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1,167 results on '"Seto, Wai-Kay"'

3. A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease

Author

Zhang, Huai, Targher, Giovanni, Byrne, Christopher D., Kim, Seung Up, Wong, Vincent Wai-Sun, Valenti, Luca, Glickman, Myer, Ponce, Jaime, Mantzoros, Christos S., Crespo, Javier, Gronbaek, Henning, Yang, Wah, Eslam, Mohammed, Wong, Robert J., Machado, Mariana Verdelho, Yu, Ming-Lung, Ghanem, Omar M., Okanoue, Takeshi, Liu, Jun-Feng, Lee, Yong-ho, Xu, Xiao-Yuan, Pan, Qiuwei, Sui, Meili, Lonardo, Amedeo, Yilmaz, Yusuf, Zhu, Li-Yong, Moreno, Christophe, Miele, Luca, Lupsor-Platon, Monica, Zhao, Lei, LaMasters, Teresa LeAnn, Gish, Robert G., Zhang, Huijie, Nedelcu, Marius, Chan, Wah Kheong, Xia, Ming-Feng, Bril, Fernando, Shi, Jun-Ping, Datz, Christian, Romeo, Stefano, Sun, Jian, Liu, Dan, Sookoian, Silvia, Mao, Yi-Min, Méndez-Sánchez, Nahum, Wang, Xiao-Yan, Pyrsopoulos, Nikolaos T., Fan, Jian-Gao, Fouad, Yasser, Sun, Dan-Qin, Giannini, Cosimo, Chai, Jin, Xia, Ze-Feng, Jun, Dae Won, Li, Guo-Jing, Treeprasertsuk, Sombat, Li, Ying-Xu, Cheung, Tan To, Zhang, Faming, Goh, George Boon-Bee, Furuhashi, Masato, Seto, Wai-Kay, Huang, Hui, Di Sessa, Anna, Li, Qing-Hong, Cholongitas, Evangelos, Zhang, Le, Silveira, Themis Reverbel, Sebastiani, Giada, Adams, Leon A., Chen, Wei, Qi, Xiaolong, Rankovic, Ivan, De Ledinghen, Victor, Lv, Wen-Jie, Hamaguchi, Masahide, Kassir, Radwan, Müller-Wieland, Dirk, Romero-Gomez, Manuel, Xu, Ying, Xu, Yi-Cong, Chen, Shi-Yao, Kermansaravi, Mohammad, Kuchay, Mohammad Shafi, Lefere, Sander, Parmar, Chetan, Lip, Gregory Y. H., Liu, Chun-Jen, Åberg, Fredrik, Lau, George, George, Jacob, Sarin, Shiv Kumar, Zhou, Jing-Ya, and Zheng, Ming-Hua

Published
2024
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4. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, Verna, Elizabeth, Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, and Bajaj, Jasmohan S

Published
2024
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6. Application of a deep learning algorithm for the diagnosis of HCC

Author

Yu, Philip Leung Ho, Chiu, Keith Wan-Hang, Lu, Jianliang, Lui, Gilbert C.S., Zhou, Jian, Cheng, Ho-Ming, Mao, Xianhua, Wu, Juan, Shen, Xin-Ping, Kwok, King Ming, Kan, Wai Kuen, Ho, Y.C., Chan, Hung Tat, Xiao, Peng, Mak, Lung-Yi, Tsui, Vivien W.M., Hui, Cynthia, Lam, Pui Mei, Deng, Zijie, Guo, Jiaqi, Ni, Li, Huang, Jinhua, Yu, Sarah, Peng, Chengzhi, Li, Wai Keung, Yuen, Man-Fung, and Seto, Wai-Kay

Published
2025
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8. Dual-tracer PET/CT in the management of hepatocellular carcinoma

Author

Chiu, Keith Wan Hang, Chiang, Chi Leung, Chan, Kenneth Sik Kwan, Hui, Yuan, Ren, Jingyun, Wei, Xiaojuan, Ng, Kwok Sing, Lee, Ho Fun Victor, Chia, Nam Hung, Cheung, Tan-To, Chan, Stephen, Chan, Albert Chi-Yan, Ng, Kwok Chai Kelvin, Seto, Wai Kay Walter, Khong, Pek-Lan, and Kong, Feng-Ming

