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1. Nutritional and hygienic quality of meals served in school canteens in Togo: A cross-sectional study

Author: Carmelle Mizéhoun-Adissoda, Koffi Alouki, Menonli Adjobimey, Achille Yémoa, Raïssa Itiblitse, Florence Alihonou, Elom K. Aglago, Jean-Claude Desport, Université d'Abomey-Calavi, Faculté des Sciences de la Santé, Faculté des sciences et techniques, Université de Kara, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], and CHU Limoges
Subjects: 2. Zero hunger, 0303 health sciences, 030309 nutrition & dietetics, digestive, oral, and skin physiology, Hygiene, School feeding, 03 medical and health sciences, 0302 clinical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030212 general & internal medicine, Food Science, Biotechnology, Food quality, Nutrition
Abstract: International audience; School feeding is important in terms of nutrition, as it contributes to the prevention of malnutrition, especially in low-income countries. However, the nutritional and hygienic quality of meals served at schools in several countries is rarely examined. We aimed to assess the quality of meals served in school canteens in Togo. We designed a descriptive cross-sectional study and collected data from eight school canteens located in Southern Togo. Hygiene compliance and potential sources of food contamination in the canteens were assessed using the 5 M approach, which evaluates the performance of hygiene parameters at each “M" i.e., medium (cooking environment), raw material (staples), cooking material (kitchenware), method (cooking) and manipulator (cooks) in the food preparation environment. Foods were sampled in each school and analysed for icrobiological (presence of Salmonella, total coliforms, and staphylococci) and nutritional (nutrient content) quality. The 5 M analysis revealed significant hygienic violations by the food preparators, as well as poor preparation conditions and utilization of low-quality raw materials in all the school canteens. Out of the 30 meal samples collected, 10 were of poor microbiological quality with the presence of total coliforms and staphylococci exceeding established limits of 10 and 100 cfu/g in 30 and 6.6% of the meals, respectively. However, none of the meals was contaminated by Salmonella spp. Nutritional analysis revealed that none of the meals served respected the nutritional balance, especially for contents in calcium, and vitamins A and C. Nonetheless, the iron content complied with the recommendations for children aged 9–13 years. Our analyses showed that several routes of contamination exist for the meals consumed in school canteens in Togo. Also, the nutritional quality of the readyto-eat foods served at school canteens needs to be improved, particularly with the inclusion in the diet of fruits and vegetables to cover the micronutrient requirements.
Published: 2022
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2. Subclinical proximal tubulopathy in hepatitis B: The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

Author: Thierry Poynard, Guillaume Lassailly, Juliette Foucher, Manh-Thông Dao, Xavier Duval, Isabelle Hourmand-Ollivier, Séverine Hommel, Vincent Di Martino, Pierre-Henri Bernard, Dominique Larrey, Nathalie Boyer, Anais Labrunie, Marc Bardou, Paul Carrier, Marilyne Debette-Gratien, Marie Essig, Eric Nguyen-Khac, Armand Abergel, Victor de Ledinghen, Véronique Loustaud-Ratti, Claire Vanlemmens, Nathalie Ganne-Carrié, Anne Gervais, Jean-Baptiste Hiriart, Fouchard-Hubert Isabelle, Christine Aurières, Pauline Pinet, Thierry Thevenot, Jérémie Jacques, Philippe Mathurin, Dominique Thabut, Christophe Renou, Daniel Cohen, Marianne Maynard, Valérie Canva, Julien Vergniol, Bertrand Hanslik, Anaïs Brayette, Sophie Alain, Matthieu Schnee, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Pôle Universitaire d’Addictologie en Limousin, CH Esquirol [Limoges] (CH Esquirol), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Plate forme de bioinformatique et biostatistique (CEBIMER), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Génomique fonctionnelle des tumeurs solides = Functional Genomics of Solid Tumors [CRC] (FunGeST), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies infectieuses et tropicales [CHU Limoges], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hepatology, Hopital, Physiopathologie des Maladies Inflammatoires de l'Intestin, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Services de Maladies Infectieuses et Tropicales [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Bordeaux [Bordeaux], Service d'Hépato-gastro-entérologie et oncologie digestive (CHU de Bordeaux), CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Paris School of Economics (PSE), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Paris Jourdan Sciences Economiques (PJSE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Normandie Université (NU), Service d'Hépatologie [CHRU Besançon], Hôpital Haut-Lévêque [CHU Bordeaux], Hôpital Claude Huriez [Lille], CHU Lille, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d’Hépatologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Université Paris Cité (UPCité), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service d'Hépato-Gastro-Entérologie, CHU Bordeaux [Bordeaux]-Hôpital Saint-André, Service de gastroentérologie (CHD Vendee - Hopital Les Oudairies, La Roche Sur Yon), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Hôpital Saint-Éloi [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation (IPPRITT), Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) (U1018 (Équipe 5)), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service Néphrologie/Dialyse [AP-HP Ambroise-Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université Paris Cité (UPC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], and Hôpital Charles Nicolle [Rouen]-CHU Rouen
Subjects: Hepatitis B virus, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Population, Renal function, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Nucleoside analogues, Internal medicine, medicine, Cumulative incidence, Renal insufficiency, education, education.field_of_study, Hepatology, business.industry, Proximal tubulopathy, Incidence (epidemiology), Hazard ratio, Entecavir, Hepatitis B, medicine.disease, 030220 oncology & carcinogenesis, Prospective Study, 030211 gastroenterology & hepatology, business, Biomarkers, medicine.drug
Abstract: International audience; BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity, such as estimated glomerular filtration rate (eGFR) and phosphatemia, are late markers of proximal tubulopathy. Multiple early markers are available, but no consensus exists on their use. AIM To determine the 24 mo prevalence of subclinical proximal tubulopathy (SPT), as defined with early biomarkers, in treated vs untreated hepatitis B virus (HBV)-monoinfected patients. METHODS A prospective, non-randomized, multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was conducted. The patients were separated into three groups: Naive, starting entecavir (ETV) treatment, or starting tenofovir disoproxil (TDF) treatment. Data on the early markers of SPT, the eGFR and phosphatemia, were collected quarterly. SPT was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%. The prevalence and cumulative incidence of SPT at month 24 (M24) were calculated. Quantitative data were analyzed using analyses of variance or Kruskal-Wallis tests, whereas chi-squared or Fisher's exact tests were used to analyze qualitative data. Multivariate analyses were used to adjust for any potential confounding factors. RESULTS Of the 196 patients analyzed, 138 (84 naive, 28 starting ETV, and 26 starting TDF) had no SPT at inclusion. At M24, the prevalence of SPT was not statistically different between naive and either treated group (21.1% vs 30.7%, P < 0.42 and 50.0% vs 30.7%, P = 0.32 for ETV and TDF, respectively); no patient had an eGFR lower than 50 mL/min/1.73 m(2) or phosphatemia less than 0.48 mmoL/L. In the multivariate analysis, no explanatory variables were identified after adjustment. The cumulative incidence of SPT over 24 mo (25.5%, 13.3%, and 52.9% in the naive, ETV, and TDF groups, respectively) tended to be higher in the TDF group vs the naive group (hazard ratio: 2.283, P = 0.05). SPT-free survival at M24 was 57.6%, 68.8%, and 23.5% for the naive, ETV, and TDF groups, respectively. The median survival time without SPT, evaluated only in the TDF group, was 5.9 mo. CONCLUSION The prevalence and incidence of SPT was higher in TDF-treated patients compared to naive patients. SPT in the naive population suggests that HBV can induce renal tubular toxicity.
Published: 2020
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3. First cases of Omicron in France are exhibiting mild symptoms, November 2021-January 2022

Author: A. Maisa, G. Spaccaferri, L. Fournier, J. Schaeffer, J. Deniau, P. Rolland, B. Coignard, A. Andrieu, O. Broustal, S. Chene, S. Chent, E. Fougère, G. Gbaguidi, M. Hamidouche, A. Lamy, Q. Mano, B. Mastrovito, A. Mercier, G. Modenesi, G. Picard, J. Prudhomme, F. Rapilly, A. Riondel, M. Rivière, B. Villegas Ramirez, A. Zhu-Soubise, M. Zurbaran, A. Amzert, L. Andreoletti, A. Bal, R. Beaurepere, S. Behillil, L. Belec, C. Bernard, L. Bocket, L. Bouri, T. Bourlet, C. Bressollette-Bodin, S. Brichler, C. Brugerolles, S. Cado, V. Calvez, N. Capron, S. Castelain, J. Castro-Alvarez, M.-L. Chaix, C. Charpentier, D. Che, C. Chillou, P. Colson, P. Coudene, A. Crinquette, A. De Rougemont, H. Delagrèverie, C. Delamare, T. Denecker-Berardino, D. Descamps, M. Desroches, G. Destras, G. Dos Santos, A. Ducancelle, S. Ducreux, T. Duret, V. Enouf, S. Fafi-Kremer, C. Felici, S. Fourati, P.-E. Fournier, C. Gaudy, H. Germain, V. Giordanengo, O. Gorge, S. Haim-Boukobza, C. Henquell, A. Holstein, L. Houhamdi, J. Izopet, V. Jacomo, A. Jacques, M.-C. Jaffar-Bandjee, M. Jimenez, L. Josset, S. Kemeny, M.-E. Lafon, A. Le Bars, G. Le Corguille, Q. Lepiller, A. Levasseur, N. Leveque, B. Lina, C. Madelaine, C. Malabat, S. Marque-Juillet, T. Martin-Dunavit, P. Mavingui, A. Merens, I. Messak, L. Morand-Joubert, X. Naudot, P. Neybecker, J.-M. Pawlotsky, L. Pilorge, J.-C. Plantier, C. Poggi, M. Pretet, C. Ragot, H. Raoul, S. Rogez, A.-M. Roque-Afonso, B. Roquebert, D. Rousset, F. Rozenberg, C. Sagot, S. Sahnoune, D. Salgado, O. Sand, C. Saudemont, E. Schvoerer, E. Simon-Loriere, R. Stephan, J. Sudour, V. Thibault, E. Tuaillon, A. Vabret, E. Vallee, S. Van Der Werf, J. Van Helden, L. Verdurme, A. Vignola, D. Wilkinson, Y. Yazdanpanah, Santé publique France - French National Public Health Agency [Saint-Maurice, France], EMERGEN consortium, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), NASA Ames Research Center (ARC), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Département lmage et Traitement Information (IMT Atlantique - ITI), IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Equipe DECIDE (Lab-STICC_DECIDE), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Santé publique France, the French national public health agency.Caisse nationale d’assurance maladie (Cnam), the national health insurance funds.'Enhancing Whole Genome Sequencing (WGS) and/or Reverse Transcription Polymerase Chain Reaction (RT-PCR) national infrastructures and capacities to respond to the COVID-19 pandemic in the European Union and European Economic Area' Grant Agreement ECDC/HERA/2021/007 ECD. 12221., Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), and COMBE, Isabelle
Subjects: Adult, Epidemiology, MESH: Hospitalization, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: COVID-19, Humans, MESH: SARS-CoV-2, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Signs and symptoms, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Humans, SARS-CoV-2, Vaccination, COVID-19, MESH: Adult, MESH: Vaccination, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, MESH: France, Hospitalization, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, France, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Surveys and questionnaires, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Abstract: International audience; ObjectivesWe aimed to investigate the first Omicron cases detected in France in order to assess case characteristics and provide supporting information on the possible impact of this variant on the healthcare system.MethodsA standardized questionnaire was used to collect information from confirmed and probable Omicron cases.ResultsMedian age of 468 investigated cases was 35 years, 376 were symptomatic (89%); 64% were vaccinated with two doses and 7% had received three doses. Loss of smell and taste were reported by 8.3% and 9% of cases, respectively. Seven cases were hospitalized, three of those were unvaccinated (including two with reported precondition). No admissions to intensive care and no deaths were reported.ConclusionsOur results confirm a mild clinical presentation among the first Omicron cases detected in France and highlight the importance for the national COVID-19 surveillance system to quickly detect and adapt to the emergence of a new variant.
Published: 2022
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4. The hypometabolic state: A good predictor of a better prognosis in amyotrophic lateral sclerosis

