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The developed HoloDoctor software package allows performing surgical operations in real time. It should be emphasized that the operation time on the HoloDoctor PC is reduced by 20-30% compared to traditional methods. The performance of HoloLens glasses with our program is high, while allowing the doctor to save time. The complex provides diagnostics, therapy planning, treatment adjustment as needed and minimizes the risk of medical error. HoloDoctor can be used in educational practice by integrating it into educational programs for medical specialties.

This article presents a proposed insight into the anti-viral potential of silver nanoparticles against novel coronavirus disease (COVID-19). Possible mechanisms of influence of silver nanoparticles on the coronavirus are considered. Models of nanosilver complexes with spike protein of coronavirus amino acids were constructed using computer quantum-chemical modeling. The values of electron density distribution, highest occupied molecular orbital, lowest unoccupied molecular orbital and electron density distribution gradient for each constructed model are obtained. Analysis of the obtained data showed that the most energy-efficient interaction is the formation of the "tryptophan–nanosilver" complex (E= - 5856.83 kkal/mol). According to the results of quantum chemical calculations, the most stable complex is the "cysteine– Ag nanoparticles" complex (ΔE = 0.16 a. u.).

In this paper, the contrasting properties of titanium dioxide nanoparticles in various compositions were considered. In the course of the work, methods for the synthesis of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2 and SiO2-TiO2-ZrO2 were developed; the microstructure of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2was studied; the stability of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 was determined. The elemental composition of the oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 has also been studied using SEM and XRD methods. It was found that SiO2-TiO2-ZrO2 nanocomposites with content of titanium dioxide from 8 to 9.5 % and zirconium dioxide from 0.5 to 2 % are completely insoluble in a highly alkaline medium. Thus, this composition is the most optimal for use as a contrast agent in optical coherence tomography.

Preoperative assessment of an echinococcal liver cyst with surrounding tissue structures is extremely important for planning the course of surgical intervention. The paper presents the first experience of treating a patient with a parasitic cyst using three-dimensional reconstruction of the liver affected by echinococcus at the preoperative stage. The use of this approach made it possible to avoid the development of intraoperative complications and get a good treatment result.

The development of modern computer technologies has made it possible to introduce into orthodontic practice the latest methods of diagnosis and treatment of dentoalveolar anomalies. Domestic orthodontics, which has an extensive scientific base, has received the opportunity for technological development since the beginning of the 90s. The Department of Orthodontics Moscow State University of Medicine and Dentistry named after A.I. Evdokimov of the Ministry of Health of Russia (Moscow, Russia), throughout its scientific experience, under the guidance of Corresponding Member of the Russian Academy of Medical Sciences, Doctor of Medical Sciences, Professor L.S. Persina, uses modern diagnostic methods in her diagnostic arsenal to analyze the morphological state of the dentition.

The purpose of this scientific article is to show the possibility of using the HoloDoctor software and hardware complex, which includes the following modules: the anatomical atlas module, the data analysis module and the surgical intervention simulation module. HoloDoctor allows us to perform surgical operations in real time. The time of operations using the HoloDoctor is reduced by 20-30% compared to traditional methods. The developed complex provides diagnostics of treatment planning, correction of the treatment plan, minimizing the risk of medical error. The developed product can be used in educational practice by introducing it into educational programs of medical specialties.

In the Russian Federation, there is a tendency to increase the incidence of a number of nosologies, the prevalence of chronic diseases and the deterioration of health among children and adolescents. Diseases of the digestive organs occupy a leading place in the structure of somatic pathology of childhood. According to the statistical data of the Ministry of Health of the Republic of North Ossetia – Alania (RNO – Alania), for seven years the prevalence of pathology of the digestive organs, including inflammatory bowel diseases, among children and adolescents has increased in the republic as a whole and regions separately. By 2022, it is predicted that the level of general and newly detected morbidity among children with pathology of the upper digestive tract will increase by 1.5-2 times.

In consequence of experimental researches on the study of new biologically active medication on brewer’s yeast, which were in the conditions of growing and dairy cattle’s operation in Moldova, and in the number of livestock breeding farms in the Stavropol Territory of the Russian Federation the physiological indicators were obtained and statistically processed in 2020. During the experiment, the cows from the first and the second lactation and herd replacements of the Holstain breed were involved. The researches included the study of the effect of the medication on mature animal and young cattle. According to the research result, the claimed medication which is used in feeding pregnant cows and rearing cows has a positive effect on some aspects of reproductive indicators in the postpartum period and contributes to the growth and development of young cattle.

