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1. Traffic-related Air Pollution and Lung Cancer Incidence: The California Multiethnic Cohort Study.

Author

Cheng, Iona, Yang, Juan, Tseng, Chiuchen, Wu, Jun, Shariff-Marco, Salma, Park, Sung-Shim Lani, Conroy, Shannon M, Inamdar, Pushkar P, Fruin, Scott, Larson, Timothy, Setiawan, Veronica W, DeRouen, Mindy C, Gomez, Scarlett Lin, Wilkens, Lynne R, Le Marchand, Loïc, Stram, Daniel O, Samet, Jonathan, Ritz, Beate, and Wu, Anna H

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Lung, Clinical Research, Climate-Related Exposures and Conditions, Cancer, Prevention, Lung Cancer, 2.2 Factors relating to the physical environment, Aetiology, Respiratory, Good Health and Well Being, Air Pollutants, Air Pollution, Benzene, California, Carbon Monoxide, Cohort Studies, Environmental Exposure, Humans, Lung Neoplasms, Nitrogen Dioxide, Particulate Matter, Vehicle Emissions, air pollution, lung cancer, racial and ethnic disparities, socioeconomic disparities, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Although the contribution of air pollution to lung cancer risk is well characterized, few studies have been conducted in racially, ethnically, and socioeconomically diverse populations. Objectives: To examine the association between traffic-related air pollution and risk of lung cancer in a racially, ethnically, and socioeconomically diverse cohort. Methods: Among 97,288 California participants of the Multiethnic Cohort Study, we used Cox proportional hazards regression to examine associations between time-varying traffic-related air pollutants (gaseous and particulate matter pollutants and regional benzene) and lung cancer risk (n = 2,796 cases; average follow-up = 17 yr), adjusting for demographics, lifetime smoking, occupation, neighborhood socioeconomic status (nSES), and lifestyle factors. Subgroup analyses were conducted for race, ethnicity, nSES, and other factors. Measurements and Main Results: Among all participants, lung cancer risk was positively associated with nitrogen oxide (hazard ratio [HR], 1.15 per 50 ppb; 95% confidence interval [CI], 0.99-1.33), nitrogen dioxide (HR, 1.12 per 20 ppb; 95% CI, 0.95-1.32), fine particulate matter with aerodynamic diameter  0.21), although participants residing in low-SES neighborhoods had increased lung cancer risk associated with nitrogen oxides, and no association was observed among those in high-SES neighborhoods. Conclusions: These findings in a large multiethnic population reflect an association between lung cancer and the mixture of traffic-related air pollution and not a particular individual pollutant. They are consistent with the adverse effects of air pollution that have been described in less racially, ethnically, and socioeconomically diverse populations. Our results also suggest an increased risk of lung cancer among those residing in low-SES neighborhoods.

Published
2022

3. Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study

Author

Wu, Anna H, Fruin, Scott, Larson, Timothy V, Tseng, Chiu-Chen, Wu, Jun, Yang, Juan, Jain, Jennifer, Shariff-Marco, Salma, Inamdar, Pushkar P, Setiawan, Veronica W, Porcel, Jacqueline, Stram, Daniel O, Le Marchand, Loic, Ritz, Beate, and Cheng, Iona

Subjects
Prevention, Cancer, Brain Disorders, Neurosciences, Clinical Research, African Americans, Aged, Airports, Brain, Brain Neoplasms, Cohort Studies, Computer Systems, Environmental Exposure, Ethnicity, Female, Humans, Los Angeles, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Olfactory Bulb, Particulate Matter, Prospective Studies, Risk, Risk Factors, United States, Black or African American, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Ultrafine particles (UFP; diameter less than or equal to 100 nm) may reach the brain via systemic circulation or the olfactory tract and have been implicated in the risk of brain tumors. The effects of airport-related UFP on the risk of brain tumors are not known. Here we determined the association between airport-related UFP and risk of incident malignant brain cancer (n = 155) and meningioma (n = 420) diagnosed during 16.4 years of follow-up among 75,936 men and women residing in Los Angeles County from the Multiethnic Cohort study. UFP exposure from aircrafts was estimated for participants who lived within a 53 km × 43 km grid area around the Los Angeles International Airport (LAX) from date of cohort entry (1993-1996) through December 31, 2013. Cox proportional hazards models were used to estimate the effects of time-varying, airport-related UFP exposure on risk of malignant brain cancer and meningioma, adjusting for sex, race/ethnicity, education, and neighborhood socioeconomic status. Malignant brain cancer risk in all subjects combined increased 12% [95% confidence interval (CI), 0.98-1.27] per interquartile range (IQR) of airport-related UFP exposure (∼6,700 particles/cm3) for subjects with any address in the grid area surrounding the LAX airport. In race/ethnicity-stratified analyses, African Americans, the subgroup who had the highest exposure, showed a HR of 1.32 (95% CI, 1.07-1.64) for malignant brain cancer per IQR in UFP exposure. UFP exposure was not related to risk of meningioma overall or by race/ethnicity. These results support the hypothesis that airport-related UFP exposure may be a risk factor for malignant brain cancers. SIGNIFICANCE: Malignant brain cancer risk increases with airport-related UFP exposure, particularly among African Americans, suggesting UFP exposure may be a modifiable risk factor for malignant brain cancer.

Published
2021

5. Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study.

