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2. Decompression Illness After Technical Diving Session in Mediterranean Sea: Oxidative Stress, Inflammation, and HBO Therapy.

Author

Mrakic-Sposta, Simona, Brizzolari, Andrea, Vezzoli, Alessandra, Graci, Carmela, Cimmino, Attilio, Giacon, Tommaso Antonio, Dellanoce, Cinzia, Barassi, Alessandra, Sesana, Giovanni, and Bosco, Gerardo

Subjects
HYPERBARIC oxygenation, JOINT pain, GAS embolism, DECOMPRESSION sickness, SCUBA diving
Abstract

SCUBA diving poses risks due to pressure changes during descent (compression) and ascent (decompression). Decompression sickness (DCS) occurs due to gas bubble formation as the pressure decreases, causing joint pain, numbness, dizziness, or even paralysis and death. Immediate treatment involves 100% oxygen to help eliminate inert gases and hyperbaric oxygen therapy (HBOT), which is essential to reduce gas emboli formation and inflammation, thus improving symptoms. We evaluated oxy-inflammation biomarkers in the saliva and urine of nine subjects pre- and post-technical dive on the Haven wreck (GE, Italy). A case of DCS occurred during the dive. The injured diver was treated immediately with O2 and transported to the hyperbaric center of "ASST Ospedale Ca Granda" in Milan. He was treated following the U.S. Navy Treatment Table 5 at 2.8 ATA and the day after with Table 15 at 2.4 ATA. Venous blood and urine samples were collected before and after each HBO treatment. Our study shows that dive increased oxy-inflammation biomarkers (ROS +126%; lipid peroxidation +23%; interleukins-6 +81%, -1β +19%, and TNFα +84%) and nitric oxide metabolites levels (+36%). HBOT after a DCS episode reduced oxidative stress, lowering the very high marker of lipid peroxidation (8-iso-PGF2α), and inhibited inflammatory interleukins. Overall, HBOT improved physiological responses in the diver affected by DCS. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Mechanical chest compression and extracorporeal life support for out-of-hospital cardiac arrest. A 30-month observational study in the metropolitan area of Milan, Italy

Author

Mistraletti, G, Lancioni, A, Bassi, G, Nespoli, F, Umbrello, M, Salini, S, Zangrillo, A, Pappalardo, F, Scandroglio, A, Foti, G, Avalli, L, Patroniti, N, Raimondi, F, Costantini, E, Catena, E, Ottolina, D, Ruffini, C, Migliari, M, Sesana, G, Fumagalli, R, Pesenti, A, Mistraletti, Giovanni, Lancioni, Armando, Bassi, Gabriele, Nespoli, Francesca, Umbrello, Michele, Salini, Silvia, Zangrillo, Alberto, Pappalardo, Federico, Scandroglio, Anna Mara, Foti, Giuseppe, Avalli, Leonello, Patroniti, Nicolò, Raimondi, Ferdinando, Costantini, Elena, Catena, Emanuele, Ottolina, Davide, Ruffini, Claudia, Migliari, Maurizio, Sesana, Giovanni, Fumagalli, Roberto, Pesenti, Antonio, Mistraletti, G, Lancioni, A, Bassi, G, Nespoli, F, Umbrello, M, Salini, S, Zangrillo, A, Pappalardo, F, Scandroglio, A, Foti, G, Avalli, L, Patroniti, N, Raimondi, F, Costantini, E, Catena, E, Ottolina, D, Ruffini, C, Migliari, M, Sesana, G, Fumagalli, R, Pesenti, A, Mistraletti, Giovanni, Lancioni, Armando, Bassi, Gabriele, Nespoli, Francesca, Umbrello, Michele, Salini, Silvia, Zangrillo, Alberto, Pappalardo, Federico, Scandroglio, Anna Mara, Foti, Giuseppe, Avalli, Leonello, Patroniti, Nicolò, Raimondi, Ferdinando, Costantini, Elena, Catena, Emanuele, Ottolina, Davide, Ruffini, Claudia, Migliari, Maurizio, Sesana, Giovanni, Fumagalli, Roberto, and Pesenti, Antonio

Abstract

Background: Return of spontaneous circulation (ROSC) is achieved in 25% of out-of-hospital cardiac arrest (OHCA) patients. Mechanical chest compression (mechCPR) may maintain better perfusion during transport, allowing hospital treatments like extracorporeal circulation life support (ECLS). We aim to assess the effectiveness of a pre-hospital protocol introduction. Methods: Observational, retrospective study assessing all OHCA patients aged 12-75, with no-flow time <20 min in a metropolitan area (Milan, Italy, 2013-2016). Primary outcomes: ROSC and Cerebral Performance Category score (CPC) <2 at hospital discharge. Logistic regressions with multiple comparison adjustments balanced with propensity scores calculated with inverse probability of treatment weighting were performed. Results: 1366 OHCA were analysed; 305 received mechCPR, 1061 manual chest compressions (manCPR), and 108 ECLS. ROSC and CPC <2 were associated with low-flow minutes (odds ratio [95% confidence interval] 0.90 [0.88-0.91] and 0.90 [0.87-0.93]), shockable rhythm (2.52 [1.71- 3.72] and 10.68 [5.63-20.28]), defibrillations number (1.15 [1.07-1.23] and 1.15 [1.04-1.26]), and mechCPR (1.86 [1.17-2.96] and 2.06 [1.11- 3.81]). With resuscitation times >13 min, mechCPR achieved more frequently ROSC compared to manCPR. Among ECLS patients, 70% had time exceeding protocol: 8 (7.5%) had CPC <= 2 (half of them with low-flow times between 45 and 90 min), 2 (1.9%) survived with severe neurological disabilities, and 13 brain-dead (12.0%) became organ donors. Conclusions: MechCPR patients achieved ROSC more frequently than manual CPR patients; mechCPR was a crucial factor in an ECLS protocol for refractory OHCA. ECLS offered a chance of survival to patients who would otherwise die.

