Search

Your search keyword '"Seo, Keunhee"' showing total 12 results
Start Over Author "Seo, Keunhee"
12 results on '"Seo, Keunhee"'

4. MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans

Author

Jung, Yoonji, primary, Artan, Murat, additional, Kim, Nari, additional, Yeom, Jeonghun, additional, Hwang, Ara B., additional, Jeong, Dae-Eun, additional, Altintas, Özlem, additional, Seo, Keunhee, additional, Seo, Mihwa, additional, Lee, Dongyeop, additional, Hwang, Wooseon, additional, Lee, Yujin, additional, Sohn, Jooyeon, additional, Kim, Eun Ji E., additional, Ju, Sungeun, additional, Han, Seong Kyu, additional, Nam, Hyun-Jun, additional, Adams, Linnea, additional, Ryu, Youngjae, additional, Moon, Dong Jin, additional, Kang, Chanhee, additional, Yoo, Joo-Yeon, additional, Park, Sang Ki, additional, Ha, Chang Man, additional, Hansen, Malene, additional, Kim, Sanguk, additional, Lee, Cheolju, additional, Park, Seung-Yeol, additional, and Lee, Seung-Jae V., additional

Published
2021
Full Text
View/download PDF

6. KIN‐4/MAST kinase promotes PTEN‐mediated longevity of Caenorhabditis elegans via binding through a PDZ domain

Author

An, Seon Woo A., primary, Choi, Eun‐Seok, additional, Hwang, Wooseon, additional, Son, Heehwa G., additional, Yang, Jae‐Seong, additional, Seo, Keunhee, additional, Nam, Hyun‐Jun, additional, Nguyen, Nhung T. H., additional, Kim, Eun Ji E., additional, Suh, Bo Kyoung, additional, Kim, Youngran, additional, Nakano, Shunji, additional, Ryu, Youngjae, additional, Man Ha, Chang, additional, Mori, Ikue, additional, Park, Sang Ki, additional, Yoo, Joo‐Yeon, additional, Kim, Sanguk, additional, and Lee, Seung‐Jae V., additional

Published
2019
Full Text
View/download PDF

7. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

Author

Son, Heehwa G., primary, Seo, Keunhee, additional, Seo, Mihwa, additional, Park, Sangsoon, additional, Ham, Seokjin, additional, An, Seon Woo A., additional, Choi, Eun-Seok, additional, Lee, Yujin, additional, Baek, Haeshim, additional, Kim, Eunju, additional, Ryu, Youngjae, additional, Ha, Chang Man, additional, Hsu, Ao-Lin, additional, Roh, Tae-Young, additional, Jang, Sung Key, additional, and Lee, Seung-Jae V., additional

Published
2018
Full Text
View/download PDF

8. Mitochondrial chaperoneHSP‐60 regulates anti‐bacterial immunity via p38MAPkinase signaling

Author

Jeong, Dae‐Eun, primary, Lee, Dongyeop, additional, Hwang, Sun‐Young, additional, Lee, Yujin, additional, Lee, Jee‐Eun, additional, Seo, Mihwa, additional, Hwang, Wooseon, additional, Seo, Keunhee, additional, Hwang, Ara B, additional, Artan, Murat, additional, Son, Heehwa G, additional, Jo, Jay‐Hyun, additional, Baek, Haeshim, additional, Oh, Young Min, additional, Ryu, Youngjae, additional, Kim, Hyung‐Jun, additional, Ha, Chang Man, additional, Yoo, Joo‐Yeon, additional, and Lee, Seung‐Jae V, additional

Published
2017
Full Text
View/download PDF

9. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Author

Son, Heehwa G., primary, Seo, Mihwa, additional, Ham, Seokjin, additional, Hwang, Wooseon, additional, Lee, Dongyeop, additional, An, Seon Woo A., additional, Artan, Murat, additional, Seo, Keunhee, additional, Kaletsky, Rachel, additional, Arey, Rachel N., additional, Ryu, Youngjae, additional, Ha, Chang Man, additional, Kim, Yoon Ki, additional, Murphy, Coleen T., additional, Roh, Tae-Young, additional, Nam, Hong Gil, additional, and Lee, Seung-Jae V., additional

Published
2017
Full Text
View/download PDF

11. Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling.

Author

Jeong, Dae‐Eun, Lee, Dongyeop, Hwang, Sun‐Young, Lee, Yujin, Lee, Jee‐Eun, Seo, Mihwa, Hwang, Wooseon, Seo, Keunhee, Hwang, Ara B, Artan, Murat, Son, Heehwa G, Jo, Jay‐Hyun, Baek, Haeshim, Oh, Young Min, Ryu, Youngjae, Kim, Hyung‐Jun, Ha, Chang Man, Yoo, Joo‐Yeon, and Lee, Seung‐Jae V

Subjects
MITOGEN-activated protein kinases, IMMUNOLOGY, EXTRACHROMOSOMAL DNA, CAENORHABDITIS elegans, PSEUDOMONAS aeruginosa
Abstract

Mitochondria play key roles in cellular immunity. How mitochondria contribute to organismal immunity remains poorly understood. Here, we show that HSP-60/ HSPD1, a major mitochondrial chaperone, boosts anti-bacterial immunity through the up-regulation of p38 MAP kinase signaling. We first identify 16 evolutionarily conserved mitochondrial components that affect the immunity of Caenorhabditis elegans against pathogenic Pseudomonas aeruginosa ( PA14). Among them, the mitochondrial chaperone HSP-60 is necessary and sufficient to increase resistance to PA14. We show that HSP-60 in the intestine and neurons is crucial for the resistance to PA14. We then find that p38 MAP kinase signaling, an evolutionarily conserved anti-bacterial immune pathway, is down-regulated by genetic inhibition of hsp-60, and up-regulated by increased expression of hsp-60. Overexpression of HSPD1, the mammalian ortholog of hsp-60, increases p38 MAP kinase activity in human cells, suggesting an evolutionarily conserved mechanism. Further, cytosol-localized HSP-60 physically binds and stabilizes SEK-1/ MAP kinase kinase 3, which in turn up-regulates p38 MAP kinase and increases immunity. Our study suggests that mitochondrial chaperones protect host eukaryotes from pathogenic bacteria by up-regulating cytosolic p38 MAPK signaling. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results