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A torsion problem on the transversally isotropic hollow light gauge cylinder with variable shear modules is studied on the ground of the homogeneous solution method. Asymptotic expansions of homogeneous solutions are obtained, and cylinder stress-strain state is analyzed.

A torsion problem on the transversally isotropic hollow light gauge cylinder with variable shear modules is studied on the ground of the homogeneous solution method. Asymptotic expansions of homogeneous solutions are obtained, and cylinder stress-strain state is analyzed.

Using the method of asymptotic integration of the equations of the theory of elasticity, the axisym- metric problem of the theory of elasticity for a radially inhomogeneous transversally isotropic cylinder of small thickness is studied. Suppose that the elastic moduli are arbitrary continuous functions of the radius of the cylinder. It is assumed that the side part of the cylinder is fixed, and stresses are set at the ends of the cylinder, leaving the cylinder in equilibrium. Solutions have been determined having the nature of a boundary layer and are localized at the ends of the cylinder. The first terms of its asymptotic expansion coincide with the Saint-Venant edge effect in the theory of plates. The nature of the stress-strain state has been studied. It is shown that some boundary layer solutions may not be extinguished by propagating far from the ends. [ABSTRACT FROM AUTHOR]

Environmental pollutants cause health problems as well as affect living or non-living things in terrestrial and aquatic ecosystems. Many harmful substances, the use of which is increasing today, directly or indirectly cause deterioration in the quality of life of living things. Pollutions originating from water-primarily affect fish health. Negative effects are observed on the physiological, biochemical, and anatomical structures of fish feeding, migrating, and breeding in the aquatic environment due to pollutants. Zebrafish is an important model organism thanks to its development and easy reproduction. Many potential pollutants in the aquatic environment degrade the quality of water. Natural, industrial, domestic, etc. To the aquatic environment. Pollutants of organic or inorganic origin emitted from sources can cause toxic effects on fish. Pesticides, which are considered as one of these pollutants, are used to destroy the effects of harmful pests while causing death in living things, their negative effects on the reproductive system like many systems have been revealed. Heavy metals negatively affect the biological systems of fish by causing bioaccumulation by ingestion of fish mostly through respiration. Although endocrine-disrupting chemicals (EBC) affect different tissues and organs for generations, their effects on the reproductive system increase by affecting the hormonal system. Nanoparticles affect different biological systems as well as the reproductive system. In this article, the histological effects of environmental pollutants on zebrafish ( Danio reiro) reproductive organs and the reasons for choosing zebrafish as a model organism re-evaluated.

Emerging evidence suggests that personalized dietary supplement regimens can significantly influence lipid metabolism and cardiovascular risk. The efficacy of AI-guided dietary supplement prescriptions, compared with standard physician-guided prescriptions, remains underexplored. In a randomized, parallel-group pilot study, 70 patients aged 40–75 years with LDL-C levels between 70 and 190 mg/dL were enrolled. Participants were randomized to receive either AI-guided dietary supplement prescriptions or standard physician-guided prescriptions for 90 days. The primary endpoint was the percent change in LDL-C levels. Secondary endpoints included changes in total cholesterol, HDL-C, triglycerides, and hsCRP. Supplement adherence and side effects were monitored. Sixty-seven participants completed the study. The AI-guided group experienced a 25.3% reduction in LDL-C levels (95% CI: −28.7% to −21.9%), significantly greater than the 15.2% reduction in the physician-guided group (95% CI: −18.5% to −11.9%; p < 0.01). Total cholesterol decreased by 15.4% (95% CI: −19.1% to −11.7%) in the AI-guided group compared with 8.1% (95% CI: −11.5% to −4.7%) in the physician-guided group (p < 0.05). Triglycerides were reduced by 22.1% (95% CI: −27.2% to −17.0%) in the AI-guided group versus 12.3% (95% CI: −16.7% to −7.9%) in the physician-guided group (p < 0.01). HDL-C and hsCRP changes were not significantly different between groups. The AI-guided group received a broader variety of supplements, including plant sterols, omega-3 fatty acids, red yeast rice, coenzyme Q10, niacin, and fiber supplements. Side effects were minimal and comparable between groups. AI-guided dietary supplement prescriptions significantly reduce LDL-C and triglycerides more effectively than standard physician-guided prescriptions, highlighting the potential for AI-driven personalization in managing hypercholesterolemia.

