In addition to global population growth due to migration from rural areas to urban areas, population density is constantly increasing in certain regions, thereby necessitating the introduction of new settlements in these regions. However, in the selection of settlement areas, no sufficient preliminary examinations have been conducted; consequently, various natural disasters may cause significant life and property losses. Herein, the most suitable settlement areas were determined using GIS (geographic information systems) in Canik District, where the population is continuously increasing. Therefore, this study aimed to incorporate a new perspective into studies on this subject. Within the scope of the study, landslide and flood risks, which are among the most important natural disasters in the region, were primarily evaluated, and high-risk areas were determined. Elevation, slope, aspect, curvature, lithology, topographic humidity index (TWI), and proximity to river parameters were used to produce flood susceptibility maps. A digital elevation model (DEM) of the study area was produced using contours on the 1/25,000 scaled topographic map. The elevation, slope, aspect, curvature, and TWI parameters were produced from the DEM using the relevant analysis routines of ArcGIS software. The raster map of each parameter was divided into 5 subclasses using the natural breaks classification method. In the reclassified raster maps, the most flood-sensitive or flood-prone subclasses were assigned a value of 5, and the least sensitive subclasses were assigned a value of 1. Then, the reclassified maps of the 7 parameters were collected using the "map algebra" function of ArcGIS 10.5 software, and the flood susceptibility index (FSI) map of the study area was obtained. The flood susceptibility map of the study area was obtained by dividing the FSI into 5 subclasses (very low, low, moderate, high, and very high) according to the natural breaks classification method. Thereafter, suitable and unsuitable areas in terms of biocomfort, which affects people's health, peace, comfort, and psychology and is significant in terms of energy efficiency, were determined. At the last stage of the study, the most suitable settlement areas that were suitable in terms of both biocomfort and low levels of landslide and flood risks were determined. The calculated proportion of such areas to the total study area was only 2.1%. Therefore, because these areas were insufficient for the establishment of new settlements, areas that had low landslide and flood risks but were unsuitable for biocomfort were secondarily determined; the ratio of these areas was calculated as 56.8%. The remaining areas were inconvenient for the establishment of settlements due to the risk of landslides and floods; the ratio of these areas was calculated as 41.1%. This study is exemplary in that the priority for the selection of settlement areas was specified, and this method can be applied for selecting new settlements for each region considering different criteria. Due to the risk of landslides or flooding in the study area, the areas unsuitable for establishing a settlement covered approximately 41.1% of the total study area. The areas that had low flood and landslide risks but were suitable for biocomfort constituted only 2.1% of the study area. In approximately 56.8% of the study area, the risk of landslides or floods was low, and these areas were unsuitable in terms of biocomfort. Therefore, these areas were secondarily preferred as settlement areas. The most suitable areas for settlements constituted only 0.19% of the total study area, and these areas will not be able to meet the increasing demand for settlement area. Therefore, it is recommended to select areas that do not have the risk of landslides and floods but are unsuitable for biocomfort. This study reveals that grading should be performed in the selection of settlement areas. When choosing a settlement area in any region, possible natural disasters in the region should be identified first, and these disasters should be ordered in terms of their threat potential. Moreover, biocomfort areas suitable for settlements should be considered. In the next stages of settlement area selection, the criteria that affect the peace and comfort of people, such as distance to pollution sources, distance to noise sources, and proximity to natural areas, should also be evaluated. Thus, a priority order should be created for the selection of settlement areas using various other criteria.