The purpose of the research work was to select the optimal conditions for the cultivation of microorganisms. As a result of the conducted research work, the modes of growing a nitrogen-fixing culture and a microorganism with high enzymatic activity were selected and worked out. At the same time, the optimal conditions for the cultivation of Azotobacter sp were determined – the temperature optimum for cell accumulation was 30°C, for increased polysaccharide production 20 °C, aeration within 5-10 l/l/min, agitator speed-150 rpm, pH value within 6.0±0.2 units, which allowed to achieve a cell titer of at least 1.0×109 CFU/ml. A cost-effective nutrient medium was selected for growing Pseudomonas sp. molasses-autolysate medium and optimal conditions for growing the culture: cultivation temperature 30-32 °C, aeration 1.0-1.5 l/l/ min, agitator speed 150-200 rpm, pH 6.8-7.2 units, sub-titration 5.0 % KOH, defoaming with adecanol, cultivation time-72 hours, which allowed to achieve a cell titer of at least 1.0×109 CFU/ml.

The article is devoted to increasing the efficiency of treatment of deep caries, which is an urgent problem of modern dentistry. The aim of this study was to evaluate the results of the treatment of deep caries using the KERR "Life" calcium hydroxide treatment liner, which is a radiopaque, durable material based on calcium hydroxide and salicylate ester, recommended for direct or indirect pulp capping and as a cementitious base for all restorative filling materials. The study involved 26 patients. The studies carried out have confirmed the efficiency of the treatment of deep caries with the Life pad and confirmed the possibility of its widespread use in practice.

The aim of the study was to determine the effect of the inhibitor of janus kinase – baricitinib ("Olumiant") on the course of COVID-19. This drug baricitinib is able to suppress the systemic inflammatory response, which is one of the common causes of death in COVID-19, is an urgent problem of the study. The study was carried out in the Regional Specialized Budget Infectious Diseases Hospital of Stavropol (Russian Federation, Stavropol Region). In a multivariate analysis, it was shown that the use of baricitinib was associated with a decrease in the frequency of the primary endpoint of death/need for invasive lung ventilation. The use of baricitinib was quite safe, but in some patients there was an increase in the level of transaminases. No cases of hypercoagulation have been reported while taking baricitinib. It was found that patients with a normal BMI are more sensitive to therapy than those who are overweight.75% of patients in the first group had a temperature above 38.0oC. However, against the background of taking the standard treatment regimen and baricitinib, it was noted that the temperature stabilized during the day and did not rise again. Against the background of taking baricitinib, the elimination of the phenomena of respiratory failure and the refusal of an oxygen mask occurred 3.1 times more often than without baricitinib. The authors concluded that the use of baricitinib can be considered as an additional therapy for moderate forms of pneumonia in patients over 65 years or in patients with concomitant chronic diseases in order to suppress the reactions of systemic inflammation and the development of serious respiratory and other system lesions caused by COVID-19.

Background: Bim is a Bcl-2 homology 3 (BH3)-only proteins, a group of pro-apoptotic proteins involved in physiological and pathological conditions. Both the overexpression and under-expression of Bim protein are associated with the diseased condition, and various isoforms of Bim protein are present with differential apoptotic potential. Objective: The present study attempted to envisage the association of various molecular signatures with the codon choices of Bim isoforms. Methods: Molecular signatures like composition, codon usage, nucleotide skews, the free energy of mRNA transcript, physical properties of proteins, codon adaptation index, relative synonymous codon usage, and dinucleotide odds ratio were determined and analyzed for their associations with codon choices of Bim gene. Results: Skew analysis of the Bim gene indicated the preference of C nucleotide over G, A, and T and preference of G over T and A nucleotides was observed. An increase in C content at the first and third codon position increased gene expression while it decreased at the second codon position. Compositional constraints on nucleotide C at all three codon positions affected gene expression. The analysis revealed an exceptionally high usage of CpC dinucleotide in all the envisaged 31 isoforms of Bim. We correlated it with the requirement of rapid demethylation machinery to fine-tune the Bimgene expression. Also, mutational pressure played a dominant role in shaping codon usage bias in Bim isoforms. Conclusion: An exceptionally high usage of CpC dinucleotide in all the envisaged 31 isoforms of Bim indicates a high order selectional force to fine tune Bim gene expression.

International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 12, 13, 12A13K: 1-7

In this article, we presents the synthesis and research of a tool for removing metal inclusions from the surface of car paint coatings. The optimal composition of the product was determined, which includes sodium laureth sulfate, citric acid, sulfosalicylic acid, hydrogen peroxide and water. As a result of the conducted studies, a connection was established between the composition and the physicochemical, surface-active properties of the developed agent. Approbation of this tool was carried out, which confirmed its effectiveness and showed that within 30–45 s after applying the developed tool, not only are metal inclusions on the surface of car paint coating removed but also mineral contaminants in the form of sand, earth, clay and other particles. The aim of the work was to develop and optimize a method for obtaining a low-toxicity, highly effective agent for removing metal inclusions from the surface of car paint coatings and to investigate its effectiveness, as well as its physicochemical, optical and surface-active properties.