Published
2024
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9. Dual-Attention Enhanced BDense-UNet for Liver Lesion Segmentation

Author

Cao, Wenming, Yu, Philip L. H., Lui, Gilbert C. S., Chiu, Keith W. H., Cheng, Ho-Ming, Fang, Yanwen, Yuen, Man-Fung, and Seto, Wai-Kay

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

In this work, we propose a new segmentation network by integrating DenseUNet and bidirectional LSTM together with attention mechanism, termed as DA-BDense-UNet. DenseUNet allows learning enough diverse features and enhancing the representative power of networks by regulating the information flow. Bidirectional LSTM is responsible to explore the relationships between the encoded features and the up-sampled features in the encoding and decoding paths. Meanwhile, we introduce attention gates (AG) into DenseUNet to diminish responses of unrelated background regions and magnify responses of salient regions progressively. Besides, the attention in bidirectional LSTM takes into account the contribution differences of the encoded features and the up-sampled features in segmentation improvement, which can in turn adjust proper weights for these two kinds of features. We conduct experiments on liver CT image data sets collected from multiple hospitals by comparing them with state-of-the-art segmentation models. Experimental results indicate that our proposed method DA-BDense-UNet has achieved comparative performance in terms of dice coefficient, which demonstrates its effectiveness., Comment: 9 pages, 3 figures

Published
2021

14. Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)

Author

Dongelmans, Edo J., Hirode, Grishma, Hansen, Bettina E., Chen, Chien-Hung, Su, Tung-Hung, Seto, Wai-Kay, Furquim d'Almeida, Arno, van Hees, Stijn, Papatheodoridi, Margarita, Lens, Sabela, Wong, Grace L.H., Brakenhoff, Sylvia M., Chien, Rong-Nan, Feld, Jordan J., Chan, Henry L.Y., Forns, Xavier, Papatheodoridis, George V., Vanwolleghem, Thomas, Yuen, Man-Fung, Hsu, Yao-Chun, Kao, Jia-Horng, Cornberg, Markus, Sonneveld, Milan J., Jeng, Wen-Juei, and Janssen, Harry L.A.

Published
2024
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15. HBV DNA and HBsAg Levels at 24 Weeks Off-Treatment Predict Clinical Relapse and HBsAg Loss in HBeAg-Negative Patients Who Discontinued Antiviral Therapy

Author

Sonneveld, Milan J., Chiu, Shao-Ming, Park, Jun Yong, Brakenhoff, Sylvia M., Kaewdech, Apichat, Seto, Wai-Kay, Tanaka, Yasuhito, Carey, Ivana, Papatheodoridi, Margarita, Colombatto, Piero, van Bömmel, Florian, Janssen, Harry L., Berg, Thomas, Zoulim, Fabien, Ahn, Sang Hoon, Dalekos, George N., Erler, Nicole S., Brunetto, Maurizia, Wedemeyer, Heiner, Cornberg, Markus, Yuen, Man-Fung, Agarwal, Kosh, Boonstra, Andre, Buti, Maria, Piratvisuth, Teerha, Papatheodoridis, George, Chen, Chien-Hung, and Maasoumy, Benjamin

Published
2024
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21. Tenofovir alafenamide and tenofovir disoproxil fumarate reduce incidence of hepatocellular carcinoma in patients with chronic hepatitis B

Author

Lim, Young-Suk, Chan, Henry L.Y., Ahn, Sang Hoon, Seto, Wai Kay, Ning, Qin, Agarwal, Kosh, Janssen, Harry L.A., Pan, Calvin Q., Chuang, Wan Long, Izumi, Namiki, Fung, Scott, Shalimar, Brunetto, Maurizia, Hui, Aric Josun, Chang, Ting-Tsung, Lim, Seng Gee, Abramov, Frida, Flaherty, John F., Wang, Hongyuan, Yee, Leland J., Kao, Jia-Horng, Gane, Edward, Hou, Jinlin, and Buti, Maria

Published
2023
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22. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study

