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Abstract This study tested the hypothesis that bowel preparation with mannitol should not affect the colonic concentration of H2 and CH4. Therefore, the SATISFACTION study, an international, multicenter, randomized, parallel‐group phase II–III study investigated this issue. The phase II dose‐finding part of the study evaluated H2, CH4, and O2 concentrations in 179 patients randomized to treatment with 50 g, 100 g, or 150 g mannitol. Phase III of the study compared the presence of intestinal gases in 680 patients randomized (1:1) to receive mannitol 100 g in single dose or a standard split‐dose 2 L polyethylene glycol (PEG)‐Asc preparation (2 L PEG‐Asc). Phase II results showed that mannitol did not influence the concentration of intestinal gases. During phase III, no patient in either group had H2 or CH4 concentrations above the critical thresholds. In patients with H2 and/or CH4 levels above detectable concentrations, the mean values were below the risk thresholds by at least one order of magnitude. The results also highlighted the effectiveness of standard washing and insufflation maneuvers in removing residual intestinal gases. In conclusion, bowel cleansing with mannitol was safe as the concentrations of H2 and CH4 were the same as those found in patients prepared with 2 L PEG‐Asc. In both groups, the concentrations of gases were influenced more by the degree of cleansing achieved and the insufflation and washing maneuvers performed than by the preparation used for bowel cleansing. The trial protocol was registered with ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885) and with EudraCT (eudract_number: 2019‐002856‐18).

Three-dimensional structure of currents in the Bransfield Strait (BS) was measured in 2017 over 50 transects across the strait using a Shipborne Acoustic Current Doppler Profiler (SADCP) onboard the R/V Akademik Sergey Vavilov and Akademik Ioffe. These data were used to determine local features of the three-dimensional velocity field of the currents. The sections crossed all three basins of the BS and the main flows in the strait including the Bransfield Current and the southwestward flow of Weddell Sea waters along the Antarctic Peninsula. Two vessels are equipped with different SADCP systems with frequencies of 76.8 kHz and 38.4 kHz, which allows us to compare the data from different SADCPs. The observations reveal that very dense waters from the Weddell Sea propagate in deep layers over the shelf break; this flow is usually not observed at the sea surface. Vertical structure of the Bransfield Current significantly differs from the flow of the Weddell Sea waters and its velocity maximum is located in the upper ocean layer. We also used two gridded altimetry products of 0.25° and 0.1° resolution for investigations of circulation in the BS. We analyzed the efficiency of satellite altimetry in reproducing currents in conditions of a narrow strait and evaluated its accuracy using field velocity observations. We found that satellite altimetry can be used for identification of the mean ocean circulation patterns within the BS. However, daily altimetry data contain significant discrepancies with the in situ data and require direct measurements for studies of the BS circulation.