Bu çalışmada lignoselülozik dolgu maddesi olarak atık gazete kâğıdı lifi, bitkisel atık yağ kullanılmış, polimer olarak da geri dönüştürülmüş polipropilen kullanılmıştır. Atık gazete kâğıdı öğütülüp ve yaklaşık 24 saat boyunca 60˚C˚'de kurutma fırınında bekletildikten sonra %10, %20 ve %30 oranlarında geri dönüştürülmüş polipropilen ile karıştırılmıştır. Atık bitkisel yağ ise %2.5 oranında ilave edilmiştir. Karışımlar 170°C,175°C,180°C,185°C ısı kademelerinde ayarlanmış olan ekstrüzyon makinasına konulmuştur. Ekstrüzyon yöntemiyle üretilen kompozitlerin mekanik ve termal özellikleri belirlenmiştir. Atık gazete kağıdı lifi oranının ilkin eğilme mukavemetini azalttığı, daha sonra ise arttırdığı gözlenmiştir. Termal özelliklerde atık bitkisel yağ kullanımının olumlu etkisi olup ısıl direnci arttırmıştır. DSC analiz sonuçları incelendiğinde, atık gazete kağıdı lifinin kristalenliği arttırdığı sonucuna varılmıştır. Bu çalışma ile tümüyle atık olan bileşenlerin kompozit üretiminde kullanılabilir olduğu ve vaks gibi atık bitkisel yağların kullanılabileceği sonucuna ulaşılmıştır.

Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this study evaluates the effect of B vitamin supplements (methylfolate, pyridoxal-5′-phosphate, and methylcobalamin) on homocysteine and lipid levels, potentially guiding personalized CVD risk management. In a randomized, double-blind, placebo-controlled trial, 54 patients aged 40–75 with elevated homocysteine and moderate LDL-C levels were divided based on MTHFR, MTR, and MTRR genetic polymorphisms. Over six months, they received either a combination of methylfolate, P5P, and methylcobalamin, or a placebo. At the 6 months follow-up, the treatment group demonstrated a significant reduction in homocysteine levels by 30.0% (95% CI: −39.7% to −20.3%) and LDL-C by 7.5% (95% CI: −10.3% to −4.7%), compared to the placebo (p < 0.01 for all). In the subgroup analysis, Homozygous Minor Allele Carriers showed a more significant reduction in homocysteine levels (48.3%, 95% CI: −62.3% to −34.3%, p < 0.01) compared to mixed allele carriers (18.6%, 95% CI: −25.6% to −11.6%, p < 0.01), with a notable intergroup difference (29.7%, 95% CI: −50.7% to −8.7%, p < 0.01). LDL-C levels decreased by 11.8% in homozygous carriers (95% CI: −15.8% to −7.8%, p < 0.01) and 4.8% in mixed allele carriers (95% CI: −6.8% to −2.8%, p < 0.01), with a significant between-group difference (7.0%, 95% CI: −13.0% to −1.0%, p < 0.01). Methylfolate, P5P, and methylcobalamin supplementation tailored to genetic profiles effectively reduced homocysteine and LDL-C levels in patients with specific MTHFR, MTR, and MTRR polymorphisms, particularly with homozygous minor allele polymorphisms.