Author

Wu, Anna H, Wu, Jun, Tseng, Chiuchen, Yang, Juan, Shariff-Marco, Salma, Fruin, Scott, Larson, Timothy, Setiawan, Veronica W, Masri, Shahir, Porcel, Jacqueline, Jain, Jennifer, Chen, Thomas C, Stram, Daniel O, Marchand, Loïc Le, Ritz, Beate, and Cheng, Iona

Abstract

BackgroundThere are increasing concerns about the potential impact of air pollution on chronic brain inflammation and microglia cell activation, but evidence of its carcinogenic effects is limited.MethodsWe used kriging interpolation and land use regression models to estimate long-term air pollutant exposures of oxides of nitrogen (NOx, NO2), kriging interpolation for ozone (O3), carbon monoxide, and particulate matter (PM2.5, PM10), and nearest monitoring station measurements for benzene for 103 308 men and women from the Multiethnic Cohort, residing largely in Los Angeles County from recruitment (1993-1996) through 2013. We used Cox proportional hazards models to examine the associations between time-varying pollutants and risk of malignant brain cancer (94 men, 116 women) and meningioma (130 men, 425 women) with adjustment for sex, race and ethnicity, neighborhood socioeconomic status, smoking, occupation, and other covariates. Stratified analyses were conducted by sex and race and ethnicity.ResultsBrain cancer risk in men increased in association with exposure to benzene (hazard ratio [HR] = 3.52, 95% confidence interval [CI] = 1.55 to 7.55) and PM10 (HR = 1.80, 95% CI = 1.00 to 3.23). Stronger associations with PM10 (HR = 3.02, 95% CI = 1.26 to 7.23), O3 (HR = 2.93, 95% CI = 1.09 to 7.88), and benzene (HR = 4.06, 95% CI = 1.17 to 18.2) were observed among Latino men. Air pollution was unrelated to risk of meningioma except that O3 exposure was associated with risk in men (HR = 1.77, 95% CI = 1.02 to 3.06). Brain cancer risk in women was unrelated to air pollution exposures.ConclusionsConfirmation of these sex differences in air pollution-brain cancer associations and the stronger findings in Latino men in additional diverse populations is warranted.

Published
2020

6. Genetic analyses of diverse populations improves discovery for complex traits.

Author

Wojcik, Genevieve L, Graff, Mariaelisa, Nishimura, Katherine K, Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher R, Highland, Heather M, Patel, Yesha M, Sorokin, Elena P, Avery, Christy L, Belbin, Gillian M, Bien, Stephanie A, Cheng, Iona, Cullina, Sinead, Hodonsky, Chani J, Hu, Yao, Huckins, Laura M, Jeff, Janina, Justice, Anne E, Kocarnik, Jonathan M, Lim, Unhee, Lin, Bridget M, Lu, Yingchang, Nelson, Sarah C, Park, Sung-Shim L, Poisner, Hannah, Preuss, Michael H, Richard, Melissa A, Schurmann, Claudia, Setiawan, Veronica W, Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan W, Young, Kristin L, Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose Luis, Barnes, Kathleen C, Boerwinkle, Eric, Bottinger, Erwin P, Bustamante, Carlos D, Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew P, Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Henn, Brenna M, Hindorff, Lucia A, Jackson, Rebecca D, Laurie, Cecelia A, Laurie, Cathy C, Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul J, Pooler, Loreall C, Reiner, Alexander P, Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli A, Stram, Daniel O, Thornton, Timothy A, Wassel, Christina L, Wilkens, Lynne R, Winkler, Cheryl A, Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher A, Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth JF, Matise, Tara C, North, Kari E, Peters, Ulrike, Kenny, Eimear E, and Carlson, Christopher S

Subjects
Humans, Body Height, Cohort Studies, Genetics, Medical, Multifactorial Inheritance, Minority Groups, African Continental Ancestry Group, Asian Continental Ancestry Group, Hispanic Americans, Women's Health, United States, Female, Male, Health Status Disparities, Genome-Wide Association Study, Health Equity, Genetics, Medical, General Science & Technology
Abstract

Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry1-3. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities. Critical variants may be missed if they have a low frequency or are completely absent in European populations, especially as the field shifts its attention towards rare variants, which are more likely to be population-specific4-10. Additionally, effect sizes and their derived risk prediction scores derived in one population may not accurately extrapolate to other populations11,12. Here we demonstrate the value of diverse, multi-ethnic participants in large-scale genomic studies. The Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioural phenotypes in 49,839 non-European individuals. Using strategies tailored for analysis of multi-ethnic and admixed populations, we describe a framework for analysing diverse populations, identify 27 novel loci and 38 secondary signals at known loci, as well as replicate 1,444 GWAS catalogue associations across these traits. Our data show evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications. In the United States-where minority populations have a disproportionately higher burden of chronic conditions13-the lack of representation of diverse populations in genetic research will result in inequitable access to precision medicine for those with the highest burden of disease. We strongly advocate for continued, large genome-wide efforts in diverse populations to maximize genetic discovery and reduce health disparities.

Published
2019

7. Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

Author

Yang, Yaohua, Wu, Lang, Shu, Xiang, Lu, Yingchang, Shu, Xiao-Ou, Cai, Qiuyin, Beeghly-Fadiel, Alicia, Li, Bingshan, Ye, Fei, Berchuck, Andrew, Anton-Culver, Hoda, Banerjee, Susana, Benitez, Javier, Bjørge, Line, Brenton, James D, Butzow, Ralf, Campbell, Ian G, Chang-Claude, Jenny, Chen, Kexin, Cook, Linda S, Cramer, Daniel W, deFazio, Anna, Dennis, Joe, Doherty, Jennifer A, Dörk, Thilo, Eccles, Diana M, Edwards, Digna Velez, Fasching, Peter A, Fortner, Renée T, Gayther, Simon A, Giles, Graham G, Glasspool, Rosalind M, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Harris, Holly R, Heitz, Florian, Hildebrandt, Michelle A, Høgdall, Estrid, Høgdall, Claus K, Huntsman, David G, Kar, Siddhartha P, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne K, Koushik, Anita, Lambrechts, Diether, Le, Nhu D, Levine, Douglas A, Massuger, Leon F, Matsuo, Keitaro, May, Taymaa, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Monteiro, Alvaro N, Moorman, Patricia G, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Olsson, Håkan, Onland-Moret, N Charlotte, Park, Sue K, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Phelan, Catherine M, Pike, Malcolm C, Ramus, Susan J, Riboli, Elio, Rodriguez-Antona, Cristina, Romieu, Isabelle, Sandler, Dale P, Schildkraut, Joellen M, Setiawan, Veronica W, Shan, Kang, Siddiqui, Nadeem, Sieh, Weiva, Stampfer, Meir J, Sutphen, Rebecca, Swerdlow, Anthony J, Szafron, Lukasz M, Teo, Soo Hwang, Tworoger, Shelley S, Tyrer, Jonathan P, Webb, Penelope M, Wentzensen, Nicolas, White, Emily, Willett, Walter C, Wolk, Alicja, Woo, Yin Ling, Wu, Anna H, Yan, Li, Yannoukakos, Drakoulis, Chenevix-Trench, Georgia, Sellers, Thomas A, Pharoah, Paul DP, Zheng, Wei, and Long, Jirong

