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2. Real-world effectiveness of dupilumab in a European cohort of chronic rhinosinusitis with nasal polyps (CHRINOSOR)

Author

Alobid, Isam, Andrianakis, Alexandros, Hellings, Peter W., Hopkins, Claire, Hox, Valérie, Kjeldsen, Anette, Laulajainen-Hongisto, Anu, Lund, Valerie, Van Gerven, Laura, Seys, Sven F., Schneider, Sven, de Kinderen, Joost, Reitsma, Sietze, Cavaliere, Carlo, Tomazic, Peter-Valentin, Morgenstern, Christina, Mortuaire, Geoffrey, Wagenmann, Martin, Bettio, Giulia, Ciofalo, Andrea, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Holzmeister, Clemens, Mariën, Gert, Masieri, Simonetta, Otten, Josje, Scheckenbach, Kathrin, Tu, Aldine, and Bachert, Claus

Published
2025
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4. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology

Author

Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, and Bachert, Claus

Published
2023
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13. Eosinophils—from cradle to grave

Author

Jesenak, Milos, primary, Diamant, Zuzana, additional, Simon, Dagmar, additional, Tufvesson, Ellen, additional, Seys, Sven F., additional, Mukherjee, Manali, additional, Lacy, Paige, additional, Vijverberg, Susanne, additional, Slisz, Tomas, additional, Sediva, Anna, additional, Simon, Hans‐Uwe, additional, Striz, Ilja, additional, Plevkova, Jana, additional, Schwarze, Jurgen, additional, Kosturiak, Radovan, additional, Alexis, Neil E., additional, Untersmayr, Eva, additional, Vasakova, Martina Koziar, additional, Knol, Edward, additional, and Koenderman, Leo, additional

Published
2023
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14. Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

Author

Muraro, Antonella, Lemanske, Robert F., Jr., Hellings, Peter W., Akdis, Cezmi A., Bieber, Thomas, Casale, Thomas B., Jutel, Marek, Ong, Peck Y., Poulsen, Lars K., Schmid-Grendelmeier, Peter, Simon, Hans-Uwe, Seys, Sven F., and Agache, Ioana

Published
2016
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18. List of Contributors

Author

Agache, Ioana, primary, Akdis, Cezmi A., additional, Alvarez-Perea, Alberto, additional, Amaral, Rita, additional, Antolín-Amérigo, Darío, additional, Bachert, Claus, additional, Baiardini, Ilaria, additional, Berkouk, Karim, additional, Bewick, Mike, additional, Bousquet, Jean, additional, Canonica, Giorgio Walter, additional, Cojanu, Catalina, additional, Crisafulli, Aldo, additional, Desrosiers, Martin, additional, Dörr, Tamara, additional, Endam, Leandra Mfuna, additional, Ferrando, Matteo, additional, Fokkens, Wytske, additional, Fonseca, João A, additional, Gajdanowicz, Paweł, additional, Haahtela, Tari, additional, Hanrahan, Finnian, additional, Heffler, Enrico, additional, Hellings, Peter W., additional, Hofmaier, Stephanie, additional, Hofman, Ingrid van, additional, Hogan, Stéphane, additional, Hopkins, Claire, additional, Huang, Xinyuan, additional, Jacinto, Tiago, additional, Jácome, Cristina, additional, Jones, Christina, additional, Jutel, Marek, additional, Kogan, Grigorij, additional, Laang, Hannu, additional, Lund, Valerie J., additional, Lunjani, Nonhlanhla, additional, Mäkelä, Mika J., additional, Mariën, Gert, additional, Matricardi, Paolo Maria, additional, Matthiessen, Line, additional, Nowak, Elisabeth, additional, O’Mahony, Liam, additional, Paoletti, Giovanni, additional, Pereira, Ana Margarida, additional, Popescu, Florin-Dan, additional, Pugin, Benoit, additional, Rogozea, Liliana, additional, Ryan, Dermot, additional, Saarinen, Kimmo, additional, Schaub, Bianca, additional, Schmidt-Weber, Carsten B., additional, Sedillot, Eve, additional, Seys, Sven F., additional, Smith, Helen E., additional, Sokolowska, Milena, additional, Steelant, Brecht, additional, Sugita, Kazunari, additional, Tomassen, Peter, additional, Tommila, Erja, additional, Trzaska, Dominika, additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Vidal-Ragout, María, additional, Wong, Gary W.K., additional, Yorgancıoğlu, Arzu, additional, and Zuberbier, Torsten, additional

Published
2019
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19. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR):Establishment of an International Outcome Registry Driven by mHealth Technology

Author

Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, Bachert, Claus, Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, and Bachert, Claus

Abstract

Background: Real-world evidence (RWE) is a valuable instrument to better understand the patient journey and effectiveness of therapies. RWE on the prevalence of uncontrolled chronic rhinosinusitis (CRS) and CRS natural course of disease across Europe is scarce. In addition, there is limited RWE that enables comparison of the effectiveness of marketed therapies including topical or systemic corticosteroids, sinus surgery, or biologics. Objective: To establish an international CHRonic rhINOSinusitis Outcome Registry (CHRINOSOR) based on real-world data collection enabled by mobile health technology. Methodology: A digital platform, Galenus Health, supporting patients and physicians in the management of chronic respiratory diseases, is used to collect data on patient profile, disease history, patient outcomes, and a set of relevant clinical outcomes. Adult patients with a diagnosis of CRS are eligible for inclusion. Results: A collaborative scientific network of 17 university ear-nose-throat (ENT) clinics from 10 European countries has been established with the aim to collect real-world data in a longitudinal and standardized manner. The Galenus Health digital platform is currently being implemented in these ENT clinics taking into account legal, privacy, and data security aspects. Up to 300 patients have already been included. Conclusions: CHRINOSOR is a collaborative effort that aims at improving our understanding of CRS, its comorbidities, and the effectiveness of its treatments. Ultimately, these insights will guide us as scientific community to develop future care pathways informed by RWE.

Published
2023

22. Activation of epithelial and inflammatory pathways in adolescent elite athletes exposed to intense exercise and air pollution

Author

Goossens, Janne, primary, Jonckheere, Anne-Charlotte, additional, Seys, Sven F, additional, Dilissen, Ellen, additional, Decaesteker, Tatjana, additional, Goossens, Camille, additional, Peers, Koen, additional, Vanbelle, Vincent, additional, Stappers, Jeroen, additional, Aertgeerts, Sven, additional, De Wilde, Barbara, additional, Leus, Jasmine, additional, Verelst, Sophie, additional, