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Our recent algorithm,Hapi, infers chromosome-scale haplotypes using genomic data of a small number of single gametes. Its advanced version,IIIandMe, is proposed here to achieve comparable phasing accuracy with as few as three gametes, pushing the analysis to its limit. The new method is validated with simulation and a citrus gamete dataset. The rapid advances in genotyping technologies promise a broad application ofIIIandMein disclosing important genetic information.

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, male, 37 years, Clinical History: A 37-year-old man with a history of dyspnea, dry cough and weight loss, significantly worsen in years. Similarly, the restrictive ventilatory defect and impairment of DLco got worse during our observation. Besides, lung CT examinations were carried out at... Final Diagnosis: Pleuroparenchymal fibroelastosis

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, female, 34 years, Clinical History: We present the case of a 34 years old African woman, to our osservation as outpatient, for a soft and palpable neck mass to be investigate with MR in view of an eventual surgical removal. Her clinical past history was irrelevant. Final Diagnosis: Systemic lymphangiomatosis

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, female, 47 years, Clinical History: A 47 year old female to our observation for worsening dyspnea and weakness. The patient was noted for HCV/HIV co-infection. Final Diagnosis: Hepatopulmonary syndrome and portopulmonary hypertension

Synovial sarcoma (SS) primarily occurs in the para-articular soft tissue of the lower extremities in young adults and it is extremely rare in the prostatic region. We report a case of a 46-year-old man who presented with urinary retention. Pelvic ultrasound (US) examination, computed tomography (CT), and magnetic resonance imaging (MRI) demonstrated an 8.5 cm mass that appeared to originate in the prostatic fascia of the right lobe. Preoperative prostatic ultrasound transrectal needle biopsy revealed mesenchymal neoplastic tissue. Patient underwent surgery. The final pathologic findings were consistent with the diagnosis of monophasic synovial sarcoma.

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, female, 84 years, Clinical History: Patient with known left adrenal mass, detected by US and CT. She refused abdominal MR and surgical excision of the mass. Therefore, CEUS was performed and CT follow-up was suggested. In her clinical history, more than ten years ago gastrectomy for maligna... Final Diagnosis: Adrenal hemangioma.

We consider a diffuse interface model for an incompressible isothermal mixture of two viscous Newtonian fluids with different densities in a bounded domain in two or three space dimensions. The model is the nonlocal version of the one recently derived by Abels, Garcke and Grün and consists of a Navier-Stokes type system coupled with a convective nonlocal Cahn-Hilliard equation. The density of the mixture depends on an order parameter. For this nonlocal system we prove existence of global dissipative weak solutions for the case of singular double-well potentials and non degenerate mobilities. To this goal we devise an approach which is completely independent of the one employed by Abels, Depner and Garcke to establish existence of weak solutions for the local Abels et al. model.

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, male, 42 years, Clinical History: We present a case of a 42 year old man with chest pain, purulent sputum and dyspnea, that persisted for several days. The patient reported an important weight loss in the last period. HIV test was positive and CD4 T-cell count was 30 cells/μL. A chest CT... Final Diagnosis: Rhodococcus equi pneumonia

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, female, 55 years, Clinical History: A case of a 55 years old female is presented, who did not have history of cigarette smoking nor chemicals or professional exposure, and did not complain of respiratory symptoms. A chest X-ray, performed for a car accident, showed abnormal findings, ... Final Diagnosis: Localized pulmonary amyloidosis

We study a diffuse interface model for incompressible isothermal mixtures of two immiscible fluids coupling the Navier--Stokes system with a convective nonlocal Cahn--Hilliard equation in two dimensions of space. We apply recently proved well-posedness and regularity results in order to establish existence of optimal controls as well as first-order necessary optimality conditions for an associated optimal control problem in which a distributed control is applied to the fluid flow., Comment: 32 pages

Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis, male, 39 years, Clinical History: We report the case of a 39-yr-old Asian man, immunocompetent, presenting with a symptomatology characterized by fever, diarrhea, weight loss and abdominal distension; these symptoms started 10 days before his admission to our hospital. Erythrocyte s... Final Diagnosis: Diagnosis of abdominal tuberculosis was confirmed by histological omental biopsy.

We consider a diffuse interface model which describes the motion of an incompressible isothermal mixture of two immiscible fluids. This model consists of the Navier-Stokes equations coupled with a convective nonlocal Cahn-Hilliard equation. Several results were already proven by two of the present authors. However, in the two-dimensional case, the uniqueness of weak solutions was still open. Here we establish such a result even in the case of degenerate mobility and singular potential. Moreover, we show the strong-weak uniqueness in the case of viscosity depending on the order parameter, provided that the mobility is constant and the potential is regular. In the case of constant viscosity, on account of the uniqueness results we can deduce the connectedness of the global attractor whose existence was obtained in a previous paper. The uniqueness technique can be adapted to show the validity of a smoothing property for the difference of two trajectories which is crucial to establish the existence of an exponential attractor.

As a complement to whole-genome sequencing efforts, we are comparing targeted genomic regions among sweet orange cultivars to identify coding and conserved noncoding regions, including regulatory elements, responsible for biological features unique to this species. Here, we report the identification of 1,018 bacterial artificial chromosome (BAC) clones containing genes relevant to fruit quality from a Citrus sinensis cv. “Vaniglia” 19.3X BAC library by two-dimensional 9 × 9 overgo hybridization. To design the overgo probes, we used the “C38” expressed sequence tag assembly ( http://harvest.ucr.edu/ ) and OligoSpawn software ( http://138.23.178.42 ). For BAC library screening, we selected 81 overgo probes associated with unigenes that putatively code for enzymes relevant to fruit quality (flavonol, anthocyanin, carotenoid, cellulose, starch, ascorbic acid, aromatic amino acid, and lignin biosynthesis; sucrose catabolism; glycolysis; oxidative/nonoxidative pentose phosphate pathway; fatty acid biosynthesis and oxidation; Krebs cycle). Hybridization probes were pooled and hybridized in groups of intersecting rows and columns to high-density BAC filters, followed by a deconvolution process that established BAC-probe addresses. BAC addresses were obtained for 75 of the 81 overgo probes initially selected, for a total of 1,018 BAC clones, a number consistent with the depth of coverage of the BAC library. BAC end sequencing was carried out, and end-sequence pairs were mapped to their best location in the Citrus clementina genome sequence assembly using the comparative genomic database Phytozome ( http://www.phytozome.net/ ). The BAC clones corresponding to each probe were mapped within the same scaffold as the target gene, demonstrating that the approach we used was successful in isolating the targeted genomic regions.