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Biotechnology, Rare Diseases, Ovarian Cancer, Cancer Genomics, Prevention, Women's Health, Cancer, Clinical Research, Human Genome, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Cohort Studies, DNA Methylation, Female, Genetic Predisposition to Disease, Humans, Models, Genetic, Ovarian Neoplasms, Predictive Value of Tests, Risk, White People, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 × 10-7. Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. SIGNIFICANCE: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.

Published
2019

8. Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Author

Crous-Bou, Marta, Du, Mengmeng, Gunter, Marc J, Setiawan, Veronica W, Schouten, Leo J, Shu, Xiao-ou, Wentzensen, Nicolas, Bertrand, Kimberly A, Cook, Linda S, Friedenreich, Christine M, Gapstur, Susan M, Goodman, Marc T, Ibiebele, Torukiri I, La Vecchia, Carlo, Levi, Fabio, Liao, Linda M, Negri, Eva, McCann, Susan E, O’Connell, Kelly, Palmer, Julie R, Patel, Alpa V, Ponte, Jeanette, Reynolds, Peggy, Sacerdote, Carlotta, Sinha, Rashmi, Spurdle, Amanda B, Trabert, Britton, van den Brandt, Piet A, Webb, Penelope M, Petruzella, Stacey, Olson, Sara H, and De Vivo, Immaculata

Published
2022
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9. Supplementary Table 2 from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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10. Supplementary Table 1 from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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11. Supplementary Table 5 from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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12. Supplementary Table 3 from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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13. Supplementary Table 4 from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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14. Data from Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study

Author

Bookstein, Arthur, primary, Po, Justine, primary, Tseng, Chiuchen, primary, Larson, Timothy V., primary, Yang, Juan, primary, Park, Sung-shim L., primary, Wu, Jun, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Ihenacho, Ugonna, primary, Setiawan, Veronica W., primary, DeRouen, Mindy C., primary, Le Marchand, Loïc, primary, Stram, Daniel O., primary, Samet, Jonathan, primary, Ritz, Beate, primary, Fruin, Scott, primary, Wu, Anna H., primary, and Cheng, Iona, primary

Published
2024
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17. Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study.

Author

Bookstein, Arthur, Po, Justine, Chiuchen Tseng, Larson, Timothy V., Juan Yang, Park, Sung-shim L., Jun Wu, Shariff-Marco, Salma, Inamdar, Pushkar P., Ihenacho, Ugonna, Setiawan, Veronica W., DeRouen, Mindy C., Le Marchand, Loïc, Stram, Daniel O., Samet, Jonathan, Ritz, Beate, Fruin, Scott, Wu, Anna H., and Cheng, Iona

Abstract

Background: Ultrafine particles (UFP) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. Methods: Within the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence. Multivariable Cox proportional hazards regression models were used to estimate the effect of UFP exposure on lung cancer incidence. Subgroup analyses by demographics, histology and smoking status were conducted. Results: Airport-related UFP exposure was not associated with lung cancer risk [per one IGR HR, 1.01; 95% confidence interval (CI), 0.97-1.05] overall and across race/ethnicity. A suggestive positive association was observed between a one IQR increase in UFP exposure and lung squamous cell carcinoma (SCC) risk (HR, 1.08; 95% CI, 1.00-1.17) with a Phet for histology = 0.05. Positive associations were observed in 5-year lag analysis for SCC (HR, 1.12; 95% CI, CI, 1.02-1.22) and large cell carcinoma risk (HR, 1.23; 95% CI, 1.01-1.49) with a Phet for histology = 0.01. Conclusions: This large prospective cohort analysis suggests a potential association between airport-related UFP exposure and specific lung histologies. The findings align with research indicating that UFPs found in aviation exhaust may induce inflammatory and oxidative injury leading to SCC. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Supplementary Figure S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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19. Supplementary Table S6 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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20. Data from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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25. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, additional, Brouwers, Martijn C.G.J., additional, Ren, Zhewen, additional, Zheng, Wei, additional, Setiawan, Veronica W., additional, Wilkens, Lynne R., additional, Shu, Xiao-Ou, additional, Arslan, Alan A., additional, Beane Freeman, Laura E., additional, Bracci, Paige M., additional, Canzian, Federico, additional, Du, Mengmeng, additional, Gallinger, Steven J., additional, Giles, Graham G., additional, Goodman, Phyllis J., additional, Haiman, Christopher A., additional, Kogevinas, Manolis, additional, Kooperberg, Charles, additional, LeMarchand, Loic, additional, Neale, Rachel E., additional, Visvanathan, Kala, additional, White, Emily, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Babic, Ana, additional, Berndt, Sonja I., additional, Brais, Lauren K., additional, Brennan, Paul, additional, Buring, Julie E., additional, Rabe, Kari G., additional, Bamlet, William R., additional, Chanock, Stephen J., additional, Fuchs, Charles S., additional, Gaziano, J. Michael, additional, Giovannucci, Edward L., additional, Hackert, Thilo, additional, Hassan, Manal M., additional, Katzke, Verena, additional, Kurtz, Robert C., additional, Lee, I.-Min, additional, Malats, Núria, additional, Murphy, Neil, additional, Oberg, Ann L., additional, Orlow, Irene, additional, Porta, Miquel, additional, Real, Francisco X., additional, Rothman, Nathaniel, additional, Sesso, Howard D., additional, Silverman, Debra T., additional, Thompson, Ian M., additional, Wactawski-Wende, Jean, additional, Wang, Xiaoliang, additional, Wentzensen, Nicolas, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, Yu, Kai, additional, Wolpin, Brian M., additional, Duell, Eric J., additional, Li, Donghui, additional, Hung, Rayjean J., additional, Perdomo, Sandra, additional, McCullough, Marjorie L., additional, Freedman, Neal D., additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Riboli, Elio, additional, Sund, Malin, additional, Tjønneland, Anne, additional, Zhong, Jun, additional, Van Den Eeden, Stephen K., additional, Kraft, Peter, additional, Risch, Harvey A., additional, Amundadottir, Laufey T., additional, Klein, Alison P., additional, Stolzenberg-Solomon, Rachael Z., additional, and Antwi, Samuel O., additional

