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1. A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

Author

Yoo, Daniel, Divard, Gillian, Raynaud, Marc, Cohen, Aaron, Mone, Tom D., Rosenthal, John Thomas, Bentall, Andrew J., Stegall, Mark D., Naesens, Maarten, Zhang, Huanxi, Wang, Changxi, Gueguen, Juliette, Kamar, Nassim, Bouquegneau, Antoine, Batal, Ibrahim, Coley, Shana M., Gill, John S., Oppenheimer, Federico, De Sousa-Amorim, Erika, Kuypers, Dirk R. J., Durrbach, Antoine, Seron, Daniel, Rabant, Marion, Van Huyen, Jean-Paul Duong, Campbell, Patricia, Shojai, Soroush, Mengel, Michael, Bestard, Oriol, Basic-Jukic, Nikolina, Jurić, Ivana, Boor, Peter, Cornell, Lynn D., Alexander, Mariam P., Toby Coates, P., Legendre, Christophe, Reese, Peter P., Lefaucheur, Carmen, Aubert, Olivier, and Loupy, Alexandre

Published
2024
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4. Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.

Author

Schinstock, Carrie, Mannon, Roslyn, Budde, Klemens, Chong, Anita, Haas, Mark, Knechtle, Stuart, Lefaucheur, Carmen, Montgomery, Robert, Nickerson, Peter, Tullius, Stefan, Ahn, Curie, Askar, Medhat, Crespo, Marta, Chadban, Steven, Jordan, Stanley, Man, Kwan, Mengel, Michael, Morris, Randall, ODoherty, Inish, Ozdemir, Binnaz, Seron, Daniel, Tambur, Anat, Tanabe, Kazunari, Taupin, Jean-Luc, OConnell, Philip, and Feng, Sandy

Subjects
Antilymphocyte Serum, Consensus, Graft Rejection, Humans, Immunosuppression Therapy, Isoantibodies, Kidney Transplantation, Societies, Medical, Tissue Donors
Abstract

With the development of modern solid-phase assays to detect anti-HLA antibodies and a more precise histological classification, the diagnosis of antibody-mediated rejection (AMR) has become more common and is a major cause of kidney graft loss. Currently, there are no approved therapies and treatment guidelines are based on low-level evidence. The number of prospective randomized trials for the treatment of AMR is small, and the lack of an accepted common standard for care has been an impediment to the development of new therapies. To help alleviate this, The Transplantation Society convened a meeting of international experts to develop a consensus as to what is appropriate treatment for active and chronic active AMR. The aim was to reach a consensus for standard of care treatment against which new therapies could be evaluated. At the meeting, the underlying biology of AMR, the criteria for diagnosis, the clinical phenotypes, and outcomes were discussed. The evidence for different treatments was reviewed, and a consensus for what is acceptable standard of care for the treatment of active and chronic active AMR was presented. While it was agreed that the aims of treatment are to preserve renal function, reduce histological injury, and reduce the titer of donor-specific antibody, there was no conclusive evidence to support any specific therapy. As a result, the treatment recommendations are largely based on expert opinion. It is acknowledged that properly conducted and powered clinical trials of biologically plausible agents are urgently needed to improve patient outcomes.

