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Recent breakthroughs in our understanding of sensorineural hearing loss etiology have encouraged the identification of novel hearing therapeutics, paving the way for precision hearing medicine. Critical to this field is the curation of health resources on hearing data. A systematic review of the literature was conducted to map existing (inter)national and regional datasets that include hearing data to inform the development of future hearing repositories. Systematic literature review was performed adhering to Preferred Reporting Items for Systematic Review and Meta-Analysis recommendations. Databases, including those from gray literature, were searched to identify publications reporting on phenotypic and/or genotypic hearing data in May 2019. The databases reviewed were Medline, PubMed, Embase databases, and Google Scholar. Publications on local datasets were excluded. All hearing datasets identified in the screening process were noted. For each dataset, geography, context, objective, period of time run, numbers and demographics of participants, genomic data, hearing measures and instruments used were extracted and cataloged. One hundred and eighty-eight datasets were identified, containing hearing data on populations ranging from 100 to 1.39 million individuals, and all extracted data have been cataloged. This searchable resource has been made accessible online. This unique catalog provides an overview of existing datasets that contain valuable information on hearing. This can be used to inform the development of national and international patient data repositories for hearing loss and guide strategic collaboration between key stakeholder groups, pivotal to the delivery and development of sensorineural hearing loss precision diagnostics and treatments. [ABSTRACT FROM AUTHOR]

To review trends in outcome domains and instruments reported by modern researchers in 100 consecutively published articles on cochlear implantation (CI). Retrograde literature review of Medline, EMBASE and Cochrane Databases of 100 consecutive scientific publications. Outcome domains and instruments from each included study were extracted in categories: speech perception, speech development, sound perception, electrophysiological and quality of life. 61 studies met inclusion criteria. 84 outcome measures were reported in total across all 61 studies. Across the 42 studies reporting speech perception, 31 different measures were utilised. Categories of Auditory Performance (CAP) and Consonant Nucleus Consonant (CNC) were the most frequently used instruments. Nine studies reported speech development, with 11 different instruments used. Speech Intelligibility Rating (SIR) was most frequently used instrument. Sixteen studies reported on sound perception, with Pure Tone Audiometry (PTA) being the most frequently used instrument. Eleven studies reported six different electrophysiological instruments, with Auditory Brainstem Response (ABR) being used most frequently used. Two studies measured quality of life outcome, with three instruments used. This study confirms a large degree of CI outcome heterogeneity within the peer reviewed literature. Determining consensus on core outcome domains and recommended instruments may increase the future impact and generalisability of work undertaken. [ABSTRACT FROM AUTHOR]

Objectives/Hypothesis To demonstrate construct validity of the ovine model as a tool for training in endoscopic sinus surgery (ESS). Study Design Prospective, cross-sectional evaluation study. Methods Over 18 consecutive months, trainees and experts were evaluated in their ability to perform a range of tasks (based on previous face validation and descriptive studies conducted by the same group) relating to ESS on the sheep-head model. Anonymized randomized video recordings of the above were assessed by two independent and blinded assessors. A validated assessment tool utilizing a five-point Likert scale was employed. Construct validity was calculated by comparing scores across training levels and experts using mean and interquartile range of global and task-specific scores. Subgroup analysis of the intermediate group ascertained previous experience. Nonparametric descriptive statistics were used, and analysis was carried out using SPSS version 21 (IBM, Armonk, NY). Results Reliability of the assessment tool was confirmed. The model discriminated well between different levels of expertise in global and task-specific scores. A positive correlation was noted between year in training and both global and task-specific scores ( P < .001). Experience of the intermediate group was variable, and the number of ESS procedures performed under supervision had the highest impact on performance. Conclusions This study describes an alternative model for ESS training and assessment. It is also the first to demonstrate construct validity of the sheep-head model for ESS training. Level of Evidence NA Laryngoscope, 125:539-543, 2015 [ABSTRACT FROM AUTHOR]