Author

Razavi-Shearer, Devin, Gamkrelidze, Ivane, Pan, Calvin, Jia, Jidong, Berg, Thomas, Gray, Richard, Lim, Young-Suk, Chen, Chien-Jen, Ocama, Ponsiano, Desalegn, Hailemichael, Abbas, Zaigham, Abdallah, Ayat, Aghemo, Alessio, Ahmadbekova, Sabohat, Ahn, Sang Hoon, Aho, Inka, Akarca, Ulus, Al Masri, Nasser, Alalwan, Abduljaleel, Alavian, Seyed, Al-Busafi, Said, Aleman, Soo, Alfaleh, Faleh, Alghamdi, Abdullah, Al-Hamoudi, Waleed, Aljumah, Abdulrahman, Al-Naamani, Khalid, Al-Rifai, Ahmad, Alserkal, Yousif, Altraif, Ibrahim, Amarsanaa, Jazag, Anderson, Motswedi, Andersson, Monique, Armstrong, Paige, Asselah, Tarik, Athanasakis, Kostas, Baatarkhuu, Oidov, Ben-Ari, Ziv, Bensalem, Aicha, Bessone, Fernando, Biondi, Mia, Bizri, Abdul Rahman, Blach, Sarah, Braga, Wornei, Brandão-Mello, Carlos, Brosgart, Carol, Brown, Kimberly, Brown, Jr, Robert, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Cabezas, Joaquin, Casanovas, Teresa, Chae, Chungman, Chan, Henry Lik Yuen, Cheinquer, Hugo, Chen, Pei-Jer, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Coffin, Carla, Contreras, Fernando, Coppola, Nicola, Cornberg, Markus, Cowie, Benjamin, Cramp, Matthew, Craxi, Antonio, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris, Dalgard, Olav, De Knegt, Robert, De Ledinghen, Victor, Dore, Gregory, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve, Elbadri, Mohammed, El-Kassas, Mohamed, El-Sayed, Manal, Estes, Chris, Etzion, Ohad, Farag, Elmobashar, Ferradini, Laurent, Ferreira, Paulo, Flisiak, Robert, Forns, Xavier, Frankova, Sona, Fung, James, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana, Gholam, Pierre, Gish, Robert, Goleij, Pouya, Gottfredsson, Magnus, Grebely, Jason, Gschwantler, Michael, Guingane, Nanelin Alice, Hajarizadeh, Behzad, Hamid, Saeed, Hamoudi, Waseem, Harris, Aaron, Hasan, Irsan, Hatzakis, Angelos, Hellard, Margaret, Hercun, Julian, Hernandez, Javier, Hockicková, Ivana, Hsu, Yao-Chun, Hu, Ching-Chih, Husa, Petr, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jelev, Deian, Jeruma, Agita, Johannessen, Asgeir, Kåberg, Martin, Kaita, Kelly, Kaliaskarova, Kulpash, Kao, Jia-Horng, Kelly-Hanku, Angela, Khamis, Faryal, Khan, Aamir, Kheir, Omer, Khoudri, Ibtissam, Kondili, Loreta, Konysbekova, Aliya, Kristian, Pavol, Kwon, Jisoo, Lagging, Martin, Laleman, Wim, Lampertico, Pietro, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice, Lee, Mei-Hsuan, Liakina, Valentina, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham, Marinho, Rui, Mendes-Correa, Maria Cássia, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mohamed, Rosmawati, Mokhbat, Jacques, Mooneyhan, Ellen, Moreno, Christophe, Mortgat, Laure, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Naveira, Marcelo, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Ning, Qing, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin, Oguche, Stephen, Omuemu, Casimir, Ong, Janus, Opare-Sem, Ohene, Örmeci, Necati, Orrego, Mauricio, Osiowy, Carla, Papatheodoridis, George, Peck-Radosavljevic, Markus, Pessoa, Mário, Pham, Trang, Phillips, Richard, Pimenov, Nikolay, Pincay-Rodríguez, Loreley, Plaseska-Karanfilska, Dijana, Pop, Cora, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Rautiainen, Henna, Razavi-Shearer, Kathryn, Remak, William, Ribeiro, Sofia, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo, Robalino, Marcia, Roberts, Lewis, Roberts, Stuart, Rodríguez, Manuel, Roulot, Dominique, Rwegasha, John, Ryder, Stephen, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa, Salupere, Riina, Sanai, Faisal, Sanchez-Avila, Juan F, Saraswat, Vivek, Sargsyants, Narina, Sarrazin, Christoph, Sarybayeva, Gulya, Schréter, Ivan, Seguin-Devaux, Carole, Seto, Wai-Kay, Shah, Samir, Sharara, Ala, Sheikh, Mahdi, Shouval, Daniel, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta, Sinn, Dong Hyun, Sonderup, Mark, Sonneveld, Milan, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek-Siam, Tanaka, Junko, Tergast, Tammo, Terrault, Norah, Thompson, Alexander, Thompson, Peyton, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsang, Tak-Yin, Uzochukwu, Benjamin, Van Welzen, Berend, Vanwolleghem, Thomas, Vince, Adriana, Voeller, Alexis, Waheed, Yasir, Waked, Imam, Wallace, Jack, Wang, Cong, Weis, Nina, Wong, Grace, Wong, Vincent, Wu, Jaw-Ching, Yaghi, Cesar, Yesmembetov, Kakharman, Yip, Terry, Yosry, Ayman, Yu, Ming-Lung, Yuen, Man-Fung, Yurdaydin, Cihan, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie

Published
2023
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23. Lower pretreatment HBV DNA levels are associated with better off-treatment outcomes after nucleo(s)tide analogue withdrawal in patients with HBeAg-negative chronic hepatitis B: A multicentre cohort study

Author

Sonneveld, Milan J., Chiu, Shao-Ming, Park, Jun Yong, Brakenhoff, Sylvia M., Kaewdech, Apichat, Seto, Wai-Kay, Tanaka, Yasuhito, Carey, Ivana, Papatheodoridi, Margarita, Colombatto, Piero, van Bömmel, Florian, Berg, Thomas, Zoulim, Fabien, Ahn, Sang Hoon, Dalekos, George N., Erler, Nicole S., Brunetto, Maurizia, Wedemeyer, Heiner, Cornberg, Markus, Yuen, Man-Fung, Agarwal, Kosh, Boonstra, Andre, Buti, Maria, Piratvisuth, Teerha, Papatheodoridis, George, Chen, Chien-Hung, and Maasoumy, Benjamin

Published
2023
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24. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Sarin, Shiv K, Kumar, Shiva, Marciano, Sebastián, Gadano, Adrián, Tudehope, Fiona, Gibson, Robert, Prudence, Alexander, Doyle, Adam, Si, Hooi Ling, Riordan, Stephen, Farias, Alberto, Zitelli, Patricia, Bera, Chinmay, Faisal, Nabiha, Tandon, Puneeta, Dahiya, Monica, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Xian, Yongchao, Guan, Jin, Zhu, Chuanwu, Wang, Yingling, Su, Minghua, Su, Man, Gao, Yanhang, Wang, Xinrui, Jiang, Yongfang, Peng, Feng, Zhao, Caiyan, Wang, Wei, Wang, Lei, Yin, Dedong, Lu, Mingqin, Cai, Yijing, Zhang, Ningping, Zhang, Wanqin, Li, Hai, Dong, Fuchen, Zheng, Xin, Liu, Jing, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Gao, Zhiliang, Xu, Zhen, Lin, Minghua, Gao, Haibin, Chen, Jinjun, Li, Beiling, Liu, Chenghai, Zhang, Yanyun, Hu, Peng, Deng, Huan, Belimi, Hibat Allah, Debzi, Nabil, Fisseha, Henok, Aravinthan, Aloysious D, Venkatachalapathy, Suresh Vasan, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Adebayo, Danielle, Kennedy, James, Yung, Diana, Seto, Wai-Kay, Fung, James, Katchman, Helena, Rabinowich, Liane, Nagral, Aabha, Jhaveri, Ajay, Kulkarni, Anand, Sharma, Mithun, Eapen, C E, Goel, Ashish, Gandotra, Akash, Duseja, Ajay, Saraya, Anoop, Yegurla, Jatin, Rela, Mohamed, Jothimani, Dinesh, Arora, Anil, Kumar, Ashish, Dhiman, Radha Krishan, Roy, Akash, Anand, Anil C, Praharaj, Dibyalochan, Hueso, Sarai Gonzalez, Cabrera, Araceli Bravo, Pérez Hérnandez, José Luis, Gutierrez, Oscar Morales, Miranda Zazueta, Godolfino, Ramos-Pineda, Abraham, Castillo Barradas, Mauricio, Velazquez, Rene Male, Made, Lilian Torres, Velarde-Ruiz Velasco, José Antonio, Félix-Tellez, Francisco, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Nik Muhamad Afendi, Nik Arsyad, Okeke, Edith N, Nyam, David P, Allam, Dalia, Kumar Patwa, Yashwi Haresh, Tan, Hiang Keat, Liou, Wei Lun, Treeprasertsuk, Sombat, Wejnaruemarn, Salisa, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Karasu, Zeki, Uysal, Alper, Ucbilek, Enver, Kosay, Tolga, Adanir, Haydar, Dinçer, Dinç, Albhaisi, Somaya, Asrani, Sumeet, Fallahadeh, Mohammad Amin, Reddy, K Rajender, Rahematpura, Suditi, Shaw, Jawaid, Vargas, Hugo E., Bayne, David, Biggins, Scott W, Filipek, Natalia, Thuluvath, Paul, Sheshadri, Somya, Keaveny, Andrew, Duarte Rojo, Andres, Cabello Negrillo, Ricardo, Bajaj, Jasmohan S, Choudhury, Ashok K, Xie, Qing, Kamath, Patrick S, Topazian, Mark, Hayes, Peter C, Torre, Aldo, Desalegn, Hailemichael, Idilman, Ramazan, Cao, Zhujun, Alvares-da-Silva, Mario R, George, Jacob, Bush, Brian J, Thacker, Leroy R, and Wong, Florence