Published
2020

7. Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis

Author

Sarafidis, Pantelis, Agarwal, Rajiv, Pitt, Bertram, Wanner, Christoph, Filippatos, Gerasimos, Boletis, John, Tuttle, Katherine R., Ruilope, Luis M., Rossing, Peter, Toto, Robert, Anker, Stefan D., Liu, Zhi-Hong, Joseph, Amer, Ahlers, Christiane, Brinker, Meike, Lawatscheck, Robert, Bakris, George, Aizenberg, Diego, Bartolacci, Inés, Besada, Diego, Bittar, Julio, Chahin, Mariano, Elbert, Alicia, Gelersztein, Elizabeth, Liberman, Alberto, Maffei, Laura, Manghi, Federico Pérez, Sanabria, Hugo, Vallejos, Augusto, Viñes, Gloria, Wassermann, Alfredo, Abhayaratna, Walter, Acharya, Shamasunder, Ekinci, Elif, Lee, Darren, MacIsaac, Richard, Mah, Peak Mann, Nelson, Craig, Packham, David, Pape, Alexia, Roger, Simon, Stephenson, Hugo, Suranyi, Michael, Wittert, Gary, Vale, Elizabeth, Colman, Peter, Colquhoun, David, Ellis, Chris, Joshua, Kim, Pedagogos, Eugenia, Regal, Paul, Topliss, Duncan, Vandeleur, James, Verjans, Johan, Wittert, Gary, Wynne, Katie-Jane, Clodi, Martin, Ebenbichler, Christoph, Fliesser-Görzer, Evelyn, Hanusch, Ursula, Krebs, Michael, Lhotta, Karl, Ludvik, Bernhard, Mayer, Gert, Neudorfer, Peter, Paulweber, Bernhard, Prager, Rudolf, Preiß, Wolfgang, Prischl, Friedrich, Schernthaner, Gerit-Holger, Sourij, Harald, Wiesholzer, Martin, Drexel, Heinz, Oberbauer, Rainer, Schönherr, Hans-Robert, Doubel, Peter, Engelen, Wendy, Gillard, Pieter, Hougardy, Jean-Michel, Krzesinski, Jean-Marie, Maes, Bart, Speeckaert, Marijn, Stas, Koen, van Gaal, Luc, Vanbelleghem, Hilde, Duyck, Francis, Scheen, André, Antunes, Daniela, Botelho, Roberto, Brito, Claudia, Canani, Luis, Canziani, Maria Eugenia, Cerqueira, Maria, de Paula, Rogerio, Eliaschewitz, Freddy, Figueiredo, Carlos Eduardo, Forti, Adriana, Hissa, Miguel, Leite, Emerson Lima Maurilo, Jr, Noronha, Irene, Paolino, Bruno, Paschoalin, Nathalia, Paschoalin, Raphael, Filho, Roberto Pecoits, Pereira, Marcio, Portes, Evandro, Precoma, Dalton, Rea, Rosangela, Riella, Miguel, Salles, Joao Eduardo, Vasconcellos, Eduardo, Vencio, Sergio, Bacci, Marcelo, Maia, Lilia, Villacorta, Aline, Apostolova, Emiliya, Boshnyashka, Radostina, Farah, Ghassan, Georgiev, Dimitar, Gushterova, Valentina, Klyuchkova, Neli, Lucheva, Mariya, Manova, Petya, Minkova, Dotska, Nonchev, Boyan, Pichmanova, Mariyana, Prakova, Zhulieta, Rangelov, Rangel, Rashkov, Rosen, Stanchev, Pavel, Stoyanovska-Elencheva, Bilyana, Tagarev, Zhivko, Temelkova-Kurktschieva, Theodora, Vasileva, Svetla, Yoncheva-Mihaylova, Mariana, Marinchev, Angel, Miteva, Mariya, Barre, Paul, Carlson, Brian, Conway, James, Cournoyer, Serge, Dumas, Richard, Fikry, Sameh, Goluch, Richard, Hamet, Pavel, Hart, Randolph, Henein, Sam, Liutkus, Joanne, Madore, Francois, Martinho, Valdemar, Mazza, Giuseppe, McFarlane, Philip, Keefe, Dennis O′, Peterson, Sean, Schwartz, Daniel, Shu, Daniel, Steele, Andrew, Tellier, Guy, Tennankore, Karthik, Tobe, Sheldon, Tsoukas, George, Tytus, Richard, Vitou, Louise, Walsh, Michael, Weisnagel, Stanley, Wilderman, Igor, Yale, Jean-Francois, El Boreky, Fadia, Kelly, Alan, Leiter, Lawrence, Teitelbaum, Ivor, Cobos, Jorge, Godoy, Juan, González, Fernando, Lobos, Sergio, Palma, Juan Carlos, Prieto Dominguez, Juan Carlos, Reyes, Eliana, Romero, Carmen, Saavedra, Victor, Vega, Mario, Medina, Marcelo, Varleta, Paola, Bu, Ruifang, Cai, Hanqing, Chen, Nan, Chen, Qinkai, Chen, Dejun, Cheng, Jinluo, Dong, Youping, Dong, Junwu, Guan, Tianjun, Hao, Chuanming, Huang, Wen, Jiang, Fangfang, Lei, Minxiang, Li, Ling, Li, Zhonghe, Li, Xuemei, Li, Jingmei, Li, Yan, Liang, Xinling, Liang, Bo, Liu, Fang, Liu, Yinghong, Liu, Yuantao, Liu, Zhihong, Long, Gang, Lu, Guoyuan, Lu, Weiping, Lu, Yibing, Luo, Ping, Ma, Jianhua, Mo, Zhaohui, Niu, Jianying, Peng, Ai, Shen, Jiansong, Shen, Feixia, Shi, Bingyin, Su, Qing, Sun, Zhuxing, Tang, Shuifu, Tong, Nanwei, Wang, Hao, Wang, Xinjun, Wang, Guixia, Wang, Jianqin, Wang, Yangang, Wang, Li, Wei, Jiali, Wu, Tianfeng, Wu, Chaoqing, Xing, Changying, Xiong, Fei, Xu, Xudong, Xu, Ning, Yan, Tiekun, Yang, Jinkui, Yin, Aiping, Zeng, Longyi, Zhang, Hao, Zhang, Yanlin, Zhang, Ying, Zhao, Wenjing, Zhao, Zhiquan, Zheng, Hongguang, Zhong, Ling, Zhu, Dalong, Zhuang, Yongze, Du, Yuming, Fang, Yi, Guo, Weiying, Jiang, Sheng, Kuang, Jian, Li, Dongmei, Li, Hongmei, Li, Yinan, Li, Yuxiu, Liu, Jian, Liu, Yu, Miao, Heng, Peng, Wen, Wang, Lihua, Xu, Mingtong, Zhong, Liyong, Zhu, Jun, Arango, Clara, Barrera, Sandra, López, Nelly Beltrán, Benitez, Diego, Blanco, Guillermo, Cadena, Andrés, Coronel, Julian, Cure, Carlos, Durán, Carlos, González, Alexander, Guzmán, Gustavo, Hernández, Eric, Ibarra, Jaime, Jaramillo, Carlos, Jaramillo, Nicolás, Kattah, William, Molina, Dora, Sánchez, Gregorio, Terront, Mónica, Trujillo, Freddy, Urina, Miguel, Vargas, Ruben, Villegas, Iván, Yupanqui, Hernán, Arcos, Edgar, Aroca, Gustavo, Barreto, Germán, Bermudez, Andres, Botero, Rodrigo, Cárdenas, Tatiana, Figueroa, Wilmer, Jaramillo, Mónica, Liévano, Manuel, López, Mónica, Molina, Dora, Rosero, Ricardo, Trillos, Pedro, Dino Alferi, Brada, Michal, Brezina, Jiri, Bucek, Petr, Edelsberger, Tomas, Gulakova, Drahomira, Zapletalova, Jitka Hasalova, Hola, Olga, Hornova, Lucie, Houdova, Jana, Hrmova, Helena, Karasek, David, Kopecka, Sarka, Kovar, Richard, Krcova, Eva, Kuchar, Jiri, Kutejova, Vlasta, Lubanda, Hana, Matyasek, Ivo, Mokrejsova, Magdalena, Okenka, Libor, Prazny, Martin, Pumprla, Jiri, Tomanek, Pavel, Andersen, Ulla, Andries, Alin, Bech, Jesper, Faber, Jens, Gislason, Gunnar, Hangaard, Jørgen, Pacyk, Grzegorz Jaroslaw, Juhl, Claus, Krarup, Thure, Lindhardt, Morten, Madsbad, Sten, Nielsen, Joan, Pedersen-Bjergaard, Ulrik, Poulsen, Per, Rasmussen, Ole, Rossing, Peter, Schousboe, Karoline, Gram, Jeppe, Lauridsen, Thomas, Pedersen, Erling, Thorsteinsson, Birger, Flöjt, Päivi, Honkasalo, Mikko, Honkasalo, Mikko, Humaloja, Kari, Kananen, Kristiina, Kantola, Ilkka, Koistinen, Arvo, Korsoff, Pirkko, Lahtela, Jorma, Nieminen, Sakari, Nieminen, Tuomo, Sadeharju, Karita, Strand, Jorma, Sulosaari, Sakari, Cariou, Bertrand, Chantrel, François, Clavel, Sylvaine, Combe, Christian, Fauvel, Jean-Pierre, Gallouj, Karim, Gouet, Didier, Guerci, Bruno, Guerrot, Dominique, Hourmant, Maryvonne, Klein, Alexandre, Mariat, Christophe, Marre, Michel, Mesbah, Rafik, Le Meur, Yannick, Monier, Arnaud, Moranne, Olivier, Roussel, Ronan, Serusclat, Pierre, Vendrely, Benoit, Verges, Bruno, Zaoui, Philippe, Axthelm, Christoph, Bergmann, Andreas, Birkenfeld, Andreas L., Braun, Hermann, Busch, Klaus, Contzen, Christel, Degenhardt, Stefan, Derwahl, Karl, Giebel, Thomas, Hagenow, Andreas, Haller, Hermann, Hasslacher, Christoph, Horacek, Thomas, Jungmair, Wolfgang, Kloos, Christof, Koch, Thorsten, Krüger, Thilo, Mühlfeld, Anja, Müller, Joachim, Pfützner, Andreas, Pistrosch, Frank, Rinke, Andrea, Rose, Ludger, Rump, Lars, Schettler, Volker, Schiefke, Ingolf, Schlichthaar, Heike, Schröppel, Bernd, Schöll, Norbert, Schubert, Kristin, Schürholz, Thomas, Sigal, Helena, Stemler, Lutz, Strack, Georg, Täschner, Heidrun, Toursarkissian, Nicole, Tschöpe, Diethelm, Ulmer, Achim, van der Giet, Markus, Wanner, Christoph, Winkelmann, Bernhard R., Boletis, Ioannis, Dimitriadis, George, Hatziagelaki, Erifili, Iatrou, Christos, Ioannidis, Ioannis, Kounadi, Theodora, Makriniotou, Ioanna, Papadopoulou, Dorothea, Papagianni, Aikaterini, Passadakis, Ploumis, Piaditis, George, Stefanidis, Ioannis, Tai Pang Ip, Lee, Paul, Andrea Luk, On Yan, Ma, Ronald, Chow, Wing Sun, Wang, Angela, Yeung, Vincent, Bajcsi, Dora, Danos, Peter, Harcsa, Eleonora, Kalina, Akos, Kazup, Szilvia, Keltai, Katalin, Kirschner, Robert, Kiss, Julianna, Kovacs, Laszlo, Lamboy, Beata, Literati-Nagy, Botond, Mileder, Margit, Nagy, Laszlo, Noori, Ebrahim, Nyirati, Gabor, Petro, Gizella, Schneider, Karoly, Simon, Judit, Szocs, Albert, Vasas, Szilard, Wudi, Krisztina, Zilahi, Zsolt, Zsom, Marianna, Eustace, Joe, Holian, John, Reddan, Donal, Meara, Yvonne