Published
2023

4. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

Author

Kaufmann, Marc, Thaler, Markus, Maier, Martin, Prause, Gerhard, Trimmel, Helmut, de Longueville, Diane, Preseau, Thierry, Biarent, Dominique, Melot, Christian, Mpotos, Nicolas, Monsieurs, Koen, Van de Voorde, Patrick, Vanhove, Marie, Lievens, Pascale, Faniel, Mathias, Keleuva, Slobodanka, Lazarevic, Milan, Ujevic, Radmila Majhen, Devcic, Mato, Bardak, Branka, Barisic, Fabijan, Anticevic, Silvija Hunyadi, Georgiou, Marios, Truhláſ, Anatolij, Knor, Jiſí, Smržová, Eva, Sviták, Roman, Šín, Robin, Mokrejš, Petr, Lippert, Freddy K., Hallikainen, Juhana, Hoikka, Marko, Iirola, Timo, Jama, Timo, Jäntti, Helena, Jokisalo, Raimo, Jousi, Milla, Kirves, Hetti, Kuisma, Markku, Laine, Jukka, Länkimäki, Sami, Loikas, Petri, Lund, Vesa, Määttä, Teuvo, Nal, Heini, Niemelä, Heimo, Portaankorva, Petra, Pylkkänen, Marko, Sainio, Marko, Setälä, Piritta, Tervo, Jerry, Väyrynen, Taneli, Murgue, Davy, Champenois, Anne, Fournier, Marc, Meyran, Daniel, Tabary, Romain, Avondo, Aurélie, Gelin, Gelin, Simonnet, Bruno, Joly, Marc, Megy-Michoux, Isabelle, Paringaux, Xavier, Duffait, Yves, Vial, Michael, Segard, Julien, Narcisse, Sophie, Hamban, David, Hennache, Jonathan, Thiriez, Sylvain, Doukhan, Mathieu, Vanderstraeten, Carine, Morel, Jean-Charles, Majour, Gilles, Michenet, Corinne, Tritsch, Laurent, Dubesset, Marc, Peguet, Olivier, Pinero, David, Guillaumee, Fréderic, Fuster, Patrick, Ciacala, Jean-François, Jardel, Benoît, Letarnec, Jean-Yves, Goes, Frank, Gosset, Pierre, Vergne, Muriel, Bar, Christian, Branche, Fabienne, Prineau, Stevens, Lagadec, Steven, Cornaglia, Carole, Ursat, Cécile, Bertrand, Philippe, Agostinucci, Jean-Marc, Nadiras, Pierre, de Linares, Géraldine Gonzales, Jacob, Line, Revaux, François, Pernot, Thomas, Roudiak, Nathalie, Ricard-Hibon, Agnès, Villain-Coquet, Laurent, Beckers, Stefan, Hanff, Thomas, Strickmann, Bernd, Wiegand, Nicolai, Wilke, Petra, Sues, Harald, Bogatzki, Stefan, Baumeier, Wolfgang, Pohl, Kai, Werner, Bert, Fischer, Hans, Zeng, Torsten, Popp, Erik, Günther, Andreas, Hochberg, Andreas, Lechleuthner, Alex, Schewe, Jens-Christian, Lemke, Hans, Wranze-Bielefeld, Erich, Bohn, Andreas, Roessler, Markus, Naujoks, Frank, Sensen, Frank, Esser, Torben, Fischer, Matthias, Messelken, Martin, Rose, Christopher, Schlüter, Gabriele, Lotz, Wolfgang, Corzilius, Michael, Muth, Claus-Martin, Diepenseifen, Christian, Tauchmann, Björn, Birkholz, Torsten, Flemming, Andreas, Herrmann, Stefanie, Kreimeier, Uwe, Kill, Clemens, Marx, Frank, Schröder, Ralph, Lenz, Wolfgang, Botini, Glykeria, Grigorios, Barakos, Giannakoudakis, Nikolaos, Zervopoulos, Michail, Papangelis, Dimitrios, Petropoulou-Papanastasiou, Sofia, Liaskos, Themistoklis, Papanikolaou, Spyridon, Karabinis, Andreas, Zentay, Attila, ÿorsteinsson, Hólmgeir, Gilsdóttir, Anna, Birgisson, Svavar A., Guðmundsson, Fjölnir Freyr, Hreiðarsson, Hallgrímur, ÿrnason, Björgvin, Hermannsson, Hermann, Björnsson, Gísli, Friðriksson, Brynjar ÿór, Baldursson, Gunnar, Höskuldsson, ÿrmann, Valgarðsdottir, Jórunn, ÿsmundardóttir, Matthildur, Guðmundsson, Guðmundur, Kristjánsson, Hjörtur, ÿórarinsson, Eyþór Rúnar, Guðlaugsson, Jón, Skarphéðinsson, Sigurður, Peratoner, Alberto, Santarelli, Andrea, Sabetta, Cesare, Gordini, Giovanni, Sesana, Giovanni, Giudici, Riccardo, Savastano, Simone, Pellis, Tommaso, Beissel, Jean, Uhrig, Jean, Manderscheid, Tom, Klop, Marco, Stammet, Pascal, Koch, Marc, Welter, Philippe, Schuman, Robert, Bruins, Wendy, Amin, Hesam, Braa, Nina, Bratland, Staale, Buanes, Eirik Alnes, Draegni, Tomas, Johnsen, Knut Roar, Mathisen, Wenche Torunn, Oedegaarden, Terje, Oppedal, Marie, Reksten, Alf Stolt-Nielsen, Roedsand, Mats Eirik, Steen-Hansen, Jon Erik, Dyrda, Marta, Frejlich, Anna, MaciĿg, Sſawomir, Osadnik, Sonia, Weryk, Ireneusz, Mendonça, Eugénio, Freitas, Carlos, Cruz, Pinto, Caldeira, Carmo, Barros, José, Vale, Luis, Brazão, António, Jardim, Nuno, Rocha, Fernanda, Duarte, Ricardo, Fernandes, Nicodemos, Ramos, Pedro, Jardim, Margarida, Reis, Miguel, Ribeiro, Romulo, Zenha, Sérgio, Fernandes, Jorge, Francisco, Juan, Assis, David, Abreu, Fernanda, Freitas, Dinarte, Ribeiro, Leonardo, Azevedo, Paulo, Calafatinho, Débora, Jardim, Rui, Pestana, Aleixo, Faria, Rui, Oprita, Bogdan, Grasu, Alis, Nedelea, Paul, Sovar, Sorina, Agapi, Florin, KliĿkoviĿ, Aleksandar, LaziĿ, Aleksandra, NikoliĿ, Bogdan, Zivanovic, Bogdan, MartinoviĿ, Branislav, MilenkoviĿ, Dušan, Damir, HuseinoviĿ, Koprivica, Jovanka, JakšiĿ, Kornelija Horvat, Pajor, Margit, MiliĿ, Saša, VidoviĿ, Mirko, Glamoclija, Radojka Petrovic, Andjelic, Sladjana, Sladjana, Vlajovic, BabiĿ, Zlatko, Fišer, Zlatko, Androvic, Peter, Bajerovska, Lubica, Chabron, Miroslav, Dobias, Viliam, Havlikova, Eva, Horanova, Bozena, Kratochvilova, Renata, Kubova, Dana, Murgas, Jan, Patras, Juraj, Simak, Ladislav, Snarskij, Vladimir, Zaviaticova, Zuzana, Zuffova, Marcela, Roig, Francesc Escalada, Santos, Luis Sánchez, Sucunza, Alfredo Echarri, Cordero Torres, Juan A., Muñoz, Guadalupe Inza, del Valle, Marta Martínez, Rozalen, Isabel Ceniceros, Sánchez, Enrique Martín, Berlanga, María Victoria Raúl Canabal, Olalde, Karlos Ibarguren, Ruiz Azpiazu, José I., García-Ochoa, María José, López-Navarro, Rafael Zoyo, Adsuar Quesada, José M., Cortés Ramas, José A., Mellado Vergel, Francisco J., López Messa, Juan B., del Valle, Patricia Fernández, Anselmi, Luciano, Benvenuti, Breganzona Claudio, Batey, Nigel, Ambulance, Yorkshire, Booth, Scott, Bucher, Patricia, Deakin, Charles D., Duckett, Jay, Ji, Chen, Loughlin, Nancy, Lumley-Holmes, Jenny, Lynde, Jessica, Mersom, Frank, Ramsey, Carly, Robinson, Clare, Spaight, Robert, Dosanjh, Sukhdeep, Virdi, Gurkamal, Whittington, Andrew, Gräsner, Jan-Thorsten, Lefering, Rolf, Koster, Rudolph W., Masterson, Siobhán, Böttiger, Bernd W., Herlitz, Johan, Wnent, Jan, Tjelmeland, Ingvild B.M., Ortiz, Fernando Rosell, Maurer, Holger, Baubin, Michael, Mols, Pierre, HadžibegoviĿ, Irzal, Ioannides, Marios, Škulec, Roman, Wissenberg, Mads, Salo, Ari, Hubert, Hervé, Nikolaou, Nikolaos I., Lóczi, Gerda, Svavarsdóttir, Hildigunnur, Semeraro, Federico, Wright, Peter J., Clarens, Carlo, Pijls, Ruud, Cebula, Grzegorz, Correia, Vitor Gouveia, Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Strömsöe, Anneli, Burkart, Roman, Perkins, Gavin D., and Bossaert, Leo L.