Author: Nicoletta Guanziroli, Philippe Fayemendy, Philippe Couratier, Nilo Riva, Ettore Corradi, Valeria A. Sansone, Philippe Corcia, Christian Lunetta, Andrea Lizio, Letizia Leocani, Massimo Filippi, Marina Cattaneo, Pierre Jésus, Cattaneo, M., Jesus, P., Lizio, A., Fayemendy, P., Guanziroli, N., Corradi, E., Sansone, V., Leocani, L., Filippi, M., Riva, N., Corcia, P., Couratier, P., Lunetta, C., ASST Grande Ospedale Metropolitano Niguarda, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, San Raffaele Hospital, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Limoges], CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, medicine.medical_specialty, 030309 nutrition & dietetics, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Internal medicine, Weight Loss, medicine, Humans, Amyotrophic lateral sclerosis, Aged, Retrospective Studies, 0303 health sciences, business.industry, Amyotrophic Lateral Sclerosis, Retrospective cohort study, Calorimetry, Indirect, Middle Aged, medicine.disease, Prognosis, Gastrostomy, 3. Good health, Psychiatry and Mental health, Malnutrition, Cohort, Breathing, Hypermetabolism, Body Composition, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Surgery, Female, Neurology (clinical), medicine.symptom, business, Energy Metabolism, 030217 neurology & neurosurgery
Abstract: BackgroundMalnutrition and weight loss are negative prognostic factors for survival in patients with amyotrophic lateral sclerosis (ALS). However, energy expenditure at rest (REE) is still not included in clinical practice, and no data are available concerning hypometabolic state in ALS.ObjectiveTo evaluate in a referral cohort of patients with ALS the prevalence of hypometabolic state as compared with normometabolic and hypermetabolic states, and to correlate it with clinical phenotype, rate of progression and survival.DesignWe conducted a retrospective study examining REE measured by indirect calorimetry in patients with ALS referred to Milan, Limoges and Tours referral centres between January 2011 and December 2017. Hypometabolism and hypermetabolism states were defined when REE difference between measured and predictive values was ≤−10% and ≥10%, respectively. We evaluated the relationship between these metabolic alterations and measures of body composition, clinical characteristics and survival.ResultsEight hundred forty-seven patients with ALS were recruited. The median age at onset was 63.79 years (IQR 55.00–71.17). The male/female ratio was 1.26 (M/F: 472/375). Ten per cent of patients with ALS were hypometabolic whereas 40% were hypermetabolic. Hypometabolism was significantly associated with later need for gastrostomy, non-invasive ventilation and tracheostomy placement. Furthermore, hypometabolic patients with ALS significantly outlived normometabolic (HR=1.901 (95% CI 1.080 to 3.345), p=0.0259) and hypermetabolic (HR=2.138 (95% CI 1.154 to 3.958), p=0.0157) patients.ConclusionHypometabolism in ALS is not uncommon and is associated with slower disease progression and better survival than normometabolic and hypermetabolic subjects. Indirect calorimetry should be performed at least at time of diagnosis because alterations in metabolism are correlated with prognosis.
Published: 2022
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5. Impact sur l'état fonctionnel d'une complémentation nutritionnelle orale (CNO) précoce des patients atteints de SLA : étude NUTRALS

Author: Jésus, Pierre, Fayemendy, Philippe, Desport, Jean-Claude, Marin, Benoît, Lautrette, Géraldine, Labrunie, Anaïs, Preux, Pierre-Marie, Luna, Jaime, Couratier, Philippe, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Centre référent Sclérose Latérale Amyotrophique et autres maladies du motoneurone [CHU Limoges] (SLA CHU Limoges), Plate forme de bioinformatique et biostatistique (CEBIMER), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Service de Neurologie [CHU Limoges], FILSLAN (Filière de Santé Maladies Rares Sclérose Latérale Amyotrophique et Maladies du Neurone Moteur) & ARSLA (Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Evolution, ALSFRS-R, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Complément nutritionnel oral
Abstract: International audience; Introduction : Dans la SLA, le statut nutritionnel est associé à l’évolution de la maladie. L’objectif était d’évaluer l’impact d’une prise précoce de CNO sur l'évolution fonctionnelle, nutritionnelle et respiratoire à 6 mois, chez des patients SLA nouvellement diagnostiqués. Méthodes : Le groupe intervention bénéficiait de CNO à l’inclusion versus groupe contrôle avec CNO en cas de perte de poids. L’étude était randomisée en double aveugle et multicentrique sur 18 centres SLA français. Les variables neurologiques (forme de début, ALSFRS-R), nutritionnelles (perte de poids, IMC, composition corporelle) et respiratoire (capacité vitale forcée [CVF]) étaient relevées. L'analyse statistique a été réalisée par pattern mixture model (PMM). Résultats : 113 patients ont été inclus dans les deux groupes. L’âge moyen était de 63,2 ± 10,7 ans avec un sex-ratio H/F de 1,17 et une forme bulbaire dans 26,5% des cas. A l’inclusion, l’ALSFRS-R était de 38,6 ± 5,1 points et sa pente de -1,1 ± 0,8 points/mois. La perte de poids était de -4,9 ± 7,5% et 9,9% des patients étaient dénutris. Il n’existait pas de différence significative entre les deux groupes. Les apports énergétiques et protéiques à l’inclusion étaient de 33,5 ± 10,5 kcal/kg/j et de 1,4 ± 0,4 g/kg/j, respectivement et étaient similaires entre les deux groupes et au cours du suivi. Le PMM ne retrouvait pas de différence significative entre les deux groupes concernant l’évolution de l’ALSFRS-R. Il existait une évolution plus favorable à 6 mois de l’IMC et de la masse grasse dans le groupe intervention. En revanche, l’évolution de la CVF était similaire. Conclusion : Bien que l’IMC et la composition corporelle évoluaient plus favorablement dans le groupe intervention, cette première étude interventionnelle, contrôlée, randomisée française n’a pas permis de montrer un impact sur l’évolution fonctionnelle d’une prise précoce de CNO au cours de la SLA
Published: 2021

6. Associations between dental problems and underweight status among rural women in Burkina Faso: Results from the first WHO STEPS survey

Author: Diendéré, Jeoffray, Zéba, Augustin Nawidimbasba, Kiemtoré, Sibraogo, Sombié, Olivier Ouahamin, Fayemendy, Philippe, Jésus, Pierre, Millogo, Athanase, Savadogo, Aly, Tinto, Halidou, Desport, Jean-Claude, Institut Supérieur des Sciences de la Santé [Bobo-Dioulasso, Burkina Faso], Université Nazi Boni [Bobo-Dioulasso, Burkina Faso], Paediatric Department [Ouagadougou, Burkina Faso], Centre Hospitalier Universitaire Yalgado Ouédraogo (CHUYO), IRSS ‐ Clinical Research Unit of Nanoro (IRSS‐CRUN), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, University Hospital Souro Sanou [Bobo-Dioulasso, Burkina Faso], LABIA/CRSBAN/Department of Biochemistry and Microbiology, UFR-SVT, Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Grelier, Elisabeth
Subjects: stomatognathic diseases, Risk factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Burkina Faso, Prevalence, Dental problems, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Underweight, Rural women
Abstract: International audience; Abstract Objective: To explore the relationships between dental problems and underweight status among rural women in Burkina Faso by using nationally representative data. Design: This was a cross-sectional secondary study of primary data obtained by the 2013 World Health Organization Stepwise Approach to Surveillance survey conducted in Burkina Faso. Descriptive and analytical analyses were performed using Student’s t test, ANOVA, the chi-square test, Fisher’s exact test and logistic regression. Setting: All 13 Burkinabè regions were categorized using quartiles of urbanization rates. Participants: The participants were 1730 rural women aged 25-64 years. Results: The prevalence of underweight was 16.0%, and 24.1% of participants experienced dental problems during the 12-month period. The women with dental problems were more frequently underweight (19.9% and 14.7%; p49 years old) and smokeless tobacco users. Age >49 years, professions with inconsistent income, a lack of education, smokeless tobacco use and low BMI were factors that were significantly associated with dental problems, while residency in a low-urbanization area was a protective factor. Conclusion: The prevalence of underweight in rural Burkinabè women is among the highest in sub-Saharan Africa, and women with dental problems are more frequently affected than those without dental problems. Public health measures for the prevention of these disorders should specifically target women aged over 49 years and smokeless tobacco users.
Published: 2021
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7. Prevalence of tachyphagia at lunch and associated factors in a population of workers

Author: Marie Perrier, Claire Millotte, Marion Vergonjeanne, Catherine Le Flahec, Jean Claude Desport, Laurence Salle, Pierre Jésus, Monique Dupont-Cuisinier, Fayemendy Philippe, Martine Gravelat, Michel Druet-Cabanac, Service de Médecine interne B, Endocrinologie, Diabète, Maladies métaboliques [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Santé au Travail [CHU Limoges], Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, 030309 nutrition & dietetics, Population, Occupational medicine, 03 medical and health sciences, 0302 clinical medicine, Occupational groups, Medicine, 030212 general & internal medicine, Obesity, education, 2. Zero hunger, 0303 health sciences, Meal, education.field_of_study, business.industry, Public health, medicine.disease, Feeding and eating disorders, 3. Good health, Psychiatry and Mental health, Clinical Psychology, Lunch, Cohort, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business, Body mass index, Weight gain, Demography
Abstract: International audience; Purpose: Obesity is a public health problem worldwide. The eating habits of French workers need to be clarified. In particular, tachyphagia (meal lasting < 15 min) promotes weight gain. The present study aimed to investigate the presence of tachyphagia at lunchtime, the factors associated with tachyphagia, and the relationship between tachyphagia and obesity among workers. Methods: This cross-sectional study was conducted between January and May 2016 in five departments of occupational medicine. An anonymous self-administered questionnaire was used to gather general declarative data, such as weight and height (to calculate body mass index [BMI]) and information about lunchtime habits, including the time spent eating. Results: A total of 415 workers with a mean age of 41.1 ± 12.6 years were included. The mean BMI was 23.8 ± 4.6 kg/m2, and the prevalence of obesity was 15.9%. Tachyphagia occurred in 20.3% of the cases and was more frequent in younger workers. Multivariate analysis revealed that skipping meals, eating standing up, and eating fast food were positively associated with tachyphagia (p = 0.015, p = 0.028, and p = 0.027, respectively). Older age and eating with colleagues/friends were negatively associated with tachyphagia (p = 0.003 and p < 0.0001, respectively). No significant association was observed between tachyphagia and obesity. Conclusion: Our study provides important information about the lunchtime habits of workers. Maintaining commensality is crucial, particularly in young workers. Companies should play a role in organising their employees' lunch breaks. Level III Evidence obtained from well-designed cohort or case-control analytic studies.
Published: 2021
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8. Nutritional status and associated factors among community-dwelling elderly

