1. Pathological lesions in colonic biopsies during Parkinson's disease
- Author
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Yann Touchefeu, J. P. Galmiche, Emmanuel Coron, S Vrignaud, Michel Neunlist, Thibaud Lebouvier, Pascal Derkinderen, Philippe Naveilhan, S. Bruley des Varannes, Philippe Damier, Tanguy Chaumette, Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Clinique neurologique, Hôpital Laennec, CIC - Nantes, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anesthésie et réanimation chirurgiale, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, and Neunlist, Michel
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Parkinson's disease ,Colon ,Biopsy ,Population ,Context (language use) ,Substantia nigra ,Pilot Projects ,Enteric Nervous System ,Dopamine ,medicine ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,education ,Pathological ,Aged ,education.field_of_study ,business.industry ,Dopaminergic ,Gastroenterology ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Parkinson Disease ,Submucous Plexus ,medicine.disease ,Immunohistochemistry ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Case-Control Studies ,Nerve Degeneration ,alpha-Synuclein ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Enteric nervous system ,business ,Constipation ,medicine.drug - Abstract
Parkinson’s disease (PD) is a neurodegenerative condition that affects 1% of the population over 65 years of age. The two pathological hallmarks of PD are a loss of dopaminergic neurons in the substantia nigra (SN) and the presence of cytoplasmic eosinophilic inclusions termed Lewy bodies (LBs), whose main component is phosphorylated α-synuclein.1 This degeneration of SN neurons leads to a dopamine deficiency responsible for the major motor symptoms. Nevertheless, it has become increasingly evident that PD is a multicentric neurodegenerative process that also affects neuronal structures outside the SN.2 In this context, various reports performed on surgical or autopsy specimens have shown that the enteric nervous system (ENS) is affected during PD.3 4 However, it is still a matter of debate whether these alterations occur early in the course of the disease. This is mainly due to a lack of accessibility to the ENS in the living patients. Therefore, demonstrating (1) the ability to study the ENS using routine colonic biopsies and (2) the presence of lesions characteristics …
- Published
- 2008
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