Published
2023
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26. Differential Relapse Patterns After Discontinuation of Entecavir vs Tenofovir Disoproxil Fumarate in Chronic Hepatitis B

Author

Choi, Hannah S.J., Hirode, Grishma, Chen, Chien-Hung, Su, Tung-Hung, Seto, Wai-Kay, Van Hees, Stijn, Papatheodoridi, Margarita, Lens, Sabela, Wong, Grace L.H., Brakenhoff, Sylvia M., Chien, Rong-Nan, Feld, Jordan J., Sonneveld, Milan J., Chan, Henry L.Y., Forns, Xavier, Papatheodoridis, George V., Vanwolleghem, Thomas, Yuen, Man-Fung, Hsu, Yao-Chun, Kao, Jia-Horng, Cornberg, Markus, Hansen, Bettina E., Jeng, Wen-Juei, and Janssen, Harry L.A.

Published
2023
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32. Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels

Author

Sonneveld, Milan J., Chiu, Shao-Ming, Park, Jun Yong, Brakenhoff, Sylvia M., Kaewdech, Apichat, Seto, Wai-Kay, Tanaka, Yasuhito, Carey, Ivana, Papatheodoridi, Margarita, van Bömmel, Florian, Berg, Thomas, Zoulim, Fabien, Ahn, Sang Hoon, Dalekos, George N., Erler, Nicole S., Höner zu Siederdissen, Christoph, Wedemeyer, Heiner, Cornberg, Markus, Yuen, Man-Fung, Agarwal, Kosh, Boonstra, Andre, Buti, Maria, Piratvisuth, Teerha, Papatheodoridis, George, Chen, Chien-Hung, and Maasoumy, Benjamin

Published
2022
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33. Prediction of Sustained Response After Nucleo(s)tide Analogue Cessation Using HBsAg and HBcrAg Levels: A Multicenter Study (CREATE)

Author

Sonneveld, Milan J., Park, Jun Yong, Kaewdech, Apichat, Seto, Wai-Kay, Tanaka, Yasuhito, Carey, Ivana, Papatheodoridi, Margarita, van Bömmel, Florian, Berg, Thomas, Zoulim, Fabien, Ahn, Sang Hoon, Dalekos, George N., Erler, Nicole S., Höner zu Siederdissen, Christoph, Wedemeyer, Heiner, Cornberg, Markus, Yuen, Man-Fung, Agarwal, Kosh, Boonstra, Andre, Buti, Maria, Piratvisuth, Teerha, Papatheodoridis, George, and Maasoumy, Benjamin

Published
2022
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34. Cigarette Smoking Is Associated With Lower Chance of Hepatitis B Surface Antigen Seroclearance and Altered Host Immunity.

