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Background: Coronary Artery Disease (CAD) is an important disease where the arteries and vessels supplying oxygen and nutrients to the heart are narrowed or blocked. Early diagnosis and recognition of CAD leads to its complete treatment. Drug therapy, angiography, coronary angioplasty, and in advanced cases, coronary artery bypass surgery restore the normal flow of blood to the heart muscle. Objectives: The present study aimed to identify the association between rs4977574 polymorphism in ANRIL gene and CAD in Iranian patients. Materials and Methods: Blood samples were collected from 100 subjects with positive angiography (case group) and 93 ones with negative angiography (control group). Using Taq Man Real Time PCR, the extracted DNAs from the patients and controls were genotyped for rs4977574 polymorphism in ANRIL gene (applied biosystem, USA). Then, the genotypes and clinical parameters were compared by the SPSS statistical software, version 18 (Chicago, USA). The results were compared by one-way ANOVA, simple T-test, and Chi-square test and were presented as mean ± Standard Deviation (SD). P values < 0.05 were considered as statistically significant. Results: The results showed a significant relationship between CAD and Diastolic Blood Pressure (DBP), Body Mass Index (BMI), uric acid, Low Density Lipoprotein (LDL), cholesterol, and triglyceride. However, no significant association was observed between rs4977574 polymorphism and biochemical characteristics in the two groups. Allele frequency was AA = 22%, AG = 44%, and GG = 34% in the case group and AA = 17%, AG = 44%, and GG = 32% in the control group. Conclusions: The present study examined the association between rs4977574 polymorphism in ANRIL gene and CAD in a population of Iranian patients. The study findings revealed no direct relationship between rs4977574 polymorphism and the disease in Iranian population.