Author: Gustave Mabiama, Dieudonné Adiogo, Philippe Fayemendy, Pierre Jésus, Jean-Claude Desport, Pierre-Marie Preux, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges]
Subjects: Male, Waist, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, Population, Nutritional Status, 030209 endocrinology & metabolism, Overweight, Body Mass Index, Head of Household, 03 medical and health sciences, 0302 clinical medicine, Elderly, Socio-demographic, Environmental health, medicine, Humans, Obesity, education, Aged, 2. Zero hunger, 0303 health sciences, education.field_of_study, Nutrition and Dietetics, business.industry, Malnutrition, 1. No poverty, Undernutrition, Anthropometry, medicine.disease, 3. Good health, Cross-Sectional Studies, Health, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Independent Living, medicine.symptom, business, Body mass index
Abstract: Summary Background and aims Although the ageing of the Cameroonian population is a public health issue in the coming years, the nutritional status of the elderly is unknown. The aim of the study was to assess the nutritional status, health status and associated socio-demographic factors among elderly in Cameroon. Methods A cross-sectional study of 599 elderly (aged ≥ 60) was conducted in urban and rural areas. Several socio-demographic, sanitary, and anthropometric (weight, height, body mass index (BMI), Waist Circumference (WC), Mid-Upper Arm Circumference (MUAC)) data were collected. Nutritional status was defined according to WHO. Multinomial analysis was performed to identify factors associated with nutritional status. The threshold of statistical significance was 5%. Results The population, representative of the elderly, was aged 68.9 ± 7.2 years, with sex ratio M/F = 0.93, weight 68.5 ± 14.7 kg, BMI 24.7 ± 5.3, WC 90.1 ± 12.8 cm and MUAC 28.2 ± 5.0 cm. According to BMI, undernutrition was 19.7%, normal status 37.9%, overweight 24.9%, obesity 17.5%. The concordance for undernutrition between BMI and MUAC was weak (kappa = 0.3). In multinomial analysis, only no medication was negatively associated with undernutrition (OR = 0.3). Obesity was positively associated with the urban environment (OR = 4.8) and inactivity (OR = 2.9) and negatively associated with male gender (OR = 0.4), widowed (OR = 0.2), head of household (OR = 0.4), no income (OR = 0.3), one pathology (OR = 0.4), no medication (OR = 0.2), having normal diastolic pressure (OR = 0.2). Conclusions Undernutrition and obesity (more frequent in women, and in urban area) affect 37.2% of the elderly. These nutritional disorders are a public health problem that cannot be ignored.
Published: 2021
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9. Efficacy of a Ready-to-Drink Gelled Water and of a Thickening Powder in Patients with Oropharyngeal Dysphagia: a Crossover Randomized Study

Author: L. Dussaulx, Achille Edem Tchalla, Jean-Yves Salle, Jean-Claude Desport, Pierre Jésus, Caroline Gayot, Annick Offret, Cécile Bonhomme, Charlotte Baudry, Etienne Hazart, Remy Thirion, Philippe Fayemendy, F. Trivin, Service de Médecine Physique et Réadaptation, CHU Bordeaux [Bordeaux], Handicap, Activité, Vieillissement, Autonomie, Environnement (HAVAE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Médecine Gériatrique [CHU Limoges], CHU Limoges, Centre hospitalier Rene Pleven de Dinan, CH de Saint-Malo [Broussais], Clinique Saint-Yves [Rennes], Neuroépidémiologie Tropicale (NET), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Lactalis Nutrition Santé, LACTALIS RECHERCHE ET DEVELOPPEMENT (LACTALIS R&D), Groupe Lactalis, Grelier, Elisabeth, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST)
Subjects: Ready-to-drink gelled water, medicine.medical_specialty, Gastroenterology, law.invention, 030507 speech-language pathology & audiology, 03 medical and health sciences, 0302 clinical medicine, Swallowing, Randomized controlled trial, law, Internal medicine, Multicenter trial, medicine, In patient, Thickened liquids, Stroke, Thickening powder, business.industry, Viscosity, Dysphagia, medicine.disease, 3. Good health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030211 gastroenterology & hepatology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Thickening, medicine.symptom, 0305 other medical science, business, Oropharyngeal dysphagia
Abstract: Management of oropharyngeal dysphagia (OD) is mainly based on modifying liquid viscosity and solid consistency in order to preserve oral feeding while avoiding unsafe swallowing. Adding thickening powders (TP) to water is the most common practice in patients suffering from OD to liquids, but ready-to-use gelled waters (RGW) can also be proposed. The main objective of this study was to assess the efficacy of a RGW and a TP on swallowing in hospitalized patients with different OD etiologies. This open, crossover, multicenter trial recruited thirty hospitalized patients with OD to liquids, confirmed by positive 3-ounce water test or positive Practical Aspiration Screening Scheme test. The patient’s ability to swallow 120 g of a RGW (IDDSI level 4) and a drink prepared with TP (nectar viscosity; NTP, 291 cP, IDDSI level 2; or if necessary, honey; HTP, 769 cP, IDDSI level 3) was evaluated in a random order at 1- to 3-day intervals. The main criterion was the efficacy of each product, defined as the proportion of patients who successfully swallowed without immediate reflexive cough. The RGW and TP were successfully swallowed in respectively 93.3% (95% CI: 77.9–99.2) and 82.8% (95% CI: 64.2–94.2) of patients with different dysphagia etiologies (stroke, neurodegenerative diseases, or aging) and unable to swallow thin water. Taste and texture of both study products were well appreciated by patients, with a preference for the RGW over TP. Therefore, the use of these thickened products could be part of the therapeutic strategy for patients with OD to liquids.
Published: 2021
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10. Long‐term survival after surgery of pancreatic primary squamous cell carcinoma: A case report and literature review

Author: Muriel Mathonnet, Sylvia M. Bardet, Abdelkader Taibi, Niki Christou, Jérémie Jacques, Aurélie Charissoux, Sylvaine Durand Fontanier, Fabien Fredon, Denis Valleix, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], Homéostasie Cellulaire et Pathologies (HCP), and Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)
Subjects: Surgical resection, squamous cell carcinoma, medicine.medical_specialty, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, pancreatic cancer, lcsh:Medicine, Case Report, Case Reports, 030204 cardiovascular system & hematology, chemotherapy, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Long term survival, Tumor stage, medicine, Basal cell, ComputingMilieux_MISCELLANEOUS, radiotherapy, Chemotherapy, lcsh:R5-920, business.industry, Optimal treatment, lcsh:R, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, General Medicine, medicine.disease, 3. Good health, Radiation therapy, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, 030220 oncology & carcinogenesis, Radiology, business, lcsh:Medicine (General)
Abstract: Pancreatic primary squamous cell carcinoma is rarer and no optimal treatment has been validated according to the tumor stage. The surgical resection was the only curative option. The radiotherapy or chemotherapy was performed for the other cases.
Published: 2019
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11. Outcomes and Future Directions of Per-Oral Endoscopic Pyloromyotomy

Author: Romain Legros, Denis Sautereau, Jacques Monteil, Jérémie Jacques, Guillaume Gourcerol, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Service de médecine nucléaire [CHU Limoges], Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), and Normandie Université (NU)-Normandie Université (NU)
Subjects: medicine.medical_specialty, Submucosal endoscopy, genetic structures, business.industry, General surgery, medicine.medical_treatment, Gastroenterology, Pyloromyotomy, medicine.disease, behavioral disciplines and activities, Clinical success, Therapeutic modalities, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Pyloric function, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, 030211 gastroenterology & hepatology, Gastroparesis, business, ComputingMilieux_MISCELLANEOUS, psychological phenomena and processes
Abstract: Gastroparesis is a challenging functional gastroenterological disorder, the complex pathophysiology of which hampers development of therapeutic modalities. Per-oral pyloromyotomy (POP) is a promising endoscopic therapy with a short-term clinical success rate of greater than 80%. Interest in POP is increasing, particularly in France, a country in which there is considerable expertise in submucosal endoscopy and functional disorders. Long-term follow-up and pyloric function evaluation are needed to assess the efficacy of POP in gastroparetic patients.
Published: 2019
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12. BDNF levels and liver stiffness in subjects with alcohol use disorder: Evaluation after alcohol withdrawal

Author: Paul Carrier, Véronique Loustaud-Ratti, Murielle Girard, Philippe Nubukpo, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Pôle Universitaire d’Addictologie en Limousin, CH Esquirol [Limoges] (CH Esquirol), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], and CHU Limoges
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, media_common.quotation_subject, Liver fibrosis, Medicine (miscellaneous), Alcohol, Alcohol use disorder, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neurotrophic factors, Liver stiffness, Internal medicine, mental disorders, medicine, alcohol withdrawal, Humans, media_common, liver fibrosis, business.industry, Brain-Derived Neurotrophic Factor, Addiction, Middle Aged, medicine.disease, Fibrosis, Substance Withdrawal Syndrome, 3. Good health, Alcoholism, Psychiatry and Mental health, Clinical Psychology, liver stiffness, 030104 developmental biology, Endocrinology, BDNF, Liver, chemistry, Elasticity Imaging Techniques, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Biomarkers, 030217 neurology & neurosurgery, Homeostasis
Abstract: International audience; Background: Brain-derived neurotrophic factor (BDNF) plays a key role in the processes of withdrawal and addiction in alcohol use disorder (AUD), and is also involved in liver homeostasis. The role of BDNF in liver damage and its link with liver stiffness are not known. We hypothesize that serum BDNF levels are linked to changes in hepatic elasticity, both of which depend on variations in alcohol consumption.Objectives: We aimed to study the evolution of BDNF levels and changes in the liver stiffness (LS) of AUD subjects, within two months following withdrawal.Methods: We measured LS by FibroScan® (as an indicator of the degree of liver fibrosis), gamma glutamyl transferase (GGT) levels (as a nonspecific but sensitive marker of liver status) and serum BDNF levels of 62 alcohol-dependent subjects without previously identified liver complications. Measures were obtained at the time of withdrawal (M0) and two months later (M2). Results: BDNF levels increased after alcohol withdrawal and small variations of LS were observed. BDNF values increased significantly according to fibrosis stages measured by LS (p = .028 at M0), and were predicted by GGT levels in a regression model (p = .007 at M0 and p = .003 at M2).Conclusion: In AUD, BDNF levels were associated with measured LS when divided into fibrosis risk categories. Changes in LS and BDNF levels after alcohol withdrawal may be related to changes in homeostatic mechanisms, in addition to those of liver status.
Published: 2021
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13. Hypermetabolism is a reality in amyotrophic lateral sclerosis compared to healthy subjects