Author

Kwok, Tsz‐Yan, Hui, Rex Wan‐Hin, Mao, XianHua, Ling, Guang‐Sheng, Wong, Danny Ka‐Ho, Huang, Fung‐Yu, Fung, James, Seto, Wai‐Kay, Yuen, Man‐Fung, and Mak, Lung‐Yi

Subjects
MONONUCLEAR leukocytes, HEPATITIS associated antigen, REGULATORY T cells, TRANSFORMING growth factors-beta, CHRONIC hepatitis B, T cells
Abstract

Cigarette smoking is associated with worse clinical outcomes in patients with chronic hepatitis B (CHB) infection, but the effects on hepatitis B surface antigen (HBsAg) seroclearance are unclear. This study aimed to investigate the effect of active smoking on HBsAg seroclearance (SC) and its impact on peripheral blood lymphocytes in patients with CHB infection. Longitudinal follow‐up data was retrieved in 7833 antiviral‐treated CHB subjects identified from a centralised electronic patient record database (Part 1). Phenotypic analysis of peripheral blood mononuclear cells (PBMCs) from 27 CHB‐infected patients (6 active smokers; 13 with SC) was performed by flow cytometry to assess programmed death‐1 (PD‐1) expression and proportion of regulatory T cells (CD4+CD25+CD127lo). Effector function of HBV‐specific T cells was examined by comparing granzyme B (GZMB) and transforming growth factor beta (TGFβ) production in undepleted PBMCs and Treg‐depleted PBMCs after 7 days in vitro stimulation with HBV envelope protein overlapping peptides (Part 2). Over a median follow‐up of 5 years, smoking was associated with lower probability of SC (aHR 0.70, 95% CI 0.57–0.87). PD‐1 expression was increased in CD4+ T cells, CD8+ T cells and CD20+ B cells among smokers compared to non‐smokers and positively correlated with pack years (all p < 0.05). Treg depletion led to partial functional recovery of HBV‐specific T cells, with significantly bigger magnitude in smokers (p = 0.0451, mean difference = 4.68%) than non‐smokers (p = 0.012, mean difference = 4.2%). Cigarette smoking is associated with lower chance of HBsAg seroclearance, higher PD‐1 expression on lymphocytes, and impairment of effector functions of HBV‐specific T cells in CHB. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Glycaemic control is a modifiable risk factor for hepatocellular carcinoma and liver‐related mortality in patients with diabetes.

Author

Mao, Xianhua, Cheung, Ka‐Shing, Tan, Jing‐Tong, Mak, Lung‐Yi, Lee, Chi‐Ho, Chiang, Chi‐Leung, Cheng, Ho‐Ming, Hui, Rex Wan‐Hin, Leung, Wai K., Yuen, Man‐Fung, and Seto, Wai‐Kay

Subjects
GLYCEMIC control, PROPENSITY score matching, FATTY liver, DIABETES, HEPATOCELLULAR carcinoma
Abstract

Summary: Background: Optimal glycaemic control has well‐established health benefits in patients with diabetes mellitus (DM). It is uncertain whether optimal glycaemic control can benefit liver‐related outcomes. Aims: To examine the association of optimal glycaemic control with hepatocellular carcinoma (HCC) and liver‐related mortality. Methods: In a population‐based cohort, we identified patients with newly diagnosed DM between 2001 and 2016 in Hong Kong. Optimal glycaemic control was defined as mean haemoglobin A1c (HbA1c) <7% during the 3‐year lead‐in period after DM diagnosis. By applying propensity score matching to balance covariates, we analysed glycaemic control via competing risk models with outcomes of interest being HCC and liver‐related mortality. Results: We identified 146,430 patients (52.2% males, mean age 61.4 ± 11.8 years). During a median follow‐up duration of 7.0 years, 1099 (0.8%) and 978 (0.7%) patients developed HCC and liver‐related deaths. Optimal glycaemic control, when compared to suboptimal glycaemic control, was associated with reduced risk of HCC (subdistribution hazard ratio [SHR] 0.70, 95% CI 0.61–0.79). The risk of HCC increased with incremental HbA1c increases beyond >7% (SHR 1.29–1.71). Significant associations with HCC were also found irrespective of age (SHR 0.54–0.80), sex (SHR 0.68–0.69), BMI <25 or ≥25 kg/m2 (SHR 0.63–0.75), smoking (SHR 0.61–0.72), hepatic steatosis (SHR 0.67–0.68) and aspirin/statin/metformin use (SHR 0.67–0.75). A lower risk of liver‐related mortality in relation to optimal glycaemic control was also observed (SHR 0.70, 95% CI 0.61–0.80). Conclusions: Glycaemic control is an independent risk factor for HCC and liver‐related mortality, and should be incorporated into oncoprotective strategies in the general DM population. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Effect of metabolic dysfunction‐associated steatotic liver disease on BNT162b2 immunogenicity against the severe acute respiratory syndrome coronavirus 2 omicron variant.