O′, Abramof Ness, Rosane, Adawi, Faiad, Armaly, Zaher, Atar, Shaul, Bashkin, Amir, Ben Chetrit, Sydney, Yanay, Noa Berar, Chernin, Gil, Darawsha, Mahmud, Efrati, Shai, Elias, Mazen, Farber, Evgeny, Glandt, Mariela, Grossman, Ehud, Halabi, Majdi, Harman-Boehm, Ilana, Khazim, Khaled, Liberty, Idit, Minuchin, Oscar, Mosenzon, Ofri, Nakhoul, Farid, Nimer, Assy, Schwartz, Doron, Wainstein, Julio, Yagil, Yoram, Zukermann, Robert, Avogaro, Angelo, Battaglia, Giovanni Giorgio, Bevilacqua, Maurizio Tiziano, Bonora, Enzo, Bossi, Carlo Antonio, Calabrò, Paolo, Cavalot, Franco Luigi, Cimino, Roberto, Cozzolino, Mario Gennaro, David, Salvatore, Emdin, Michele, Fiaccadori, Enrico, Fiorina, Paolo, Giorda, Carlo Bruno, Gregorini, Maria Cristina, La Manna, Gaetano, Maggi, Davide Carlo, Manti, Roberta, Meregalli, Giancarla, Pani, Antonello, Parvanova, Aneliy Ilieva, Perico, Norberto, Piatti, PierMarco, Pisani, Antonio, Pontiroli, Antonio Ettore, Ponzani, Paola, Santorelli, Gennaro, Santoro, Domenico, Scanziani, Renzo, Teatini, Ugo, Tonolo, Giancarlo, Trevisan, Roberto, Veronelli, Anna Maria, Viviani, Giorgio Luciano, Araki, Hideo, Bando, Yukihiro, Ebisui, Osamu, Fujita, Naruhiro, Fukasawa, Hirotaka, Furuya, Ryuichi, Hamamoto, Yoshiyuki, Hamasaki, Akihiro, Hasegawa, Kotaro, Hatazaki, Masahiro, Hayashi, Terumasa, Higashi, Takayuki, Hirohata, Yoshihide, Horinouchi, Shuji, Hoshi, Ayumu, Imoto, Hirofumi, Inagaki, Akemi, Inagaki, Masayuki, Inaguma, Daijo, Inoue, Toshihiko, Ishii, Masao, Ishiko, Tamayo, Isono, Motohide, Jinnouchi, Hideaki, Kanai, Hidetoshi, Kanda, Daisuke, Kanehara, Hideo, Kashima, Masayuki, Kataoka, Yuko, Katayama, Shigehiro, Kato, Kiyoe, Katsuki, Takeshi, Kawamitsu, Katsunori, Kawasaki, Satsuki, Kikuchi, Fumi, Kikuchi, Hidetoshi, Kishimoto, Rui, Kobayashi, Kunihisa, Koide, Junko, Komi, Rieko, Kubota, Miyuki, Kuriya, Genpei, Kurose, Takeshi, Kusano, Yoshiro, Hajime, Maeda, Matsubayashi, Sunao, Matsumoto, Kazunari, Matsumura, Naoya, Matsuo, Yasuto, Matsuoka, Naoki, Miyaoka, Hiroaki, Miyata, Satoshi, Morita, Takeshi, Murakami, Isao, Murao, Satoshi, Nakamura, Udai, Nakayama, Mikihiro, Nakazawa, Jun, Nohara, Sakae, Nomiyama, Takashi, Noritake, Masayuki, Oda, Yoshiaki, Ogiwara, Takayuki, Ohashi, Hiroshi, Okamoto, Hideki, Okino, Shinichi, Osonoi, Takeshi, Sasaki, Nobuhiro, Sayo, Yoshitaka, Sekigami, Taiji, Shibasaki, Taro, Shibata, Hirotaka, Shimoyama, Tatsushi, Shinoda, Junji, Sobajima, Hiroshi, Sugitatsu, Kazuya, Sugiura, Toshiyuki, Sugiyama, Toru, Suzuki, Daisuke, Suzuki, Hiroyuki, Suzuki, Masaaki, Takeda, Asami, Tanaka, Asami, Tanaka, Seiichi, Tsunematsu, Izumi, Ueda, Yasuo, Uekihara, Soichi, Ujihara, Makoto, Yajima, Ken, Yamada, Daishiro, Yamada, Masayo, Yamagata, Kazuo, Yamakawa, Ken, Yamakawa, Fumiko, Yamasaki, Yoshimitsu, Yambe, Yuko, Yanagida, Taihei, Yanai, Hidekatsu, Yanase, Toshihiko, Yasuda, Tetsuyuki, Kriauciuniene, Dovile, Lasiene, Jurate, Navickas, Antanas, Radzeviciene, Lina, Urbanaviciene, Egle, Urbonas, Gediminas, Velaviciene, Audrone, Abd Ghani, Rohana, Aziz, Nor Azizah, Lee, Li Yuan, Loh, Chek Loong, Ali, Norhaliza Mohd, Noor, Nurain Mohd, Fatnoon Nik Ahmad, Nik Nur, Ratnasingam, Jeyakantha, Halimi Bin Wan Hasan, Wan Hasnul, Izani Wan Mohamed, Wan Mohd, Khir, Rizmy Najme, Mohamad, Masni, Alexander Tan, Tong Boon, Avila Pardo, Sandro, Adrian, Miriam Bastidas, Wong, Alfredo Chew, Escobedo de la Peña, Jorge, Salmón, Guillermo Fanghänel, Gálvez, Guillermo González, Ochoa, Ramiro Gutiérrez, Santana, Saúl Irizar, Rovalo, Magdalena Madero, Machado, Gustavo Méndez, Ruiz, Luis Nevarez, Ibarra, Denisse Ramos, López, Gabriel Ramos, Reyna, Leobardo Sauque, Ortiz, Gustavo Solache, Ortiz, Rafael Valdez, Mesa, Juan Villagordoa, Salazar, Melchor Alpizar, Hernández, Pedro García, González, José, Soto, José Lazcano, Mendoza, Arturo Saldaña, Santana, Sergio Irizar, Vilchis, Elvira González, Bakker, R.C., Barendregt, J.N.M., Boonstra, A.H., Bos, Willem, Brouwer, C.B., Buren, M. van, Gansevoort, Ron, Kooy, Adriaan, Krekels, Marielle, Leendert, Ruud J.M. van, Lieverse, Louis A.G., Luik, P.T., Penne, E. Lars, Gregoor, Peter Smak, Vogt, Liffert, Born, Bert-Jan van den, John Baker, Crawford, Veronica, Cutfield, Rick, Dunn, Peter, Krebs, Jeremy, Nirmalaraj, Kingsley, Scott, Russell, Smuts, Nine, Titchener, Janet, Eriksen, Erik, Finnes, Trine, Høivik, Hans, Karlsson, Thomas, Munk, Peter Scott, Radtke, Maria, Risberg, Knut, Rocke, Jan, Solnør, Leidulv, Stenehjem, Aud-Eldrid, Tafjord, Anne-Beathe, Asprusten, Emil, Hagemeier, Robert, Høye, Kjetil, Selsås, Hilde, Thorup, Frode, Wium, Cecilie, Pamugas, Glenda, Panelo, Araceli, Perez, Ronald, Tanque, Maribel, Tirador, Louie, Villa, Michael, Bautista, Albert, Catindig, Elizabeth, Manalo, Carlo, Mirasol, Roberto, Butrymowicz, Patrycja, Ciechanowski, Kazimierz, Cieslik, Grazyna, Franek, Edward, Gumprecht, Janusz, Hoffmann, Michal, Krzykowska, Jolanta, Kurnatowska, Ilona, Landa, Katarzyna, Madrzejewski, Adam, Madziarska, Katarzyna, Mazur, Stanislaw, Napora, Piotr, Nowicki, Michal, Ocicka-Kozakiewicz, Anna, Rewerska, Barbara, Rusicka, Teresa, Ruxer, Jan, Skokowska, Ewa, Stankiewicz, Andrzej, Stompor, Tomasz, Tiuryn-Petrulewicz, Agnieszka, Wasilewska, Katarzyna, Wierusz-Wysocka, Bogna, Wnetrzak-Michalska, Renata, Jedynasty, Krystyna, Anand, Izabela Sein, Almeida, Edgar, Ballesteros, Rosa, Barreto, Carlos, Beirao, Idalina, Birne, Rita, Esteves, Cesar, Guia, Jose, Heitor, Susana, Marques, Olinda, Melo, Pedro, Nolasco, Fernando, Pereira, Amalia, Roque, Cristina, Rosario, Francisco, Silva, Gil, Silva, Ana, Teixeira e Costa, Fernando, Lobos, Ana Vila, Alves, Ana Rita, Brandao, Ilidio, Carvalho, Rui, Coelho, Joao, Lourenco, Ana, Matos, Pedro, Rosario, Vanisa, Neves, Joao Sergio, Cortes-Maisonet, Gregorio, Roman-Miranda, Amaury, Brito-Peguero, Yudit, Colon-Vega, Gildred, Albota, Adrian, Bala, Cornelia, Barbonta, Hortensia, Caceaune, Elena, Catrinoui, Doina, Constantin, Ciprian, Dumitrescu, Adriana, Mindrescu, Nicoleta, Mistode, Cristina, Negrisanu, Gabriela, Onaca, Adriana, Paveliu, Silvia, Pintilei, Ella, Pop, Lavinia, Popa, Amorin, Popescu, Alexandrina, Radulian, Gabriela, Szilagyi, Iosif, Turcu, Liana, Vacaru, Georgeta, Vlad, Adrian, Filimon, Adriana, Veresiu, Ioan, Antsiferov, Mikhail, Arkhipov, Mikhail, Babkin, Andrey, Barbarash, Olga, Baranov, Vitaliy, Chernyavskaya, Elena, Demko, Arkadiy, Dreval, Alexander, Edin, Anton, Ermakova, Polina, Fadeev, Valentin, Galyavich, Albert, Gaysina, Leyla, Gordeev, Ivan, Ipatko, Irina, Kalashnikova, Marina, Khalimov, Yuriy, Klimontov, Vadim, Kobalava, Zhanna, Kosmacheva, Elena, Koziolova, Natalya, Sergey Levashov, Lyudmila Kvitkova, Libis, Roman, Marasaev, Vyacheslav, Malykh, Natalia, Martynenko, Vladimir, Malyutina, Sofya, Merai, Imad, Mkrtumyan, Ashot, Nechaeva, Galina, Petunina, Nina, Palyutin, Shamil, Pimenov, Leonid, Rechkova, Elena, Rodionova, Tatyana, Rymar, Oksana, Sardinov, Ruslan, Semenova, Olga, Sherenkov, Alexander, Solovev, Oleg, Smolyarchuk, Elena, Strongin, Leonid, Ukhanova, Olga, Verlan, Nadezhda, Vorokhobina, Natalya, Yakhontov, Davyd, Yakushin, Sergey, Zakharova, Elena, Zalevskaya, Alsu, Zanozina, Olga, Zhdanova, Elena, Zhukova, Larisa, Zykova, Tatyana, Argunova, Yulia, Nikolaev, Konstantin, Villevalde, Svetlana, Fang Sum, Chee, Suhail, Sufi Muhummad, San Tan, Ru, Vathsala, Anantharaman, Wong, Edmund, Bee, Yong Mong, Babikova, Jana, Buganova, Ingrid, Dzupina, Andrej, Ochodnicka, Zuzana, Sosovec, Dalibor, Spodniakova, Denisa, Minarik, Peter, Fayzal Ahmed, Amod, Aslam, Bhana, Sindeep, Distiller, Larry, Jansen van