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25 results on '"Severina, Inna I."'

2. A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector

Author

Khailova, Ljudmila S., Silachev, Denis N., Rokitskaya, Tatyana I., Avetisyan, Armine V., Lyamsaev, Konstantin G., Severina, Inna I., Il'yasova, Tatyana M., Gulyaev, Mikhail V., Dedukhova, Vera I., Trendeleva, Tatyana A., Plotnikov, Egor Y., Zvyagilskaya, Renata A., Chernyak, Boris V., Zorov, Dmitry B., Antonenko, Yuri N., and Skulachev, Vladimir P.

Published
2014
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4. In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives

Author

Severina, Inna I., Severin, Fedor F., Korshunova, Galina A., Sumbatyan, Natalya V., Ilyasova, Tatyana M., Simonyan, Ruben A., Rogov, Anton G., Trendeleva, Tatyana A., Zvyagilskaya, Renata A., Dugina, Vera B., Domnina, Lidia V., Fetisova, Elena K., Lyamzaev, Konstantin G., Vyssokikh, Mikhail Yu, Chernyak, Boris V., Skulachev, Maxim V., Skulachev, Vladimir P., and Sadovnichii, Viktor A.

Published
2013
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6. Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers

Author

Antonenko, Yuri N., Avetisyan, Armine V., Cherepanov, Dmitry A., Knorre, Dmitry A., Korshunova, Galina A., Markova, Olga V., Ojovan, Silvia M., Perevoshchikova, Irina V., Pustovidko, Antonina V., Rokitskaya, Tatyana I., Severina, Inna I., Simonyan, Ruben A., Smirnova, Ekaterina A., Sobko, Alexander A., Sumbatyan, Natalia V., Severin, Fedor F., and Skulachev, Vladimir P.

Published
2011
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7. Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs)

Author

Skulachev, Vladimir P., Antonenko, Yury N., Cherepanov, Dmitry A., Chernyak, Boris V., Izyumov, Denis S., Khailova, Ludmila S., Klishin, Sergey S., Korshunova, Galina A., Lyamzaev, Konstantin G., Pletjushkina, Olga Yu., Roginsky, Vitaly A., Rokitskaya, Tatiana I., Severin, Fedor F., Severina, Inna I., Simonyan, Ruben A., Skulachev, Maxim V., Sumbatyan, Natalia V., Sukhanova, Evgeniya I., Tashlitsky, Vadim N., Trendeleva, Tatyana A., Vyssokikh, Mikhail Yu., and Zvyagilskaya, Renata A.

Published
2010
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8. An attempt to prevent senescence: A mitochondrial approach

Author

Skulachev, Vladimir P., Anisimov, Vladimir N., Antonenko, Yuri N., Bakeeva, Lora E., Chernyak, Boris V., Erichev, Valery P., Filenko, Oleg F., Kalinina, Natalya I., Kapelko, Valery I., Kolosova, Natalya G., Kopnin, Boris P., Korshunova, Galina A., Lichinitser, Mikhail R., Obukhova, Lidia A., Pasyukova, Elena G., Pisarenko, Oleg I., Roginsky, Vitaly A., Ruuge, Enno K., Senin, Ivan I., Severina, Inna I., Skulachev, Maxim V., Spivak, Irina M., Tashlitsky, Vadim N., Tkachuk, Vsevolod A., Vyssokikh, Mikhail Yu., Yaguzhinsky, Lev S., and Zorov, Dmitry B.

Published
2009
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11. Novel Mitochondria-Targeted Antioxidants: Plastoquinone Conjugated with Cationic Plant Alkaloids Berberine and Palmatine

Author

Lyamzaev, Konstantin G., Pustovidko, Antonina V., Simonyan, Ruben A., Rokitskaya, Tatyana I., Domnina, Lidia V., Ivanova, Olga Yu., Severina, Inna I., Sumbatyan, Natalia V., Korshunova, Galina A., Tashlitsky, Vadim N., Roginsky, Vitaly A., Antonenko, Yuriy N., Skulachev, Maxim V., Chernyak, Boris V., and Skulachev, Vladimir P.

Published
2011
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16. Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

Author

Antonenko, Yuri N., primary, Khailova, Ljudmila S., additional, Knorre, Dmitry A., additional, Markova, Olga V., additional, Rokitskaya, Tatyana I., additional, Ilyasova, Tatyana M., additional, Severina, Inna I., additional, Kotova, Elena A., additional, Karavaeva, Yulia E., additional, Prikhodko, Anastasia S., additional, Severin, Fedor F., additional, and Skulachev, Vladimir P., additional

Published
2013
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17. Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

Author

Severin, Fedor F., primary, Severina, Inna I., additional, Antonenko, Yury N., additional, Rokitskaya, Tatiana I., additional, Cherepanov, Dmitry A., additional, Mokhova, Elena N., additional, Vyssokikh, Mikhail Yu., additional, Pustovidko, Antonina V., additional, Markova, Olga V., additional, Yaguzhinsky, Lev S., additional, Korshunova, Galina A., additional, Sumbatyan, Nataliya V., additional, Skulachev, Maxim V., additional, and Skulachev, Vladimir P., additional

Published
2009
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18. Accumulation of lipophilic dications by mitochondria and cells

Author

Ross, Meredith F., primary, Da Ros, Tatiana, additional, Blaikie, Frances H., additional, Prime, Tracy A., additional, Porteous, Carolyn M., additional, Severina, Inna I., additional, Skulachev, Vladimir P., additional, Kjaergaard, Henrik G., additional, Smith, Robin A. J., additional, and Murphy, Michael P., additional

Published
2006
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21. Ethylrhodamine as a fluorescent penetrating cation and a membrane potential‐sensitive probe in cyanobacterial cells

Author

Severina, Inna I. and Skulachev, Vladimir P.

