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27 results on '"Seok, Jong Hyeon"'

4. Mosaic display of stable hemagglutinin monomers induces broad immune responses

Author

Kim, Hyojin, primary, Min, Seong Cheol, additional, Lee, Dan Bi, additional, Jeong, Ju Hwan, additional, Kim, Eun Jeong, additional, Maeng, Jin Young, additional, Seok, Jong Hyeon, additional, Lee, Ji-Hye, additional, Jang, Yuyeon, additional, Jang, Ui Soon, additional, Ysenbaert, Tine, additional, Catani, Joao Paulo Portela, additional, Lee, JeongAh, additional, Lee, Yeongeun, additional, Kim, Youn Kyung, additional, Lee, Gyudo, additional, Mun, Ji Young, additional, Jun, Hyun Sik, additional, Baek, Yun Hee, additional, Saelens, Xavier, additional, Lee, Jiwon, additional, Chung, Mi Sook, additional, Song, Min-Suk, additional, and Kim, Kyung Hyun, additional

Published
2024
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5. Mutational analysis of severe acute respiratory syndrome coronavirus 2 in immunocompromised patients with persistent viral detection using whole genome sequencing

Author

Chang, Euijin, primary, Lee, Jungmin, additional, Kim, Jun‐Won, additional, Seok, Jong Hyeon, additional, Bae, Joon‐Yong, additional, Kim, Jeonghun, additional, Park, Heedo, additional, Jang, Choi‐Young, additional, Kang, Sung‐Woon, additional, Lim, So Yun, additional, Kim, Ji Yeun, additional, Yang, Jeong‐Sun, additional, Kim, Kyung‐Chang, additional, Lee, Joo‐Yeon, additional, Park, Man‐Seong, additional, and Kim, Sung‐Han, additional

Published
2023
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7. Genome-informed investigation of the molecular evolution and genetic reassortment of severe fever with thrombocytopenia syndrome virus

Author

Lee, Kyuyoung, primary, Seok, Jong Hyeon, additional, Kim, Hyunbeen, additional, Park, Sejik, additional, Lee, Sohyun, additional, Bae, Joon-Yong, additional, Jeon, Kyeongseok, additional, Kang, Jun-Gu, additional, Yoo, Jeong Rae, additional, Heo, Sang Taek, additional, Cho, Nam-Hyuk, additional, Lee, Keun Hwa, additional, Kim, Kisoon, additional, Park, Man-Seong, additional, and Kim, Jin Il, additional

Published
2023
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10. Humoral and cellular immunogenicity of homologous and heterologous booster vaccination in Ad26.COV2.S-primed individuals: Comparison by breakthrough infection

Author

Hyun, Hakjun, primary, Jang, A-Yeung, additional, Park, Heedo, additional, Heo, Jung Yeon, additional, Seo, Yu Bin, additional, Nham, Eliel, additional, Yoon, Jin Gu, additional, Seong, Hye, additional, Noh, Ji Yun, additional, Cheong, Hee Jin, additional, Kim, Woo Joo, additional, Yoon, Soo-Young, additional, Seok, Jong Hyeon, additional, Kim, Jineui, additional, Park, Man-Seong, additional, and Song, Joon Young, additional

Published
2023
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12. MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants

Author

Lee, Sua, primary, Jang, Shina, additional, Kang, Jihoon, additional, Park, Soo Bin, additional, Han, Young Woo, additional, Nam, Hyemi, additional, Kim, Munkyung, additional, Lee, Jeewon, additional, Cho, Ki Joon, additional, Kim, Jeonghun, additional, Oh, Miyoung, additional, Ryu, Jihye, additional, Seok, Jong Hyeon, additional, Kim, Yunhwa, additional, Lee, Jee-Boong, additional, Park, Man-Seong, additional, Kim, Yong-Sung, additional, Park, Hosun, additional, and Kim, Dong-Sik, additional

Published
2021
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17. Author Correction: Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

Author

Lee, Dan Bi, primary, Kim, Jong-Min, additional, Seok, Jong Hyeon, additional, Lee, Ji-Hye, additional, Jo, Jae Deok, additional, Mun, Ji Young, additional, Conrad, Chelsie, additional, Coe, Jesse, additional, Nelson, Garrett, additional, Hogue, Brenda, additional, White, Thomas A., additional, Zatsepin, Nadia, additional, Weierstall, Uwe, additional, Barty, Anton, additional, Chapman, Henry, additional, Fromme, Petra, additional, Spence, John, additional, Chung, Mi Sook, additional, Oh, Chang-Hyun, additional, and Kim, Kyung Hyun, additional