Published
2016
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5. Mechanical chest compression and extracorporeal life support for out-of-hospital cardiac arrest. A 30-month observational study in the metropolitan area of Milan, Italy

Author

Mistraletti, Giovanni, primary, Lancioni, Armando, additional, Bassi, Gabriele, additional, Nespoli, Francesca, additional, Umbrello, Michele, additional, Salini, Silvia, additional, Zangrillo, Alberto, additional, Pappalardo, Federico, additional, Scandroglio, Anna Mara, additional, Foti, Giuseppe, additional, Avalli, Leonello, additional, Patroniti, Nicolò, additional, Raimondi, Ferdinando, additional, Costantini, Elena, additional, Catena, Emanuele, additional, Ottolina, Davide, additional, Ruffini, Claudia, additional, Migliari, Maurizio, additional, Sesana, Giovanni, additional, Fumagalli, Roberto, additional, and Pesenti, Antonio, additional

Published
2023
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6. Negative Pressure Wound Therapy for the Treatment of Fournier’s Gangrene: A Rare Case with Rectal Fistula and Systematic Review of the Literature

Author

Altomare, Michele, primary, Benuzzi, Laura, additional, Molteni, Mattia, additional, Virdis, Francesco, additional, Spota, Andrea, additional, Cioffi, Stefano Piero Bernardo, additional, Reitano, Elisa, additional, Renzi, Federica, additional, Chiara, Osvaldo, additional, Sesana, Giovanni, additional, and Cimbanassi, Stefania, additional

Published
2022
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7. Regenerative Medicine to Improve Outcomes of Ventral Hernia Reconstruction (REPAIR Study) Phase 1: Find the Best Decellularization Protocol for the Human Dermis