Published
2023
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26. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Author

Lin, Yingsong, Nakatochi, Masahiro, Hosono, Yasuyuki, Ito, Hidemi, Kamatani, Yoichiro, Inoko, Akihito, Sakamoto, Hiromi, Kinoshita, Fumie, Kobayashi, Yumiko, Ishii, Hiroshi, Ozaka, Masato, Sasaki, Takashi, Matsuyama, Masato, Sasahira, Naoki, Morimoto, Manabu, Kobayashi, Satoshi, Fukushima, Taito, Ueno, Makoto, Ohkawa, Shinichi, Egawa, Naoto, Kuruma, Sawako, Mori, Mitsuru, Nakao, Haruhisa, Adachi, Yasushi, Okuda, Masumi, Osaki, Takako, Kamiya, Shigeru, Wang, Chaochen, Hara, Kazuo, Shimizu, Yasuhiro, Miyamoto, Tatsuo, Hayashi, Yuko, Ebi, Hiromichi, Kohmoto, Tomohiro, Imoto, Issei, Kasugai, Yumiko, Murakami, Yoshinori, Akiyama, Masato, Ishigaki, Kazuyoshi, Matsuda, Koichi, Hirata, Makoto, Shimada, Kazuaki, Okusaka, Takuji, Kawaguchi, Takahisa, Takahashi, Meiko, Watanabe, Yoshiyuki, Kuriki, Kiyonori, Kadota, Aya, Okada, Rieko, Mikami, Haruo, Takezaki, Toshiro, Suzuki, Sadao, Yamaji, Taiki, Iwasaki, Motoki, Sawada, Norie, Goto, Atsushi, Kinoshita, Kengo, Fuse, Nobuo, Katsuoka, Fumiki, Shimizu, Atsushi, Nishizuka, Satoshi S., Tanno, Kozo, Suzuki, Ken, Okada, Yukinori, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi, Yu, Herbert, Zhong, Jun, Amundadottir, Laufey T., Doki, Yuichiro, Ishii, Hideshi, Eguchi, Hidetoshi, Bogumil, David, Haiman, Christopher A., Le Marchand, Loic, Mori, Masaki, Risch, Harvey, Setiawan, Veronica W., Tsugane, Shoichiro, Wakai, Kenji, Yoshida, Teruhiko, Matsuda, Fumihiko, Kubo, Michiaki, Kikuchi, Shogo, and Matsuo, Keitaro

Published
2020
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27. Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer

Author

Harris, Holly R., primary, Peres, Lauren C., additional, Johnson, Courtney E., additional, Guertin, Kristin A., additional, Beeghly, Alicia, additional, Bandera, Elisa V., additional, Bethea, Traci N., additional, Joslin, Charlotte E., additional, Wu, Anna H., additional, Moorman, Patricia G., additional, Ochs-Balcom, Heather M., additional, Petrick, Jessica L., additional, Setiawan, Veronica W., additional, Rosenberg, Lynn, additional, Schildkraut, Joellen M., additional, and Myers, Evan, additional

Published
2023
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28. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes

Author

Reams, R. Renee, primary, Odedina, Folakemi T., additional, Carpten, John D., additional, Redda, Kinfe, additional, Stern, Mariana C., additional, Krieger, Janice L., additional, Aparicio, Jose, additional, Hensel, Brooke, additional, Askins, Nissa, additional, Abreu, Andre, additional, Adams, Angela, additional, Agyare, Edward, additional, Ali, Jamel, additional, Allen, John M., additional, Aló, Richard, additional, Baezconde-Garbanati, Lourdes, additional, Brant, Jason, additional, Brown, Clyde P., additional, Buxbaum, Sarah G., additional, Cohen, Pinchas, additional, Cozen, Wendy, additional, Ezenwa, Miriam O., additional, Falzarano, Sara, additional, Fillingim, Roger B., additional, Flores-Rozas, Hernan, additional, Fredenburg, Kristianna M., additional, George, Thomas, additional, Han, Bo, additional, Huang, Yong, additional, Hughes Halbert, Chanita, additional, Kiros, Gebre-Egziabher, additional, Lamango, Nazarius S., additional, Lee, Ji-Hyun, additional, Lyon, Debra E., additional, Mitchell, Duane A., additional, Mochona, Bereket, additional, Nieva, Jorge J., additional, Offringa, Ite A., additional, Okunieff, Paul, additional, Parker, Alexander, additional, Rhie, Suhn K., additional, Richey, Joyce M., additional, Rogers, Sherise C., additional, Salhia, Bodour, additional, Schmittgen, Thomas D., additional, Segal, Richard, additional, Setiawan, Veronica W., additional, Smith, Ukamaka, additional, Su, Li-Ming, additional, Suther, Sandra, additional, Trevino, Jose, additional, Velazquez-Villarreal, Enrique I., additional, Webb, Fern J., additional, Wu, Anna H., additional, Yao, Yingwei, additional, and Wilkie, Diana J., additional