Author: Yves Boirie, Philippe Couratier, Pierre Jésus, Benoît Marin, Stéphane Walrand, Najate Achamrah, Moïse Coëffier, Philippe Fayemendy, Jean-Claude Desport, Géraldine Lautrette, Pierre-Marie Preux, Anaïs Labrunie, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Plate forme de bioinformatique et biostatistique (CEBIMER), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Service de Neurologie [CHU Limoges], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and CCSD, Accord Elsevier
Subjects: medicine.medical_specialty, Multivariate analysis, Hypermetabolism, Logistic regression, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Resting energy expenditure, 030212 general & internal medicine, Amyotrophic lateral sclerosis, business.industry, Metabolic disorder, Calorimetry, Indirect, medicine.disease, Healthy Volunteers, 3. Good health, Neurology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, Body Composition, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), Energy Metabolism, business, Bioelectrical impedance analysis, 030217 neurology & neurosurgery
Abstract: International audience; RationaleHypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the reflection of a high energy metabolic level, but this alteration seems controversial. The main objective of the study was to confirm the existence of HM during ALS compared to healthy subjects.MethodsA cohort of ALS patients was compared to a control group without metabolic disorder. The assessment included anthropometric criteria measurements, body composition by bioelectric impedance analysis and resting energy expenditure (REE) by indirect calorimetry. HM was defined as a variation > +10% between measured and calculated REE. Statistical analysis used Mann-Withney and Chi2 tests. Multivariate analysis included logistic regression.Results287 patients and 75 controls were included. The metabolic level was higher in ALS patients (1500 kcal/24 h [1290–1693] vs. 1230 kcal/24 h [1000–1455], p < 0.0001) as well as the REE/fat free mass ratio (33.5 kcal/kg/24 h [30.4–37.8] vs. 28.3 kcal/kg/24 h [26.1–33.6], p < 0.0001). 55.0% of ALS patients had HM vs. 13.3% of controls (p < 0.0001). HM was strongly and positively associated with ALS (OR = 9.50 [4.49–20.10], p < 0.0001).ConclusionsHM in ALS is a reality, which affects more than half of the patients and is associated with ALS. This work confirms a very frequent metabolic deterioration during ALS. The identification of HM can allow a better adaptation of the patients' nutritional intake.
Published: 2021
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14. Nutritional status, dementia, and mobility among nursing home's residents: First exhaustive cross-sectional study in Limousin territory (France)

Author: Philippe Fayemendy, Pierre Jésus, Gustave Mabiama, C. Villemonteix, Thibault Vernier, Aude Massoulard-Gainant, Jean-Claude Desport, CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Réseau limousin nutrition (Linut), Université de Douala, MABIAMA, Gustave, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Service de Médecine Gériatrique [CHU Limoges], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST)
Subjects: Male, Aging, Cross-sectional study, Physiology, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Geographical locations, Body Mass Index, 0302 clinical medicine, Medicine and Health Sciences, Homes for the Aged, 030212 general & internal medicine, 2. Zero hunger, Aged, 80 and over, Multidisciplinary, medicine.diagnostic_test, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, 030503 health policy & services, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Nutritional status, Europe, Physiological Parameters, Neurology, Medicine, Female, France, 0305 other medical science, Research Article, Science, Nutritional Status, 03 medical and health sciences, Mental Health and Psychiatry, medicine, Dementia, Humans, Obesity, European Union, Aged, Nutrition, Mini–Mental State Examination, business.industry, Body Weight, Malnutrition, Biology and Life Sciences, medicine.disease, Nursing Homes, Health Care, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Health Care Facilities, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Geriatric Care, People and places, Nursing homes, business, Body mass index, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Demography
Abstract: Background Aging is accompanied by a drop in the level of health and autonomy, within Western countries more and more people being cared for in nursing homes (NH). The nutritional data in NH in France remain poor, not exhaustive and not representative. The objective of the study was to assess the nutritional status, dementia and mobility patterns among residents of NH in the Limousin territory of France. Methods The study was cross-sectional, descriptive and exhaustive, conducted with the residents of 13 voluntary NH. Undernutrition was identified using French High Authority for Health criteria, and obesity if Body Mass Index >30, in the absence undernutrition criterion. The Mini Mental State examination scores was used for dementia assessment at the threshold of 24. The Mini Nutritional AssessmentTM was used for mobilitity assessment. The statistics were significant at the 5% threshold. Results 866 residents (70.6% women) included with an average age of 85.3 ± 9.3 years. Undernutrition was 27.5%, obesity 22.9%, dementia 45.7% and very low mobility 68.9%. Women were older than men, more often undernourished, more often demented and more often had very low mobility (p Conclusions Undernutrition and obesity are important problems in NH in France. Being a woman, having dementia and having a very low mobility may induce undernutrition.
Published: 2020
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15. Liver elastometry and alcohol withdrawal: Median-term follow-up in a psychiatric unit

Author: Natacha Ouedraogo, Philippe Nubukpo, Paul Carrier, Véronique Loustaud-Ratti, Murielle Girard, Marilyne Debette-Gratien, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Pôle Universitaire d’Addictologie en Limousin, CH Esquirol [Limoges] (CH Esquirol), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and CCSD, Accord Elsevier
Subjects: medicine.medical_specialty, Health (social science), media_common.quotation_subject, Liver fibrosis, Alcohol, Toxicology, Biochemistry, 03 medical and health sciences, Behavioral Neuroscience, chemistry.chemical_compound, Liver disease, 0302 clinical medicine, Medicine, Psychiatric hospital, Humans, Alcohol consumption, Prospective Studies, Prospective cohort study, Psychiatry, media_common, Motivation, business.industry, General Medicine, Abstinence, medicine.disease, 030227 psychiatry, Substance Withdrawal Syndrome, Clinical trial, Alcoholism, Neurology, chemistry, Liver, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, Every Two Months, Elasticity Imaging Techniques, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Alcohol withdrawal, business, Liver stiffness, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: International audience; The measurement of liver stiffness (LS) shows promise as a follow-up tool after alcohol withdrawal, but it has mainly been studied in the early phase or in patients with severe liver disease. A 6-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Trial NCT01491347). Clinical and biological data and LS values were collected every 2 months. A total of 129 patients were included in the study; 93 had an LS assessment within the first 7 days, and 37 had all four LS measurements. Only seven (7.5%) patients had an initial LS > 12.1 kPa, the threshold used to define severe fibrosis. Abstinence was not associated with changes inLS at the various median-term follow-up periods. However, LS of abstinent subjects decreased significantly relative to that of non-abstinent subjects between M0 and M2. CAP™ values were not associated with abstinence. The systematic median-term follow-up of withdrawn patients does not appear to be contributory. However, LS could help to detect relapse in the first 2 months after withdrawal for subjects treated in a psychiatric hospital for dependence. It thus could serve as a motivation tool. Prospective studies with various and higher baseline LS values are warranted for simultaneous longitudinal assessment, including for very short- and long-term LS after withdrawal.
Published: 2020
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16. Follow-up and survival after gastrostomy indication in patients with amyotrophic lateral sclerosis

Author: Marion Vergonjeanne, Philippe Couratier, Géraldine Lautrette, Pierre Jésus, H. Sourisseau, Philippe Fayemendy, N. Calmel, P.M. Preux, Jean Claude Desport, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: 2. Zero hunger, 0303 health sciences, medicine.medical_specialty, Nutrition and Dietetics, 030309 nutrition & dietetics, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, medicine.disease, Gastrostomy, 3. Good health, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine, In patient, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Amyotrophic lateral sclerosis, business
Abstract: International audience; Rationale: In Amyotrophic lateral sclerosis (ALS), gastrostomy is indicated when the weight loss is over 10%, in case of repeated aspirations and if the meal time duration is over 45 min. The benefit of gastrostomy on survival in ALS is unclear and its placement is probably too late. The main works on the subject studied survival from diagnosis but not from indication of gastrostomy. The aims of our work were in ALS patients with indication of gastrostomy and who accepted or refused gastrostomy to study from the indication of gastrostomy to the last assessment or death i) the evolution of nutritional and neurological status and ii) the survival.Methods: ALS patients included started follow-up in the referral ALS centre in 2006 and were all dead at 31 december 2017. They had assessment of their neurological (onset form, ALS functional rating scale revised [ALSFRS-R]), nutritional (weight, weight loss, body mass index and body composition by bioelectrical impedancemetry analysis) and respiratory status (forced vital capacity, non-invasive ventilation [NIV]). Statistical analysis was done by using Mann-Whitney test, Chi2 tests, Kaplan-Meier with Log-rank and Cox model for multivariate survival analysis. Results were expressed as median (interquartile range).Results: One hundred and fifty-five patients with indication of gastrostomy were included, 68.4% had accepted the gastrostomy placement. The median delay diagnosis-gastrostomy indication and gastrostomy indication-last assessment were 5.1 months (2.3 – 12.5) and 8.7 months (4.2 – 12.3), respectively. Patient who accepted gastrostomy were less often male (42.5% vs. 63.3%, p= 0.016) and had more often bulbar onset (57.6% vs. 26.5%, p=0.0003). Nutritional status and body composition at indication and at last assessment were not significantly different in patients with or without gastrostomy. At last assessment, in patient with gastrostomy ALSFRS-R was lower (14.0 points [10.8 – 22.0] vs. 20.5 points [12.8 – 26.3], p=0.01). Since gastrostomy indication median survival was higher in patient who accepted gastrostomy (10.3 months [6.7 – 17.5] vs 7.9 month [4.2 – 10.5], p=0.01). Gastrostomy was negatively associated with the risk of death in univariate analysis (HR: 0.64, p=0.01), but not in multivariate analysis. In multivariate analysis, weight loss (-1%/month) and ALSFRS-R slope (-1point/month) during follow-up were positively associated with the risk of death (aHR: 1.62; p=0.0002 and aHR: 2.37; p
Published: 2020
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17. Nutritional and metabolic status at diagnosis and survival of patients with Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD) compared to patients with ALS alone

Author: H. Sourisseau, Géraldine Lautrette, Philippe Couratier, Pierre Jésus, N. Calmel, Pierre-Marie Preux, Philippe Fayemendy, Jean-Claude Desport, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Gastroenterology, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Weight loss, Interquartile range, Internal medicine, medicine, Resting energy expenditure, Amyotrophic lateral sclerosis, 2. Zero hunger, Univariate analysis, Nutrition and Dietetics, business.industry, Proportional hazards model, Hazard ratio, medicine.disease, 3. Good health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business
Abstract: Rationale: About 5%e10% of ALS patients suffer from frank ALS/FTD. In ALS, the increase of resting energy expenditure (REE) is a prognostic factor for the survival. No studies have investigated nutritional and metabolic status in ALS/FTD and its impact on survival. The aims of this study were i) to study nutritional and metabolic status of ALS/FTD compared to ALS patients, ii) to study the survival according to the disease and the metabolic status. Methods: Three months after diagnosis, nutritional assessments and body composition (by bioimpedance analysis) were performed in all patients. REE measured (mREE) by indirect calorimetry and calculated (cREE) by Harris and Benedict 1919 formula were used for the calculation of REE variation. Neurological (bulbar onset), functional (ALS Functional Rating Scale e Revised [ALSFRS-R]) and respiratory (Forced Vital Capacity [FVC]) assessments were collected. Survival by Log-rank test (Hazard Ratio [HR], confidence interval 95%) and multivariate analysis with Cox model were also used. Results were expressed as median (interquartile range). Results: 446 patients were included, 421 ALS patients and 25 (5.6%) ALS/FTD patients. Age at diagnosis and sex were not significantly different. ALS/ FTD patients had more bulbar onset (100.0% vs. 34.5%, p
Published: 2020