Author

Altomare, Michele, primary, Ferrario, Luca, additional, Benuzzi, Laura, additional, Tosca, Marta Cecilia, additional, Gipponi, Marta, additional, Khodri, Imam, additional, Sesana, Giovanni, additional, Cimbanassi, Stefania, additional, Cioffi, Stefano Piero Bernardo, additional, Spota, Andrea, additional, Bini, Roberto, additional, Chiara, Osvaldo, additional, and Mingoli, Andrea, additional

Published
2022
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11. Impact of Point-of-Care Ultrasound on Secondary Triage: A Pilot Study

Author

Stucchi, Riccardo, Weinstein, Eric S, Ripoll-Gallardo, Alba, Franc, Jeffery M, Azzaretto, Massimo, Sesana, Giovanni, Corte, Francesco Della, and Neri, Luca

Abstract

AbstractObjectivesIn mass casualty scenarios, patients with apparent hemodynamic and respiratory stability might have occult life-threatening injuries. These patients could benefit from more accurate triage methods. This study assessed the impact of point-of-care ultrasound (POCUS) on the accuracy of secondary triage conducted at an advanced medical post (AMP) to enhance the detection of patients who, despite their apparent clinically stable condition, could benefit from immediate life-saving interventions or priority earlier transport to definitive care.MethodsA mass casualty simulated event consisting of a bomb blast in a remote area was conducted with 10 simulated casualties classified as YELLOW at the primary triage scene; patients were evaluated by 4 physicians at an AMP. Three patients had, respectively, hemoperitoneum, pneumothorax, and hemothorax. Two of the four physicians were provided the use of POCUS.ResultsAll 4 physicians were able to suspect hemoperitoneum, but only physicians utilizing POCUS detected pneumothorax and hemothorax.ConclusionThis study suggests that POCUS-enhanced secondary MCI triage at an AMP may represent an effective methodology to accurately detect nonapparent injuries that require time-dependent priority transport or life-saving interventions. Further studies with larger samples conducted in varied MCI scenarios are warranted.

Published
2024
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12. GMP-compliant sponge-like dressing containing MSC lyo-secretome: Proteomic network of healing in a murine wound model

Author

Bari, Elia, primary, Di Silvestre, Dario, additional, Mastracci, Luca, additional, Grillo, Federica, additional, Grisoli, Pietro, additional, Marrubini, Giorgio, additional, Nardini, Marta, additional, Mastrogiacomo, Maddalena, additional, Sorlini, Marzio, additional, Rossi, Rossana, additional, Torre, Maria Luisa, additional, Mauri, Pierluigi, additional, Sesana, Giovanni, additional, and Perteghella, Sara, additional

Published
2020
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18. A breathtaking picnic: A fairy tale to save lives

Author

Semeraro, Federico, primary, Scapigliati, Andrea, additional, Rota, Elena, additional, De Luca, Marco, additional, Tammaro, Gaetano, additional, Landini, Chiara, additional, Giulini, Gabriele, additional, Farabegoli, Lucia, additional, Taggi, Floriana, additional, Sesana, Giovanni, additional, Moli, Ornella Li, additional, and Ristagno, Giuseppe, additional

Published
2016
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19. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry

Author

Gräsner, Jan-Thorsten, primary, Lefering, Rolf, additional, Koster, Rudolph W., additional, Masterson, Siobhán, additional, Böttiger, Bernd W., additional, Herlitz, Johan, additional, Wnent, Jan, additional, Tjelmeland, Ingvild B.M., additional, Ortiz, Fernando Rosell, additional, Maurer, Holger, additional, Baubin, Michael, additional, Mols, Pierre, additional, HadžibegoviĿ, Irzal, additional, Ioannides, Marios, additional, Škulec, Roman, additional, Wissenberg, Mads, additional, Salo, Ari, additional, Hubert, Hervé, additional, Nikolaou, Nikolaos I., additional, Lóczi, Gerda, additional, Svavarsdóttir, Hildigunnur, additional, Semeraro, Federico, additional, Wright, Peter J., additional, Clarens, Carlo, additional, Pijls, Ruud, additional, Cebula, Grzegorz, additional, Correia, Vitor Gouveia, additional, Cimpoesu, Diana, additional, Raffay, Violetta, additional, Trenkler, Stefan, additional, Markota, Andrej, additional, Strömsöe, Anneli, additional, Burkart, Roman, additional, Perkins, Gavin D., additional, Bossaert, Leo L., additional, Kaufmann, Marc, additional, Thaler, Markus, additional, Maier, Martin, additional, Prause, Gerhard, additional, Trimmel, Helmut, additional, de Longueville, Diane, additional, Preseau, Thierry, additional, Biarent, Dominique, additional, Melot, Christian, additional, Mpotos, Nicolas, additional, Monsieurs, Koen, additional, Van de Voorde, Patrick, additional, Vanhove, Marie, additional, Lievens, Pascale, additional, Faniel, Mathias, additional, Keleuva, Slobodanka, additional, Lazarevic, Milan, additional, Ujevic, Radmila Majhen, additional, Devcic, Mato, additional, Bardak, Branka, additional, Barisic, Fabijan, additional, Anticevic, Silvija Hunyadi, additional, Georgiou, Marios, additional, Truhláſ, Anatolij, additional, Knor, Jiſí, additional, Smržová, Eva, additional, Sviták, Roman, additional, Šín, Robin, additional, Mokrejš, Petr, additional, Lippert, Freddy K., additional, Hallikainen, Juhana, additional, Hoikka, Marko, additional, Iirola, Timo, additional, Jama, Timo, additional, Jäntti, Helena, additional, Jokisalo, Raimo, additional, Jousi, Milla, additional, Kirves, Hetti, additional, Kuisma, Markku, additional, Laine, Jukka, additional, Länkimäki, Sami, additional, Loikas, Petri, additional, Lund, Vesa, additional, Määttä, Teuvo, additional, Nal, Heini, additional, Niemelä, Heimo, additional, Portaankorva, Petra, additional, Pylkkänen, Marko, additional, Sainio, Marko, additional, Setälä, Piritta, additional, Tervo, Jerry, additional, Väyrynen, Taneli, additional, Murgue, Davy, additional, Champenois, Anne, additional, Fournier, Marc, additional, Meyran, Daniel, additional, Tabary, Romain, additional, Avondo, Aurélie, additional, Gelin, Gelin, additional, Simonnet, Bruno, additional, Joly, Marc, additional, Megy-Michoux, Isabelle, additional, Paringaux, Xavier, additional, Duffait, Yves, additional, Vial, Michael, additional, Segard, Julien, additional, Narcisse, Sophie, additional, Hamban, David, additional, Hennache, Jonathan, additional, Thiriez, Sylvain, additional, Doukhan, Mathieu, additional, Vanderstraeten, Carine, additional, Morel, Jean-Charles, additional, Majour, Gilles, additional, Michenet, Corinne, additional, Tritsch, Laurent, additional, Dubesset, Marc, additional, Peguet, Olivier, additional, Pinero, David, additional, Guillaumee, Fréderic, additional, Fuster, Patrick, additional, Ciacala, Jean-François, additional, Jardel, Benoît, additional, Letarnec, Jean-Yves, additional, Goes, Frank, additional, Gosset, Pierre, additional, Vergne, Muriel, additional, Bar, Christian, additional, Branche, Fabienne, additional, Prineau, Stevens, additional, Lagadec, Steven, additional, Cornaglia, Carole, additional, Ursat, Cécile, additional, Bertrand, Philippe, additional, Agostinucci, Jean-Marc, additional, Nadiras, Pierre, additional, de Linares, Géraldine Gonzales, additional, Jacob, Line, additional, Revaux, François, additional, Pernot, Thomas, additional, Roudiak, Nathalie, additional, Ricard-Hibon, Agnès, additional, Villain-Coquet, Laurent, additional, Beckers, Stefan, additional, Hanff, Thomas, additional, Strickmann, Bernd, additional, Wiegand, Nicolai, additional, Wilke, Petra, additional, Sues, Harald, additional, Bogatzki, Stefan, additional, Baumeier, Wolfgang, additional, Pohl, Kai, additional, Werner, Bert, additional, Fischer, Hans, additional, Zeng, Torsten, additional, Popp, Erik, additional, Günther, Andreas, additional, Hochberg, Andreas, additional, Lechleuthner, Alex, additional, Schewe, Jens-Christian, additional, Lemke, Hans, additional, Wranze-Bielefeld, Erich, additional, Bohn, Andreas, additional, Roessler, Markus, additional, Naujoks, Frank, additional, Sensen, Frank, additional, Esser, Torben, additional, Fischer, Matthias, additional, Messelken, Martin, additional, Rose, Christopher, additional, Schlüter, Gabriele, additional, Lotz, Wolfgang, additional, Corzilius, Michael, additional, Muth, Claus-Martin, additional, Diepenseifen, Christian, additional, Tauchmann, Björn, additional, Birkholz, Torsten, additional, Flemming, Andreas, additional, Herrmann, Stefanie, additional, Kreimeier, Uwe, additional, Kill, Clemens, additional, Marx, Frank, additional, Schröder, Ralph, additional, Lenz, Wolfgang, additional, Botini, Glykeria, additional, Grigorios, Barakos, additional, Giannakoudakis, Nikolaos, additional, Zervopoulos, Michail, additional, Papangelis, Dimitrios, additional, Petropoulou-Papanastasiou, Sofia, additional, Liaskos, Themistoklis, additional, Papanikolaou, Spyridon, additional, Karabinis, Andreas, additional, Zentay, Attila, additional, ÿorsteinsson, Hólmgeir, additional, Gilsdóttir, Anna, additional, Birgisson, Svavar A., additional, Guðmundsson, Fjölnir Freyr, additional, Hreiðarsson, Hallgrímur, additional, ÿrnason, Björgvin, additional, Hermannsson, Hermann, additional, Björnsson, Gísli, additional, Friðriksson, Brynjar ÿór, additional, Baldursson, Gunnar, additional, Höskuldsson, ÿrmann, additional, Valgarðsdottir, Jórunn, additional, ÿsmundardóttir, Matthildur, additional, Guðmundsson, Guðmundur, additional, Kristjánsson, Hjörtur, additional, ÿórarinsson, Eyþór Rúnar, additional, Guðlaugsson, Jón, additional, Skarphéðinsson, Sigurður, additional, Peratoner, Alberto, additional, Santarelli, Andrea, additional, Sabetta, Cesare, additional, Gordini, Giovanni, additional, Sesana, Giovanni, additional, Giudici, Riccardo, additional, Savastano, Simone, additional, Pellis, Tommaso, additional, Beissel, Jean, additional, Uhrig, Jean, additional, Manderscheid, Tom, additional, Klop, Marco, additional, Stammet, Pascal, additional, Koch, Marc, additional, Welter, Philippe, additional, Schuman, Robert, additional, Bruins, Wendy, additional, Amin, Hesam, additional, Braa, Nina, additional, Bratland, Staale, additional, Buanes, Eirik Alnes, additional, Draegni, Tomas, additional, Johnsen, Knut Roar, additional, Mathisen, Wenche Torunn, additional, Oedegaarden, Terje, additional, Oppedal, Marie, additional, Reksten, Alf Stolt-Nielsen, additional, Roedsand, Mats Eirik, additional, Steen-Hansen, Jon Erik, additional, Dyrda, Marta, additional, Frejlich, Anna, additional, MaciĿg, Sſawomir, additional, Osadnik, Sonia, additional, Weryk, Ireneusz, additional, Mendonça, Eugénio, additional, Freitas, Carlos, additional, Cruz, Pinto, additional, Caldeira, Carmo, additional, Barros, José, additional, Vale, Luis, additional, Brazão, António, additional, Jardim, Nuno, additional, Rocha, Fernanda, additional, Duarte, Ricardo, additional, Fernandes, Nicodemos, additional, Ramos, Pedro, additional, Jardim, Margarida, additional, Reis, Miguel, additional, Ribeiro, Romulo, additional, Zenha, Sérgio, additional, Fernandes, Jorge, additional, Francisco, Juan, additional, Assis, David, additional, Abreu, Fernanda, additional, Freitas, Dinarte, additional, Ribeiro, Leonardo, additional, Azevedo, Paulo, additional, Calafatinho, Débora, additional, Jardim, Rui, additional, Pestana, Aleixo, additional, Faria, Rui, additional, Oprita, Bogdan, additional, Grasu, Alis, additional, Nedelea, Paul, additional, Sovar, Sorina, additional, Agapi, Florin, additional, KliĿkoviĿ, Aleksandar, additional, LaziĿ, Aleksandra, additional, NikoliĿ, Bogdan, additional, Zivanovic, Bogdan, additional, MartinoviĿ, Branislav, additional, MilenkoviĿ, Dušan, additional, Damir, HuseinoviĿ, additional, Koprivica, Jovanka, additional, JakšiĿ, Kornelija Horvat, additional, Pajor, Margit, additional, MiliĿ, Saša, additional, VidoviĿ, Mirko, additional, Glamoclija, Radojka Petrovic, additional, Andjelic, Sladjana, additional, Sladjana, Vlajovic, additional, BabiĿ, Zlatko, additional, Fišer, Zlatko, additional, Androvic, Peter, additional, Bajerovska, Lubica, additional, Chabron, Miroslav, additional, Dobias, Viliam, additional, Havlikova, Eva, additional, Horanova, Bozena, additional, Kratochvilova, Renata, additional, Kubova, Dana, additional, Murgas, Jan, additional, Patras, Juraj, additional, Simak, Ladislav, additional, Snarskij, Vladimir, additional, Zaviaticova, Zuzana, additional, Zuffova, Marcela, additional, Roig, Francesc Escalada, additional, Santos, Luis Sánchez, additional, Sucunza, Alfredo Echarri, additional, Cordero Torres, Juan A., additional, Muñoz, Guadalupe Inza, additional, del Valle, Marta Martínez, additional, Rozalen, Isabel Ceniceros, additional, Sánchez, Enrique Martín, additional, Berlanga, María Victoria Raúl Canabal, additional, Olalde, Karlos Ibarguren, additional, Ruiz Azpiazu, José I., additional, García-Ochoa, María José, additional, López-Navarro, Rafael Zoyo, additional, Adsuar Quesada, José M., additional, Cortés Ramas, José A., additional, Mellado Vergel, Francisco J., additional, López Messa, Juan B., additional, del Valle, Patricia Fernández, additional, Anselmi, Luciano, additional, Benvenuti, Breganzona Claudio, additional, Batey, Nigel, additional, Ambulance, Yorkshire, additional, Booth, Scott, additional, Bucher, Patricia, additional, Deakin, Charles D., additional, Duckett, Jay, additional, Ji, Chen, additional, Loughlin, Nancy, additional, Lumley-Holmes, Jenny, additional, Lynde, Jessica, additional, Mersom, Frank, additional, Ramsey, Carly, additional, Robinson, Clare, additional, Spaight, Robert, additional, Dosanjh, Sukhdeep, additional, Virdi, Gurkamal, additional, and Whittington, Andrew, additional

