Sergio Rius-Pérez, Carmen Choya-Foces, Jordi Muntané, María A. Rodríguez-Hernández, Antonio Miranda-Vizuete, C. Alicia Padilla, Raúl González, Antonio Martínez-Ruiz, Juan Sastre, María Negrete, Patricia de la Cruz-Ojeda, Kalina Ranguelova, Anne-Odile Hueber, José Antonio Bárcena, Aurélie Rossin, [González,R, Rodríguez-Hernández,MA, Negrete,M, de la Cruz-Ojeda,P, Miranda-Vizuete,A, Muntané,J] Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen Del Rocío'/CSIC/University of Seville, Seville, Spain. [Ranguelova,K] Bruker BioSpin Corporation, Billerica, MA, USA. [Rossin,A, Hueber,AO] Université Côte D'Azur, CNRS, Inserm, iBV, Nice, France. [Choya-Foces,C, Martínez-Ruiz,A] Research Unit, Hospital University 'Santa Cristina', Health Research Institute 'La Princesa' (IIS-IP), Madrid, Spain. [Choya-Foces,C, Martínez-Ruiz,A] Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Rius-Pérez,S, Sastre,J] Department of Physiology, Faculty of Pharmacy, University of Valencia. Burjassot, Valencia, Spain. [Bárcena,JA, Padilla,CA] Department of Biochemistry and Molecular Biology, University of Cordoba, Cordoba, Spain. [Bárcena,JA, Padilla,CA] Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain. [Muntané,J] Department of General Surgery, Hospital University 'Virgen del Rocío'/IBiS/CSIC/University of Seville, Seville, Spain. [González,R, Muntané,J] Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd), Madrid, Spain., This study was funded by Institute of Health Carlos III (ISCIII) (PI13/00021, PI15/00107, PI16/00090 and PI19/01266), Spanish Ministry of Economy and Competitiveness (SAF2015-71208-R, BFU2016-8006-P, PGC2018-094276-B-I00 and RED2018-102576-T), Andalusian Ministry of Economy, Innovation, Science and Employment (BIO-216 and CTS-6264) and Andalusian Ministry of Equality, Health and Social Policies (PI-00025-2013 and PI-0198-2016). P de la C–O was supported by FPU predoctoral fellowship (FPU17/00026) from Ministry of Education, Culture and Sports. We thank the Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), and the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCIII and co-financed by European Development Regional Fund 'A way to achieve Europe' ERDF for their financial support., Institute of Biomedicine of Seville (IBIS), Bruker Biospin Corporation, Billerica, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Santa Cristina University Hospital, University of Valencia, Valencia, University of Córdoba [Córdoba], Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Servicio de Immunologia, Hospital Universitario de la Princesa-Instituto de Investigacion Sanitaria Princesa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), and European Commission