeutic target to prevent the onset of acute myocarditis or cardiac apoptosis. Key words: H9c2, experimental autoimmune myocarditis, apoptosis, high glucose, Aldoart1. La myocardite aigue est une maladie cardiaque imprevisible causee par une mort cellulaire associee a de l'inflammation. On sait que des infections virales ainsi que l'exposition a certains medicaments peuvent provoquer une myocardite aigue, mais les bases moleculaires de son apparition demeurent a definir. A l'aide de la proteomique et d'analyses moleculaires dans un modele de myocardite auto-immune experimentale (MAE) provoquee par la myosine chez le rat, nous avons etabli qu'une augmentation de l'expression de l'aldolase 1A, retrogene 1 (Aldoart1) est cruciale pour engendrer un dysfonctionnement mitochondrial et l'apparition d'une myocardite aigue. Ici, nous montrons que la mort des cellules cardiaques est associee avec une augmentation de l'expression de genes pro-apoptotiques, en plus d'une augmentation des taux de glucose, de lactate et de triglycerides dans le profilage des metabolites. L'analyse de reseaux d'association de proteines fonctionnelles laisse aussi entrevoir que la regulation a la hausse de l'Aldoart1 est proportionnelle a l'augmentation des taux de dihydroxyacetone kinase et des triglycerides. Dans les cellules cardiaques H9c2, l'exposition a des lipopolysaccharides (LPS) ou a des taux de glucose eleves entraine une augmentation notable de la liberation de cytochrome c, ainsi que la conversion de la pro-caspase 3 en caspase 3, sa forme clivee. Nous avons aussi observe que la toxicite engendree par les LPS ou le glucose est presque entierement inversee avec la repression (<< knockdown >>) de l'Aldoartl a l'aide de siRNA, ce qui entraine une augmentation consecutive de la vitalite des cellules. Dans l'ensemble, notre etude laisse fortement entendre que l'Aldoart1 pourrait jouer un role dans l'induction de processus apoptotiques mitochondriaux, et qu'il pourrait constituer une nouvelle cible therapeutique en vue de prevenir l'apparition de la myocardite aigue ou l'apoptose cardiaque. [Traduit par la Redaction] Mots-cles: H9c2, myocardite auto-immune experimentale, apoptose, taux de glucose eleves, Aldoart1., Introduction Myocarditis is one of the inflammatory diseases caused by viral infection or drug exposure (Rose and Hill 1996). Myocarditis caused by viral infection begins when immune cells recognize particles [...]

Published
2020
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9. Large-Scale Interlaboratory DI-FT-ICR MS Comparability Study Employing Various Systems

Author

Forcisi, Sara, primary, Moritz, Franco, additional, Thompson, Christopher J., additional, Kanawati, Basem, additional, Uhl, Jenny, additional, Afonso, Carlos, additional, Bader, Chantal D., additional, Barsch, Aiko, additional, Boughton, Berin A., additional, Chu, Rosalie K., additional, Ferey, Justine, additional, Fernandez-Lima, Francisco, additional, Guéguen, Céline, additional, Heintz, Dimitri, additional, Gomez-Hernandez, Mario, additional, Jang, Kyoung-Soon, additional, Kessler, Nikolas, additional, Mangal, Vaughn, additional, Müller, Rolf, additional, Nakabayashi, Ryo, additional, Nicol, Edith, additional, Nicolardi, Simone, additional, Palmblad, Magnus, additional, Paša-Tolić, Ljiljana, additional, Porter, Jacob, additional, Schmitz-Afonso, Isabelle, additional, Seo, Jong Bok, additional, Sommella, Eduardo, additional, van der Burgt, Yuri E. M., additional, Villette, Claire, additional, Witt, Matthias, additional, Wittrig, Ashley, additional, Wolff, Jeremy J., additional, Easterling, Michael L., additional, Laukien, Frank H., additional, and Schmitt-Kopplin, Philippe, additional

Published
2022
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18. Correction: Elevated aldolase 1A, retrogene 1 expression induces cardiac apoptosis in rat experimental autoimmune myocarditis model

Author

Choi, Seungmin, Chung, Joo Hee, Nam, Myung-Hee, Bang, Eunjung, Hong, Kwan Soo, Kim, Yong-Hwan, Seo, Jong Bok, and Chi, Sung-Gil

Subjects
Research institutes, Biological sciences, Korea University
Abstract

In the original article on p. 373, Seungmin Choi was incorrectly included in the corresponding authors list. The list should read as in the ID box below. Seungmin Choi, Joo [...]

Published
2020
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21. Comparative proteomic analysis of early salt stress-responsive proteins in roots of SnRK2 transgenic rice

Author

Nam Myung Hee, Huh Sun Mi, Kim Kyung Mi, Park Woong June, Seo Jong Bok, Cho Kun, Kim Dool Yi, Kim Beom Gi, and Yoon In Sun

Subjects
Cytology, QH573-671
Abstract

Abstract Background The rice roots are highly salt-sensitive organ and primary root growth is rapidly suppressed by salt stress. Sucrose nonfermenting 1-related protein kinase2 (SnRK2) family is one of the key regulator of hyper-osmotic stress signalling in various plant cells. To understand early salt response of rice roots and identify SnRK2 signaling components, proteome changes of transgenic rice roots over-expressing OSRK1, a rice SnRK2 kinase were investigated. Results Proteomes were analyzed by two-dimensional electrophoresis and protein spots were identified by LC-MS/MS from wild type and OSRK1 transgenic rice roots exposed to 150 mM NaCl for either 3 h or 7 h. Fifty two early salt -responsive protein spots were identified from wild type rice roots. The major up-regulated proteins were enzymes related to energy regulation, amino acid metabolism, methylglyoxal detoxification, redox regulation and protein turnover. It is noted that enzymes known to be involved in GA-induced root growth such as fructose bisphosphate aldolase and methylmalonate semialdehyde dehydrogenase were clearly down-regulated. In contrast to wild type rice roots, only a few proteins were changed by salt stress in OSRK1 transgenic rice roots. A comparative quantitative analysis of the proteome level indicated that forty three early salt-responsive proteins were magnified in transgenic rice roots at unstressed condition. These proteins contain single or multiple potential SnRK2 recognition motives. In vitro kinase assay revealed that one of the identified proteome, calreticulin is a good substrate of OSRK1. Conclusions Our present data implicate that rice roots rapidly changed broad spectrum of energy metabolism upon challenging salt stress, and suppression of GA signaling by salt stress may be responsible for the rapid arrest of root growth and development. The broad spectrum of functional categories of proteins affected by over-expression of OSRK1 indicates that OSRK1 is an upstream regulator of stress signaling in rice roots. Enzymes involved in glycolysis, branched amino acid catabolism, dnaK-type molecular chaperone, calcium binding protein, Sal T and glyoxalase are potential targets of OSRK1 in rice roots under salt stress that need to be further investigated.

Published
2012
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22. Molecular pathological signatures of gastric cancer in Koreans revealed by label-free proteomics

Author

Sul, Hee Jung, primary, Seo, Jong Bok, additional, Sohn, Sung-Hwa, additional, Cho, Ji Woong, additional, Kim, Kab Choong, additional, Kim, A-Young, additional, Han, Boram, additional, Kim, Hyeong Su, additional, Lim, Hyun, additional, Kang, Ho Suk, additional, Soh, Jae Seung, additional, Seo, Jinwon, additional, Koh, Young Ho, additional, and Zang, Dae Young, additional

Published
2019
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25. The freeze-drying does not influence the proteomic profiles of human milk.