Published
2023
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29. Table S1 from A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Author

Lu, Yingchang, primary, Beeghly-Fadiel, Alicia, primary, Wu, Lang, primary, Guo, Xingyi, primary, Li, Bingshan, primary, Schildkraut, Joellen M., primary, Im, Hae Kyung, primary, Chen, Yian A., primary, Permuth, Jennifer B., primary, Reid, Brett M., primary, Teer, Jamie K., primary, Moysich, Kirsten B., primary, Andrulis, Irene L., primary, Anton-Culver, Hoda, primary, Arun, Banu K., primary, Bandera, Elisa V., primary, Barkardottir, Rosa B., primary, Barnes, Daniel R., primary, Benitez, Javier, primary, Bjorge, Line, primary, Brenton, James, primary, Butzow, Ralf, primary, Caldes, Trinidad, primary, Caligo, Maria A., primary, Campbell, Ian, primary, Chang-Claude, Jenny, primary, Claes, Kathleen B.M., primary, Couch, Fergus J., primary, Cramer, Daniel W., primary, Daly, Mary B., primary, deFazio, Anna, primary, Dennis, Joe, primary, Diez, Orland, primary, Domchek, Susan M., primary, Dörk, Thilo, primary, Easton, Douglas F., primary, Eccles, Diana M., primary, Fasching, Peter A., primary, Fortner, Renée T., primary, Fountzilas, George, primary, Friedman, Eitan, primary, Ganz, Patricia A., primary, Garber, Judy, primary, Giles, Graham G., primary, Godwin, Andrew K., primary, Goldgar, David E., primary, Goodman, Marc T., primary, Greene, Mark H., primary, Gronwald, Jacek, primary, Hamann, Ute, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Høgdall, Claus K., primary, Hollestelle, Antoinette, primary, Hulick, Peter J., primary, Huntsman, David G., primary, Imyanitov, Evgeny N., primary, Isaacs, Claudine, primary, Jakubowska, Anna, primary, James, Paul, primary, Karlan, Beth Y., primary, Kelemen, Linda E., primary, Kiemeney, Lambertus A., primary, Kjaer, Susanne K., primary, Kwong, Ava, primary, Le, Nhu D., primary, Leslie, Goska, primary, Lesueur, Fabienne, primary, Levine, Douglas A., primary, Mattiello, Amalia, primary, May, Taymaa, primary, McGuffog, Lesley, primary, McNeish, Iain A., primary, Merritt, Melissa A., primary, Modugno, Francesmary, primary, Montagna, Marco, primary, Neuhausen, Susan L., primary, Nevanlinna, Heli, primary, Nielsen, Finn C., primary, Nikitina-Zake, Liene, primary, Nussbaum, Robert L., primary, Offit, Kenneth, primary, Olah, Edith, primary, Olopade, Olufunmilayo I., primary, Olson, Sara H., primary, Olsson, Håkan, primary, Osorio, Ana, primary, Park, Sue K., primary, Parsons, Michael T., primary, Peeters, Petra H.M., primary, Pejovic, Tanja, primary, Peterlongo, Paolo, primary, Phelan, Catherine M., primary, Pujana, Miquel Angel, primary, Ramus, Susan J., primary, Rennert, Gad, primary, Risch, Harvey, primary, Rodriguez, Gustavo C., primary, Rodríguez-Antona, Cristina, primary, Romieu, Isabelle, primary, Rookus, Matti A., primary, Rossing, Mary Anne, primary, Rzepecka, Iwona K., primary, Sandler, Dale P., primary, Schmutzler, Rita K., primary, Setiawan, Veronica W., primary, Sharma, Priyanka, primary, Sieh, Weiva, primary, Simard, Jacques, primary, Singer, Christian F., primary, Song, Honglin, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, Sutphen, Rebecca, primary, Swerdlow, Anthony J., primary, Teixeira, Manuel R., primary, Teo, Soo H., primary, Thomassen, Mads, primary, Tischkowitz, Marc, primary, Toland, Amanda E., primary, Trichopoulou, Antonia, primary, Tung, Nadine, primary, Tworoger, Shelley S., primary, van Rensburg, Elizabeth J., primary, Vanderstichele, Adriaan, primary, Vega, Ana, primary, Edwards, Digna Velez, primary, Webb, Penelope M., primary, Weitzel, Jeffrey N., primary, Wentzensen, Nicolas, primary, White, Emily, primary, Wolk, Alicja, primary, Wu, Anna H., primary, Yannoukakos, Drakoulis, primary, Zorn, Kristin K., primary, Gayther, Simon A., primary, Antoniou, Antonis C., primary, Berchuck, Andrew, primary, Goode, Ellen L., primary, Chenevix-Trench, Georgia, primary, Sellers, Thomas A., primary, Pharoah, Paul D.P., primary, Zheng, Wei, primary, and Long, Jirong, primary

Published
2023
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30. Online Supplementary Materials from A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Author