Introduction:The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) associated pneumonia that emerged in Wuhan, China in December 2019 and was later declared by the World Health Organization to be a pandemic has called coronavirus disease-2019 (COVID-19). Our study aims to determine the anxiety levels, post-traumatic stress disorder (PTSD) symptoms levels and psychiatric symptoms of healthcare workers working at pandemic hospital and effects of these symptoms on psychological adjustment to healthcare professionals during the COVID-19 pandemic in Turkey.Methods:This study was cross-sectional survey study and conducted between March 2020-June 2020 with 973 consenting participants working at the pandemic hospital. For the study, we used an online questionnaire, which consisted of three parts: an online-informed consent, basic sociodemographic information and a set of online questions. The data were collected by the researchers. All procedures were approved by our hospital’s Ethics Committee. Traumatic Stress Symptom Scale (TSSS) was used for the study.Results:Nine hundred and seventy-three persons participated in the study. Among the three groups, nurses also had the highest fear of dying during the COVID-19 pandemic (p

Emerging evidence suggests that PPARG gene polymorphisms may influence lipid metabolism and cardiovascular risk, with omega-3 fatty acids proposed to modulate these effects. This study aims to assess the effects of fish oil supplementation on cardiovascular markers among adults with PPARG gene polymorphisms in a randomized, double-blind, placebo-controlled trial. A cohort of 102 patients with LDL-C 70–190 mg/dL was randomized to receive either 2000 mg of omega-3 fatty acids or a placebo daily for 90 days. In the omega-3 group with PPARG polymorphisms, LDL-C was reduced by 15.4% (95% CI: −19.8% to −11.0%), compared with a 2.6% decrease in the placebo group (95% CI: −4.1% to −1.1%; p < 0.01). In the omega-3 group without PPARG polymorphisms, LDL-C was reduced by 3.7% (95% CI: −6.9% to −0.6%), not significantly different from the placebo group’s reduction of 2.9% (95% CI: −5.1% to −0.8%; p = 0.28). The reduction in LDL-C was notably 11.7% greater in those with PPARG polymorphisms than in those without (95% CI: −19.3% to −4.0%; p < 0.01). Triglycerides decreased by 21.3% in omega-3 recipients with PPARG polymorphisms (95% CI: −26.5% to −16.2%; p < 0.01), with no significant changes in HDL-C, total cholesterol, or hsCRP levels in any groups. Minor allele frequencies and baseline characteristics were comparable, ensuring a balanced genetic representation. Omega-3 fatty acids significantly reduce LDL-C and triglycerides in carriers of PPARG polymorphisms, underlining the potential for genetic-driven personalization of cardiovascular interventions.

Pomegranate has a unique evolutionary history given that different cultivars have eight or nine bivalent chromosomes with possible crossability between the two classes. Therefore, it is important to study chromosome evolution in pomegranate to understand the dynamics of its population. Here, we de novo assembled the Azerbaijani cultivar “Azerbaijan guloyshasi” (AG2017; 2n = 16) and re-sequenced six cultivars to track the evolution of pomegranate and to compare it with previously published de novo assembled and re-sequenced cultivars. High synteny was observed between AG2017, Bhagawa (2n = 16), Tunisia (2n = 16), and Dabenzi (2n = 18), but these four cultivars diverged from the cultivar Taishanhong (2n = 18) with several rearrangements indicating the presence of two major chromosome evolution events. Major presence/absence variations were not observed as >99% of the five genomes aligned across the cultivars, while >99% of the pan-genic content was represented by Tunisia and Taishanhong only. We also revisited the divergence between soft- and hard-seeded cultivars with less structured population genomic data, compared to previous studies, to refine the selected genomic regions and detect global migration routes for pomegranate. We reported a unique admixture between soft- and hard-seeded cultivars that can be exploited to improve the diversity, quality, and adaptability of local pomegranate varieties around the world. Our study adds body knowledge to understanding the evolution of the pomegranate genome and its implications for the population structure of global pomegranate diversity, as well as planning breeding programs aiming to develop improved cultivars.