Author

Hahn, Won-Ho, Bae, Seong Phil, Song, Seunghyun, Park, Suyeon, Lee, Joohyun, Seo, Jong-Bok, and Kang, Nam Mi

Subjects
BREAST milk, FREEZE-drying, WILCOXON signed-rank test, PROTEIN expression, PROTEIN analysis
Abstract

Purpose: Human milk (HM) proteins are known as important factors in growing and development of neonates. For longer and easier storage of HM, freeze-drying is suggested as one of the promising methods for HM banks. However, the effects of freeze-drying on HM proteins were not evaluated yet. The purpose of this study is to analyze and compare proteomic data before and after the freeze-drying.Material and methods: Totally nine fresh HM samples were collected from three healthy mothers at 15 and 60 days of lactation period. The samples were freeze-dried and the proteomic analysis was performed by shotgun proteomic method with mass spectrometry. The results were compared between samples of different lactation periods, and before and after the freeze-drying using Wilcoxon signed-rank test for paired comparisons. Moreover, the functional grouping and analysis were performed for the detected proteins by bioinformatics analysis.Results: Totally, 245 proteins were detected in the HM samples. The expression of proteins was not affected by both of the different lactation periods and the freeze-drying status (P>.050). Moreover, the functional analysis of proteomic data revealed no significant difference between both groups as well.Conclusion: HM proteins were found not to be significantly affected by the lactation periods (15 and 60 days) and freeze-drying status. As significant changes of HM proteins were not found after the freeze-drying, we hope that the present study would support introducing freeze-drying in the HM banks. However, the number of samples was quite small to provide strong evidence. Moreover, the evaluation of the safe storage length in the view of infectious agents and the composition changes after freeze-drying is warranted in the further study. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Drosophila Torsin Protein Regulates Motor Control and Stress Sensitivity and Forms a Complex with Fragile-X Mental Retardation Protein.

Author

Nguyen, Phuong, Seo, Jong Bok, Ahn, Hyo-Min, and Koh, Young Ho

Subjects
*TORSIN A, *INTELLECTUAL disabilities, *MOTOR ability, *PSYCHOLOGICAL stress, *DOUBLE-stranded RNA, *ALCOHOL dehydrogenase
Abstract

We investigated unknown in vivo functions of Torsin by using Drosophila as a model. Downregulation of Drosophila Torsin (DTor) by DTor-specific inhibitory double-stranded RNA (RNAi) induced abnormal locomotor behavior and increased susceptibility to H2O2. In addition, altered expression of DTor significantly increased the numbers of synaptic boutons. One important biochemical consequence of DTor-RNAi expression in fly brains was upregulation of alcohol dehydrogenase (ADH). Altered expression of ADH has also been reported in Drosophila Fragile-X mental retardation protein (DFMRP) mutant flies. Interestingly, expression of DFMRP was altered in DTor mutant flies, and DTor and DFMRP were present in the same protein complexes. In addition, DTor and DFMRP immunoreactivities were partially colocalized in several cellular organelles in larval muscles. Furthermore, there were no significant differences between synaptic morphologies of dfmrp null mutants and dfmrp mutants expressing DTor-RNAi. Taken together, our evidences suggested that DTor and DFMRP might be present in the same signaling pathway regulating synaptic plasticity. In addition, we also found that human Torsin1A and human FMRP were present in the same protein complexes, suggesting that this phenomenon is evolutionarily conserved. [ABSTRACT FROM AUTHOR]

Published
2016
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36. Guidelines for the use and interpretation of assays for monitoring autophagy