Lu, Yingchang, primary, Beeghly-Fadiel, Alicia, primary, Wu, Lang, primary, Guo, Xingyi, primary, Li, Bingshan, primary, Schildkraut, Joellen M., primary, Im, Hae Kyung, primary, Chen, Yian A., primary, Permuth, Jennifer B., primary, Reid, Brett M., primary, Teer, Jamie K., primary, Moysich, Kirsten B., primary, Andrulis, Irene L., primary, Anton-Culver, Hoda, primary, Arun, Banu K., primary, Bandera, Elisa V., primary, Barkardottir, Rosa B., primary, Barnes, Daniel R., primary, Benitez, Javier, primary, Bjorge, Line, primary, Brenton, James, primary, Butzow, Ralf, primary, Caldes, Trinidad, primary, Caligo, Maria A., primary, Campbell, Ian, primary, Chang-Claude, Jenny, primary, Claes, Kathleen B.M., primary, Couch, Fergus J., primary, Cramer, Daniel W., primary, Daly, Mary B., primary, deFazio, Anna, primary, Dennis, Joe, primary, Diez, Orland, primary, Domchek, Susan M., primary, Dörk, Thilo, primary, Easton, Douglas F., primary, Eccles, Diana M., primary, Fasching, Peter A., primary, Fortner, Renée T., primary, Fountzilas, George, primary, Friedman, Eitan, primary, Ganz, Patricia A., primary, Garber, Judy, primary, Giles, Graham G., primary, Godwin, Andrew K., primary, Goldgar, David E., primary, Goodman, Marc T., primary, Greene, Mark H., primary, Gronwald, Jacek, primary, Hamann, Ute, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Høgdall, Claus K., primary, Hollestelle, Antoinette, primary, Hulick, Peter J., primary, Huntsman, David G., primary, Imyanitov, Evgeny N., primary, Isaacs, Claudine, primary, Jakubowska, Anna, primary, James, Paul, primary, Karlan, Beth Y., primary, Kelemen, Linda E., primary, Kiemeney, Lambertus A., primary, Kjaer, Susanne K., primary, Kwong, Ava, primary, Le, Nhu D., primary, Leslie, Goska, primary, Lesueur, Fabienne, primary, Levine, Douglas A., primary, Mattiello, Amalia, primary, May, Taymaa, primary, McGuffog, Lesley, primary, McNeish, Iain A., primary, Merritt, Melissa A., primary, Modugno, Francesmary, primary, Montagna, Marco, primary, Neuhausen, Susan L., primary, Nevanlinna, Heli, primary, Nielsen, Finn C., primary, Nikitina-Zake, Liene, primary, Nussbaum, Robert L., primary, Offit, Kenneth, primary, Olah, Edith, primary, Olopade, Olufunmilayo I., primary, Olson, Sara H., primary, Olsson, Håkan, primary, Osorio, Ana, primary, Park, Sue K., primary, Parsons, Michael T., primary, Peeters, Petra H.M., primary, Pejovic, Tanja, primary, Peterlongo, Paolo, primary, Phelan, Catherine M., primary, Pujana, Miquel Angel, primary, Ramus, Susan J., primary, Rennert, Gad, primary, Risch, Harvey, primary, Rodriguez, Gustavo C., primary, Rodríguez-Antona, Cristina, primary, Romieu, Isabelle, primary, Rookus, Matti A., primary, Rossing, Mary Anne, primary, Rzepecka, Iwona K., primary, Sandler, Dale P., primary, Schmutzler, Rita K., primary, Setiawan, Veronica W., primary, Sharma, Priyanka, primary, Sieh, Weiva, primary, Simard, Jacques, primary, Singer, Christian F., primary, Song, Honglin, primary, Southey, Melissa C., primary, Spurdle, Amanda B., primary, Sutphen, Rebecca, primary, Swerdlow, Anthony J., primary, Teixeira, Manuel R., primary, Teo, Soo H., primary, Thomassen, Mads, primary, Tischkowitz, Marc, primary, Toland, Amanda E., primary, Trichopoulou, Antonia, primary, Tung, Nadine, primary, Tworoger, Shelley S., primary, van Rensburg, Elizabeth J., primary, Vanderstichele, Adriaan, primary, Vega, Ana, primary, Edwards, Digna Velez, primary, Webb, Penelope M., primary, Weitzel, Jeffrey N., primary, Wentzensen, Nicolas, primary, White, Emily, primary, Wolk, Alicja, primary, Wu, Anna H., primary, Yannoukakos, Drakoulis, primary, Zorn, Kristin K., primary, Gayther, Simon A., primary, Antoniou, Antonis C., primary, Berchuck, Andrew, primary, Goode, Ellen L., primary, Chenevix-Trench, Georgia, primary, Sellers, Thomas A., primary, Pharoah, Paul D.P., primary, Zheng, Wei, primary, and Long, Jirong, primary

Published
2023
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31. Supplementary Table 1 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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32. Data from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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33. Supplementary Table 2 from The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, primary, Tworoger, Shelley S., primary, O'Brien, Katie M., primary, Townsend, Mary K., primary, Fortner, Renée T., primary, Iversen, Edwin S., primary, Hartge, Patricia, primary, White, Emily, primary, Amiano, Pilar, primary, Arslan, Alan A., primary, Bernstein, Leslie, primary, Brinton, Louise A., primary, Buring, Julie E., primary, Dossus, Laure, primary, Fraser, Gary E., primary, Gaudet, Mia M., primary, Giles, Graham G., primary, Gram, Inger T., primary, Harris, Holly R., primary, Bolton, Judith Hoffman, primary, Idahl, Annika, primary, Jones, Michael E., primary, Kaaks, Rudolf, primary, Kirsh, Victoria A., primary, Knutsen, Synnove F., primary, Kvaskoff, Marina, primary, Lacey, James V., primary, Lee, I-Min, primary, Milne, Roger L., primary, Onland-Moret, N. Charlotte, primary, Overvad, Kim, primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Poynter, Jenny N., primary, Riboli, Elio, primary, Robien, Kim, primary, Rohan, Thomas E., primary, Sandler, Dale P., primary, Schairer, Catherine, primary, Schouten, Leo J., primary, Setiawan, Veronica W., primary, Swerdlow, Anthony J., primary, Travis, Ruth C., primary, Trichopoulou, Antonia, primary, van den Brandt, Piet A., primary, Visvanathan, Kala, primary, Wilkens, Lynne R., primary, Wolk, Alicja, primary, Zeleniuch-Jacquotte, Anne, primary, and Wentzensen, Nicolas, primary