18. Impact of Body Composition in Overweight and Obese Patients With Localised Renal Cell Carcinoma

Author: Nicole Tubiana-Mathieu, Pierre Jésus, Denis Lachatre, Aurélien Descazeaud, Elise Deluche, Tiffany Darbas, Geraud Forestier, Sophie Leobon, J. Pestre, Service d'Oncologie médicale [CHU Limoges], CHU Limoges, Service de Radiologie et Imagerie Médicale [CHU Limoges], Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Service de Chirurgie urologique et andrologie [CHU Limoges]
Subjects: Male, Cancer Research, Poor prognosis, medicine.medical_specialty, obesity, Population, Computed tomography, Overweight, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, Body Mass Index, sarcopenia, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Internal medicine, medicine, Humans, overweight, In patient, Muscle, Skeletal, education, Carcinoma, Renal Cell, Pharmacology, education.field_of_study, medicine.diagnostic_test, business.industry, skeletal muscle mass, Prognosis, medicine.disease, Obesity, Kidney Neoplasms, 3. Good health, 030220 oncology & carcinogenesis, Sarcopenia, Body Composition, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business, Research Article
Abstract: International audience; Background/aim: To investigate the impact of body composition on morbidity and mortality at the initial diagnosis of localised renal cell carcinoma (RCC) in patients with overweight or obesity. Patients and methods: Sarcopenia was defined using sex-specific cut-off points and other body composition parameters by median values with computed tomography imaging. Results: Among the 96 patients, 40 had sarcopenia (43.0%) at diagnosis. Body composition had no effect on morbidity and 5-year disease-free survival contrary to the classic factors (p
Published: 2020
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19. Predictive formulas for estimation of height in sub-Saharan African older people: A new formula (EPIDEMCA study)

Author: Benoît Marin, Pascal M'Belesso, Pierre-Marie Preux, Pierre Jésus, Jean-Claude Desport, Bébène Ndamba-Bandzouzi, Maëlenn Guerchet, Philippe Fayemendy, Sophie Pilleron, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: Male, 0301 basic medicine, Sub saharan, Future studies, Endocrinology, Diabetes and Metabolism, Population, Black People, 030209 endocrinology & metabolism, White People, 03 medical and health sciences, 0302 clinical medicine, Humans, American black, education, Africa South of the Sahara, Aged, Mathematics, 2. Zero hunger, Estimation, education.field_of_study, 030109 nutrition & dietetics, Nutrition and Dietetics, Central africa, Body Height, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Older people, Body mass index, Drugs, Chinese Herbal, Demography
Abstract: Objectives Chumlea's formulas are a way of predicting height from knee height (KHt), including among individuals >60 y of age who cannot stand upright. However, the formulas were developed with white and African American people and have not yet been validated in native Africans >60 y of age. The aims of the study were to assess Chumlea's formulas in older people in central Africa and to propose a new validated formula for the same population. Methods Height (MHt) and KHt were measured in a population of individuals >65 y of age from the Republic of Congo and the central African Republic. Predicted height (PHt) was calculated using Chumlea's formulas for the American black population (CBP) and for whites (CC). The percentages of accurate predictions (±5 cm) were compared between MHt and PHt. A new formula was estimated after randomization in a derivation sample (n = 877) and assessed for accuracy in a validation sample (n = 877). Results The study included 1754 individuals. Prediction was accurate (±5 cm) in 66.8% and 63.2% of CBP and CC, respectively. Overestimation was as high as 24.1% and 29%, respectively. Because an overestimation is unacceptable in clinical practice and population surveys, a new formula was proposed: height (cm) = 72.75 + (1.86 × KHt [cm]) – (0.13 × age [y]) + 3.41 × sex (0: women; 1: men). This new formula significantly increases accuracy (71.3%) and decreases overestimation (14.7%). The nutritional status based on body mass index did not differ with the MHt and the PHt by the new formula. Conclusion Chumlea's formulas provided a poor estimate of height in this population sample. The proposed formula more accurately estimates height in older native Africans. This formula should be tested in other sub-Saharan African countries to extend its use in clinical practice and in future studies.
Published: 2020
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20. Changes in care of home artificial nutrition patients during the COVID-19 epidemics in France position of the French-speaking Society for Clinical Nutrition and Metabolism (SFNCM)’s Home Artificial Nutrition Committee

Author: Philippe Fayemendy, Corinne Bouteloup, D. Lescut, Florian Poullenot, Stéphane M. Schneider, Didier Quilliot, Sébastien Neuville, Francisca Joly, Didier Barnoud, Dominique Guimber, Adam Jirka, Marie Astrid Piquet, Olivier Goulet, Nathalie Barbier, Ronan Thibault, D. Seguy, N. Flori, Véronique Albert, Jeanick Stocco, Cécile Chambrier, Pierre Déchelotte, Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Casselardit - Junod, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Clermont-Ferrand, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Université de Montpellier (UM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Nantes (UN), Hôpital Beaujon [AP-HP], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: 2. Zero hunger, 0303 health sciences, Home parenteral nutrition, Nutrition and Dietetics, Surgical masks, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], COVID-19, Nutrition parentérale à domicile, Article, 3. Good health, 03 medical and health sciences, Masques chirurgicaux, Nutrition entérale à domicile, Internal Medicine, Hand sanitizers, Solutions hydro-alcooliques, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Home enteral nutrition
Abstract: Resume La nutrition artificielle a domicile, enterale ou parenterale, s’adresse a des malades chroniques fragiles. La situation actuelle de pandemie COVID-19 peut compromettre leur prise en charge a plusieurs niveaux : difficultes d’acces aux etablissements de sante largement reorientes vers la prise en charge des malades COVID-19, possible penurie d’infirmieres a domicile, forte reduction des visites des prestataires de service a domicile, tensions sur les solutions hydro-alcooliques, les masques et les regulateurs de debit. Le but de ces recommandations etablies par le Comite de nutrition a domicile de la Societe Francophone de Nutrition Clinique et Metabolisme (SFNCM) est, d’une part, de preciser la prise en charge minimale de ces patients, tant en termes de suivi que de materiels, mais surtout de s’adapter aux tensions actuelles relatives aux personnes et aux materiels, afin de poursuivre une prise en charge de qualite et de ne pas compromettre l’etat de sante des patients en nutrition artificielle a domicile pendant la crise.
Published: 2020
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21. Post-stroke Complications and Mortality in Burkinabè Hospitals: Relationships with Deglutition Disorders and Nutritional Status

Author: Jeoffray Diendéré, Anselme Dabilgou, Pierre Jésus, Jean Kaboré, Jean-Claude Desport, Jean-Yves Salle, Pierre-Marie Preux, Christian Napon, Fayemendy Philippe, Marie Paule Boncoeur-Martel, Athanase Millogo, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Service de Radiologie et Imagerie Médicale [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Service de Médecine Physique et de Réadaptation [CHU Limoges]
Subjects: medicine.medical_specialty, Pediatrics, Multivariate analysis, Complications, 03 medical and health sciences, Speech and Hearing, 0302 clinical medicine, Swallowing, Nutritional status, Internal medicine, Burkina Faso, medicine, 030212 general & internal medicine, Risk factor, Mortality, Stroke, 2. Zero hunger, business.industry, Gastroenterology, Hepatology, medicine.disease, Deglutition disorders, 3. Good health, Deglutition, Otorhinolaryngology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Complication, business, 030217 neurology & neurosurgery
Abstract: International audience; Stroke frequently causes deglutition disorders, leading to a decline in nutritional status and complications, and increasing mortality. Sub-Saharan data are scarce. The objectives of this study were to assess complications and mortality among hospitalized patients in Burkina Faso during the first two weeks after stroke, and to investigate associated factors. Patients with stroke were followed prospectively in Ouagadougou and Bobo-Dioulasso hospitals. Deglutition disorders and nutritional parameters were assessed at baseline (D0) and on Days 8 (D8) and 14 (D14). Complications and mortality were recorded up to D14. Factors associated with complications and mortality were investigated using multivariate analysis. Of the 222 patients included, 81.5% developed at least one complication, and mortality was 17.1%. At D0, D8, and D14, the rate of deglutition disorders was 37.4%, 28.4%, and 15.8%, respectively, and that of undernourishment 25.2%, 29.4%, and 31.0%, respectively. In multivariate analysis, only the presence of deglutition disorders was a risk factor for developing at least one complication (OR = 5.47, 95% CI 1.81–16.51). Factors predicting death were the presence of deglutition disorders at D0 (OR = 7.19, 95% CI 3.10–16.66), and at least one seizure during follow-up (OR = 3.69, 95% CI 1.63–8.36). After stroke, the rates of complications, death, and undernourishment were high compared to Western countries. Prevention and management of deglutition disorders, and specific follow-up of patients with seizures could reduce post-stroke mortality.
Published: 2020
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22. Vitamin D status among patients with drug-resistant and non-drug-resistant epilepsy

Author: Françoise Abdallah-Lebeau, Jean Claude Desport, Laetitia Gimenez, Pierre Jésus, Lucile Darthou-Pouchard, Philippe Couratier, Olivier Villeneuve, Claire Marcon, Philippe Fayemendy, Pierre-Marie Preux, Bertrand Godet, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: Adult, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Drug resistance, Pharmacology, anthropometric assessment, vitamin D deficiency, Body Mass Index, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, drug-resistance, medicine, Vitamin D and neurology, Humans, Obesity, Vitamin D, 2. Zero hunger, Nutrition and Dietetics, business.industry, General Medicine, Vitamins, Middle Aged, medicine.disease, Drug Resistant Epilepsy, Vitamin D Deficiency, 3. Good health, epilepsy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, 030217 neurology & neurosurgery
Abstract: Abstract. Background & Aims: Epilepsy affects nearly 70 million people worldwide. Vitamin D deficiency may influence the balance of certain epilepsies. The purpose of this study was to determine the vitamin D status and anthropometric measurements of people with epilepsy (PWE), according to their pharmacosensitivity. Methods: Forty-six PWE, with or without drug resistance, underwent nutritional assessment after giving consent. Weight, body mass index (BMI), triceps skinfold thickness (TSF), fat mass (FM) and free fat mass (FFM) by bioelectrical impedance analysis were measured. Serum vitamin D was determined without supplementation. Deficiency was defined as a level 2. Results: Patients were aged 44.5 ± 14.3 years, with 60.9% of drug-resistance. BMI was 28.7 ± 7.0, 2.2% were malnourished and 30.4% obese according to the BMI. The average vitamin D level was 15.3 ± 9.9 ng/mL, with 87.0% of deficiency, and 40.0% of severe deficiency (
Published: 2020
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23. Risk factors of de novo malignancies after liver transplantation: a French national study on 11004 adult patients