Rensburg, Dirkie, Joshi, Mukesh, Joshi, Shaifali, Lakha, Deepak, Mitha, Essack, Podgorski, Gracjan, Ranjith, Naresh, Rayner, Brian, Rheeder, Paul, Sarvan, Mohamed, Seeber, Mary, Siebert, Heidi, Tayob, Mohammed, Trokis, Julien, Urbach, Dorothea, van Zyl, Louis, Jansen van Rensburg, Dirkie, Bum-Soon Choi, Choi, Moon Gi, Chung, ChoonHee, Hwang, YouCheol, Kim, ChongHwa, Kim, InJoo, Kim, JaeHyeon, Kim, SinGon, Kim, SungGyun, Kim, Tae Hee, Lee, WooJe, Lee, ByungWan, Lee, Kang Wook, Oh, Kook-Hwan, Oh, Ji Eun, Oh, Yun Kyu, Oh, Dong-Jin, Park, Junbeom, Shin, Seok Joon, Sung, Su-Ah, Yu, Jae Myung, Chung, HyeSoo, Huh, Ji Hye, Kang, JunGoo, Kim, ChulSik, Kim, HyeSoon, Kim, NamHoon, Lim, Soo, Cho, Young Min, Park, Cheol Young, Agraz, Irene, Ampudia, Francisco Javier, Bouarich, Hanane, Calero, Francesca, Castro, Cristina, Guldris, Secundino Cigarrán, Garrit, Josep Cruzado, de Álvaro, Fernando, Galcerán, Josep, Albarrán, Olga González, Jaras, Julio Hernández, Ibernón, Meritxell, Deben, Francisco Martínez, Ma, Esteban, Dolores Martínez, Pascual Izuel, José María, Martins, Judith, Mediavilla, Juan, Michán, Alfredo, Santos, Julio Pascual, Poch, Esteban, Rusillo, Manuel Polaina, Juan, Carlos Sánchez, Olmo, Rafael Santamaría, Segura de la Morena, José Julián, Soto, Alfonso, Troya, Maribel, Castro, Fernando Cereto, Fernández, Pablo Gómez, Sánchez, Laura Fuentes, Moya, Mercedes González, Marrero, Domingo Hernández, Maroto, Gonzalo Piedrola, Redón, Josep, Seron, Daniel, Bruchfeld, Annette, Curiac, Dan, Eliasson, Ken, Frank, Malin, Guron, Gregor, Hellberg, Olof, Hellgren, Margareta, Larnefeldt, Hans, Lindholm, Carl-Johan, Löndahl, Magnus, Rein-Hedin, Erik, Soveri, Inga, Spaak, Jonas, Tengmark, Bengt-Olov, Lif-Tiberg, Cornelia, Månflod, Johan, Nguyen, Han, Ackermann, Daniel, Bilz, Stefan, Burnier, Michel, Forster, Christian, Kalbermatter, Stefan, Kistler, Andreas, Pechère-Bertschi, Antoinette, Schultes, Bernd, Laimer, Markus, Rudofsky, Gottfried, Strey, Christopher, Wuerzner, Gregoire, Chiz-Tzung Chang, Hung, Cheng-Chieh, Jiang, Ju-Ying, Lee, Chien-Te, Lin, Shuei-Liong, Tarng, Der-Cherng, Tu, Shih-Te, Wu, Mai-Szu, Wu, Ming-Ju, Chuang, Lee-Ming, Deerochanawong, Chaicharn, Kitiyakara, Chagriya, Ophascharoensuk, Vuddhidej, Pongchaiyakul, Chatlert, Satirapoj, Bancha, Kosachunhanan, Natapong, Sritara, Piyamitr, Eren, Necmi, Gul, Ibrahim, Gulel, Okan, Kocyigit, Ismail, Kumbasar, Abdulbaki, Sahin, Idris, Sari, Ramazan, Sayin, Burak, Tavli, Talat, Ustundag, Sedat, Yenicerioglu, Yavuz, Badak, Ozer, Cayli, Murat, Oguz, Aytekin, Ozdogan, Oner, Sari, Ibrahim, Temizhan, Ahmet, Tigen, Mustafa, Turk, Ugur, Yilmaz, Huseyin, Yilmaz, Mehmet, Bondarets, Iryna, Botsyurko, Volodymyr, Chernikova, Viktoriia, Donets, Oleksandra, Fushtey, Ivan, Grachova, Mariia, Isayeva, Anna, Kogut, Dmytro, Komisarenko, Julia, Kravchun, Nonna, Malyar, Kateryna, Mankovsky, Borys, Martynyuk, Liliya, Maslyanko, Vitaliy, Myshanych, Halyna, Pererva, Larysa, Pertseva, Nataliia, Serhiyenko, Oleksandr, Smirnov, Ivan, Sokolova, Liubov, Stryzhak, Vasyl, Vlasenko, Maryna, Isayeva, Ganna, Larin, Oleksandr, Ahmad AbouSaleh, Barratt, Jonathan, Dang, Cuong, Kahal, Hassan, Kirk, Adam, Kilvert, Anne, Kon, Sui Phi, McCafferty, Kieran, Patel, Dipesh, Rice, Sam, Vijayaraman, Arutchelvam, Wong, Yuk-ki, Gibson, Martin, Wahba, Mona, Zaidi, Reza, Bilous, Rudy, Johnson, Andrew, Kalathil, Dhanya, Kilvert, Anne, Kyriakidou, Christina, Mathew, Amit, Mukhtar, Rasha, Munsoor, Imrozia, Poterajlo, Anton, Swift, Pauline, Idalia Acosta, Adams, Atoya, Adler, Sharon, Ajani, Dilawar, Ali, Slamat, Alicic, Radica, Al-Karadsheh, Amer, Alla, Sreedhara, Allison, D., Andrawis, Nabil, Arif, Ahmed, Awad, Ahmed, Azizad, Masoud, Bahrami, Michael, Bansal, Shweta, Barag, Steven, Barakzoy, Ahmad, Barney, Mark, Barzilay, Joshua, Bashir, Khalid, Bautista, Jose, Beddhu, Srinivasan, Belo, Diogo, Benjamin, Sabrina, Berenji, Ramin, Bhargava, Anuj, Birriel, Jose, Brietzke, Stephen, Brosius, Frank, Brusco, Osvaldo, Burgner, Anna, Busch, Robert, Canadas, Rafael, Caramori, Maria, Cardona, Jose, Case, Christopher, Cruz, Humberto, Dandillaya, Ramprasad, Dawoud, Dalia, Din, Zia, Dixon, Bradley, Doshi, Ankur, Drakakis, James, El Shahawy, Mahfouz, El-Meanawy, Ashraf, El-Shahawy, Mohammed, Evans, John, Fadda, George, Farooq, Umar, Fernando, Roland, Fink, Raymond, First, Brian, Fitz-Patrick, David, Flack, John, Fluck, Patrick, Fogelfeld, Leon, Fonseca, Vivian, Frias, Juan, Galphin, Claude, Garcia-Mayol, Luis, Goldstein, Gary, Gonzalez, Edgar, Gonzalez-Abreu, Francisco, Gore, Ashwini, Grant, David, Habwe, Violet, Hamilton, Maxine, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Heigerick, Glenn, Henry, Andrew, Hernandez, German, Hernandez-Cassis, Carlos, Herrera, Carlos, Hertel, Joachim, Huang, Wenyu, Iglesias, Rogelio, Iranmanesh, Ali, Jackson, Timothy, Jain, Mahendra, Jamerson, Kenneth, Johnson, Karen, Judd, Eric, Kaplan, Joshua, Kayali, Zeid, Khan, Bobby, Khan, Muhammad, Kharait, Sourabh, Kirkman, M. Sue, Kopyt, Nelson, Kotzker, Wayne, Kovesdy, Csaba, Kreit, Camil, Krishna, Arvind, Kronfli, Saeed, Lee, Keung, LeJeune, Derek, Lemus, Brenda, Leon-Forero, Carlos, Linfert, Douglas, Lora, Henry, Lurie, Alexander, Maddukuri, Geetha, Magno, Alexander, Maletz, Louis, Mandayam, Sreedhar, Markell, Mariana, Mayfield, Ronald, Mbogua, Caroline, McMullen, Dierdre, Meisner, Carl, Minton, Stephen, Mocherla, Bharat, Mohandas, Rajesh, Montero, Manuel, Moustafa, Moustafa, Nadkarni, Salil, Nakhle, Samer, Navarro, Jesus, Neyra, Nilda, Nica, Romanita, Nicol, Philip, Norwood, Paul, Numrungroad, Visal, Donovan, Richard O′, Odugbesan, A., Paoli-Bruno, Jorge, Parikh, Samir, Patel, Rakesh, Peixoto, Aldo, Pergola, Pablo, Perlman, Alan, Pettis, Karlton, Pisoni, Roberto, Ponduchi, Mirela, Posada, Jorge, Prabhakar, Sharma, Radhakrishnan, Jai, Rahman, Mahboob, Raina, Rupesh, Rastogi, Anjay, Reisin, Efrain, Rendell, Marc, Robertson, David, Rocco, Michael, Romeu, Hugo, Rosas, Sylvia, Rosenfeld, Jack, Ross, Dennis, Rothman, Jeffrey, Rudolph, Lance, Ruhullah, Yusuf, Ruoff, Gary, Ryu, Jeffrey, Sahani, Mandeep, Sam, Ramin, Samuels, Garfield, Sanchez, William, Santos, Vladimir, Satko, Scott, Saxena, Sanjeev, Scott, David, Seco, Gilberto, Seek, Melvin, Serota, Harvey, Shafi, Tariq, Shahid, Nauman, Shanik, Michael, Sharma, Santosh, Sinha, Arjun, Smelser, James, Smith, Mark, Soe, Kyaw, Solomon, Richard, Soroka, Eugene, Soufer, Joseph, Spinowitz, Bruce, Spry, Leslie, Suarez, Rosa, Subramanian, Bala, Szerlip, Harold, Tamirisa, Aparna, Thomson, Stephen, Tran, Tuan-Huy, Treger, Richard, Trullenque, Gretel, Turk, Thomas, Umpierrez, Guillermo, Urbach, Daniel, Valdes, Martin, Valika, Shujauddin, Vega, Damaris, Weissman, Peter, Whaley-Connell, Adam, Winston, Jonathan, Wise, Jonathan, Wynne, Alan, Zeig, Steven, Abdel-Rahman, Emaad, Abreu, Edel, Awad, Alaa, Bahri, Nader, Bertsch, John, Bleich, David, Bornfreund, Jonathan, Brar, Harjeet, Brian, Susan, Brinson, Cynthia, Bruschetta, Humberto, Carpio, Jose, Cohen, Steven, Cosby, John, Dhanireddy, Soni, Diaz, Jorge, Dunn, Fredrick, Eppanapally, Sabitha, Fayad, Joseph, Goel, Archana, Govindaraju, Kanakadurga, Halpern, Stephen, Jones, Audrey, Kaye, William, Knight, Herbert, Koch, Stanley, Kohli, Nandini, Lastra, Guido, Lerman, Sam, Loredo, Jorge, Lovre, Dragana, Mandviwala, Mustafa, Martin, Earl, Meyer, Jill, Murray, John, Oliver, David, Oparil, Suzanne, Penabad, Jesus, Pereira, Isabel, Popeil, Larry, Quesada, Gonzalo, Ramanathan, Kodangudi, Ramos-Gonez, Luis, Rastegar, Mandana, Rastogi, Padmashri, Rondon, Juan, Roy-Chaudhury, Prabir, Smith, David, Williamson, Don, Womack, Catherine, Yamout, Hala, Yuryev, Michael, Chu, Phuong, Van Hoang, Lam, Khanh, Tran, Phi Nga, Nguyen Thi, Son, Pham Nguyen, Tran, Lan Phuong, Le, Thuy Khuong, Nguyen, Boi Ngoc, Nguyen, Thao, Nui, Nguyen Minh, Nam, Tran Quang, and Tran, Kim Chi