Introduction:In this study, we wanted to evaluate the variability relationship between the criteria used in the disease course of anxiety and obsessive-compulsive disorder (OCD) in a group of patients with knee osteoarthritis (OA).Methods:We assessed 104 patients who were diagnosed with grade 2-4 knee OA and fifty healthy individuals. Their sociodemographic characteristics were recorded. Maudsley Obsessive-Compulsive Inventory (MOCI) was used to measure the type and extent of obsessive-compulsive symptoms, Beck Anxiety Inventory (BAI) was used to assess emotional status, Short Form-36 (SF-36) was used to assess the quality of life, visual analogue scale (VAS) was used to assess pain severity and Western Ontario McMaster Questionnaire Index (WOMAC) and Lequesne index were used to assess physical activity.Results:BAI was higher in old patients (13.6±9.94) than in young patients (12.4±5.91) and healthy individuals (7±6.4) (p

Breast milk is a liquid that can meet all the needs of the newborn in the first 6 months. Breastfeeding is encouraged all over the world so that every baby can benefit from breast milk, which is considered unique for the development of the baby. This study includes a literature review to determine the effect of mother’s education level on initiation of breastfeeding in Turkey. For this purpose, first the breastfeeding literature was examined on the basis of education, and then the situation in Turkey was evaluated through the Turkey Demographic and Health Survey reports published the first of which was published in 1993 and the last one in 2018. According to the Turkey Demographic and Health Survey reports, breastfeeding is quite common in Turkey. Although many factors play a role in the initiation and maintenance of breastfeeding, breastfeeding rates increase as the education level of the mother increases.

Managing the logistics and safety of an election system, from delivering voting machines to the right locations at the right time to ensuring that voting lines remain reasonable in length is a complex problem due to the scarcity of resources, especially human poll workers, and the impact of human behavior and disrupting events on the performance of this critical system. These complexities grew with the need for physical distancing during the COVID-19 pandemic coinciding with multiple key national elections, including the 2020 general presidential election in the USA. In this paper, we propose a digital clone platform leveraging agent-based simulation to model and experiment with resource allocation decisions and voter turnout fluctuations and facilitate “what-if” scenario testing of any election. As a use case, we consider three different concurrent polling location problems, namely, resource allocation, polling layout, and management. The main aim is to reduce voter waiting time and provide visibility of different scenarios for polling and state-level managers. We explain the proposed simulation platform based on Fulton County for the 2020 presidential US election. Fulton County had 238 polling locations in 2020, which provided publicly available voter turnout data. The developed platform realistically models at the county level and at specific locations, suggesting the possible allocation of finite resources among locations in the county and the configuration of each location, accounting for physical, legal, and technical constraints. Multiple realistic scenarios were developed and embedded into the simulation platform to evaluate and verify the different systems. The system performance and key attributes of the election system, such as waiting time, resource utilization, and layout safety, were tested and validated.

Introduction: This study aimed to evaluate the effects of depression severity on stress coping methods of mothers with mentally disabled children. Methods: This study included 50 mothers of children with intellectual disabilities who were admitted to the psychiatric outpatient clinic of our hospital. Sociodemographic data form, Beck Depression scale, and Stress Coping scale were applied to all participants. Results: The mean Beck Depression score of participants was 17.42±6.32. A One-Way relationship was found between the Beck Depression score and Stress Coping scale-desperate and submissive subscales. The Stress Coping Scale-desperate approach score is higher in those with severe depression than those with mild depression, whereas the Stress Coping scale-self-confidence subscale is higher in those with severe depression. The Stress Coping scale-submissive approach score is higher in participants with moderate depression than those with mild depression (p

The purpose of this study was to antibacterial, and antibiofilm activity of two Lactobacillus strains secretome and extraction against E. coli isolated from women with urinary tract infection (UTI). We isolated 100 E. coli samples from women with UTI. Lactobacillus acidophilus and Lactobacillus casei characteristics were evaluated, and their secretome and extraction were prepared. The antibacterial and antibiofilm activity of secretome and extraction of both Lactobacillus strains were evaluated against isolated E. coli samples. L. acidophilus and L. casei were able to tolerate pH 3, bile salts, and pancreatic enzymes. Both probiotics were not resistant to antibiotics and demonstrated an appropriate ability to adhere to the intestinal epithelial cells. Secretome and extraction of L. acidophilus and L. casei strains showed a good antibacterial and antibiofilm against E. coli isolates. Generally, present study suggested that the secretome and extraction of L. acidophilus and L. casei strains exhibits a good antimicrobial activity.