Author: Christophe Duvoux, Mario Altieri, Nassim Kamar, Jean Gugenheim, Sébastien Dharancy, Filomena Conti, Armand Abergel, Olivier Sérée, Georges-Philippe Pageaux, Ephrem Salamé, Jean Hardwigsen, Karim Boudjema, Pascal Lebray, Philippe Segol, Camille Besch, Vincent Leroy, Didier Samuel, Guy Launoy, Claire Vanlemmens, Sylvie Radenne, Maryline Debette-Gratien, Olivier Chazouillères, Xavier Blaizot, Martine Neau-Cransac, Claire Francoz, Marianne Latournerie, Jérôme Dumortier, Audrey Coilly, Pauline Houssel-Debry, François Durand, Olivier Boillot, Faouzi Saliba, Thierry Lobbedez, CCSD, Accord Elsevier, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, CHU Pontchaillou [Rennes], Physiopathologie et traitement des maladies du foie, Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hépato-Biliaire [Hôpital Paul Brousse] (CHB), Hôpital Paul Brousse-Assistance Publique - Hôpitaux de Paris, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Centre de Référence des Maladies Rares - Maladies Inflammatoires des Voies Biliaires et Service d’Hépatologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Pharmacologie des Immunosuppresseurs et de la Transplantation (PIST), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Henri Mondor, Ecole Polytechnice Universitaire de Nice (EPU Nice -Polytech'Nice-Sophia), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital de la Timone [CHU - APHM] (TIMONE), Service de Néphrologie - Immunologie Clinique [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-PRES Université de Toulouse, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hospices Civils de Lyon (HCL), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and CHU Strasbourg
Subjects: Oncology, Adult, Male, medicine.medical_specialty, MESH: Liver Transplantation, Liver tumor, medicine.medical_treatment, Liver transplantation, Malignancy, Primary sclerosing cholangitis, 03 medical and health sciences, Liver disease, 0302 clinical medicine, MESH: Liver Neoplasms, MESH: Risk Factors, Risk Factors, Internal medicine, medicine, Humans, MESH: Incidence, Lung cancer, Retrospective Studies, MESH: Humans, Hepatology, business.industry, Incidence, Liver Neoplasms, Gastroenterology, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Competing risk, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, MESH: Male, Liver Transplantation, 030220 oncology & carcinogenesis, Population study, 030211 gastroenterology & hepatology, business, Liver transplantationde novomalignancies
Abstract: International audience; Background: After liver transplantation (LT),de novo malignancies are one of the leading causes of late mortality. The aim of the present retrospective study was to identify the risk factors of de novo malignancies in a large cohort of LT recipients in France, using Fine and Gray competing risks regression analysis.Methods: The study population consisted in 11004 adults transplanted between 2000 and 2013, who had no history of pre-transplant malignancy, except primary liver tumor. A Cox model adapted to the identification of prognostic factors (competitive risks) was used.Results: From the entire cohort, one (or more)de novo malignancy was reported in 1480 L T recipients (13.45%). The probability to develop a de novo malignancy after LT was 2.07% at 1 year, 13.30% at 5 years, and 28.01% at 10 years. Of the known reported malignancies, the most common malignancies were hematological malignancy (22.36%), non-melanoma skin cancer (19.53%) and lung cancer (12.36%). According to Fine and Gray competing risks regression multivariate analysis, were significant risk factors for post-LT de novo malignancy: recipient age (Subdistribution Hazard Ratio (SHR) = 1.03 95%CI 1.03-1.04), male gender (SHR = 1.45 95%CI 1.27-1.67), non-living donor (SHR = 1.67 95%CI 1.14-2.38), a first LT (SHR = 1.35 95%CI 1.09-1.69) and the type of initial liver disease (alcohol-related liver disease (SHR = 1.63 95%CI 1.22-2.17), primary sclerosing cholangitis (SHR = 1.98 95%CI 1.34-2.91), and primary liver tumor (SHR = 1.88 95%CI 1.41-2.54)). Initial immunosuppressive regimen had no significant impact.Conclusion: The present study confirms that LT recipient characteristics are associated with the risk ofde novo malignancy and this underlines the need for personalized screening in order to improve survival.
Published: 2020
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24. Pyloric distensibility measurement after gastric surgery: Which surgeries are associated with pylorospasm?

Author: Anne-Marie Leroi, Fabien Wuestenberghs, Alberto Zalar, Charlotte Desprez, Guillaume Gourcerol, Emmanuel Huet, Chloé Melchior, Jérémie Jacques, Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Service de chirurgie digestive [CHU Rouen], CHU Rouen, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, and UCL - (MGD) Service de gastro-entérologie
Subjects: Adult, Male, medicine.medical_specialty, Sleeve gastrectomy, Gastroparesis, gastroparesis, Physiology, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Lesion, 03 medical and health sciences, 0302 clinical medicine, Gastrectomy, Healthy volunteers, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Endoscopy, Digestive System, Digestive System Surgical Procedures, Aged, Antireflux surgery, sphincter, Endocrine and Autonomic Systems, business.industry, Gastroenterology, Middle Aged, medicine.disease, Pylorus, 3. Good health, Surgery, Esophagectomy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, pylorus, Sphincter, Female, 030211 gastroenterology & hepatology, medicine.symptom, distensibility, business, sleeve gastrectomy, antireflux surgery
Abstract: Free Access; International audience; Background and study aimsHistory of gastric surgery is found in 10% of patients with gastroparesis, and vagal lesion is often suspected to be the cause of pylorospasm. Recently, pyloric distensibility measurement using the EndoFLIP® system showed that pylorospasm was present in 30%‐50% of gastroparetic patients. Our objective was to assess whether pylorospasm, diagnosed using EndoFLIP® system was observed in three different types of gastric surgeries: antireflux surgery, sleeve gastrectomy, and esophagectomy.Patients and MethodsPyloric distensibility and pressure were measured using the EndoFLIP® system in 43 patients from two centers (18 antireflux surgery, 16 sleeve gastrectomy, and nine esophagectomy) with dyspeptic symptoms after gastric surgery, and in 21 healthy volunteers. Altered pyloric distensibility was defined as distensibility below 10 mm2/mm Hg as previously reported.ResultsCompared to healthy volunteers (distensibility: 25.2 ± 2.4 mm2/mm Hg; pressure: 9.7 ± 4.4 mm Hg), pyloric distensibility was decreased in 61.1% of patients in the antireflux surgery group (14.5 ± 3.4 mm2/mm Hg; P < .01) and 75.0% of patients in the esophagectomy group (10.8 ± 2.1 mm2/mm Hg; P < .05), while pyloric pressure was only increased in the antireflux surgery group (18.9 ± 2.2 mm Hg; P < .01). Pyloric distensibility and pressure were similar in healthy volunteers and in sleeve gastrectomy (distensibility: 20.3 ± 3.8 mm2/mm Hg; pressure: 15.8 ± 1.6 mm Hg) groups, with decreased pyloric distensibility affecting 18.7% of sleeve gastrectomy patients.ConclusionAntireflux surgery and esophagectomy were associated with pylorospasm although pylorospasm was not found in all patients. Sleeve gastrectomy was not associated with altered pyloric distensibility nor altered pyloric pressure.
Published: 2020
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25. Liens entre l’état nutritionnel des personnes âgées en communauté au Cameroun, les conditions de santé et les facteurs sociodémographiques : 1ère étude nationale

Author: Dieudonné Adiogo, P.M. Preux, Jean Claude Desport, P. Jésus, Gustave Mabiama, Grelier, Elisabeth, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Université de Douala, Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], and MABIAMA, Gustave
Subjects: 0303 health sciences, Nutrition and Dietetics, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, Etat nutritionnel, 030209 endocrinology & metabolism, Facteurs sociodémographiques, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 03 medical and health sciences, 0302 clinical medicine, Cameroun, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Internal Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Personnes âgées, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Introduction et but de l’étude: Le vieillissement de la population camerounaise sera un problème de santé publique dansles prochaines années. L’état socio-économique et nutritionnel des personnes âgées est mal connu. Une seulepublication a montré une prévalence de dénutrition de 5,5%, d'obésité de 19,0 % chez des personnes âgées de plus de55 ans en zone rurale. L’étude avait pour but de réaliser une évaluation nationale de l'état nutritionnel, de l'état de santéet des facteurs sociodémographiques associés chez des personnes âgées au Cameroun.Matériel et méthodes: L’étude était menée dans des quartiers et villages pris au hasard et auprès de 599 personnesd’âge de 60 ans et plus, dont 33,6% vivaient en zone urbaine. Des données sociodémographiques (sexe, âge,éducation), sanitaire (pathologie, traitement) et anthropométriques (poids, indice de masse corporelle (IMC), tour detaille, circonférence brachiale (CB)) étaient recueillies L'état nutritionnel était défini par la classification OMS. Etudeapprouvée par le Comité d’Ethique de l’Université de Douala. Les analyses comprenaient les tests de Mann-Whitney etdu Chi2. Significativité au seuil de 5%.Résultats et Analyse statistique : L’âge des personnes était de 68,9±7,2 ans, leur sex-ratio H/F=0,93, leur poids de 68,5±14,7 kg. Leur IMC était de 24,7±5,3 plus élevé en zone urbaine (25,7 ±5,3) que rurale (24,1±5,3, p=0,001), faiblementcorrélé aux pressions artérielles systolique (r=0,12 p=0,02) et diastolique (r=0,15 p=0,0001). Le tour de taille moyen étaitde 90,1±12,8 cm, la CB était de 28,2±5,0 cm et plus élevé en zone urbaine (p
Published: 2020
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26. Predictive factors for gastrostomy at time of diagnosis and impact on survival in patients with amyotrophic lateral sclerosis