Published
2023
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10. Clinical characteristics and risk factors for severe COVID-19 in hospitalized kidney transplant recipients: A multicentric cohort study

Author

Favà, Alexandre, Cucchiari, David, Montero, Nuria, Toapanta, Nestor, Centellas, Francisco J., Vila-Santandreu, Anna, Coloma, Ana, Meneghini, Maria, Manonelles, Anna, Sellarés, Joana, Torres, Irina, Gelpi, Rosana, Lorenzo, Inmaculada, Ventura-Aguiar, Pedro, Cofan, Frederic, Torregrosa, Jose V., Perelló, Manel, Facundo, Carme, Seron, Daniel, Oppenheimer, Federico, Bestard, Oriol, Cruzado, Josep M., Moreso, Francesc, and Melilli, Edoardo

Published
2020
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12. Derivation and external validation of the SIMPLICITY score as a simple immune-based risk score to predict infection in kidney transplant recipients

Author

Fernández-Ruiz, Mario, Seron, Daniel, Alonso, Ángel, Lora, David, Hernández, Domingo, González, Esther, Pérez-Sáez, María José, Gómez, Gonzalo, Pallardó-Mateu, Luis Manuel, Jimeno-García, Luisa, Cofán, Frederic, Gutierrez-Dalmau, Alex, Ruiz, Juan Carlos, Ramírez-Puga, Ana, Santana Estupiñán, Raquel, Marcén, Roberto, Portolés, José María, Muñoz-Cepeda, Miguel Ángel, López-Medrano, Francisco, San Juan, Rafael, Andrés, Amado, and Aguado, José María

Published
2020
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14. Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant

Author

Vincenti, Flavio, primary, Bestard, Oriol, additional, Brar, Amarpali, additional, Cruzado, Josep M., additional, Seron, Daniel, additional, Gaber, A. Osama, additional, Ali, Nicole, additional, Tambur, Anat R., additional, Lee, Helen, additional, Abbadessa, Giovanni, additional, Paul, Jo-Anne, additional, Dudek, Markus, additional, Siegel, Ruby J., additional, Torija, Alba, additional, Semiond, Dorothee, additional, Lépine, Lucie, additional, Ternes, Nils, additional, Montgomery, Robert A., additional, and Stegall, Mark, additional

Published
2023
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20. Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial

Author

Denny, Jason E., Kulkarni, Sanjay, Hricik, Donald, Bresnahan, Barbara A., Bunnapradist, Suphamai, El-Sabrout, Rafik A., Chan, Laurence K., Ciancio, Gaetano, El-Ghoroury, Mohamed A., Goldstein, Michael J., Gaston, Robert S., Gohh, Reginald Y., Killackey, Mary T., King, Anne, Knight, Richard J., Kore, Arputharaj H., Sudan, Debra L., Chapochnick Friedmann, Javier, Mulgaonkar, Shamkant P., Nolan, Charles, Pankewycz, Oleh G., Pirsch, John D., Schaefer, Heidi M., Steinberg, Steven M., Gelb, Bruce E., True, Karin A., West-Thielke, Patricia M., Waybill, Mary M., Wolf, Joshua H., Ketel, Beverley L., Harland, Robert C., Shihab, Fuad S., Cassuto, Elisabeth, Le Meur, Yannick, Rostaing, Lionel, Mariat, Christophe, Grinyó, Josep Maria, Puig, Jose, Seron, Daniel, Tisone, Giuseppe, Ciechanowski, Kazimierz, Foroncewicz, Bartosz, Wlodarczyk, Zbigniew, Budde, Klemens, Witzke, Oliver, Mondragon, Guillermo A., Mancilla Urrea, Eduardo, Alberu Gomez, Josefina, Reyes Acevedo, Rafael, Rial, Maria del Carmen, Novoa, Pablo A., Silva, Helio T., Jr., Garcia, Valter D., Carvalho, Deise D., Santamaria Saber, Luciana T., Contieri, Fabiana L., Bastos, Marcos G., Manfro, Roberto C., Kanellis, John, Eris, Josette, O’Connell, Philip, Hughes, Peter, Russ, Graeme, Pidgeon, Grant B., Dittmer, Ian D., Kee, Terence, Vathsala, Anantharaman, Naumovic, Radomir, Mitic, Igor, Parmjeet, Randhawa, Grinyó, Josep M., and Silva, Helio Tedesco, Jr.

Published
2016
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21. Compliance to Multidisciplinary Lifestyle Intervention Decreases Blood Pressure in Patients with Resistant Hypertension: A Cross-Sectional Pilot Study

Author

Espinel Garuz, Eugenia, Azancot, María A, Gomez-Garrido, Alba, Beneria, Anna, Caraben, Anna, Andurell, Laura, Delgado Martínez, María Pilar, Castañé, Helena, Joven, Jorge, Seron, Daniel, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Espinel E, Azancot MA, Caraben A, Seron D] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gomez A] Servei de Medicina Física i Rehabilitació, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Beneria A] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Andurell L] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Delgado P] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castañé H, Joven J] Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Estils de vida, conducta y mecanismos de la conducta::psicología social::estilo de vida [PSIQUIATRÍA Y PSICOLOGÍA], General Medicine, Therapeutics, Cardiovascular Diseases::Vascular Diseases::Hypertension [DISEASES], Other subheadings::/therapy [Other subheadings], Pressió sanguínia, Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure::Arterial Pressure [PHENOMENA AND PROCESSES], Weight management, Hipertensió - Tractament, Hypertension, hypertension, therapeutics, weight management, fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::hemodinámica::presión sanguínea::presión arterial [FENÓMENOS Y PROCESOS], Behavior and Behavior Mechanisms::Psychology, Social::Life Style [PSYCHIATRY AND PSYCHOLOGY], enfermedades cardiovasculares::enfermedades vasculares::hipertensión [ENFERMEDADES], Otros calificadores::/terapia [Otros calificadores]
Abstract