Author

Klionsky, Daniel J., primary, Abdalla, Fabio C., additional, Abeliovich, Hagai, additional, Abraham, Robert T., additional, Acevedo-Arozena, Abraham, additional, Adeli, Khosrow, additional, Agholme, Lotta, additional, Agnello, Maria, additional, Agostinis, Patrizia, additional, Aguirre-Ghiso, Julio A., additional, Ahn, Hyung Jun, additional, Ait-Mohamed, Ouardia, additional, Ait-Si-Ali, Slimane, additional, Akematsu, Takahiko, additional, Akira, Shizuo, additional, Al-Younes, Hesham M., additional, Al-Zeer, Munir A., additional, Albert, Matthew L., additional, Albin, Roger L., additional, Alegre-Abarrategui, Javier, additional, Aleo, Maria Francesca, additional, Alirezaei, Mehrdad, additional, Almasan, Alexandru, additional, Almonte-Becerril, Maylin, additional, Amano, Atsuo, additional, Amaravadi, Ravi K., additional, Amarnath, Shoba, additional, Amer, Amal O., additional, Andrieu-Abadie, Nathalie, additional, Anantharam, Vellareddy, additional, Ann, David K., additional, Anoopkumar-Dukie, Shailendra, additional, Aoki, Hiroshi, additional, Apostolova, Nadezda, additional, Arancia, Giuseppe, additional, Aris, John P., additional, Asanuma, Katsuhiko, additional, Asare, Nana Y.O., additional, Ashida, Hisashi, additional, Askanas, Valerie, additional, Askew, David S., additional, Auberger, Patrick, additional, Baba, Misuzu, additional, Backues, Steven K., additional, Baehrecke, Eric H., additional, Bahr, Ben A., additional, Bai, Xue-Yuan, additional, Bailly, Yannick, additional, Baiocchi, Robert, additional, Baldini, Giulia, additional, Balduini, Walter, additional, Ballabio, Andrea, additional, Bamber, Bruce A., additional, Bampton, Edward T.W., additional, Juhász, Gábor, additional, Bartholomew, Clinton R., additional, Bassham, Diane C., additional, Bast, Robert C., additional, Batoko, Henri, additional, Bay, Boon-Huat, additional, Beau, Isabelle, additional, Béchet, Daniel M., additional, Begley, Thomas J., additional, Behl, Christian, additional, Behrends, Christian, additional, Bekri, Soumeya, additional, Bellaire, Bryan, additional, Bendall, Linda J., additional, Benetti, Luca, additional, Berliocchi, Laura, additional, Bernardi, Henri, additional, Bernassola, Francesca, additional, Besteiro, Sébastien, additional, Bhatia-Kissova, Ingrid, additional, Bi, Xiaoning, additional, Biard-Piechaczyk, Martine, additional, Blum, Janice S., additional, Boise, Lawrence H., additional, Bonaldo, Paolo, additional, Boone, David L., additional, Bornhauser, Beat C., additional, Bortoluci, Karina R., additional, Bossis, Ioannis, additional, Bost, Frédéric, additional, Bourquin, Jean-Pierre, additional, Boya, Patricia, additional, Boyer-Guittaut, Michaël, additional, Bozhkov, Peter V., additional, Brady, Nathan R, additional, Brancolini, Claudio, additional, Brech, Andreas, additional, Brenman, Jay E., additional, Brennand, Ana, additional, Bresnick, Emery H., additional, Brest, Patrick, additional, Bridges, Dave, additional, Bristol, Molly L., additional, Brookes, Paul S., additional, Brown, Eric J., additional, Brumell, John H., additional, Brunetti-Pierri, Nicola, additional, Brunk, Ulf T., additional, Bulman, Dennis E., additional, Bultman, Scott J., additional, Bultynck, Geert, additional, Burbulla, Lena F., additional, Bursch, Wilfried, additional, Butchar, Jonathan P., additional, Buzgariu, Wanda, additional, Bydlowski, Sergio P., additional, Cadwell, Ken, additional, Cahová, Monika, additional, Cai, Dongsheng, additional, Cai, Jiyang, additional, Cai, Qian, additional, Calabretta, Bruno, additional, Calvo-Garrido, Javier, additional, Camougrand, Nadine, additional, Campanella, Michelangelo, additional, Campos-Salinas, Jenny, additional, Candi, Eleonora, additional, Cao, Lizhi, additional, Caplan, Allan B., additional, Carding, Simon R., additional, Cardoso, Sandra M., additional, Carew, Jennifer S., additional, Carlin, Cathleen R., additional, Carmignac, Virginie, additional, Carneiro, Leticia A.M., additional, Carra, Serena, additional, Caruso, Rosario A., additional, Casari, Giorgio, additional, Casas, Caty, additional, Castino, Roberta, additional, Cebollero, Eduardo, additional, Cecconi, Francesco, additional, Celli, Jean, additional, Chaachouay, Hassan, additional, Chae, Han-Jung, additional, Chai, Chee-Yin, additional, Chan, David C., additional, Chan, Edmond Y., additional, Chang, Raymond Chuen-Chung, additional, Che, Chi-Ming, additional, Chen, Ching-Chow, additional, Chen, Guang-Chao, additional, Chen, Guo-Qiang, additional, Chen, Min, additional, Chen, Quan, additional, Chen, Steve S.-L., additional, Chen, WenLi, additional, Chen, Xi, additional, Chen, Xiangmei, additional, Chen, Xiequn, additional, Chen, Ye-Guang, additional, Chen, Yingyu, additional, Chen, Yongqiang, additional, Chen, Yu-Jen, additional, Chen, Zhixiang, additional, Cheng, Alan, additional, Cheng, Christopher H.K., additional, Cheng, Yan, additional, Cheong, Heesun, additional, Cheong, Jae-Ho, additional, Cherry, Sara, additional, Chess-Williams, Russ, additional, Cheung, Zelda H., additional, Chevet, Eric, additional, Chiang, Hui-Ling, additional, Chiarelli, Roberto, additional, Chiba, Tomoki, additional, Chin, Lih-Shen, additional, Chiou, Shih-Hwa, additional, Chisari, Francis V., additional, Cho, Chi Hin, additional, Cho, Dong-Hyung, additional, Choi, Augustine M.K., additional, Choi, DooSeok, additional, Choi, Kyeong Sook, additional, Choi, Mary E., additional, Chouaib, Salem, additional, Choubey, Divaker, additional, Choubey, Vinay, additional, Chu, Charleen T., additional, Chuang, Tsung-Hsien, additional, Chueh, Sheau-Huei, additional, Chun, Taehoon, additional, Chwae, Yong-Joon, additional, Chye, Mee-Len, additional, Ciarcia, Roberto, additional, Ciriolo, Maria R., additional, Clague, Michael J., additional, Clark, Robert S.B., additional, Clarke, Peter G.H., additional, Clarke, Robert, additional, Codogno, Patrice, additional, Coller, Hilary A., additional, Colombo, María I., additional, Comincini, Sergio, additional, Condello, Maria, additional, Condorelli, Fabrizio, additional, Cookson, Mark R., additional, Coombs, Graham H., additional, Coppens, Isabelle, additional, Corbalan, Ramon, additional, Cossart, Pascale, additional, Costelli, Paola, additional, Costes, Safia, additional, Coto-Montes, Ana, additional, Couve, Eduardo, additional, Coxon, Fraser P., additional, Cregg, James M., additional, Crespo, José L., additional, Cronjé, Marianne J., additional, Cuervo, Ana Maria, additional, Cullen, Joseph J., additional, Czaja, Mark J., additional, D'Amelio, Marcello, additional, Darfeuille-Michaud, Arlette, additional, Davids, Lester M., additional, Davies, Faith E., additional, De Felici, Massimo, additional, de Groot, John F., additional, de Haan, Cornelis A.M., additional, De Martino, Luisa, additional, De Milito, Angelo, additional, De Tata, Vincenzo, additional, Debnath, Jayanta, additional, Degterev, Alexei, additional, Dehay, Benjamin, additional, Delbridge, Lea M.D., additional, Demarchi, Francesca, additional, Deng, Yi Zhen, additional, Dengjel, Jörn, additional, Dent, Paul, additional, Denton, Donna, additional, Deretic, Vojo, additional, Desai, Shyamal D., additional, Devenish, Rodney J., additional, Di Gioacchino, Mario, additional, Di Paolo, Gilbert, additional, Di Pietro, Chiara, additional, Díaz-Araya, Guillermo, additional, Díaz-Laviada, Inés, additional, Diaz-Meco, Maria T., additional, Diaz-Nido, Javier, additional, Dikic, Ivan, additional, Dinesh-Kumar, Savithramma P., additional, Ding, Wen-Xing, additional, Distelhorst, Clark