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287 results on '"Sepp Norbert"'

1. Homocysteine metabolism in different human cells

Author

Kurz Katharina, Frick Barbara, Fürhapter Christina, Weiss Günter, Wirleitner Barbara, Sepp Norbert, and Fuchs Dietmar

Subjects
cells, homocysteine, neopterin, Crystallography, QD901-999
Abstract

The effects of cytokine and mitogen stimulation on homocysteine (HCY) metabolism in different cells were investigated: in human dermal microvascular endothelial cells (HDMEC), T lymphocytes, mature and immature dendritic cells, and myelomonocytic (THP-1) and monocytic cell lines (U-937). Furthermore, the influence of supplementation of cells with folate acid, methionine and the combination of both on HCY metabolism was investigated. Unstimulated HDMEC and dendritic cells only produced very little amounts of HCY, and stimulation did not change HCY formation significantly either. However, higher HCY concentrations were detected in HDMEC and dendritic cells under supplementation with methionine and slightly less under supplementation with folate. Proliferating T lymphocytes showed an increase in HCY production on stimulation with increasing doses of mitogens; proliferative activity was associated with HCY formation. THP-1 and U-937 cells produced significantly more HCY than endothelial cells; U-937 cells produced most HCY, which was mainly due to their high proliferation rate. Stimulation of both cell lines with lipopolysaccharide and interferon-γ, respectively, showed a significant effect on HCY production of cells; in THP-1 cells, stimulation with IFN-γ and lipopolysaccharide induced neopterin formation. Methionine supplementation strongly increased and folate supplementation slightly decreased HCY formation in both cell lines. Thus, inflammation may play a role in moderate hyperhomocysteinemia.

Published
2013
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2. Soluble Fas ligand and neopterin in patients with systemic and cutaneous discoid lupus erythematosus

Author

Wirleitner Barbara, Kowald Elisabeth, Widner Bernhard, Ortner Ulrike, Baier-Bitterlich Gabriele, Sepp Norbert, and Fuchs Dietmar

Subjects
sle, cdle, sfasl, pteridines, neopterin, Crystallography, QD901-999
Abstract

Evidence accumulates suggesting that the pathogenesis in systemic lupus erythematosus (SLE) is associated with modulations in the Fas/FasL system. Serum concentrations of soluble Fas ligand (sFasL) were found to be elevated in patients with SLE. In this study we wanted to determine the levels of sFasL and the status of immune activation - monitored by neopterin secretion - in patients with SLE and cutaneous discoid lupus erythematosus (CDLE). Sixty-five serum samples were assayed. We found elevated concentrations of sFasL in patients with SLE and CDLE. The levels of sFasL in COLE patients were significant lower compared to SLE patients. Neopterin concentrations in serum were found to be slightly increased in patients with CDLE. Compared to patients with SLE, activation of the immune system was significant lower in COLE. Taken together, we found d evated levels of sFasL in patients with SLE as well as CDLE, connected with ar activation of the immune system and thereby increased concentration of neopterin in serum.

Published
2000
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6. Autoimmunerkrankungen

Author

Jainta, Silke, Sepp, Norbert, Zillikens, Detlef, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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7. Vaskulitis

Author

Sepp, Norbert, Braun-Falco, Otto, editor, Plewig, Gerd, editor, Wolff, Helmut H., editor, Burgdorf, Walter H. C., editor, and Landthaler, Michael, editor

Published
2005
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8. Hauterkrankungen

Author

Landthaler, Michael, Sachs, Bernhardt, Merk, Hans E., von Schmiedeberg, Sherko, Ruzicka, Thomas, Jainta, Silke, Sepp, Norbert, Zillkens, Detlef, Vogt, Thomas, Stolz, Wilhelm, Strom, Kerstin, Abeck, Dietrich, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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9. Biomedicines / Plasma metabolomic profiling reveals four possibly dsrupted mechanisms in systemic sclerosis

Author

Bögl, Thomas, Mlynek, Franz, Himmelsbach, Markus, Sepp, Norbert, Buchberger, Wolfgang, and Geroldinger-Simic, Marija

Subjects
lipids, ion mobility, gut dysbiosis, integumentary system, systemic sclerosis, urea cycle, MS, skin and connective tissue diseases, metabolomics, LC-MS, kynurenine pathway
Abstract

Systemic sclerosis (SSc) is a rare systemic autoimmune disorder marked by high morbidity and increased risk of mortality. Our study aimed to analyze metabolomic profiles of plasma from SSc patients by using targeted and untargeted metabolomics approaches. Furthermore, we aimed to detect biochemical mechanisms relevant to the pathophysiology of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry technology. The investigation of plasma samples from SSc patients (n = 52) compared to a control group (n = 48) allowed us to identify four different dysfunctional metabolic mechanisms, which can be assigned to the kynurenine pathway, the urea cycle, lipid metabolism, and the gut microbiome. These significantly altered metabolic pathways are associated with inflammation, vascular damage, fibrosis, and gut dysbiosis and might be relevant for the pathophysiology of SSc. Further studies are needed to explore the role of these metabolomic networks as possible therapeutic targets of SSc. Version of record

Published
2022

14. Diagnostics / Changes in plasma phospholipid metabolism are associated with clinical manifestations of systemic sclerosis

Author

Geroldinger-Simic, Marija, Bögl, Thomas, Himmelsbach, Markus, Sepp, Norbert, and Buchberger, Wolfgang

Subjects
sicca, integumentary system, systemic sclerosis, lung fibrosis, digital ulcers, lipidomics, lipids (amino acids, peptides, and proteins), skin fibrosis, skin and connective tissue diseases, plasmalogens, calcinosis cutis, phospholipids, sphingomyelin
Abstract

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that lipid metabolism was relevant for autoimmune diseases, but little is known about the role of lipids in SSc. In the present study, we sought to explore the phospholipid profile of SSc by using the lipidomics approach. We also aimed to analyze lipidomics results for different clinical manifestations of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry for the lipidomic profiling of plasma samples from patients with SSc. Our study showed, for the first time, significant changes in the level of phospholipids such as plasmalogens and sphingomyelins from the plasma of SSc patients as compared to controls. Phosphatidylcholine plasmalogens species and sphingomyelins were significantly increased in SSc patients as compared to controls. Our results also demonstrated a significant association of changes in the metabolism of phospholipids (phosphatidylcholine and phosphatidylethanolamine plasmalogens species and sphingomyelins) with different clinical manifestations of SSc. Further lipidomic studies might lead to the detection of lipids as new biomarkers or therapeutic targets of SSc. Version of record

Published
2021

35. Mastozytosen

Author

Fritsch, Peter, primary, Topar, Gerda, additional, and Sepp, Norbert, additional

Published
1999
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