Hypertension; Therapeutics; Weight management Hipertensió; Terapèutica; Gestió del pes Hipertensión; Terapéutica; Control de peso Hypertension is a common chronic medical condition. Treatment is not satisfactory in a significant proportion of patients with primary hypertension, despite the concurrent use of three or more medications with different mechanisms of action. Such treatment-resistant hypertension is a clinical challenge associated with poor prognosis and needs further investigation. The efficacy of lifestyle changes has not been established yet in patients with resistant hypertension, and educational efforts appear clinically irrelevant in patients who must achieve behavioral changes without supervision. A 6-month multidisciplinary pilot intervention enrolled 50 patients with established resistant hypertension. The aims were: (1) to examine whether intensive and supervised lifestyle changes contribute to decreasing blood pressure in this condition, and (2) to identify which components affect compliance and feasibility. The program provided intensive changes in nutrition, physical exercise, and control of sleep disturbances supervised by nutritionists, physiotherapists, and psychologists. Nurses and pharmacists followed up on adherence to the antihypertensive medication. The primary outcome was 24 h blood pressure control. Data in patients with full compliance (n = 30) indicate that lifestyle modifications in resistant hypertension significantly reduced 24 h both systolic and diastolic blood pressure (p < 0.01), body mass index (p < 0.01), medication burden (p = 0.04), improving physical fitness, and cardiovascular risk markers such as heart rate (p = 0.01) and augmentation index (p = 0.02). The adherence to the intervention was moderate, with an attrition rate of 12%. A modified version reducing visits and explorations will likely improve compliance and can be used to assess the long-term maintenance of these benefits in managing resistant hypertension by diverse healthcare providers. The program against Resistant Hypertension was supported, in part, by the Hospital Vall d’Hebron, the Menarini Foundation, and the Instituto de Salud Carlos III grant (PI21/00510) co-funded by the Fondo Europeo de Desarrollo Regional. H.C. is a recipient of a fellowship of the Department of Health of Catalonia (Government of Catalonia) “Pla Estratègic de Recerca i Innovació en Salut” (PERIS-SLT017/3501/2020).

Published
2023

22. Prediction of clinical events by liver stiffness and chronic kidney disease by NAFLD in patients with type-2 diabetes

Author

Rivera-Esteban, Jesús, primary, Pons, Mònica, additional, Planas, Alejandra, additional, Manzano-Nuñez, Ramiro, additional, Hernández, Cristina, additional, Simó-Servat, Olga, additional, Bañeras, Jordi, additional, Soler, María José, additional, Seron, Daniel, additional, Boixadera, Anna, additional, Augustin, Salvador, additional, Simó, Rafael, additional, Ferreira-González, Ignacio, additional, Genescà, Joan, additional, and Pericàs, Juan M., additional

Published
2022
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23. Treatment of early borderline lesions in low immunological risk kidney transplant patients: a Spanish multicenter, randomized, controlled parallel-group study protocol: the TRAINING study

Author

Hernández, Domingo, Vázquez-Sánchez, Teresa, Sola, Eugenia, Lopez, Veronica, Ruiz-Esteban, Pedro, Caballero, Abelardo, Salido, Eduardo, León, Myriam, Rodriguez, Aurelio, Serra, Núria, Rodriguez, Consuelo, Facundo, Carme, Perello, Manel, Silva, Irene, Marrero-Miranda, Domingo, Cidraque, Ignacio, Moreso, Francesc, Guirado, Luis, Seron, Daniel, Torres, Armando, and Universitat Autònoma de Barcelona

Subjects
kidney transplant, Inflammation, Graft Rejection, α-klotho, low immunological risk, Clinical Trials, Phase IV as Topic, Kidney, Kidney Transplantation, subclinical inflammation, Research Design, Nephrology, Humans, Multicenter Studies as Topic, Kidney Diseases, borderline lesions, Randomized Controlled Trials as Topic
Abstract

Background Subclinical inflammation, including borderline lesions (BL), is very common (30–40%) after kidney transplantation (KT), even in low immunological risk patients, and can lead to interstitial fibrosis/tubular atrophy (IFTA) and worsening of renal function with graft loss. Few controlled studies have analyzed the therapeutic benefit of treating these BL on renal function and graft histology. Furthermore, these studies have only used bolus steroids, which may be insufficient to slow the progression of these lesions. Klotho, a transmembrane protein produced mainly in the kidney with antifibrotic properties, plays a crucial role in the senescence-inflammation binomial of kidney tissue. Systemic and local inflammation decrease renal tissue expression and soluble levels of α-klotho. It is therefore important to determine whether treatment of BL prevents a decrease in α-klotho levels, progression of IFTA, and loss of kidney function. Methods The TRAINING study will randomize 80 patients with low immunological risk who will receive their first KT. The aim of the study is to determine whether the treatment of early BL (3rd month post-KT) with polyclonal rabbit antithymocyte globulin (Grafalon®) (6 mg/kg/day) prevents or decreases the progression of IFTA and the worsening of graft function compared to conventional therapy after two years post-KT, as well as to analyze whether treatment of BL with Grafalon® can modify the expression and levels of klotho, as well as the pro-inflammatory cytokines that regulate its expression. Discussion This phase IV investigator-driven, randomized, placebo-controlled clinical trial will examine the efficacy and safety of Grafalon® treatment in low-immunological-risk KT patients with early BL. Trial registration clinicaltrials.gov: NCT04936282. Registered June 23, 2021, https://clinicaltrials.gov/ct2/show/NCT04936282?term=NCT04936282&draw=2&rank=1. Protocol Version 2 of 21 January 2022. Sponsor: Canary Isles Institute for Health Research Foundation, Canary Isles (FIISC). mgomez@fciisc.org.

Published
2022

24. NAFLD association with renal impairment in type 2 diabetes patients

Author

Rivera, Jesús, primary, Pons, Monica, additional, Planas, Alejandra, additional, Canonge, Rafael Simo, additional, Bañeras, Jordi, additional, Ferreira, Ignacio, additional, Soler, María José, additional, Seron, Daniel, additional, Genesca, Joan, additional, and Pericàs, Juan Manuel, additional

Published
2022
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26. Different Patterns of Risk Factors for Mortality according Recipient Age after Renal Transplantation. A Multicenter and Prospective Study at Ten Years in the Clinical Practice

Author

Morales, Jose Maria, Marcen, Roberto, Anaya, Fernando, Andres, Amado, Arias, Manuel, Bustamante, Jesus, Cabello, Mercedes, Del Castillo, Domingo, Escuin, Fernando, Vernet, Salvador Gil, Molina, Miguel Gonzalez, Gainza, Javier, Oppenheimer, Federico, Pallardo, Luis, Seron, Daniel, and Valdes, Francisco

Published
2018
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27. Apolipoprotein A-Ib as Biomarker of FSGS Recurrence After Kidney Transplantation: Diagnostic Performance in a Prospective Cohort and Assessment of its Prognostic Value

Author

Cachá, Conxita Jacobs, Gay, Natalia Puig, Sellares, Joana, Guirado, Lluis, Roncero, Francisco Gonzalez, Jimenez, Carlos, Zárraga, Sofia, Paul, Javier, Ricardo, Lauzurica, Alonso, Angel, Ana, Fernandez, Isabel, Beneyto, Auxiliadora, Mazuecos, Domingo, Hernandez, Alberto, Rodriguez-Benot, Franco, Antonio, Luisa, Jimeno, Crespo, Marta, Meseguer, Anna, Moreso, Francesc, Seron, Daniel, Hellín, Joan López, and Cantarell, Carmen

Published
2018
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28. Proposed Definitions of Antibody-Mediated Rejection for Use as a Clinical Trial Endpoint in Kidney Transplantation

Author

Roufosse, Candice, primary, Becker, Jan Ulrich, additional, Rabant, Marion, additional, Seron, Daniel, additional, Bellini, Maria Irene, additional, Böhmig, Georg A., additional, Budde, Klemens, additional, Diekmann, Fritz, additional, Glotz, Denis, additional, Hilbrands, Luuk, additional, Loupy, Alexandre, additional, Oberbauer, Rainer, additional, Pengel, Liset, additional, Schneeberger, Stefan, additional, and Naesens, Maarten, additional

Published
2022
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30. Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation

Author

Seron, Daniel, primary, Rabant, Marion, additional, Becker, Jan Ulrich, additional, Roufosse, Candice, additional, Bellini, Maria Irene, additional, Böhmig, Georg A., additional, Budde, Klemens, additional, Diekmann, Fritz, additional, Glotz, Denis, additional, Hilbrands, Luuk, additional, Loupy, Alexandre, additional, Oberbauer, Rainer, additional, Pengel, Liset, additional, Schneeberger, Stefan, additional, and Naesens, Maarten, additional

Published
2022
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32. The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection

Author

Loupy, Alexandre, Haas, Mark, Roufosse, Candice, Naesens, Maarten, Adam, Benjamin, Afrouzian, Marjan, Akalin, Enver, Alachkar, Nada, Bagnasco, Serena, Becker, Jan U., Cornell, Lynn, Clahsen-van Groningen, Marian C., Demetris, Anthony J., Dragun, Duska, Duong van Huyen, Jean-Paul, Farris, Alton B., Fogo, Agnes B., Gibson, Ian W., Glotz, Denis, Gueguen, Juliette, Kikic, Zeljko, Kozakowski, Nicolas, Kraus, Edward, Lefaucheur, Carmen, Liapis, Helen, Mannon, Roslyn B., Montgomery, Robert A., Nankivell, Brian J., Nickeleit, Volker, Nickerson, Peter, Rabant, Marion, Racusen, Lorraine, Randhawa, Parmjeet, Robin, Blaise, Rosales, Ivy A., Sapir-Pichhadze, Ruth, Schinstock, Carrie A., Seron, Daniel, Singh, Harsharan K., Smith, Rex N., Stegall, Mark D., Zeevi, Adriana, Solez, Kim, Colvin, Robert, Mengel, Michael, Universitat Autònoma de Barcelona, Imperial College Healthcare NHS Trust- BRC Funding, and Pathology

Subjects
Graft Rejection, Oncology, medicine.medical_specialty, classification systems: Banff classification, translational research/science, T-Lymphocytes, T cell, Kidney (allograft) function/dysfunction, kidney transplantation/nephrology, kidney (allograft) function/dysfunction, 030230 surgery, Meeting Report, Kidney, clinical research/practice, Kidney transplant, Rejection, Interstitial inflammation, Meeting Reports, 03 medical and health sciences, 0302 clinical medicine, Artificial Intelligence, Internal medicine, mRNA/mRNA expression [Molecular biology], medicine, Immunology and Allergy, molecular biology: mRNA/mRNA expression, Pharmacology (medical), Microvascular inflammation, 11 Medical and Health Sciences, Banff classification [Classification systems], clinical decision-making, Transplantation, Kidney transplantation/nephrology, business.industry, Pathology/histopathology, Kidney Transplantation, Histocompatibility, clinical decision‐making, medicine.anatomical_structure, Antibody mediated rejection, Clinical research/practice, Surgery, Translational research/science, rejection, Solid organ transplantation, business, pathology/histopathology, Clinical decision-making
Abstract

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell–mediated rejection (TCMR), borderline, and antibody‐mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor‐specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation., This report focuses on the clarification of the criteria for chronic active T cell–mediated rejection and antibody‐mediated rejection and the optimization of the inflammation threshold for the diagnosis of borderline for acute T cell–mediated rejection, and discusses the potential to use machine learning in diagnostics and personalized therapeutics in solid organ transplantation.

Published
2020

38. Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients

Author

Hernández, Domingo, Alonso-Titos, Juana, Vázquez, Teresa, León, Myriam, Caballero, Abelardo, Cobo, María Angeles, Sola, Eugenia, López Jiménez, Verónica, Ruiz-Esteban, Pedro, Cruzado, Josep María, Sellarés, Joana, Moreso, Francesc, Manonelles, Anna, Torío, Alberto, Cabello, Mercedes, Delgado-Burgos, Juan, Casas, Cristina, Gutiérrez, Elena, Jironda, Cristina, Kanter, Julia, Seron, Daniel, Torres, Armando, Universitat Autònoma de Barcelona, [Hernández,D, Alonso-Titos,J, Vázquez,T, Sola,E, López,V, Ruiz-Esteban,P, Cabello,M, Delgado-Burgos,J, Casas,C, Gutiérrez,E, Jironda,C] Nephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain. [León,M] Pathology Department, Hospital Regional Universitario de Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain. [Caballero,A, Torío,A] Immunology Department, Hospital Regional Universitario de Málaga, University of Málaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain. [Cobo,MA, Torres,A] Nephrology Department, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas-Universidad La Laguna, REDinREN (RD16/0009/0031), Tenerife, Spain. [Cruzado,JM, Manonelles,A] Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, REDinREN (RD16/0009/0003), Barcelona, Spain. [Sellarés,J, Moreso,F, Serón,D] Nephrology Department, Hospital Universitari Valld’Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), Barcelona, Spain. [Kanter,J] Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain., This study was funded by grants from the Instituto de Salud Carlos III, Madrid, Spain (ICI14/0016, PI17/02043, CM19-00210, and REDinREN Network, RD16/0009/0006, RD16/0009/0003, RD16/0009/0030 and RD16/0009/0031), FONDOS FEDER and the Spanish Society of Transplanta tion. We also appreciate support from Astellas Pharma Inc. with a grant via the Andalusian Society of Solid Organ Transplantation (SATOT).

Subjects
Protocol biopsy, corticosteroids withdrawal, medicine.medical_treatment, Biopsy, 030232 urology & nephrology, Trasplantament renal, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation [Medical Subject Headings], 030230 surgery, Gastroenterology, Kidney transplant, Anatomy::Body Regions::Transplants::Allografts [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Kidney transplantation, Low immunological risk, 0302 clinical medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Biopsy [Medical Subject Headings], subclinical inflammation, Trasplante de riñón, chronic graft histological changes, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings], Adrenocortical hormones, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Clinical Trials, Phase IV as Topic [Medical Subject Headings], Immunosuppression, General Medicine, Presión sanguínea, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression [Medical Subject Headings], Chronic graft histological changes, Corticosteroids withdrawal, Blood pressure, Corticosteroid, Medicine, medicine.symptom, rejection, Biòpsia, kidney transplant, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], medicine.drug_class, Inflammation, Rejection, Article, 03 medical and health sciences, Internal medicine, Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure [Medical Subject Headings], medicine, protocol biopsy, Clinical significance, Borderline lesions, Corticoesteroides, Subclinical inflammation, Inflamación, business.industry, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones [Medical Subject Headings], Corticosteroides, Tacrolimus, Terapia de inmunosupresión, Clinical trial, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings], low immunological risk, Rechazo, business, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Tacrolimus [Medical Subject Headings], borderline lesions
Abstract

The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC, n = 52) or corticosteroid withdrawal (CSW, n = 53). Both groups received tacrolimus and MMF and had another protocol-biopsy at 24 months. The acute rejection rate, including subclinical inflammation (SCI), was comparable between groups (21.2 vs. 24.5%). No patients developed dnDSA. Inflammatory and chronicity scores increased from 3 to 24 months in patients with, at baseline, no inflammation (NI) or SCI, regardless of treatment. CSW patients with SCI at 3 months had a significantly increased chronicity score at 24 months. HbA1c levels were lower in CSW patients (6.4 ± 1.2 vs. 5.7 ± 0.6%, p = 0.013) at 24 months, as was systolic blood pressure (134.2 ± 14.9 vs. 125.7 ± 15.3 mmHg, p = 0.016). Allograft function was comparable between groups and no patients died or lost their graft. An increase in chronicity scores at 2-years post-transplantation was observed in low-immunological-risk KT recipients with initial NI or SCI, but CSW may accelerate chronicity changes, especially in patients with early SCI. This strategy did, however, improve the cardiovascular profiles of patients.

Published
2021

39. Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients

Author

Hernández, Domingo, Vázquez, Teresa, Alonso-Titos, Juana, León, Myriam, Caballero, Abelardo, Cobo, María Angeles, Sola, Eugenia, López Jiménez, Verónica, Ruiz-Esteban, Pedro, Cruzado, Josep María, Sellarés, Joana, Moreso, Francesc, Manonelles, Anna, Torio, Alberto, Cabello, Mercedes, Delgado-Burgos, Juan, Casas, Cristina, Gutiérrez, Elena, Jironda, Cristina, Kanter, Julia, Seron, Daniel, Torres, Armando, Universidad Autònoma de Barcelona, [Hernández,D, Vázquez,T, Alonso-Titos,J, Sola,E, López,V, Ruiz-Esteban,P, Cabello,M, Delgado-Burgos,J, Casas,C, Gutiérrez,E, Jironda,C] Nephrology Department, Hospital Regional Universitario de Málaga, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [León,M] Pathology Department, Hospital Regional Universitario de Malaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [Caballero,A, Torio,A] Immunology Department, Hospital Regional Universitario de Málaga, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), REDinREN (RD16/0009/0006), Málaga, Spain. [Cobo,MA, Torres,A] Nephrology Department, Instituto de Tecnologías Biomédicas-Universidad La Laguna, Hospital Universitario de Canarias, REDinREN (RD16/0009/0031), Tenerife, Spain. [Cruzado,JM, Manonelles,A, ] Nephrology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, REDinREN (RD16/0009/0003), Barcelona, Spain. [Sellarés,J, Moreso,F, Serón,D] Nephrology Department, Hospital Universitari Valld’Hebron, Universitat Autonoma, Barcelona, REDinREN (RD16/0009/0030), Barcelona, Spain. [Kanter,J] Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain., This study was funded by grants from the Instituto de Salud Carlos III, Madrid, Spain (ICI14/0016, PI17/02043, CM19-00210, and REDinREN Network, RD16/0009/0006, RD16/0009/0003, RD16/0009/0030 and RD16/0009/0031), FONDOS FEDER and Spanish Society of Transplantation. We also appreciate support from Astellas Pharma Inc. with a grant via the Andalusian Society of Solid Organ Transplantation (SATOT).