W., additional, Diwan, Abhinav, additional, Djavaheri-Mergny, Mojgan, additional, Dokudovskaya, Svetlana, additional, Dong, Zheng, additional, Dorsey, Frank C., additional, Dosenko, Victor, additional, Dowling, James J., additional, Doxsey, Stephen, additional, Dreux, Marlène, additional, Drew, Mark E., additional, Duan, Qiuhong, additional, Duchosal, Michel A., additional, Duff, Karen E., additional, Dugail, Isabelle, additional, Durbeej, Madeleine, additional, Duszenko, Michael, additional, Edelstein, Charles L., additional, Edinger, Aimee L., additional, Egea, Gustavo, additional, Eichinger, Ludwig, additional, Eissa, N. Tony, additional, Ekmekcioglu, Suhendan, additional, El-Deiry, Wafik S., additional, Elazar, Zvulun, additional, Elgendy, Mohamed, additional, Ellerby, Lisa M., additional, Eng, Kai Er, additional, Engelbrecht, Anna-Mart, additional, Engelender, Simone, additional, Erenpreisa, Jekaterina, additional, Escalante, Ricardo, additional, Esclatine, Audrey, additional, Eskelinen, Eeva-Liisa, additional, Espert, Lucile, additional, Espina, Virginia, additional, Fan, Huizhou, additional, Fan, Jia, additional, Fan, Qi-Wen, additional, Fan, Zhen, additional, Fang, Shengyun, additional, Fang, Yongqi, additional, Fanto, Manolis, additional, Fanzani, Alessandro, additional, Farkas, Thomas, additional, Farre, Jean-Claude, additional, Faure, Mathias, additional, Fechheimer, Marcus, additional, Feng, Carl G., additional, Feng, Jian, additional, Feng, Qili, additional, Feng, Youji, additional, Fésüs, László, additional, Feuer, Ralph, additional, Figueiredo-Pereira, Maria E., additional, Fimia, Gian Maria, additional, Fingar, Diane C., additional, Finkbeiner, Steven, additional, Finkel, Toren, additional, Finley, Kim D., additional, Fiorito, Filomena, additional, Fisher, Edward A., additional, Fisher, Paul B., additional, Flajolet, Marc, additional, Florez-McClure, Maria L., additional, Florio, Salvatore, additional, Fon, Edward A., additional, Fornai, Francesco, additional, Fortunato, Franco, additional, Fotedar, Rati, additional, Fowler, Daniel H., additional, Fox, Howard S., additional, Franco, Rodrigo, additional, Frankel, Lisa B., additional, Fransen, Marc, additional, Fuentes, José M., additional, Fueyo, Juan, additional, Fujii, Jun, additional, Fujisaki, Kozo, additional, Fujita, Eriko, additional, Fukuda, Mitsunori, additional, Furukawa, Ruth H., additional, Gaestel, Matthias, additional, Gailly, Philippe, additional, Gajewska, Malgorzata, additional, Galliot, Brigitte, additional, Galy, Vincent, additional, Ganesh, Subramaniam, additional, Ganetzky, Barry, additional, Ganley, Ian G., additional, Gao, Fen-Biao, additional, Gao, George F., additional, Gao, Jinming, additional, Garcia, Lorena, additional, Garcia-Manero, Guillermo, additional, Garcia-Marcos, Mikel, additional, Garmyn, Marjan, additional, Gartel, Andrei L., additional, Gatti, Evelina, additional, Gautel, Mathias, additional, Gawriluk, Thomas R., additional, Gegg, Matthew E., additional, Geng, Jiefei, additional, Germain, Marc, additional, Gestwicki, Jason E., additional, Gewirtz, David A., additional, Ghavami, Saeid, additional, Ghosh, Pradipta, additional, Giammarioli, Anna M., additional, Giatromanolaki, Alexandra N., additional, Gibson, Spencer B., additional, Gilkerson, Robert W., additional, Ginger, Michael L., additional, Ginsberg, Henry N., additional, Golab, Jakub, additional, Goligorsky, Michael S., additional, Golstein, Pierre, additional, Gomez-Manzano, Candelaria, additional, Goncu, Ebru, additional, Gongora, Céline, additional, Gonzalez, Claudio D., additional, Gonzalez, Ramon, additional, González-Estévez, Cristina, additional, González-Polo, Rosa Ana, additional, Gonzalez-Rey, Elena, additional, Gorbunov, Nikolai V., additional, Gorski, Sharon, additional, Goruppi, Sandro, additional, Gottlieb, Roberta A., additional, Gozuacik, Devrim, additional, Granato, Giovanna Elvira, additional, Grant, Gary D., additional, Green, Kim N., additional, Gregorc, Ales, additional, Gros, Frédéric, additional, Grose, Charles, additional, Grunt, Thomas W., additional, Gual, Philippe, additional, Guan, Jun-Lin, additional, Guan, Kun-Liang, additional, Guichard, Sylvie M., additional, Gukovskaya, Anna S., additional, Gukovsky, Ilya, additional, Gunst, Jan, additional, Gustafsson, Åsa B., additional, Halayko, Andrew J., additional, Hale, Amber N., additional, Halonen, Sandra K., additional, Hamasaki, Maho, additional, Han, Feng, additional, Han, Ting, additional, Hancock, Michael K., additional, Hansen, Malene, additional, Harada, Hisashi, additional, Harada, Masaru, additional, Hardt, Stefan E., additional, Harper, J. Wade, additional, Harris, Adrian L., additional, Harris, James, additional, Harris, Steven D., additional, Hashimoto, Makoto, additional, Haspel, Jeffrey A., additional, Hayashi, Shin-ichiro, additional, Hazelhurst, Lori A., additional, He, Congcong, additional, He, You-Wen, additional, Hébert, Marie-Josée, additional, Heidenreich, Kim A., additional, Helfrich, Miep H., additional, Helgason, Gudmundur V., additional, Henske, Elizabeth P., additional, Herman, Brian, additional, Herman, Paul K., additional, Hetz, Claudio, additional, Hilfiker, Sabine, additional, Hill, Joseph A., additional, Hocking, Lynne J., additional, Hofman, Paul, additional, Hofmann, Thomas G., additional, Höhfeld, Jörg, additional, Holyoake, Tessa L., additional, Hong, Ming-Huang, additional, Hood, David A., additional, Hotamisligil, Gökhan S., additional, Houwerzijl, Ewout J., additional, Høyer-Hansen, Maria, additional, Hu, Bingren, additional, Hu, Chien-an A., additional, Hu, Hong-Ming, additional, Hua, Ya, additional, Huang, Canhua, additional, Huang, Ju, additional, Huang, Shengbing, additional, Huang, Wei-Pang, additional, Huber, Tobias B., additional, Huh, Won-Ki, additional, Hung, Tai-Ho, additional, Hupp, Ted R., additional, Hur, Gang Min, additional, Hurley, James B., additional, Hussain, Sabah N.A., additional, Hussey, Patrick J., additional, Hwang, Jung Jin, additional, Hwang, Seungmin, additional, Ichihara, Atsuhiro, additional, Ilkhanizadeh, Shirin, additional, Inoki, Ken, additional, Into, Takeshi, additional, Iovane, Valentina, additional, Iovanna, Juan L., additional, Ip, Nancy Y., additional, Isaka, Yoshitaka, additional, Ishida, Hiroyuki, additional, Isidoro, Ciro, additional, Isobe, Ken-ichi, additional, Iwasaki, Akiko, additional, Izquierdo, Marta, additional, Izumi, Yotaro, additional, Jaakkola, Panu M., additional, Jäättelä, Marja, additional, Jackson, George R., additional, Jackson, William T., additional, Janji, Bassam, additional, Jendrach, Marina, additional, Jeon, Ju-Hong, additional, Jeung, Eui-Bae, additional, Jiang, Hong, additional, Jiang, Hongchi, additional, Jiang, Jean X., additional, Jiang, Ming, additional, Jiang, Qing, additional, Jiang, Xuejun, additional, Jiménez, Alberto, additional, Jin, Meiyan, additional, Jin, Shengkan V., additional, Joe, Cheol O., additional, Johansen, Terje, additional, Johnson, Daniel E., additional, Johnson, Gail V.W., additional, Jones, Nicola L., additional, Joseph, Bertrand, additional, Joseph, Suresh K., additional, Joubert, Annie M., additional, Juillerat-Jeanneret, Lucienne, additional, Jung, Chang Hwa, additional, Jung, Yong-Keun, additional, Kaarniranta, Kai, additional, Kaasik, Allen, additional, Kabuta, Tomohiro, additional, Kadowaki, Motoni, additional, Kågedal, Katarina, additional, Kamada, Yoshiaki, additional, Kaminskyy, Vitaliy O., additional, Kampinga, Harm H., additional, Kanamori, Hiromitsu, additional, Kang, Chanhee, additional, Kang, Khong Bee, additional, Kang, Kwang Il, additional, Kang, Rui, additional, Kang, Yoon-A, additional, Kanki, Tomotake, additional, Kanneganti, Thirumala-Devi, additional, Kanno, Haruo, additional, Kanthasamy, Anumantha G., additional, Kanthasamy, Arthi, additional, Karantza, Vassiliki, additional, Kaushal, Gur P., additional, Kaushik, Susmita, additional, Kawazoe, Yoshinori, additional, Ke, Po-Yuan, additional, Kehrl, John H., additional, Kelekar, Ameeta, additional, Kerkhoff, Claus, additional, Kessel, David H., additional, Khalil, Hany, additional, Kiel, Jan A.K.W., additional, Kiger, Amy A., additional, Kihara, Akio, additional, Kim, Deok Ryong, additional, Kim, Do-Hyung, additional, Kim, Dong-Hou, additional, Kim, Eun-Kyoung, additional, Kim, Hyung-Ryong, additional, Kim, Jae-Sung, additional, Kim, Jeong Hun, additional, Kim, Jin Cheon, additional, Kim, John K., additional, Kim, Peter K., additional, Kim, Seong Who, additional, Kim, Yong-Sun, additional, Kim, Yonghyun, additional, Kimchi, Adi, additional, Kimmelman, Alec C., additional, King, Jason S., additional, Kinsella, Timothy J., additional, Kirkin, Vladimir, additional, Kirshenbaum, Lorrie A., additional, Kitamoto, Katsuhiko, additional, Kitazato, Kaio, additional, Klein, Ludger, additional, Klimecki, Walter T., additional, Klucken, Jochen, additional, Knecht, Erwin, additional, Ko, Ben C.B., additional, Koch, Jan C., additional, Koga, Hiroshi, additional, Koh, Jae-Young, additional, Koh, Young Ho, additional, Koike, Masato, additional, Komatsu, Masaaki, additional, Kominami, Eiki, additional, Kong, Hee Jeong, additional, Kong, Wei-Jia, additional, Korolchuk, Viktor I., additional, Kotake, Yaichiro, additional, Koukourakis, Michael I., additional, Flores, Juan B. Kouri, additional, Kovács, Attila L., additional, Kraft, Claudine, additional, Krainc, Dimitri, additional, Krämer, Helmut, additional, Kretz-Remy, Carole, additional, Krichevsky, Anna M., additional, Kroemer, Guido, additional, Krüger, Rejko, additional, Krut, Oleg, additional, Ktistakis, Nicholas T., additional, Kuan, Chia-Yi, additional, Kucharczyk, Roza, additional, Kumar, Ashok, additional, Kumar, Raj, additional, Kumar, Sharad, additional, Kundu, Mondira, additional, Kung, Hsing-Jien, additional, Kurz, Tino, additional, Kwon, Ho Jeong, additional, La Spada, Albert R., additional, Lafont, Frank, additional, Lamark, Trond, additional, Landry, Jacques, additional, Lane, Jon D., additional, Lapaquette, Pierre, additional, Laporte, Jocelyn F., additional, László, Lajos, additional, Lavandero, Sergio, additional, Lavoie, Josée N., additional, Layfield, Robert, additional, Lazo, Pedro A., additional, Le, Weidong, additional, Le Cam, Laurent, additional, Ledbetter, Daniel J., additional, Lee, Alvin J.X., additional, Lee, Byung-Wan, additional, Lee, Gyun Min, additional, Lee, Jongdae, additional, lee, Ju-hyun, additional, Lee, Michael, additional, Lee, Myung-Shik, additional, Lee, Sug Hyung, additional, Leeuwenburgh, Christiaan, additional, Legembre, Patrick, additional, Legouis, Renaud, additional, Lehmann, Michael, additional, Lei, Huan-Yao, additional, Lei, Qun-Ying, additional, Leib, David A., additional, Leiro, José, additional, Lemasters, John J., additional, Lemoine, Antoinette, additional, Lesniak, Maciej S., additional, Lev, Dina, additional, Levenson, Victor V., additional, Levine, Beth, additional, Levy, Efrat, additional, Li, Faqiang, additional, Li, Jun-Lin, additional, Li, Lian, additional, Li, Sheng, additional, Li, Weijie, additional, Li, Xue-Jun, additional, Li, Yan-Bo, additional, Li, Yi-Ping, additional, Liang, Chengyu, additional, Liang, Qiangrong, additional, Liao, Yung-Feng, additional, Liberski, Pawel P., additional, Lieberman, Andrew, additional, Lim, Hyunjung J., additional, Lim, Kah-Leong, additional, Lim, Kyu, additional, Lin, Chiou-Feng, additional, Lin, Fu-Cheng, additional, Lin, Jian, additional, Lin, Jiandie D., additional, Lin, Kui, additional, Lin, Wan-Wan, additional, Lin, Weei-Chin, additional, Lin, Yi-Ling, additional, Linden, Rafael, additional, Lingor, Paul, additional, Lippincott-Schwartz, Jennifer, additional, Lisanti, Michael P., additional, Liton, Paloma B., additional, Liu, Bo, additional, Liu, Chun-Feng, additional, Liu, Kaiyu, additional, Liu, Leyuan, additional, Liu, Qiong A., additional, Liu, Wei, additional, Liu, Young-Chau, additional, Liu, Yule, additional, Lockshin, Richard A., additional, Lok, Chun-Nam, additional, Lonial, Sagar, additional, Loos, Benjamin, additional, Lopez-Berestein, Gabriel, additional, López-Otín, Carlos, additional, Lossi, Laura, additional, Lotze, Michael T., additional, Low, Peter, additional, Lu, Binfeng, additional, Lu, Bingwei, additional, Lu, Bo, additional, Lu, Zhen, additional, Luciano, Fréderic, additional, Lukacs, Nicholas W., additional, Lund, Anders H., additional, Lynch-Day, Melinda A., additional, Ma, Yong, additional, Macian, Fernando, additional, MacKeigan, Jeff P., additional, Macleod, Kay F., additional, Madeo, Frank, additional, Maiuri, Luigi, additional, Maiuri, Maria Chiara, additional, Malagoli, Davide, additional, Malicdan, May Christine V., additional, Malorni, Walter, additional, Man, Na, additional, Mandelkow, Eva-Maria, additional, Manon, Stephen, additional, Manov, Irena, additional, Mao, Kai, additional, Mao, Xiang, additional, Mao, Zixu, additional, Marambaud, Philippe, additional, Marazziti, Daniela, additional, Marcel, Yves L., additional, Marchbank, Katie, additional, Marchetti, Piero, additional, Marciniak, Stefan J., additional, Marcondes, Mateus, additional, Mardi, Mohsen, additional, Marfe, Gabriella, additional, Mariño, Guillermo, additional, Markaki, Maria, additional, Marten, Mark R., additional, Martin, Seamus J., additional, Martinand-Mari, Camille, additional, Martinet, Wim, additional, Martinez-Vicente, Marta, additional, Masini, Matilde, additional, Matarrese, Paola, additional, Matsuo, Saburo, additional, Matteoni, Raffaele, additional, Mayer, Andreas, additional, Mazure, Nathalie M., additional, McConkey, David J., additional, McConnell, Melanie J., additional, McDermott, Catherine, additional, McDonald, Christine, additional, McInerney, Gerald M., additional, McKenna, Sharon L., additional, McLaughlin, BethAnn, additional, McLean, Pamela J., additional, McMaster, Christopher R., additional, McQuibban, G. Angus, additional, Meijer, Alfred J., additional, Meisler, Miriam H., additional, Meléndez, Alicia, additional, Melia, Thomas J., additional, Melino, Gerry, additional, Mena, Maria A., additional, Menendez, Javier A., additional, Menna-Barreto, Rubem F. S., additional, Menon, Manoj B., additional, Menzies, Fiona M., additional, Mercer, Carol A., additional, Merighi, Adalberto, additional, Merry, Diane E., additional, Meschini, Stefania, additional, Meyer, Christian G., additional, Meyer, Thomas F., additional, Miao, Chao-Yu, additional, Miao, Jun-Ying, additional, Michels, Paul A.M., additional, Michiels, Carine, additional, Mijaljica, Dalibor, additional, Milojkovic, Ana, additional, Minucci, Saverio, additional, Miracco, Clelia, additional, Miranti, Cindy K., additional, Mitroulis, Ioannis, additional, Miyazawa, Keisuke, additional, Mizushima, Noboru, additional, Mograbi, Baharia, additional, Mohseni, Simin, additional, Molero, Xavier, additional, Mollereau, Bertrand, additional, Mollinedo, Faustino, additional, Momoi, Takashi, additional, Monastyrska, Iryna, additional, Monick, Martha M., additional, Monteiro, Mervyn J., additional, Moore, Michael N., additional, Mora, Rodrigo, additional, Moreau, Kevin, additional, Moreira, Paula I., additional, Moriyasu, Yuji, additional, Moscat, Jorge, additional, Mostowy, Serge, additional, Mottram, Jeremy C., additional, Motyl, Tomasz, additional, Moussa, Charbel E.