Abstract

Ethylrhodamine, a homolog of rhodamine 123, was found to generate a diffusion potential across a planar bilayer phospholipid membrane (the compartment with the lower ethylrhodamine concentration positive). Addition of a penetrating synthetic anion increased the sensitivity of the membrane to ethylrhodamine, an effect similar to that previously described for triphenylmethylammonium, tetraphenylphosphonium and other synthetic penetrating cations. In experiments with the filamentous multicellular cyanobacteria Phormidium uncinatum,ethylrhodamine was used as a cationic penetrant and vital fluorescent probe for membrane potential (δΨ). It is shown that a treatment increasing protonic potential (illumination) and converting δpH to δΨ (nigericin) enhanced the fluorescence of cyanobacteria, as ethylrhodamine accumulated inside the cells. Uncouplers discharging δΨ completely abolished the fluorescence increase. Individual variations in the fluorescence of cells composing cyanobacterial trichomes could be observed. Illumination of a small part of a trichome with a narrow beam of the light actuating photosynthesis was shown to induce a fluorescence increase in both illuminated and non‐illuminated regions of this trichome, indicating δΨ transmission from cell to cell.

Published
1984
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24. Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase.

Author

Muntyan MS, Cherepanov DA, Malinen AM, Bloch DA, Sorokin DY, Severina II, Ivashina TV, Lahti R, Muyzer G, and Skulachev VP

Subjects
Electron Transport Complex IV chemistry, Models, Molecular, Molecular Sequence Data, Protein Conformation, Electron Transport Complex IV metabolism, Proteobacteria enzymology, Sodium-Potassium-Exchanging ATPase metabolism
Abstract

Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), which are widespread among pathogenic bacteria, are the least understood. In particular, the proton-pumping machinery of these Coxs has not yet been elucidated despite the availability of X-ray structure information. Here, we report the discovery of the first (to our knowledge) sodium-pumping Cox (Scox), a cbb3 cytochrome from the extremely alkaliphilic bacterium Thioalkalivibrio versutus. This finding offers clues to the previously unknown structure of the ion-pumping channel in the C-type Coxs and provides insight into the functional properties of this enzyme.

Published
2015
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25. Novel penetrating cations for targeting mitochondria.

Author

Chernyak BV, Antonenko YN, Domnina LV, Ivanova OY, Lyamzaev KG, Pustovidko AV, Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, and Zvyagilskaya RA

Subjects
Cations, HeLa Cells, Humans, Lipid Bilayers, Membranes, Artificial, Phospholipids metabolism, Mitochondria metabolism
Abstract

Novel penetrating cations were used for the design of mitochondria-targeted compounds and tested in model lipid membranes, in isolated mitochondria and in living human cells in culture. Rhodamine-19, berberine and palmatine were conjugated by aliphatic linkers with plastoquinone possessing antioxidant activity. These conjugates (SkQR1,SkQBerb, SkQPalm) and their analogs lacking plastoquinol moiety (C12R1,C10Berb and C10Palm) penetrated bilayer phospholipid membrane in their cationic forms and accumulated in isolated mitochondria or in mitochondria of living cells due to membrane potential negative inside. Reduced forms of SkQR1, SkQBerb and SkQPalm inhibited lipid peroxidation in isolated mitochondria at nanomolar concentrations. In human fibroblasts SkQR1, SkQBerb and SkQPalm prevented fragmentation of mitochondria and apoptosis induced by hydrogen peroxide. SkQR1 was effective at subnanomolar concentrations while SkQberb, SkQPalm and SkQ1 (prototypic conjugate of plastoquinone with dodecyltriphenylphosphonium) were effective at 10-times higher concentrations. The aliphatic conjugates of berberine and palmatine (as well as the conjugates of triphenylphosphonium) induced proton transport mediated by free fatty acids (FA) both in the model and mitochondrial membrane. In mitochondria this process was facilitated by the adenine nucleotide carrier. In contrast to the other cationic conjugates, SkQR1 and C12R1 induced FA-independent proton conductivity due to protonation/deprotonation of the rhodamine residue. This property in combination with the antioxidant activity probably makes rhodamine conjugates highly effective in protection against oxidative stress. The novel cationic conjugates described here are promising candidates for drugs against various pathologies and aging as mitochondria-targeted antioxidants and selective mild uncouplers.

Published
2013
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