Microcrystalline cellulose (MCC) and nutshell fiber reinforced high-density polyethylene (HDPE) composites were exposed to accelerated weathering for total of 672 h. The effects of weathering exposure on the mechanical, surface and morphological properties of the composites were investigated. The results revealed that the weathering exposure caused a slight decrease on tensile and flexural strengths whilst the modulus of elasticity increased up to 62%. The MCC / nutshell reinforced composites had higher color changes and gloss loss than MCC reinforced composites. Addition of MCC and nutshell to HDPE composites increased surface roughness of samples. After the weathering, the polymer band intensities decreased due to the degradation. The SEM observations on the exposed composites are in accordance with the surface roughness of composites after weathering. The investigated properties of MCC/nutshell filled HDPE composites were less affected by weathering exposure than those of composites without nutshell.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), usually referred to as CADASIL, is an inherited autosomal dominant condition that can cause stroke, dementia and other neurological impairments. Clinically, it presents most frequently as neurogical disturbances, although psychiatric symptoms may also be seen in about 20%-41% of cases. Psychiatric disturbances encountered most often in CADASIL include mood and adjustment disorders, particularly depression. In this case report, we highlight a patient with CADASIL syndrome, who had adjustment disorder with neurological signs appearing only later, leading to diagnosis of CADASIL. Treatment of the condition and patient follow-up are also discussed below.

It is known that there is a correlation between hydration heat and physico-mechanical properties of wood based cement panels. Cement hydration is affected by many variables, such as chemical composition, water/cement ratio, wood/cement ratio, wood chemical properties, mineral additions and producing conditions. This study mainly aimed to investigate the effects of press temperature on some properties of three-layer cement bonded particleboard made from the particles of spruce (Picea orientalis) and poplar (Populus tremula). For this purpose, a total of 16 experimental board groups with 1200 kg/m3 target density and 1/3 wood-cement ratio were produced at the press temperatures of (20, 30, 40, 50, 60, 70 and 80) °C. As cement curing accelerator, CaCl2 was used at a rate of 5 % (cement weight basis). The physical, mechanical and thermal properties of the boards were determined. The results indicated that the press temperature substantially affected the properties of cement-bonded particleboard depending on the wood species. In the light of this study, the optimum temperatures in producing of cement-bonded particleboard were found as 40 °C for poplar wood and 60 °C for spruce wood.

Selective serotonin reuptake inhibitors are antidepressant drugs commonly used in psychiatric diseases. The most common side effects of sertraline are diarrhea, constipation, sexual side effects, fatigue, dizziness, nausea, but sertralinerelated bleeding disorder is a less common side effect. In our case, we aimed to present a case where we started sertraline, as a result of the diagnosis of depression and ıt seems abnormal bleeding other than menstrual time after the drug dose was increased called as menometrorrhagia and after the cessation of sertraline bleeding is ended.

Human immunodeficiency virus (HIV) is a retrovirus that affects CD4 lymphocytes. Inflammation and neoplasms occur as a consequence of the destruction of the cellular origin of immunity and disruption of the general immunity regulation. HIV enters the nervous system during the first hours of infection and persists throughout the entire infection. Many psychiatric syndromes can be observed in HIV-infected individuals, such as depressive disorders, anxiety disorders, personality disorders, bipolar disorder, sleep disorders, alcohol-substance abuse disorders, delirium, dementia, and psychosis. Here we present a case of hypomania that developed in an HIV positive patient, aiming to point out the importance of screening, diagnosing, and treating psychiatric disorders related to HIV presence. A 41-year-old male patient was diagnosed with acquired immunodeficiency 6 months ago, and while he was being followed up at an infection diseases clinic, he presented sudden onset of insomnia, nervousness, overtalking, and overspending money behaviors. He was referred to a psychiatry clinic, and at psychological examination of the patient, increased mood and psychomotor activity were detected. Haloperidol ampule 10 mg/day and biperiden ampule 5 mg/day were started and given for 3 days. There were neither hallucinations or delusions nor homicide or suicide ideas. No substance abuse history was present. He was diagnosed with hypomania due to acquired immunodeficiency. The patient has been in remission for the last 3 months and is still being followed up in our clinic.