-H., additional, Müller, Sylke, additional, Muller, Sylviane, additional, Münger, Karl, additional, Münz, Christian, additional, Murphy, Leon O., additional, Murphy, Maureen E., additional, Musarò, Antonio, additional, Mysorekar, Indira, additional, Nagata, Eiichiro, additional, Nagata, Kazuhiro, additional, Nahimana, Aimable, additional, Nair, Usha, additional, Nakagawa, Toshiyuki, additional, Nakahira, Kiichi, additional, Nakano, Hiroyasu, additional, Nakatogawa, Hitoshi, additional, Nanjundan, Meera, additional, Naqvi, Naweed I., additional, Narendra, Derek P., additional, Narita, Masashi, additional, Navarro, Miguel, additional, Nawrocki, Steffan T., additional, Nazarko, Taras Y., additional, Nemchenko, Andriy, additional, Netea, Mihai G., additional, Neufeld, Thomas P., additional, Ney, Paul A., additional, Nezis, Ioannis P., additional, Nguyen, Huu Phuc, additional, Nie, Daotai, additional, Nishino, Ichizo, additional, Nislow, Corey, additional, Nixon, Ralph A., additional, Noda, Takeshi, additional, Noegel, Angelika A., additional, Nogalska, Anna, additional, Noguchi, Satoru, additional, Notterpek, Lucia, additional, Novak, Ivana, additional, Nozaki, Tomoyoshi, additional, Nukina, Nobuyuki, additional, Nürnberger, Thorsten, additional, Nyfeler, Beat, additional, Obara, Keisuke, additional, Oberley, Terry D., additional, Oddo, Salvatore, additional, Ogawa, Michinaga, additional, Ohashi, Toya, additional, Okamoto, Koji, additional, Oleinick, Nancy L., additional, Oliver, F. Javier, additional, Olsen, Laura J., additional, Olsson, Stefan, additional, Opota, Onya, additional, Osborne, Timothy F., additional, Ostrander, Gary K., additional, Otsu, Kinya, additional, Ou, Jing-hsiung James, additional, Ouimet, Mireille, additional, Overholtzer, Michael, additional, Ozpolat, Bulent, additional, Paganetti, Paolo, additional, Pagnini, Ugo, additional, Pallet, Nicolas, additional, Palmer, Glen E., additional, Palumbo, Camilla, additional, Pan, Tianhong, additional, Panaretakis, Theocharis, additional, Pandey, Udai Bhan, additional, Papackova, Zuzana, additional, Papassideri, Issidora, additional, Paris, Irmgard, additional, Park, Junsoo, additional, Park, Ohkmae K., additional, Parys, Jan B., additional, Parzych, Katherine R., additional, Patschan, Susann, additional, Patterson, Cam, additional, Pattingre, Sophie, additional, Pawelek, John M., additional, Peng, Jianxin, additional, Perlmutter, David H., additional, Perrotta, Ida, additional, Perry, George, additional, Pervaiz, Shazib, additional, Peter, Matthias, additional, Peters, Godefridus J., additional, Petersen, Morten, additional, Petrovski, Goran, additional, Phang, James M., additional, Piacentini, Mauro, additional, Pierre, Philippe, additional, Pierrefite-Carle, Valérie, additional, Pierron, Gérard, additional, Pinkas-Kramarski, Ronit, additional, Piras, Antonio, additional, Piri, Natik, additional, Platanias, Leonidas C., additional, Pöggeler, Stefanie, additional, Poirot, Marc, additional, Poletti, Angelo, additional, Poüs, Christian, additional, Pozuelo-Rubio, Mercedes, additional, Prætorius-Ibba, Mette, additional, Prasad, Anil, additional, Prescott, Mark, additional, Priault, Muriel, additional, Produit-Zengaffinen, Nathalie, additional, Progulske-Fox, Ann, additional, Proikas-Cezanne, Tassula, additional, Przedborski, Serge, additional, Przyklenk, Karin, additional, Puertollano, Rosa, additional, Puyal, Julien, additional, Qian, Shu-Bing, additional, Qin, Liang, additional, Qin, Zheng-Hong, additional, Quaggin, Susan E., additional, Raben, Nina, additional, Rabinowich, Hannah, additional, Rabkin, Simon W., additional, Rahman, Irfan, additional, Rami, Abdelhaq, additional, Ramm, Georg, additional, Randall, Glenn, additional, Randow, Felix, additional, Rao, V. Ashutosh, additional, Rathmell, Jeffrey C., additional, Ravikumar, Brinda, additional, Ray, Swapan K., additional, Reed, Bruce H., additional, Reed, John C., additional, Reggiori, Fulvio, additional, Régnier-Vigouroux, Anne, additional, Reichert, Andreas S., additional, Reiners, Jr., John J., additional, Reiter, Russel J., additional, Ren, Jun, additional, Revuelta, José L., additional, Rhodes, Christopher J., additional, Ritis, Konstantinos, additional, Rizzo, Elizete, additional, Robbins, Jeffrey, additional, Roberge, Michel, additional, Roca, Hernan, additional, Roccheri, Maria C., additional, Rocchi, Stephane, additional, Rodemann, H. Peter, additional, Rodríguez de Córdoba, Santiago, additional, Rohrer, Bärbel, additional, Roninson, Igor B., additional, Rosen, Kirill, additional, Rost-Roszkowska, Magdalena M., additional, Rouis, Mustapha, additional, Rouschop, Kasper M.A., additional, Rovetta, Francesca, additional, Rubin, Brian P., additional, Rubinsztein, David C., additional, Ruckdeschel, Klaus, additional, Rucker, Edmund B., additional, Rudich, Assaf, additional, Rudolf, Emil, additional, Ruiz-Opazo, Nelson, additional, Russo, Rossella, additional, Rusten, Tor Erik, additional, Ryan, Kevin M., additional, Ryter, Stefan W., additional, Sabatini, David M., additional, Sadoshima, Junichi, additional, Saha, Tapas, additional, Saitoh, Tatsuya, additional, Sakagami, Hiroshi, additional, Sakai, Yasuyoshi, additional, Salekdeh, Ghasem Hoseini, additional, Salomoni, Paolo, additional, Salvaterra, Paul M., additional, Salvesen, Guy, additional, Salvioli, Rosa, additional, Sanchez, Anthony M.J., additional, Sánchez-Alcázar, José A., additional, Sánchez-Prieto, Ricardo, additional, Sandri, Marco, additional, Sankar, Uma, additional, Sansanwal, Poonam, additional, Santambrogio, Laura, additional, Saran, Shweta, additional, Sarkar, Sovan, additional, Sarwal, Minnie, additional, Sasakawa, Chihiro, additional, Sasnauskiene, Ausra, additional, Sass, Miklós, additional, Sato, Ken, additional, Sato, Miyuki, additional, Schapira, Anthony H.V., additional, Scharl, Michael, additional, Schätzl, Hermann M., additional, Scheper, Wiep, additional, Schiaffino, Stefano, additional, Schneider, Claudio, additional, Schneider, Marion E., additional, Schneider-Stock, Regine, additional, Schoenlein, Patricia V., additional, Schorderet, Daniel F., additional, Schüller, Christoph, additional, Schwartz, Gary K., additional, Scorrano, Luca, additional, Sealy, Linda, additional, Seglen, Per O., additional, Segura-Aguilar, Juan, additional, Seiliez, Iban, additional, Seleverstov, Oleksandr, additional, Sell, Christian, additional, Seo, Jong Bok, additional, Separovic, Duska, additional, Setaluri, Vijayasaradhi, additional, Setoguchi, Takao, additional, Settembre, Carmine, additional, Shacka, John J., additional, Shanmugam, Mala, additional, Shapiro, Irving M., additional, Shaulian, Eitan, additional, Shaw, Reuben J., additional, Shelhamer, James H., additional, Shen, Han-Ming, additional, Shen, Wei-Chiang, additional, Sheng, Zu-Hang, additional, Shi, Yang, additional, Shibuya, Kenichi, additional, Shidoji, Yoshihiro, additional, Shieh, Jeng-Jer, additional, Shih, Chwen-Ming, additional, Shimada, Yohta, additional, Shimizu, Shigeomi, additional, Shintani, Takahiro, additional, Shirihai, Orian S., additional, Shore, Gordon C., additional, Sibirny, Andriy A., additional, Sidhu, Stan B., additional, Sikorska, Beata, additional, Silva-Zacarin, Elaine C.M., additional, Simmons, Alison, additional, Simon, Anna Katharina, additional, Simon, Hans-Uwe, additional, Simone, Cristiano, additional, Simonsen, Anne, additional, Sinclair, David A., additional, Singh, Rajat, additional, Sinha, Debasish, additional, Sinicrope, Frank A., additional, Sirko, Agnieszka, additional, Siu, Parco M., additional, Sivridis, Efthimios, additional, Skop, Vojtech, additional, Skulachev, Vladimir P., additional, Slack, Ruth S., additional, Smaili, Soraya S., additional, Smith, Duncan R., additional, Soengas, Maria S., additional, Soldati, Thierry, additional, Song, Xueqin, additional, Sood, Anil K., additional, Soong, Tuck Wah, additional, Sotgia, Federica, additional, Spector, Stephen A., additional, Spies, Claudia D., additional, Springer, Wolfdieter, additional, Srinivasula, Srinivasa M., additional, Stefanis, Leonidas, additional, Steffan, Joan S., additional, Stendel, Ruediger, additional, Stenmark, Harald, additional, Stephanou, Anastasis, additional, Stern, Stephan T., additional, Sternberg, Cinthya, additional, Stork, Björn, additional, Strålfors, Peter, additional, Subauste, Carlos S., additional, Sui, Xinbing, additional, Sulzer, David, additional, Sun, Jiaren, additional, Sun, Shi-Yong, additional, Sun, Zhi-Jun, additional, Sung, Joseph J.Y., additional, Suzuki, Kuninori, additional, Suzuki, Toshihiko, additional, Swanson, Michele S., additional, Swanton, Charles, additional, Sweeney, Sean T., additional, Sy, Lai-King, additional, Szabadkai, György, additional, Tabas, Ira, additional, Taegtmeyer, Heinrich, additional, Tafani, Marco, additional, Takács-Vellai, Krisztina, additional, Takano, Yoshitaka, additional, Takegawa, Kaoru, additional, Takemura, Genzou, additional, Takeshita, Fumihiko, additional, Talbot, Nicholas J., additional, Tan, Kevin S.W., additional, Tanaka, Keiji, additional, Tanaka, Kozo, additional, Tang, Daolin, additional, Tang, Dingzhong, additional, Tanida, Isei, additional, Tannous, Bakhos A., additional, Tavernarakis, Nektarios, additional, Taylor, Graham S., additional, Taylor, Gregory A., additional, Taylor, J. Paul, additional, Terada, Lance S., additional, Terman, Alexei, additional, Tettamanti, Gianluca, additional, Thevissen, Karin, additional, Thompson, Craig B., additional, Thorburn, Andrew, additional, Thumm, Michael, additional, Tian, FengFeng, additional, Tian, Yuan, additional, Tocchini-Valentini, Glauco, additional, Tolkovsky, Aviva M., additional, Tomino, Yasuhiko, additional, Tönges, Lars, additional, Tooze, Sharon A., additional, Tournier, Cathy, additional, Tower, John, additional, Towns, Roberto, additional, Trajkovic, Vladimir, additional, Travassos, Leonardo H., additional, Tsai, Ting-Fen, additional, Tschan, Mario P., additional, Tsubata, Takeshi, additional, Tsung, Allan, additional, Turk, Boris, additional, Turner, Lorianne S., additional, Tyagi, Suresh C., additional, Uchiyama, Yasuo, additional, Ueno, Takashi, additional, Umekawa, Midori, additional, Umemiya-Shirafuji, Rika, additional, Unni, Vivek K., additional, Vaccaro, Maria I., additional, Valente, Enza Maria, additional, Van den Berghe, Greet, additional, van der Klei, Ida J., additional, van Doorn, Wouter G., additional, van Dyk, Linda F., additional, van Egmond, Marjolein, additional, van Grunsven, Leo A., additional, Vandenabeele, Peter, additional, Vandenberghe, Wim P., additional, Vanhorebeek, Ilse, additional, Vaquero, Eva C., additional, Velasco, Guillermo, additional, Vellai, Tibor, additional, Vicencio, José Miguel, additional, Vierstra, Richard D., additional, Vila, Miquel, additional, Vindis, Cécile, additional, Viola, Giampietro, additional, Viscomi, Maria Teresa, additional, Voitsekhovskaja, Olga V., additional, von Haefen, Clarissa, additional, Votruba, Marcela, additional, Wada, Keiji, additional, Wade-Martins, Richard, additional, Walker, Cheryl L., additional, Walsh, Craig M., additional, Walter, Jochen, additional, Wan, Xiang-Bo, additional, Wang, Aimin, additional, Wang, Chenguang, additional, Wang, Dawei, additional, Wang, Fan, additional, Wang, Fen, additional, Wang, Guanghui, additional, Wang, Haichao, additional, Wang, Hong-Gang, additional, Wang, Horng-Dar, additional, Wang, Jin, additional, Wang, Ke, additional, Wang, Mei, additional, Wang, Richard C., additional, Wang, Xinglong, additional, Wang, Xiujie J., additional, Wang, Ying-Jan, additional, Wang, Yipeng, additional, Wang, Zhen-Bo, additional, Wang, Zhigang Charles, additional, Wang, Zhinong, additional, Wansink, Derick G., additional, Ward, Diane M., additional, Watada, Hirotaka, additional, Waters, Sarah L., additional, Webster, Paul, additional, Wei, Lixin, additional, Weihl, Conrad C., additional, Weiss, William A., additional, Welford, Scott M., additional, Wen, Long-Ping, additional, Whitehouse, Caroline A., additional, Whitton, J. Lindsay, additional, Whitworth, Alexander J., additional, Wileman, Tom, additional, Wiley, John W., additional, Wilkinson, Simon, additional, Willbold, Dieter, additional, Williams, Roger L., additional, Williamson, Peter R., additional, Wouters, Bradly G., additional, Wu, Chenghan, additional, Wu, Dao-Cheng, additional, Wu, William K.K., additional, Wyttenbach, Andreas, additional, Xavier, Ramnik J., additional, Xi, Zhijun, additional, Xia, Pu, additional, Xiao, Gengfu, additional, Xie, Zhiping, additional, Xie, Zhonglin, additional, Xu, Da-zhi, additional, Xu, Jianzhen, additional, Xu, Liang, additional, Xu, Xiaolei, additional, Yamamoto, Ai, additional, Yamamoto, Akitsugu, additional, Yamashina, Shunhei, additional, Yamashita, Michiaki, additional, Yan, Xianghua, additional, Yanagida, Mitsuhiro, additional, Yang, Dun-Sheng, additional, Yang, Elizabeth, additional, Yang, Jin-Ming, additional, Yang, Shi Yu, additional, Yang, Wannian, additional, Yang, Wei Yuan, additional, Yang, Zhifen, additional, Yao, Meng-Chao, additional, Yao, Tso-Pang, additional, Yeganeh, Behzad, additional, Yen, Wei-Lien, additional, Yin, Jia-Jing, additional, Yin, Xiao-Ming, additional, Yoo, Ook-Joon, additional, Yoon, Gyesoon, additional, Yoon, Seung-Yong, additional, Yorimitsu, Tomohiro, additional, Yoshikawa, Yuko, additional, Yoshimori, Tamotsu, additional, Yoshimoto, Kohki, additional, You, Ho Jin, additional, Youle, Richard J., additional, Younes, Anas, additional, Yu, Li, additional, Yu, Long, additional, Yu, Seong-Woon, additional, Yu, Wai Haung, additional, Yuan, Zhi-Min, additional, Yue, Zhenyu, additional, Yun, Cheol-Heui, additional, Yuzaki, Michisuke, additional, Zabirnyk, Olga, additional, Silva-Zacarin, Elaine, additional, Zacks, David, additional, Zacksenhaus, Eldad, additional, Zaffaroni, Nadia, additional, Zakeri, Zahra, additional, Zeh, III, Herbert J., additional, Zeitlin, Scott O., additional, Zhang, Hong, additional, Zhang, Hui-Ling, additional, Zhang, Jianhua, additional, Zhang, Jing-Pu, additional, Zhang, Lin, additional, Zhang, Long, additional, Zhang, Ming-Yong, additional, Zhang, Xu Dong, additional, Zhao, Mantong, additional, Zhao, Yi-Fang, additional, Zhao, Ying, additional, Zhao, Zhizhuang J., additional, Zheng, Xiaoxiang, additional, Zhivotovsky, Boris, additional, Zhong, Qing, additional, Zhou, Cong-Zhao, additional, Zhu, Changlian, additional, Zhu, Wei-Guo, additional, Zhu, Xiao-Feng, additional, Zhu, Xiongwei, additional, Zhu, Yuangang, additional, Zoladek, Teresa, additional, Zong, Wei-Xing, additional, Zorzano, Antonio, additional, Zschocke, Jürgen, additional, and Zuckerbraun, Brian, additional