Published
2016
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24. Impact of Point-of-Care Ultrasound on Secondary Triage: A Pilot Study

Author

Stucchi, Riccardo, Weinstein, Eric S., Ripoll-Gallardo, Alba, Franc, Jeffrey M., Azzaretto, Massimo, Sesana, Giovanni, Della Corte, Francesco, and Neri, Luca

Abstract

AbstractObjectives:In mass casualty scenarios, patients with apparent hemodynamic and respiratory stability might have occult life-threatening injuries. These patients could benefit from more accurate triage methods. This study assessed the impact of point-of-care ultrasound on the accuracy of secondary triage conducted at an advanced medical post to enhance the detection of patients who, despite their apparent clinically stable condition, could benefit from earlier evacuation to definitive care or immediate life-saving treatment.Methods:A mass casualty simulated event consisting of a bomb blast in a remote area was conducted with 10 simulated casualties classified as YELLOW at the primary triage scene; patients were evaluated by 4 physicians at an advanced medical post. Three patients had, respectively, hemoperitoneum, pneumothorax, and hemothorax. Only 2 physicians had sonographic information.Results:All 4 physicians were able to suspect hemoperitoneum as a possible critical condition to be managed first, but only physicians with additional sonographic information accurately detected pneumothorax and hemothorax, thus deciding to immediately evacuate or treat.

