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Olga Sergeeva,1 Yifan Zhang,1 Songqi Gao,2 E Ricky Chan,3 Maxim Sergeev,4 Renuka Iyer,5 Sandra Sexton,5 Norbert Avril,4 Zheng-Rong Lu,2 Zhenghong Lee1 1Department of Radiology, Case Western Reserve University, Cleveland, OH, USA; 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 3Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA; 4Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; 5Medical Oncology and Laboratory Animal Shared Resources, Roswell Park Cancer Institute, Buffalo, NY, USACorrespondence: Zhenghong Lee, Nuclear Medicine, Radiology, Case Western Reserve University, Bolwell S107, 11100 Euclid Avenue, Cleveland, OH, 44106, USA, Tel +1216-844-7920, Email zxl11@case.edu Zheng-Rong Lu, Biomedical Engineering, Case Western Reserve University, Wickenden 427, Mail Stop 7207, 10900 Euclid Ave, Cleveland, OH, 44106, USA, Tel +1 216-368-0187, Email zxl125@case.eduPurpose: We tested a recently developed short peptide radioligand for PET imaging of hepatocellular carcinoma (HCC) by targeting an oncoprotein, extra-domain B fibronectin (EDB-FN) in the tumor microenvironment.Methods: The radioligand consists of a small linear peptide ZD2 with 68Ga-NOTA chelator, and specifically binds to EDB-FN. PET images were acquired dynamically for 1 hour after intravenously (i.v.) injecting 37 MBq (1.0 mCi) of the radioligand into the woodchuck model of naturally occurring HCC. Woodchuck HCC originated from chronic viral hepatitis infection, which recapitulates the corresponding human primary liver cancer. The animals were euthanized post-imaging for tissue collection and validation.Results: For ZD2 avid liver tumors, the radioligand accumulation plateaued a few minutes after injection, while the liver background uptake stabilized 20 min post-injection. The status of EDB-FN in woodchuck HCC was confirmed by histology and validated by PCR and western blocking.Conclusion: We have showed the viability of using the ZD2 short peptide radioligand targeting EDB-FN in liver tumor tissue for PET imaging of HCC, which can potentially impact the clinical care for HCC patients.Keywords: peptide ligand, EDB fibronectin, positron emission tomography, woodchuck model

Organizational identification has gained popularity in the organizational sciences and has important implications for the experiences of new undergraduate business students. Researchers have focused largely on how characteristics of organizations influence organizational identification, but limited work has explored how characteristics of the environment and the individual work together. In the present study, relationships between the dimensions of organizational socialization of undergraduate business students and university identification are investigated. Further, students' core self-evaluations are explored as a moderator of the relationship between socialization dimensions and organizational identification. The data for the study was collected from 209 entering-college first-year undergraduates in an introductory business course in the United States. We found that two socialization dimensions, people and organizational goals and values, are positively related to university identification. Furthermore, core self-evaluations interact with the history dimension to influence university identification, such that history socialization has a positive effect on university identification for students with high core self-evaluations but not for those with low core self-evaluations. Discussion, implications, and future research areas are included.

This paper reports on a study investigating the effectiveness of a new professional learning development (PLD) initiative in New Zealand, The Sir Paul Callaghan Science Academy (The Academy). The Academy is designed to provide primary and intermediate (students aged 5 to 13) classroom teachers with the knowledge, materials and support needed for The New Zealand Curriculum (Ministry of Education, 2007). After the Academy's first two years of operation, results indicate that The Academy has shown how relevant, useful and meaningful education through science can impact on both individual classroom teacher's practice and entire school programmes. The implications of this paper support the critical importance effective PLD plays in continued teaching practice.

This paper presents the benefits and costs of providing students with unlimited access to programmable boards in digital design education, allowing hands-on experiences outside traditional laboratory settings. Studies were conducted at three universities in two different countries--Rose Hulman Institute of Technology, Terre Haute, IN; Washington State University, Pullman; and Technical University of Cluj-Napoca, Romania--to measure the effect on student learning and student performance of students having their own programmable hardware systems and unrestricted access to the most commonly used design tools. The results of the studies, supported by assessment data from various sources, suggest that the overall learning process is improved, and students gain a better knowledge of modern technologies and design methods if they are given full time access to programmable logic boards. (Contains 8 tables and 4 figures.)

Organizational identification has gained popularity in the organizational sciences and has important implications for the experiences of new undergraduate business students. Researchers have focused largely on how characteristics of organizations influence organizational identification, but limited work has explored how characteristics of the environment and the individual work together. In the present study, relationships between the dimensions of organizational socialization of undergraduate business students and university identification are investigated. Further, students' core self-evaluations are explored as a moderator of the relationship between socialization dimensions and organizational identification. The data for the study was collected from 209 entering-college first-year undergraduates in an introductory business course in the United States. We found that two socialization dimensions, people and organizational goals and values, are positively related to university identification. Furthermore, core self-evaluations interact with the history dimension to influence university identification, such that history socialization has a positive effect on university identification for students with high core self-evaluations but not for those with low core self-evaluations. Discussion, implications, and future research areas are included. [ABSTRACT FROM AUTHOR]

This paper reports on a study investigating the effectiveness of a new professional learning development (PLD) initiative in New Zealand, The Sir Paul Callaghan Science Academy (The Academy). The Academy is designed to provide primary and intermediate (students aged 5 to 13) classroom teachers with the knowledge, materials and support needed for The New Zealand Curriculum (Ministry of Education, 2007). After the Academy's first two years of operation, results indicate that The Academy has shown how relevant, useful and meaningful education through science can impact on both individual classroom teacher's practice and entire school programmes. The implications of this paper support the critical importance effective PLD plays in continued teaching practice. [ABSTRACT FROM AUTHOR]