Published
2023
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34. Supplementary Data from Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study

Author

Wu, Anna H., primary, Fruin, Scott, primary, Larson, Timothy V., primary, Tseng, Chiu-Chen, primary, Wu, Jun, primary, Yang, Juan, primary, Jain, Jennifer, primary, Shariff-Marco, Salma, primary, Inamdar, Pushkar P., primary, Setiawan, Veronica W., primary, Porcel, Jacqueline, primary, Stram, Daniel O., primary, Le Marchand, Loic, primary, Ritz, Beate, primary, and Cheng, Iona, primary

Published
2023
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35. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., Veliginti, Swathi, Brouwers, Martijn C G J, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica W., Wilkens, Lynne R., Shu, Xiao-Ou, Arslan, Alan A., Beane Freeman, Laura E., Bracci, Paige M., Canzian, Federico, Du, Mengmeng, Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Haiman, Christopher A., Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel E., Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja I., Brais, Lauren K., Brennan, Paul, Buring, Julie E., Rabe, Kari G., Bamlet, William R., Chanock, Stephen J., Fuchs, Charles S., Gaziano, J Michael, Giovannucci, Edward L., Hackert, Thilo, Hassan, Manal M., Katzke, Verena, Kurtz, Robert C., Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann L., Orlow, Irene, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian M., Duell, Eric J., Li, Donghui, Hung, Rayjean J., Perdomo, Sandra, McCullough, Marjorie L., Freedman, Neal D., Patel, Alpa V., Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen K., Kraft, Peter, Risch, Harvey A., Amundadottir, Laufey T., Klein, Alison P., Stolzenberg-Solomon, Rachael Z., Antwi, Samuel O., King, Sontoria D., Veliginti, Swathi, Brouwers, Martijn C G J, Ren, Zhewen, Zheng, Wei, Setiawan, Veronica W., Wilkens, Lynne R., Shu, Xiao-Ou, Arslan, Alan A., Beane Freeman, Laura E., Bracci, Paige M., Canzian, Federico, Du, Mengmeng, Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Haiman, Christopher A., Kogevinas, Manolis, Kooperberg, Charles, LeMarchand, Loic, Neale, Rachel E., Visvanathan, Kala, White, Emily, Albanes, Demetrius, Andreotti, Gabriella, Babic, Ana, Berndt, Sonja I., Brais, Lauren K., Brennan, Paul, Buring, Julie E., Rabe, Kari G., Bamlet, William R., Chanock, Stephen J., Fuchs, Charles S., Gaziano, J Michael, Giovannucci, Edward L., Hackert, Thilo, Hassan, Manal M., Katzke, Verena, Kurtz, Robert C., Lee, I-Min, Malats, Núria, Murphy, Neil, Oberg, Ann L., Orlow, Irene, Porta, Miquel, Real, Francisco X., Rothman, Nathaniel, Sesso, Howard D., Silverman, Debra T., Thompson, Ian M., Wactawski-Wende, Jean, Wang, Xiaoliang, Wentzensen, Nicolas, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Yu, Kai, Wolpin, Brian M., Duell, Eric J., Li, Donghui, Hung, Rayjean J., Perdomo, Sandra, McCullough, Marjorie L., Freedman, Neal D., Patel, Alpa V., Peters, Ulrike, Riboli, Elio, Sund, Malin, Tjønneland, Anne, Zhong, Jun, Van Den Eeden, Stephen K., Kraft, Peter, Risch, Harvey A., Amundadottir, Laufey T., Klein, Alison P., Stolzenberg-Solomon, Rachael Z., and Antwi, Samuel O.

Abstract

BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer. METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n = 5,090, controls n = 8,733) and the Pancreatic Cancer Case Control Consortium (PanC4; cases n = 4,163, controls n = 3,792) were analyzed. We used data on 68 genetic variants with four different MR methods [inverse variance weighting (IVW), MR-Egger, simple median, and penalized weighted median] separately to predict genetic heritability of NAFLD. We then assessed the relationship between each of the four MR methods and pancreatic cancer risk, using logistic regression to calculate ORs and 95% confidence intervals (CI), adjusting for PC risk factors, including obesity and diabetes. RESULTS: No association was found between genetically predicted NAFLD and pancreatic cancer risk in the PanScan or PanC4 samples [e.g., PanScan, IVW OR, 1.04; 95% confidence interval (CI), 0.88-1.22; MR-Egger OR, 0.89; 95% CI, 0.65-1.21; PanC4, IVW OR, 1.07; 95% CI, 0.90-1.27; MR-Egger OR, 0.93; 95% CI, 0.67-1.28]. None of the four MR methods indicated an association between genetically predicted NAFLD and pancreatic cancer risk in either sample. CONCLUSIONS: Genetic predisposition to NAFLD is not associated with pancreatic cancer risk. IMPACT: Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and pancreatic cancer might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and pancreatic cancer.

Published
2023
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36. PFAS Exposures and the Human Metabolome:A Systematic Review of Epidemiological Studies

Author

India-Aldana, Sandra, Yao, Meizhen, Midya, Vishal, Colicino, Elena, Chatzi, Leda, Chu, Jaime, Gennings, Chris, Jones, Dean P., Loos, Ruth J.F., Setiawan, Veronica W., Smith, Mathew Ryan, Walker, Ryan W., Barupal, Dinesh, Walker, Douglas I., Valvi, Damaskini, India-Aldana, Sandra, Yao, Meizhen, Midya, Vishal, Colicino, Elena, Chatzi, Leda, Chu, Jaime, Gennings, Chris, Jones, Dean P., Loos, Ruth J.F., Setiawan, Veronica W., Smith, Mathew Ryan, Walker, Ryan W., Barupal, Dinesh, Walker, Douglas I., and Valvi, Damaskini

Abstract

Purpose of Review: There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines. Recent Findings: We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics. Summary: Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.

Published
2023

38. Risk prediction models for endometrial cancer: development and validation in an international consortium

Author

Shi, Joy, primary, Kraft, Peter, additional, Rosner, Bernard, additional, Benavente, Yolanda, additional, Black, Amanda, additional, Brinton, Louise A, additional, Chen, Chu, additional, Clarke, Megan A, additional, Cook, Linda S, additional, Costas, Laura, additional, Dal Maso, Luigino, additional, Freudenheim, Jo L, additional, Frias-Gomez, Jon, additional, Friedenreich, Christine M, additional, Garcia-Closas, Montserrat, additional, Goodman, Marc T, additional, Johnson, Lisa, additional, La Vecchia, Carlo, additional, Levi, Fabio, additional, Lissowska, Jolanta, additional, Lu, Lingeng, additional, McCann, Susan E, additional, Moysich, Kirsten B, additional, Negri, Eva, additional, O'Connell, Kelli, additional, Parazzini, Fabio, additional, Petruzella, Stacey, additional, Polesel, Jerry, additional, Ponte, Jeanette, additional, Rebbeck, Timothy R, additional, Reynolds, Peggy, additional, Ricceri, Fulvio, additional, Risch, Harvey, additional, Sacerdote, Carlotta, additional, Setiawan, Veronica W, additional, Shu, Xiao-Ou, additional, Spurdle, Amanda B, additional, Trabert, Britton, additional, Webb, Penelope M, additional, Wentzensen, Nicolas, additional, Wilkens, Lynne R, additional, Xu, Wang Hong, additional, Yang, Hannah P, additional, Yu, Herbert, additional, Du, Mengmeng, additional, and De Vivo, Immaculata, additional

Published
2023
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40. Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry consortium

Author

Harris, Holly R., primary, Guertin, Kristin A., additional, Camacho, Tareq F., additional, Johnson, Courtney E., additional, Wu, Anna H., additional, Moorman, Patricia G., additional, Myers, Evan, additional, Bethea, Traci N., additional, Bandera, Elisa V., additional, Joslin, Charlotte E., additional, Ochs‐Balcom, Heather M., additional, Peres, Lauren C., additional, Rosenow, Will T., additional, Setiawan, Veronica W., additional, Beeghly‐Fadiel, Alicia, additional, Dempsey, Lauren F., additional, Rosenberg, Lynn, additional, and Schildkraut, Joellen M., additional

Published
2022
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43. Abstract 33: Racial disparities in epithelial ovarian cancer survival: An examination of contributing factors in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium

Author

Guertin, Kristin A., primary, Harris, Holly R., additional, Camacho, Tareq F., additional, Johnson, Courtney E., additional, Wu, Anna H., additional, Moorman, Patricia G., additional, Myers, Evan, additional, Bethea, Traci N., additional, Bandera, Elisa V., additional, Joslin, Charlotte E., additional, Ochs-Balcom, Heather M., additional, Peres, Lauren C., additional, Rosenow, Will T., additional, Setiawan, Veronica W., additional, Beeghly-Fadiel, Alicia, additional, Dempsey, Lauren F., additional, Rosenberg, Lynn, additional, and Schildkraut, Joellen M., additional

Published
2021
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44. The gut microbiome and type 2 diabetes status in the Multiethnic Cohort

Author

Maskarinec, Gertraud, primary, Raquinio, Phyllis, additional, Kristal, Bruce S., additional, Setiawan, Veronica W., additional, Wilkens, Lynne R., additional, Franke, Adrian A., additional, Lim, Unhee, additional, Le Marchand, Loïc, additional, Randolph, Timothy W., additional, Lampe, Johanna W., additional, and Hullar, Meredith A. J., additional

Published
2021
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45. Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium

Author

Davis, Colette P., primary, Bandera, Elisa V., additional, Bethea, Traci N., additional, Camacho, Fabian, additional, Joslin, Charlotte E., additional, Wu, Anna H., additional, Beeghly-Fadiel, Alicia, additional, Moorman, Patricia G., additional, Myers, Evan R., additional, Ochs-Balcom, Heather M., additional, Peres, Lauren C., additional, Rosenow, Will T., additional, Setiawan, Veronica W., additional, Rosenberg, Lynn, additional, Schildkraut, Joellen M., additional, and Harris, Holly R., additional

Published
2021
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46. Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium

Author

Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, Webb, Penelope M., Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, and Webb, Penelope M.

Abstract

A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 control women. We used one- and two-stage meta-analytic approaches to estimate pooled odds ratios (ORs) for the association between exposures and endometrial cancer risk. Ever having a full-term pregnancy was associated with a 41% reduction in risk of endometrial cancer compared to never having a full-term pregnancy (OR = 0.59, 95% confidence interval [CI] 0.56-0.63). The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further similar to 15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. Incomplete pregnancy was also associated with decreased endometrial cancer risk (7%-9% reduction per pregnancy). Twin births appeared to have the same effect as singleton pregnancies. Our pooled analysis shows that, while the magnitude of the risk reduction is greater for a full-term pregnancy than an incomplete pregnancy, each additional pregnancy is associated with further reduction in endometrial cancer risk, independent of age at last full-term pregnancy. These results suggest that the very high progesterone level in the last trimester of pregnancy is not the sole explanation for the protective effect of pregnancy.

Published
2021

48. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site : The Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.

Abstract

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.

Published
2020
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49. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

Author

Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas

Abstract

Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.

Published
2020
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50. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site:The Ovarian Cancer Cohort Consortium

Author

Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.

Abstract

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases.Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site.Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.

Published
2020

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