Published
2023
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25. EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

Author

Gräsner, Jan-Thorsten, Lefering, Rolf, Koster, Rudolph W., Masterson, Siobhán, Böttiger, Bernd W., Herlitz, Johan, Wnent, Jan, Tjelmeland, Ingvild B.M., Ortiz, Fernando Rosell, Maurer, Holger, Baubin, Michael, Mols, Pierre, Hadžibegović, Irzal, Ioannides, Marios, Škulec, Roman, Wissenberg, Mads, Salo, Ari, Hubert, Hervé, Nikolaou, Nikolaos I., Lóczi, Gerda, Svavarsdóttir, Hildigunnur, Semeraro, Federico, Wright, Peter J., Clarens, Carlo, Pijls, Ruud, Cebula, Grzegorz, Correia, Vitor Gouveia, Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Strömsöe, Anneli, Burkart, Roman, Perkins, Gavin D., Bossaert, Leo L., Kaufmann, Marc, Thaler, Markus, Maier, Martin, Prause, Gerhard, Trimmel, Helmut, de Longueville, Diane, Preseau, Thierry, Biarent, Dominique, Melot, Christian, Mpotos, Nicolas, Monsieurs, Koen, Van de Voorde, Patrick, Vanhove, Marie, Lievens, Pascale, Faniel, Mathias, Keleuva, Slobodanka, Lazarevic, Milan, Ujevic, Radmila Majhen, Devcic, Mato, Bardak, Branka, Barisic, Fabijan, Anticevic, Silvija Hunyadi, Georgiou, Marios, Truhlář, Anatolij, Knor, Jiří, Smržová, Eva, Sviták, Roman, Šín, Robin, Mokrejš, Petr, Franek, Ondrej, Lippert, Freddy K., Hallikainen, Juhana, Hoikka, Marko, Iirola, Timo, Jama, Timo, Jäntti, Helena, Jokisalo, Raimo, Jousi, Milla, Kirves, Hetti, Kuisma, Markku, Laine, Jukka, Länkimäki, Sami, Loikas, Petri, Lund, Vesa, Määttä, Teuvo, Nal, Heini, Niemelä, Heimo, Portaankorva, Petra, Pylkkänen, Marko, Sainio, Marko, Setälä, Piritta, Tervo, Jerry, Väyrynen, Taneli, Murgue, Davy, Champenois, Anne, Fournier, Marc, Meyran, Daniel, Tabary, Romain, Avondo, Aurélie, Gelin, Gelin, Simonnet, Bruno, Joly, Marc, Megy-Michoux, Isabelle, Paringaux, Xavier, Duffait, Yves, Vial, Michael, Segard, Julien, Narcisse, Sophie, Hamban, David, Hennache, Jonathan, Thiriez, Sylvain, Doukhan, Mathieu, Vanderstraeten, Carine, Morel, Jean-Charles, Majour, Gilles, Michenet, Corinne, Tritsch, Laurent, Dubesset, Marc, Peguet, Olivier, Pinero, David, Guillaumee, Fréderic, Fuster, Patrick, Ciacala, Jean-François, Jardel, Benoît, Letarnec, Jean-Yves, Goes, Frank, Gosset, Pierre, Vergne, Muriel, Bar, Christian, Branche, Fabienne, Prineau, Stevens, Lagadec, Steven, Cornaglia, Carole, Ursat, Cécile, Bertrand, Philippe, Agostinucci, Jean-Marc, Nadiras, Pierre, de Linares, Géraldine Gonzales, Jacob, Line, Revaux, François, Pernot, Thomas, Roudiak, Nathalie, Ricard-Hibon, Agnès, Villain-Coquet, Laurent, Beckers, Stefan, Hanff, Thomas, Strickmann, Bernd, Wiegand, Nicolai, Wilke, Petra, Sues, Harald, Bogatzki, Stefan, Baumeier, Wolfgang, Pohl, Kai, Werner, Bert, Fischer, Hans, Zeng, Torsten, Popp, Erik, Günther, Andreas, Hochberg, Andreas, Lechleuthner, Alex, Schewe, Jens-Christian, Lemke, Hans, Wranze-Bielefeld, Erich, Bohn, Andreas, Roessler, Markus, Naujoks, Frank, Sensen, Frank, Esser, Torben, Fischer, Matthias, Messelken, Martin, Rose, Christopher, Schlüter, Gabriele, Lotz, Wolfgang, Corzilius, Michael, Muth, Claus-Martin, Diepenseifen, Christian, Tauchmann, Björn, Birkholz, Torsten, Flemming, Andreas, Herrmann, Stefanie, Kreimeier, Uwe, Kill, Clemens, Marx, Frank, Schröder, Ralph, Lenz, Wolfgang, Botini, Glykeria, Grigorios, Barakos, Giannakoudakis, Nikolaos, Zervopoulos, Michail, Papangelis, Dimitrios, Petropoulou-Papanastasiou, Sofia, Liaskos, Themistoklis, Papanikolaou, Spyridon, Karabinis, Andreas, Zentay, Attila, Þorsteinsson, Hólmgeir, Gilsdóttir, Anna, Birgisson, Svavar A., Guðmundsson, Fjölnir Freyr, Hreiðarsson, Hallgrímur, Árnason, Björgvin, Hermannsson, Hermann, Björnsson, Gísli, Friðriksson, Brynjar Þór, Baldursson, Gunnar, Höskuldsson, Ármann, Valgarðsdottir, Jórunn, Ásmundardóttir, Matthildur, Guðmundsson, Guðmundur, Kristjánsson, Hjörtur, Þórarinsson, Eyþór Rúnar, Guðlaugsson, Jón, Skarphéðinsson, Sigurður, National Ambulance Service of the Health Service Executive Dublin Fire Brigade, Dublin, Peratoner, Alberto, Santarelli, Andrea, Sabetta, Cesare, Gordini, Giovanni, Sesana, Giovanni, Giudici, Riccardo, Savastano, Simone, Pellis, Tommaso, Beissel, Jean, Uhrig, Jean, Manderscheid, Tom, Klop, Marco, Stammet, Pascal, Koch, Marc, Welter, Philippe, Schuman, Robert, Bruins, Wendy, Amin, Hesam, Braa, Nina, Bratland, Staale, Buanes, Eirik Alnes, Draegni, Tomas, Johnsen, Knut Roar, Mathisen, Wenche Torunn, Oedegaarden, Terje, Oppedal, Marie, Reksten, Alf Stolt-Nielsen, Roedsand, Mats Eirik, Steen-Hansen, Jon Erik, Dyrda, Marta, Frejlich, Anna, Maciąg, Sławomir, Osadnik, Sonia, Weryk, Ireneusz, Mendonça, Eugénio, Freitas, Carlos, Cruz, Pinto, Caldeira, Carmo, Barros, José, Vale, Luis, Brazão, António, Jardim, Nuno, Rocha, Fernanda, Duarte, Ricardo, Fernandes, Nicodemos, Ramos, Pedro, Jardim, Margarida, Reis, Miguel, Ribeiro, Romulo, Zenha, Sérgio, Fernandes, Jorge, Francisco, Juan, Assis, David, Abreu, Fernanda, Freitas, Dinarte, Ribeiro, Leonardo, Azevedo, Paulo, Calafatinho, Débora, Jardim, Rui, Pestana, Aleixo, Faria, Rui, Oprita, Bogdan, Grasu, Alis, Nedelea, Paul, Sovar, Sorina, Agapi, Florin, Kličković, Aleksandar, Lazić, Aleksandra, Nikolić, Bogdan, Zivanovic, Bogdan, Martinović, Branislav, Milenković, Dušan, Damir, Huseinović, Koprivica, Jovanka, Jakšić, Kornelija Horvat, Pajor, Margit, Milić, Saša, Vidović, Mirko, Glamoclija, Radojka Petrovic, Andjelic, Sladjana, Sladjana, Vlajovic, Babić, Zlatko, Fišer, Zlatko, Androvic, Peter, Bajerovska, Lubica, Chabron, Miroslav, Dobias, Viliam, Havlikova, Eva, Horanova, Bozena, Kratochvilova, Renata, Kubova, Dana, Murgas, Jan, Patras, Juraj, Simak, Ladislav, Snarskij, Vladimir, Zaviaticova, Zuzana, Zuffova, Marcela, Roig, Francesc Escalada, Santos, Luis Sánchez, Sucunza, Alfredo Echarri, Cordero Torres, Juan A., Muñoz, Guadalupe Inza, del Valle, Marta Martínez, Rozalen, Isabel Ceniceros, Sánchez, Enrique Martín, Berlanga, María Victoria Raúl Canabal, Olalde, Karlos Ibarguren, Ruiz Azpiazu, José I., García-Ochoa, María José, López-Navarro, Rafael Zoyo, Adsuar Quesada, José M., Cortés Ramas, José A., Mellado Vergel, Francisco J., López Messa, Juan B., del Valle, Patricia Fernández, López Cabeza, Nuria, Navalpotro Pascual, José M., The Swedish Association of Local Authorities and Regions, Anselmi, Luciano, Federazione Cantonale Ticinese Servizi Ambulanze, Benvenuti, Breganzona Claudio, Batey, Nigel, Ambulance, Yorkshire, Booth, Scott, Bucher, Patricia, Deakin, Charles D., Duckett, Jay, Ji, Chen, Loughlin, Nancy, Lumley-Holmes, Jenny, Lynde, Jessica, Mersom, Frank, Ramsey, Carly, Robinson, Clare, Spaight, Robert, Dosanjh, Sukhdeep, Virdi, Gurkamal, and Whittington, Andrew