Subjects
Biopsy, 030232 urology & nephrology, Trasplantament renal, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation [Medical Subject Headings], Persons::Persons::Occupational Groups::Health Personnel::Physicians [Medical Subject Headings], 030230 surgery, Logistic regression, Anatomy::Body Regions::Transplants::Allografts [Medical Subject Headings], Gastroenterology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Kidney transplantation, 0302 clinical medicine, subclinical inflammation, Trasplante de riñón, Medicine, medicine.diagnostic_test, Confounding, General Medicine, Inflamació, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings], Funcionamiento retardado del injerto, Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens [Medical Subject Headings], medicine.medical_specialty, low-immunological risk, kidney transplantation, Human leukocyte antigen, Tacrolimus, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Delayed Graft Function [Medical Subject Headings], Article, 03 medical and health sciences, Internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy [Medical Subject Headings], Risk factor, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::ROC Curve [Medical Subject Headings], Inflammation, Inflamación, business.industry, HLA compatibility, Curva ROC, Delayed graft function, medicine.disease, ROC curve, Clinical trial, Biopsia, Antígenos HLA, business, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Banff criteria, Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Tacrolimus [Medical Subject Headings]
Abstract

The impact of human leukocyte antigen (HLA)-mismatching on the early appearance of subclinical inflammation (SCI) in low-immunological-risk kidney transplant (KT) recipients is undetermined. We aimed to assess whether HLA-mismatching (A-B-C-DR-DQ) is a risk factor for early SCI. As part of a clinical trial (Clinicaltrials.gov, number NCT02284464), a total of 105 low-immunological-risk KT patients underwent a protocol biopsy on the third month post-KT. As a result, 54 presented SCI, showing a greater number of total HLA-mismatches (p = 0.008) and worse allograft function compared with the no inflammation group (48.5 ± 13.6 vs. 60 ± 23.4 mL/min, p = 0.003). Multiple logistic regression showed that the only risk factor associated with SCI was the total HLA-mismatch score (OR 1.32, 95%CI 1.06–1.64, p = 0.013) or class II HLA mismatching (OR 1.51, 95%CI 1.04–2.19, p = 0.032) after adjusting for confounder variables (recipient age, delayed graft function, transfusion prior KT, and tacrolimus levels). The ROC curve illustrated that the HLA mismatching of six antigens was the optimal value in terms of sensitivity and specificity for predicting the SCI. Finally, a significantly higher proportion of SCI was seen in patients with &gt, 6 vs. ≤6 HLA-mismatches (62.3 vs. 37.7%, p = 0.008). HLA compatibility is an independent risk factor associated with early SCI. Thus, transplant physicians should perhaps be more aware of HLA mismatching to reduce these early harmful lesions.

Published
2021

41. Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies: The Influence of TAC Exposure and Metabolism

Author

Chamoun, Betty, primary, Torres, Irina B., additional, Gabaldón, Alejandra, additional, Sellarés, Joana, additional, Perelló, Manel, additional, Castellá, Eva, additional, Guri, Xavier, additional, Salcedo, Maite, additional, Toapanta, Nestor G., additional, Cidraque, Ignacio, additional, Moreso, Francesc, additional, and Seron, Daniel, additional

Published
2021
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42. A Rejection Gene Expression Score in Indication and Surveillance Biopsies Is Associated with Graft Outcome

Author

Chamoun, Betty, Caraben, Anna, Torres, Irina B., Sellares, Joana, Jiménez, Raquel, Toapanta, Néstor, Cidraque, Ignacio, Gabaldón, Alejandra, Perelló, Manel, Gonzalo, Ricardo, O'Valle, Francisco, Moreso, Francesc, Seron, Daniel, and Universitat Autònoma de Barcelona

Subjects
Graft Rejection, Male, Microarrays, Biopsy, 030232 urology & nephrology, 030230 surgery, Kidney, Gastroenterology, lcsh:Chemistry, transcriptomics, 0302 clinical medicine, Risk Factors, Histological diagnosis, Gene expression, Medicine, lcsh:QH301-705.5, microarrays, Spectroscopy, Subclinical infection, Hazard ratio, Area under the curve, General Medicine, Middle Aged, renal transplantation, Prognosis, Borderline changes, Computer Science Applications, borderline changes, Treatment Outcome, Research Design, Female, Kidney Diseases, rejection, interstitial fibrosis and tubular atrophy, Adult, medicine.medical_specialty, Renal function, Rejection, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, Humans, Transplantation, Homologous, Physical and Theoretical Chemistry, Transcriptomics, Molecular Biology, Aged, Monitoring, Physiologic, Biopsies, Interstitial fibrosis and tubular atrophy, business.industry, Organic Chemistry, biopsies, Renal transplantation, Microarray Analysis, Kidney Transplantation, Confidence interval, lcsh:Biology (General), lcsh:QD1-999, Asymptomatic Diseases, Renal allograft, business, Transcriptome
Abstract

Rejection-associated gene expression has been characterized in renal allograft biopsies for cause. The aim is to evaluate rejection gene expression in subclinical rejection and in biopsies with borderline changes or interstitial fibrosis and tubular atrophy (IFTA). We included 96 biopsies. Most differentially expressed genes between normal surveillance biopsies (n = 17) and clinical rejection (n = 12) were obtained. A rejection-associated gene (RAG) score was defined as its geometric mean. The following groups were considered: (a) subclinical rejection (REJ-S, n = 6), (b) borderline changes in biopsies for cause (BL-C, n = 13), (c) borderline changes in surveillance biopsies (BL-S, n = 12), (d) IFTA in biopsies for cause (IFTA-C, n = 20), and (e) IFTA in surveillance biopsies (IFTA-S, n = 16). The outcome variable was death-censored graft loss or glomerular filtration rate decline &ge, 30 % at 2 years. A RAG score containing 109 genes derived from normal and clinical rejection (area under the curve, AUC = 1) was employed to classify the study groups. A positive RAG score was observed in 83% REJ-S, 38% BL-C, 17% BL-S, 25% IFTA-C, and 5% IFTA-S. A positive RAG score was an independent predictor of graft outcome from histological diagnosis (hazard ratio: 3.5 and 95% confidence interval: 1.1&ndash, 10.9, p = 0.031). A positive RAG score predicts graft outcome in surveillance and for cause biopsies with a less severe phenotype than clinical rejection.

Published
2020
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45. Secondary antibody deficiency is associated with development of infection in kidney transplantation: Results of a multicenter study

Author

Sarmiento, Elizabeth, primary, Jimenez, Maricela, additional, Natale, Marisa, additional, Rodriguez‐Ferrero, Marisa, additional, Anaya, Fernando, additional, Lopez‐Hoyos, Marcos, additional, Rodrigo, Emilio, additional, Arias, Manuel, additional, Perello, Manel, additional, Seron, Daniel, additional, Karanovic, Boris, additional, Ezzahouri, Ikram, additional, Mezzano, Sergio, additional, Jaramillo, Maria, additional, Calahorra, Leticia, additional, Alarcon, Alba, additional, Navarro, Joaquin, additional, Muñoz, Patricia, additional, and Carbone, Javier, additional

Published
2020
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46. PROGRESSION OF RENAL DISEASE IN RENAL TRANSPLANT RECIPIENTS: RO-259

Author

Marcen, Roberto, Morales, Jose M., Del Castillo, Domingo, Molina, Miguel Gonzalez, Valdes, Francisco, Seron, Daniel, Pallardo, Luis, Oppenheimer, Federico, Lampreabe, Ildefonso, Gilvernet, Salvador, Gainza, Javier F., Escuin, Fernando, Capdevila, Luis, Campistol, Jose M., Cabello, Mercedes, Bustamante, Jesus, Arias, Manuel, Andres, Amado, and Anaya, Fernando

Published
2011

47. THE CRITICAL ROLE OF RENAL FUNCTION, PROTEINURIA AND CARDIOVASCULAR DISEASE ON THE RESULTS AFTER RENAL TRANSPLANTATION.A PROSPECTIVE MULTICENTRE STUDY AT FIVE YEARS ACCORDING RECIPIENT AGE: O-213

Author

Morales, Jose M., Marcen, Roberto, Del Castillo, Domingo, Molina, Miguel Gonzalez, Anaya, Fernando, Andrés, Amado, Arias, Manuel, Bustamante, Jesus, Cabello, Mercedes, Campistol, Jose M., Capdevila, L., Escuin, Fernando, Gainza, Javier F., Gilvernet, Salvador, Lampreabe, Ildefonso, Oppenheimer, Federico, Pallardo, Luis, Seron, Daniel, and Valdes, Francisco

Published
2011

50. Cellular Immunity to Predict the Risk of Cytomegalovirus Infection in Kidney Transplantation: A Prospective, Interventional, Multicenter Clinical Trial

Author

Jarque, Marta, primary, Crespo, Elena, primary, Melilli, Edoardo, primary, Gutiérrez, Alex, primary, Moreso, Francesc, primary, Guirado, Lluís, primary, Revuelta, Ignacio, primary, Montero, Nuria, primary, Torras, Joan, primary, Riera, Lluís, primary, Meneghini, Maria, primary, Taco, Omar, primary, Manonelles, Anna, primary, Paul, Javier, primary, Seron, Daniel, primary, Facundo, Carme, primary, Cruzado, Josep M, primary, Gil Vernet, Salvador, primary, Grinyó, Josep M, primary, and Bestard, Oriol, primary

Published
2020
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