Author: Philippe Fayemendy, Marion Vergonjeanne, Jean-Claude Desport, Benoît Marin, Philippe Couratier, Pierre Jésus, H. Sourisseau, Pierre-Marie Preux, Géraldine Lautrette, Marie Penoty, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Centre référent Sclérose Latérale Amyotrophique et autres maladies du motoneurone [CHU Limoges] (SLA CHU Limoges), and CCSD, Accord Elsevier
Subjects: Male, Pediatrics, medicine.medical_specialty, Weight loss, Time Factors, Survival, medicine.medical_treatment, Nutritional Status, Critical Care and Intensive Care Medicine, Logistic regression, Risk Assessment, Gastrostomy recommendation, 03 medical and health sciences, 0302 clinical medicine, Respiratory Aspiration of Gastric Contents, Predictive Value of Tests, Risk Factors, medicine, Humans, In patient, 030212 general & internal medicine, Amyotrophic lateral sclerosis, Prospective cohort study, Feeding tube, Aged, 2. Zero hunger, Gastrostomy, Neurologic Examination, Nutrition and Dietetics, Proportional hazards model, business.industry, Diagnosis indicators, Middle Aged, medicine.disease, 3. Good health, Nutrition Assessment, Treatment Outcome, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: International audience; .Background: Gastrostomy is recommended in patients with Amyotrophic Lateral Sclerosis (ALS) in the presence of weight loss over 10% as compared to usual weight, repeated aspirations or meal time duration longer than 45 min. Currently, the impact of gastrostomy on survival of ALS patients is not clear. Aims: i) to describe diagnosis factors associated with the indication for gastrostomy ii) to evaluate survival of ALS patients with gastrostomy indication according to their acceptance of feeding tube placement. Methods: Patients with ALS were included and followed in the ALS referral centre of Limoges's teaching hospital between 2006 and 2017. Neurological, nutritional and respiratory status was assessed prospectively from diagnosis to death. Statistical analysis was performed using Mann-Whitney test, Chi2 tests, Cox model and multivariate logistic regression. Results: Two hundred and eighty-five patients were included. Among the 182 for whom gastrostomy was indicated, 63.7% accepted the placement. The median time was 7.3 months [IQR: 3.2-15.0] and 2.7 months [IQR: 0.9-5.8] respectively from diagnosis to indication and from indication to placement. Weight loss >5% significantly increased the risk of death by 17% (p < 0.0001). At time of diagnosis, bulbar onset, a loss of one point in the body mass index or on the bulbar functional scale were all positively associated with indication for gastrostomy (aOR = 10.0 [95%CI: 1.96-25.0]; p = 0.002, aOR = 1.17 [95%CI: 1.02-1.36]; p = 0.025 and aOR = 1.19 [95%CI: 1.06-1.32]; p = 0.002, respectively). However, gastrostomy placement did not have any impact on survival (aHR = 1.25 [95%CI: 0.88-1.79]; p = 0.22). Conclusion: Both neurological and nutritional criteria were associated with an indication for gastrostomy at diagnosis. Gastrostomy placement had no impact on survival. The study of earlier gastrostomy placement might be of interest in further prospective studies.
Published: 2020
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27. Increased resting energy expenditure compared with predictive theoretical equations in amyotrophic lateral sclerosis

Author: Pierre-Marie Preux, Stéphane Walrand, Najate Achamrah, Yves Boirie, Jean-Claude Desport, Philippe Couratier, Géraldine Lautrette, Philippe Fayemendy, H. Sourisseau, Benoît Marin, Marie Nicol, Pierre Jésus, Moïse Coëffier, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Rouen, and Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN)
Subjects: 0301 basic medicine, medicine.medical_specialty, Survival, Evolution, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Metabolic rate, Gastroenterology, World health, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Predictive equation, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Resting energy expenditure, In patient, Amyotrophic lateral sclerosis, 2. Zero hunger, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Calorimetry, Indirect, medicine.disease, Clinical Practice, Bioimpedance Analysis, Current practice, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Basal Metabolism, Energy Metabolism, business
Abstract: Objectives Approximately 50% to 60% of amyotrophic lateral sclerosis (ALS) is characterized by an increase in metabolic rate. The Harris and Benedict (HB) 1919 formula is the equation mainly used to calculate resting energy expenditure (cREE) compared with measured REE (mREE) by indirect calorimetry (IC), but other formulas are also applied in current practice. The present study aimed to assess mREE in patients with ALS compared with 12 cREE formulas and study the relevant threshold of REE variation to screen patients with a higher evolving risk. Methods Nutritional assessments and body composition (by bioimpedance analysis) were performed in patients with ALS. mREE was measured by IC, and cREE was calculated using the HB 1919, HB 1984, World Schofield, De Lorenzo, Johnstone, Mifflin, World Health Organization/Food and Agriculture Organization, Owen, Fleisch, Wang, Rosenbaum, and Nelson formulas. Functional and respiratory evolution and survival by log-rank test according to two thresholds of REE variation (10% and 20%) were studied. Results A total of 315 patients with ALS were included in the study. The median mREE was 1503 kcal/24 h (range, 1290–1698 kcal/24 h), which was higher than all predictive equations (P 10% and 20% was found in 35.2% to 76.3% and 14.6% to 53.3% of patients with ALS, respectively. Patients with an REE variation >20% with HB 1919 and HB 1984 had a lower survival. Moreover, with this same threshold and the Mifflin formula, patients had higher functional and respiratory evolutions and lower survival. Conclusions The increase in metabolic rate is present according to the different cREE formulas used compared with IC. In clinical practice, REE formulas (e.g., HB 1919, HB 1984, or Mifflin) can be used as a reference value compared with IC to screen patients with ALS with an REE variation >20% and a higher evolving risk.
Published: 2020
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28. Survival according to resting energy expenditure (REE) variation using two ree formulas and without indirect calorimetry in patients with amyotrophic lateral sclerosis (ALS)

Author: Géraldine Lautrette, Jean Claude Desport, Philippe Fayemendy, Pierre Jésus, N. Calmel, P.M. Preux, H. Sourisseau, Philippe Couratier, Grelier, Elisabeth, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: 2. Zero hunger, 0303 health sciences, medicine.medical_specialty, Nutrition and Dietetics, 030309 nutrition & dietetics, business.industry, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Calorimetry, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Internal medicine, medicine, Resting energy expenditure, In patient, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Amyotrophic lateral sclerosis, business
Abstract: International audience; Rationale: The increase of resting energy expenditure (REE) variation in ALS is a prognostic factor for the survival mainly in patients with a REE variation over +20%. Measurement of REE by indirect calorimetry (IC) compared to REE predicted with formula (Harris and Benedict [HB] 1919, HB 1984 or Mifflin) is necessary to obtain the REE variation. However, IC is not available in many centres. Jésus et al. formula is a validate formula to predict REE in ALS and can be used in the absence of an IC. The aim of this work was to study the survival of ALS patients according to REE variation with IC or Jésus formula.Methods: Nutritional assessments and body composition fat-free mass (FFM) and fat mass (FM) (by bioimpedance analysis) were performed in ALS patients at diagnosis. REE was measured by IC (mREE) and by Jésus formula (Jésus REE) using FFM, FM and sex. cREE was calculated using HB 1919, HB 1984 and Mifflin. REE variation (%) was calculated according to the formula: (mREE or Jésus REE) – cREE / cREE * 100. Survival was studied by Log-rank test (Hazard Ratio [HR], confidence interval [CI] 95%) according REE variation under or over 20%.Results: 395 ALS patients with a median age at IC of 66.8 years (Interquartile range: 58.6–74.1) with a sex ratio of 1.1 were included. Median body mass index was of 22.4 kg/m2 (22.2 – 27.5). REE was of 1500 kcal/24h (1274 – 1708) with IC and not significantly different than with Jésus formula 1500 kcal/24h (1291 – 1679) (p=0.83). With REE measured by IC, REE variation over 20% was found in 21.0%, 18.0% and 43.0% with HB 1919, HB 1984 and Mifflin formulas as cREE respectively. With Jésus REE, REE variation over 20% was found in 5.1%, 1.5% and 25.6% with HB 1919, HB 1984 and Mifflin formulas as cREE, respectively. REE variation over 20% was more frequently found using IC than with Jésus formula (p
Published: 2020

29. Direct-acting antiviral agent–based regimen for HCV recurrence after combined liver-kidney transplantation: Results from the ANRS CO23 CUPILT study

Author: Jérôme Dumortier, A. Rohel, Jean-Charles Duclos-Vallée, Christophe Duvoux, Vincent Di Martino, Christine Silvain, Sébastien Dharancy, Danielle Botta-Fridlund, Sylvie Radenne, Maryline Debette-Gratien, Nassim Kamar, Audrey Coilly, Vincent Leroy, Georges-Philippe Pageaux, Armand Abergel, Louis d’Alteroche, Emilie Rossignol, Claire Francoz, Pauline Houssel-Debry, P. Perré, Filomena Conti, Claire Fougerou-Leurent, François Habersetzer, Camille Besch, Christophe Moreno, H. Montialoux, Valérie Canva, Albert Tran, Didier Samuel, Victor de Lédinghen, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Paul Brousse, Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Service d'Hépatologie, Hôpital Henri Mondor, AP-HP, Créteil, France., Hôpital Henri Mondor, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Gastroentérologie et hépatologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépato-gastro-entérologie, Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Département d'hépatologie, Service d'hépatologie, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital de la Croix-Rousse [CHU - HCL], Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital de la Milétrie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Chirurgie Digestive, Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Interactions Virus-Hôte et Maladies Hépatiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Virologie, Chirurgie digestive et hépatobiliaire, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Pharmacologie des Immunosuppresseurs et de la Transplantation (PIST), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, ANRS France Recherche Nord & sud Sida-hiv hépatites, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Paul Brousse-Université Paris-Sud - Paris 11 (UP11), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Université de Limoges (UNILIM)-CHU Limoges, Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent
Subjects: Graft Rejection, Male, Sofosbuvir, [SDV]Life Sciences [q-bio], medicine.medical_treatment, kidney transplantation/nephrology, Hepacivirus, 030230 surgery, Liver transplantation, medicine.disease_cause, 0302 clinical medicine, Recurrence, Risk Factors, Immunology and Allergy, liver disease: infectious, Pharmacology (medical), Prospective Studies, Prospective cohort study, education.field_of_study, Graft Survival, Middle Aged, Prognosis, Hepatitis C, 3. Good health, [SDV] Life Sciences [q-bio], kidney failure/injury, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, medicine.drug, Adult, medicine.medical_specialty, infectious disease, Hepatitis C virus, Population, clinical research/practice, Antiviral Agents, 03 medical and health sciences, Internal medicine, medicine, Humans, Adverse effect, education, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Transplantation, business.industry, Kidney Transplantation, Liver Transplantation, Regimen, Immunology, infection and infectious agents - viral: hepatitis C, business, liver transplantation/hepatology, Follow-Up Studies
Abstract: International audience; Hepatitis C virus (HCV) infection is associated with reduced patient survival following combined liver-kidney transplantation (LKT). The aim of this study was to assess the efficacy and safety of second-generation direct-acting antivirals (DAAs) in this difficult-to-treat population. The ANRS CO23 "Compassionate use of Protease Inhibitors in Viral C Liver Transplantation" (CUPILT) study is a prospective cohort including transplant recipients with recurrent HCV infection treated with DAAs. The present work focused on recipients with recurrent infection following LKT. The study population included 23 patients. All patients received at least one NS5B inhibitor (sofosbuvir) in their antiviral regimen an average of 90 months after LKT. Ninety-six percent of recipients achieved a sustained virological response (SVR) at week 12 (SVR12). In terms of tolerance, 39% of recipients presented with at least one serious adverse event. None of the patients experienced acute rejection during therapy and there were no deaths during follow-up. The glomerular filtration rate (GFR) decreased significantly from baseline to the end of therapy. However, this study did not show that the decline in GFR persisted over time or that it was directly related to DAAs. The DAA-based regimen is well tolerated with excellent results in terms of efficacy. It will become the gold standard for the treatment of recurrent HCV following LKT.
Published: 2017
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30. Study of the fat-free mass obtained by two different body composition methods in patients with amyotrophic lateral sclerosis: Impedancemetry versus measurement of the four skin folds

Author: N. Calmel, P.M. Preux, Pierre Jésus, H. Sourisseau, Philippe Fayemendy, F. Rebière, Philippe Couratier, Jean Claude Desport, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Service de Neurologie [CHU Limoges]
Subjects: 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, 030309 nutrition & dietetics, business.industry, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Anatomy, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Fat free mass, medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, In patient, Amyotrophic lateral sclerosis, business, Composition methods
Abstract: International audience; Rationale: Amyotrophic lateral sclerosis (ALS) is a severe neurological disease very often accompanied by malnutrition. Nutritional status and body composition are factors associated with survival. The total body bioelectric impedance analysis (BIA) with a validated equation (Desport et al.) allows to assess the body composition during this disease, but requires the appropriate equipment. Measuring body composition using the four skin folds is simple to perform but not validated in ALS. The aim of our work was to study the agreement of measurements of Fat-Free Mass (FFM) by BIA compared to the skin folds method.Methods: We included all the measurements between 2000 and 2018, for which the ALS patients had a BIA and the measurement of the four skin folds. Skin fold measurements (tricipital, bicipital, subscapular and super-iliac) were performed 3 times on each side and then averaged. The Fat Mass (FM) obtained from the formula of Siri and Durnin & Womersley, allowed us to obtain the FFMsf (weight minus FM). The BIA was performed at 50 kHz. The FFMimp in BIA was calculated using the validated equation of Desport et al. also requiring the measurement of the tricipital skin fold. The correlation between the two methods was evaluated by linear regression and the agreement by the Bland-Altman method.Results: 1045 measurements were studied. The mean age of the patients was 65.0 ± 11.6 years and the sex ration M / F ratio was of 1.1. In BIA, the mean FFMimp was of 46.1 ± 9.1 kg and FFMsf of 44.5 ± 9.3 kg. There was a good correlation between the two methods (R = 0.91, p
Published: 2020
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31. Une belle histoire de 36 ans

Author: Jean Claude Desport, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
Subjects: 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Nutrition and Dietetics, 030309 nutrition & dietetics, 030220 oncology & carcinogenesis, Endocrinology, Diabetes and Metabolism, Internal Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018
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32. Peser les patients habillés induit un risque de surestimation de leur statut nutritionnel

Author: Jean-Claude Desport, H. Sourisseau, B. Morin, Pierre Jésus, Philippe Fayemendy, S. Bonhommo, Manon Arnal, Yara Nasser, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
Subjects: 0301 basic medicine, 0303 health sciences, 030109 nutrition & dietetics, Nutrition and Dietetics, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Poids des vêtements, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Poids corporel, Statut nutritionnel
Abstract: International audience; En institution comme à domicile, certains patients peuvent avoir des difficultés à se mobiliser et à se déshabiller ou refuser de se mettre en sous-vêtements. Il est donc probable que peser les patients habillés est une pratique fréquente. La surestimation du poids corporel ainsi obtenue pourrait induire une erreur d’évaluation du statut nutritionnel. L’objectif de l’étude était de déterminer dans quelle mesure peser les patients adultes habillés versus en sous-vêtements pouvait modifier leur statut nutritionnel. Cinquante et un patients étaient inclus. La pesée habillée surestimait le poids réel de 1,6 ± 0,6 kg et induisait une surestimation de classification du statut nutritionnel dans près de 14 % des cas. De plus, le poids des vêtements était différent selon le sexe et selon les conditions de température extérieure. Ces résultats suggèrent qu’il est souhaitable autant que possible de peser tous les patients adultes en sous-vêtements.
Published: 2018
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33. Dépistage des troubles du comportement alimentaire à l'aide du SCOFF-F chez 330 patients obèses pris en charge en Limousin

Author: Arnal-Couderc, Manon, Fayemendy, Philippe, Morin, B., Laroumagne, G., de Rouvray, C., Thellier, D., Teissier, Marie-Pierre, Desport, Jean-Claude, Jésus, Pierre, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine interne B, Endocrinologie, Diabète, Maladies métaboliques [CHU Limoges], and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

34. Comparaison de la masse maigre obtenue en impedancemétrie chez des patients atteints de Sclérose latérale amyotrophique : mesure directe par un impédancemètre versus formule de référence

Author: Desbordes, Florine, Fayemendy, Philippe, Sourisseau, Huguette, Calmel, N., Preux, Pierre-Marie, Couratier, Philippe, Jésus, Pierre, Desport, Jean-Claude, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Service de Neurologie [CHU Limoges], and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

35. Nouvelles normes de dénutrition en France selon l'HAS

Author: Desport, Jean-Claude, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

36. Importance des fausses routes respiratoires chez 50 résidents testés aléatoirement en établissement d'hébergement pour personnes âgées dépendantes (EHPAD)

Author: Desport, Jean-Claude, Villemonteix, C., Fraysse, JL, Fayemendy, Philippe, Jésus, Pierre, Douzon, V., Thuillard, O., Leymarie, I., Roger, Charlotte, Estager, J.P., Bouvet, G., Labat, R., Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

37. Identification et impact de la sarcopénie chez les patients en surpoids et obèses avec un carcinome à cellules rénales localisé

Author: Darbas, T., Forestier, G., Leobon, S, Pestre, J., Jésus, Pierre, Lachatre, D., Descazeaud, Aurelien, Tubiana-Mathieu, Nicole, Deluche, Elise, Service d'Oncologie médicale [CHU Limoges], CHU Limoges, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de Néphrologie, Dialyse, Transplantations [CHU Limoges], and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

38. Évaluation du statut en vitamine C de patients vus en consultation de Nutrition et recherche de facteurs associés entre le statut nutritionnel et la carence en vitamine C

Author: Misset, B., Jésus, Pierre, Arnal-Couderc, Manon, Calmel, N., Sourisseau, Huguette, Morin, B., Fayemendy, Philippe, Desport, Jean-Claude, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

39. Etude de la masse maigre obtenue par deux méthodes de composition corporelle différentes chez des patients atteints de Sclérose latérale amyotrophique : impedancemétrie versus mesure des quatre plis cutanés

Author: Rebière, F., Fayemendy, Philippe, Calmel, N., Sourisseau, Huguette, Preux, Pierre-Marie, Couratier, Philippe, Jésus, Pierre, Desport, Jean-Claude, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Service de Neurologie [CHU Limoges], and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

40. Evaluation du statut nutritionnel de 866 résidents en EHPAD dans le territoire du Limousin et liens avec la démence et la mobilité

Author: Vernier, T., Desport, Jean-Claude, Villemonteix, C., Massoulard, Aude, Fraysse, J.L, Jésus, Pierre, Fayemendy, Philippe, Arnal-Couderc, Manon, Guemas, C., Salacroup, C, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

41. Etat des lieux des carences et de la supplémentation dans un groupe de patientes après bypass gastrique

Author: Sodji, J., Desport, Jean-Claude, Marre-Fournier, F., Dalmay, François, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

42. Utilisation du score SCOFF pour détecter les troubles du comportement alimentaire chez les patients obèses

Author: Arnal-Couderc, Manon, Fayemendy, Philippe, Morin, B., Laroumagne, G., de Rouvray, C., Thellier, D., Teissier, Marie-Pierre, Desport, Jean-Claude, Jésus, Pierre, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

43. Obésité et addictions au sucre

Author: Jésus, Pierre, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

44. Vision de l'obésité pédiatrique par les médecins généralistes

Author: Guibert, H, Lienhardt-Roussie, Anne, Fayemendy, Philippe, Morin, B., Voisin, A., Thibault, H., Desport, Jean-Claude, Jésus, Pierre, Service de Pédiatrie médicale [CHU Limoges], CHU Limoges, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

45. Body mass index and peripheral arterial disease, a 'U-shaped' relationship in elderly African population - the EPIDEMCA study

Author: Pierre-Marie Preux, Epidemca investigators, Bébène Ndamba-Bandzouzi, Maëlenn Guerchet, Philippe Lacroix, Julien Magne, Benoît Marin, Pierre Jésus, Victor Aboyans, Ileana Desormais, Pascal M'Belesso, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de cardiologie [CHU Limoges], Department of Psychology, King's College, Institute of Psychiatry, University of London, Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Clinical sciences
Subjects: Male, Arterial disease, 030204 cardiovascular system & hematology, peripheral artery disease, Body Mass Index, 03 medical and health sciences, Peripheral Arterial Disease, 0302 clinical medicine, underweight, Thinness, medicine, Prevalence, Humans, 030212 general & internal medicine, Obesity, Aged, 2. Zero hunger, business.industry, nutritional and metabolic diseases, Overweight, 3. Good health, Peripheral, African population, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Rural area, Underweight, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Body mass index, Demography
Abstract: Summary: Background: There is no study available concerning specifically the role of underweight in PAD prevalence. Patients and methods: Individuals ≥ 65 years living in urban and rural areas of two countries in Central Africa (Central African Republic and the Republic of Congo) were invited. Demographic, clinical and biological data were collected, and ankle-brachial index measured. BMI was calculated as weight/height2 and participants were categorized according to the World Health Organization as with underweight (2), normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), and obese (≥ 30 kg/m2). Results: Among the 1815 participants (age 73.0 years, 61.8 % females), the prevalence of underweight was 34.1 %, higher in subjects with PAD than in PAD free subjects (37.1 % vs. 33.5 %, p = 0.0333). The overall prevalence of PAD was 14.3 %. Underweight and obesity were still significantly associated with PAD after adjustment to all potential confounding factors (OR: 2.09, p = 0.0009 respectively OR: 1.90, p = 0.0336) while overweight was no more significantly associated with PAD after multivariate analysis. Conclusions: While obesity is a well-known PAD associated marker, low BMI provides novel independent and incremental information on African subject’s susceptibility to present PAD, suggesting a “U-shaped” relationship between BMI and PAD in this population.
Published: 2019
Full Text: View/download PDF

46. Alimentation restrictive en établissements de soins : quelles recommandations ?

Author: Fayemendy, Philippe, Jésus, Pierre, Arnal-Couderc, Manon, Vernier, T., Salacroup, C, Guemas, C., Desport, Jean-Claude, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

47. Clinibot : un robot conversationnel pour repérer les troubles de la déglutition et faciliter la prise de décision

Author: Villemonteix, C., Desport, Jean-Claude, Fraysse, J.L., Fayemendy, Philippe, Jésus, Pierre, Douzon, V., Thuillart, O., Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

48. Tabac, alimentation et activité physique : comment faire ?

Author: Fayemendy, Philippe, Jésus, Pierre, Arnal-Couderc, Manon, Desport, Jean-Claude, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

49. Dénutrition : physiopathologie et conséquences

Author: Desport, Jean-Claude, Jésus, Pierre, Fayemendy, Philippe, Arnal-Couderc, Manon, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

50. Quelles stratégies thérapeutiques chez les patients dénutris ?

Author: Desport, Jean-Claude, Fayemendy, Philippe, Jésus, Pierre, Arnal-Couderc, Manon, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges], CHU Limoges, and Grelier, Elisabeth
Subjects: [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

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