Published
2012
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39. A Combination of Biochemical and Proteomic Analyses Reveals Bx-LEC-1 as an Antigenic Target for the Monoclonal Antibody 3-2A7-2H5-D9-F10 Specific to the Pine Wood Nematode

Author

Lee, Dae-Weon, primary, Seo, Jong Bok, additional, Nam, Myung Hee, additional, Kang, Jae Soon, additional, Kim, Soo Young, additional, Kim, A-Young, additional, Kim, Won Tae, additional, Choi, Jin Kyu, additional, Um, Yurry, additional, Lee, Yi, additional, Moon, Il-Sung, additional, Han, Hye Rim, additional, Koh, Sang-Hyun, additional, Je, Yeon Ho, additional, Lim, Kook Jin, additional, Lee, Si Hyeock, additional, and Koh, Young Ho, additional

Published
2011
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40. E6 and E7 fusion immunoglobulin from human papilloma virus 16 induces dendritic cell maturation and antigen specific activation of T helper 1 response

Author

Kim, Sang-Hoon, primary, Hur, Yu Jin, additional, Lee, Suk Jun, additional, Kim, Sang Joon, additional, Park, Chung-Gyu, additional, Oh, Yu-Koung, additional, Jung, Woon-Won, additional, Seo, Jong Bok, additional, Nam, Myung Hee, additional, Choi, Inho, additional, and Chun, Taehoon, additional

Published
2010
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44. Analysis of low molecular weight plasma proteins using ultrafiltration and large gel two-dimensional electrophoresis

Author

Jung, Woon-Won, primary, Phark, Sohee, additional, Oh, Sangnam, additional, Khim, Jin-Young, additional, Lee, Juneyoung, additional, Nam, Myung Hee, additional, Seo, Jong Bok, additional, Park, So-Young, additional, Jo, Eunkyung, additional, Choi, Seonyoung, additional, Zheng, Zhi, additional, Lee, Ji Young, additional, Lee, Min, additional, Lee, Eunil, additional, and Sul, Donggeun, additional

Published
2009
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49. Comparative Proteomic Label-Free Analysis of Campylobacter jejuniNCTC 11168 Cultured with Porcine Mucin

Author

Hong, Sahyun, Cha, Injun, Kim, Nan-Ok, Seo, Jong-Bok, Kim, Soo-Young, Kim, Jong-Hyun, Chung, Gyung Tae, Jeon, Byeonghwa, and Kang, Yeon-Ho

Abstract

AbstractCampylobacter jejuniis a major gastrointestinal pathogen in humans. Poultry is a primary reservoir for C. jejuni, and C. jejuniappears to be highly adapted to the gastrointestinal tracts of avian species. We determined the protein expression profiles of C. jejuniNCTC 11168 cultured in medium containing porcine mucin. Differentially expressed proteins in the presence and absence of porcine mucin were identified using the label-free method. We identified 52 proteins with expression that was either upregulated (32 proteins) or downregulated (20 proteins) by porcine mucin. These proteins are involved in diverse cellular functions, such as motility, cell wall synthesis, iron transport, energy production, and amino acid metabolism. In particular, the upregulated proteins were involved in chemotaxis (CheV and CetA), motility (FlaA), colonization and adherence (CadF, FrdA, CfrA, MapA, and HydA), and stress tolerance (TrxB and ClpB). These results suggest that C. jejunichanges its protein expression in response to porcine mucin and that this change in expression may contribute to host adaptation of C. jejuniNCTC 11168.

Published
2014
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50. Comparisons of proteomic profiles of whey protein between donor human milk collected earlier than 3 months and 6 months after delivery.

Author

Won-Ho Hahn, Joon-Hwan Song, Jong-Bok Seo, Jung Eun Lee, Jeong-Sang Lee, Seunghyun Song, Joohyun Lee, Nam Mi Kang, Hahn, Won-Ho, Song, Joon-Hwan, Seo, Jong-Bok, Lee, Jung Eun, Lee, Jeong-Sang, Song, Seunghyun, Lee, Joohyun, and Kang, Nam Mi

Subjects
*BREAST milk, *NUTRITIONAL value of milk, *DEVELOPMENT of premature infants, *BIOINFORMATICS, *MASS spectrometry, *CARBOHYDRATE metabolism, *THERAPEUTICS, *CARRIER proteins, *PUERPERIUM, *PROTEOMICS, *WHEY proteins
Abstract

Background and Objectives: Human milk has nutritional, protective, and developmental advantages for premature infants. However, proteomic information of low abundant protein of donor milk is insufficient. The purpose of this study is to analyze and compare the proteome of low abundant protein of donor milk obtained at different postpartum ages other than the colostrum.Methods and Study Design: Donor breast milk from 12 healthy mothers was collected 15 days, 2 months and 6 months after delivery and stored by medically approved methods. The whey milk proteomes were analyzed by mass spectrometry and classified using bioinformatics analysis.Results: Human milk obtained 15 days and 2 months after delivery showed more abundant expression of whey proteins related to the generation of precursor metabolites and energy, metabolism, and catalytic activity, compared with milk collected at 3 months. Immune and transport-related proteins were abundant at all time points. Proteins involved in cellular movement, immune cell trafficking, and the carbohydrate metabolism network was more abundant in whey milk collected at 15 day and 2 months using a network analysis.Conclusions: We report proteomic information for human donor whey protein. As significant changes were found in whey proteome collected earlier than 2 months and 6 months after delivery, selecting human donor milk earlier than 2 months might be more helpful for early postnatal recipients. [ABSTRACT FROM AUTHOR]

Published
2018
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