Author

Lam, Lok Ka, Tan, Jing Tong, Ooi, Poh Hwa, Zhang, Ruiqi, Chan, Kwok Hung, Mao, Xianhua, Hung, Ivan F N, Seto, Wai Kay, Yuen, Man Fung, and Cheung, Ka Shing

Abstract

Background and Aim: We aimed to investigate the effect of metabolic dysfunction‐associated steatotic liver disease (MASLD) on three‐dose BNT162b2 immunogenicity to the omicron variant. Methods: Adult recipients of three doses of BNT162b2 were prospectively recruited between May and December 2021. The serology of the neutralizing antibody by live virus microneutralization (vMN) to the omicron variant was measured at baseline, day 180, and day 360 after the first dose. The primary outcome was seroconversion (vMN titer ≥ 10) at day 360. Exposure of interest was MASLD, defined as hepatic steatosis (controlled attenuation parameter ≥ 248 dB/m on transient elastography) plus at least one of five cardiometabolic risk factors. Subjects with prior COVID‐19 were excluded. A multivariable logistic regression model was used to derive the adjusted odds ratio of seroconversion with MASLD by adjusting for age, sex, antibiotic use, and proton pump inhibitor use. Results: One hundred forty‐eight BNT162b2 recipients (male: 48 [32.4%]; median age: 51.0 years [interquartile range, IQR: 44.5–57.3]) were recruited. The median time from the first dose to the third dose was 8.5 months (IQR: 7.9–8.9). MASLD subjects had a lower seroconversion rate than non‐MASLD ones (89.6% vs 99.0%; P = 0.007). MASLD was the only independent risk factor for seroconversion (adjusted odds ratio: 0.051, 95% confidence interval: 0.002–0.440). Subgroup analysis of immunogenicity at 4 months after the third dose shows significantly lower vMN titer (13.06 [IQR: 7.69–22.20] vs 33.49 [IQR: 24.05–46.53]; P = 0.004) and seroconversion rate (76.9% vs 97.4%; P = 0.016) in MASLD than non‐MASLD subjects, but not within 4 months from the third dose (vMN titer: 46.87 [IQR: 33.12–66.02] vs 41.86 [IQR: 34.47–50.91], P = 0.240; seroconversion rate: 94.3% vs 100%, P = 0.131). Conclusion: Metabolic dysfunction‐associated steatotic liver disease was a risk factor for poorer immunogenicity to the omicron variant, with a more pronounced waning effect compared among three‐dose BNT162b2 recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Off-Therapy Response After Nucleos(t)ide Analogue Withdrawal in Patients With Chronic Hepatitis B: An International, Multicenter, Multiethnic Cohort (RETRACT-B Study)

Author

Hirode, Grishma, Choi, Hannah S.J., Chen, Chien-Hung, Su, Tung-Hung, Seto, Wai-Kay, Van Hees, Stijn, Papatheodoridi, Margarita, Lens, Sabela, Wong, Grace, Brakenhoff, Sylvia M., Chien, Rong-Nan, Feld, Jordan, Sonneveld, Milan J., Chan, Henry L.Y., Forns, Xavier, Papatheodoridis, George V., Vanwolleghem, Thomas, Yuen, Man-Fung, Hsu, Yao-Chun, Kao, Jia-Horng, Cornberg, Markus, Hansen, Bettina E., Jeng, Wen-Juei, and Janssen, Harry L.A.