Subjects
Emergency medicine, Europe, Epidemiology, Resuscitation, Resuscitation registry, Cardiac arrest
Abstract

IntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events.

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26. [Cardiological emergency network in Lombardy].

Author

Marzegalli M, Fontana G, Sesana G, Grieco N, Lombardi F, Elena C, Ieva F, and Paganoni AM

Subjects
Clinical Protocols, Electrocardiography instrumentation, Electrocardiography methods, Emergencies, Humans, Italy, Telemetry, Transportation of Patients organization & administration, Arrhythmias, Cardiac therapy, Coronary Care Units organization & administration, Emergency Medical Services organization & administration, Myocardial Infarction therapy
Abstract

Aims: To achieve a reduction of time to reperfusion through the organization of an interhospital network and the involvement of the Regional Health Authority., Methods: Four major endpoints were identified: institutional governance action, clinical management of acute ST-elevation myocardial infarction (STEMI), priority actions for cardiac arrest and early defibrillation, actions to avoid the delay related to decision-making, and logistic factors. Since 2001 in the urban area of Milan a network has been operating among 23 coronary care units, the 118 Dispatch Center (national free number for medical emergencies) and the Health Country Government Agency named Group for Prehospital Cardiac Emergency. In order to monitor the network activity and time to treatment and clinical outcomes a periodic monthly survey, called MOMI (One Month Monitoring Myocardial Infarction), was undertaken and repeated twice yearly. Data were evaluated according to hospital admission modality., Results: Global times are: symptom onset to first medical contact 116 min (interquartile range [IQR] 189), time to first ECG 7 min (IQR 12), door-to-balloon time 77 min (IQR 81.7). Non-parametric test showed that the modality of hospital admittance was the most critical determinant of door-to-balloon time. The shortest one (49.5 min) was that of patients transported by means of advanced rescue units with 12-lead ECG teletransmission and activation of a fast track directly to the cath lab., Conclusions: Our data show how in a complex urban area the organization of an interhospital network and the availability of ECG teletransmission are effective in reducing time to reperfusion, in the treatment of major arrhythmias and in pre-alert of coronary care units and cath labs in case of confirmed STEMI. This experience also stimulated an improvement in technological equipment of rescue units with extension of 12-lead teletransmission to basic life support units. Through the Health Country Government Agency and the Scientific Societies we carry on with our job to create a regional network for cardiac emergency involving all the hospitals.

Published
2008

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