Published
2018
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18. Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography

Author

Lee, Dan Bi, primary, Kim, Jong-Min, additional, Seok, Jong Hyeon, additional, Lee, Ji-Hye, additional, Jo, Jae Deok, additional, Mun, Ji Young, additional, Conrad, Chelsie, additional, Coe, Jesse, additional, Nelson, Garrett, additional, Hogue, Brenda, additional, White, Thomas A., additional, Zatsepin, Nadia, additional, Weierstall, Uwe, additional, Barty, Anton, additional, Chapman, Henry, additional, Fromme, Petra, additional, Spence, John, additional, Chung, Mi Sook, additional, Oh, Chang-Hyun, additional, and Kim, Kyung Hyun, additional

Published
2018
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21. Crystal Structure of Dimeric Human Peroxiredoxin-1 C83S Mutant

Author

Cho, Ki Joon, primary, Park, YiHo, additional, Khan, Taslima, additional, Lee, Ji-Hye, additional, Kim, Sella, additional, Seok, Jong Hyeon, additional, Chung, Yeon Bin, additional, Cho, Art E., additional, Choi, Yongseok, additional, Chang, Tong-Shin, additional, and Kim, Kyung Hyun, additional

Published
2015
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22. Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody

Author

Cho, Ki Joon, primary, Schepens, Bert, additional, Seok, Jong Hyeon, additional, Kim, Sella, additional, Roose, Kenny, additional, Lee, Ji-Hye, additional, Gallardo, Rodrigo, additional, Van Hamme, Evelien, additional, Schymkowitz, Joost, additional, Rousseau, Frederic, additional, Fiers, Walter, additional, Saelens, Xavier, additional, and Kim, Kyung Hyun, additional

Published
2015
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25. Insight into structural diversity of influenza virus haemagglutinin

Author

Cho, Ki Joon, primary, Lee, Ji-Hye, additional, Hong, Kwang W., additional, Kim, Se-Ho, additional, Park, Yiho, additional, Lee, Jun Young, additional, Kang, Seokha, additional, Kim, Sella, additional, Yang, Ji Hoon, additional, Kim, Eui-Ki, additional, Seok, Jong Hyeon, additional, Unzai, Satoru, additional, Park, Sam Yong, additional, Saelens, Xavier, additional, Kim, Chul-Joong, additional, Lee, Joo-Yeon, additional, Kang, Chun, additional, Oh, Hee-Bok, additional, Chung, Mi Sook, additional, and Kim, Kyung Hyun, additional

Published
2013
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27. Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection.

Author

Lee JH, Oh M, Seok JH, Kim S, Lee DB, Bae G, Bae HI, Bae SY, Hong YM, Kwon SO, Lee DH, Song CS, Mun JY, Chung MS, and Kim KH

Subjects
Animals, Antiviral Agents administration & dosage, Antiviral Agents isolation & purification, Chromatography, Liquid, Disease Models, Animal, Gallic Acid administration & dosage, Gallic Acid isolation & purification, Influenza A virus physiology, Influenza B virus physiology, Mice, Inbred BALB C, Orthomyxoviridae Infections drug therapy, Survival Analysis, Tandem Mass Spectrometry, Viral Plaque Assay, Antiviral Agents pharmacology, Gallic Acid pharmacology, Influenza A virus drug effects, Influenza B virus drug effects, Rubus chemistry, Seeds chemistry, Virus Replication drug effects
Abstract

Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to show antiviral activities against influenza type A and B viruses. Using the time-of-addition plaque assay, viral replication was almost completely abolished by simultaneous treatment with the RCS fraction of less than a 1-kDa molecular weight (RCSF1). One of the polyphenols derived from RCSF1, gallic acid (GA), identified by liquid chromatography-tandem mass spectrometry, showed inhibitory effects against both influenza type A and B viruses, albeit at relatively high concentrations. RCSF1 was bound to hemagglutinin protein, inhibited hemagglutination significantly and disrupted viral particles, whereas GA was found to only disrupt the viral particles by using transmission electron microscopy. In BALB/c mice infected with influenza virus, oral administration of RCSF1 significantly improved the survival rate and reduced the viral titers in the lungs. Our results demonstrate that RCSF1 and GA show potent and broad antiviral activity against influenza A and B type viruses and are promising sources of agents that target virus particles.

Published
2016
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