Published
2022
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40. LBP-019 Safety and antiviral activity of AHB-137, a novel antisense oligonucleotide, in healthy volunteers and subjects with chronic hepatitis B

Author

Gane, Edward J., primary, Yuen, Man-Fung, additional, Wang, Wen, additional, Chen, Chi-Yi, additional, Hsu, Yao-Chun (Holden), additional, Lawitz, Eric, additional, Chua, Joel, additional, Hou, Jinlin, additional, Ren, Hong, additional, Yu, Xian, additional, Xu, Chongyuan, additional, Kwo, Paul Yien, additional, Kottilil, Shyamasundaran, additional, Jacobson, Ira, additional, Chuang, Wan-Long, additional, Mak, Lung-Yi, additional, Seto, Wai-Kay, additional, Schwabe, Christian, additional, Chen, Mingyue, additional, Zhao, Di, additional, Yang, Chen, additional, Wang, Miao, additional, Yang, Cheng Yong, additional, Cheng, Guofeng, additional, Niu, Junqi, additional, and Ding, Yanhua, additional

Published
2024
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41. FRI-088 Patterns and predictors of postacute discharge location other than home in a global cohort of 3, 678 patients hospitalized with cirrhosis

Author

Seto, Wai-Kay, primary, Xie, Qing, additional, Kumar Choudhury, Ashok, additional, Kamath, Patrick S., additional, Topazian, Mark, additional, Hayes, Peter, additional, Torre, Aldo, additional, Desalegn, Hailemichael, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Álvares-da-Silva, Mario, additional, George, Jacob, additional, Wong, Florence, additional, Bush, Brian, additional, Thacker, Leroy, additional, Kumar Sarin, Shiv, additional, Mani, Iliana, additional, Dincer, Dinc, additional, van Doorn, Diederick, additional, Sonavane, Amey, additional, Amin Fallahzadeh, Mohammad, additional, Wei, Linlin, additional, Bravo Cabrera, Araceli, additional, Goel, Ashish, additional, Ponan Claude Regis Lah, Ponan, additional, Kumar, Shiva, additional, Jun Wong, Yu, additional, Jothimani, Dinesh, additional, Robert Kappus, Matthew, additional, Emre Yıldırım, Abdullah, additional, H Forrest, Ewan, additional, Félix Tellez, Francisco, additional, Momoyo Zitelli, Patricia, additional, Barbero, Manuel, additional, Luis Pérez-Hernández, José, additional, Marciano, Sebastián, additional, Malé Velazquez, René, additional, Jhaveri, Ajay, additional, Gibson, Robert, additional, Chandra Anand, Anil, additional, Kayes, Tahrima, additional, Gunduz, Feyza, additional, Bayne, David, additional, Lin, Minghua, additional, Ucbilek, Enver, additional, Debzi, Nabil, additional, Wang, Jian, additional, Haresh Kumar Patwa, Yashwi, additional, Kumar Duseja, Ajay, additional, Arrese, Marco, additional, Faulkes, Rosemary, additional, Kennedy, James, additional, Sung Kim, Yu, additional, Krishan Dhiman, Radha, additional, Li, Hai, additional, Yin, Dedong, additional, Zhang, Yanyun, additional, MacQuillan, Gerry, additional, Kumar, Ashish, additional, Katchman, Helena, additional, Wang, Yingling, additional, Rao, Qunfang, additional, Cai, Yijing, additional, Wu, Liyang, additional, Jiang, Yongfang, additional, Xu, Zhen, additional, Xian, Yongchao, additional, Bettinger, Dominik, additional, Dahiya, Monica, additional, Faisal, Nabiha, additional, Rojo Andres, Duarte, additional, Filipek, Natalia, additional, Tudehope, Fiona, additional, Zhang, Wanqin, additional, and Bajaj, Jasmohan, additional

Published
2024
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44. SAT-314 Impact of hepatic steatosis on risk of acute liver injury among people with chronic hepatitis B and SARS-CoV-2 infection

Author

Hin Chung, Matthew Shing, primary, Ho Wong, Carlos King, additional, Li, Xue, additional, Tsun Lai, Francisco Tsz, additional, Fai Wan, Eric Yuk, additional, Ling Chui, Celine Sze, additional, Tak Cheng, Franco Wing, additional, Chan, EstherWai Yin, additional, Cheung, Ching Lung, additional, Xiong, Xi, additional, Li, Lanlan, additional, Seto, Wai-Kay, additional, Yuen, Man-Fung, additional, Loey Mak, Lung Yi, additional, and Kei Wong, Ian Chi, additional

Published
2024
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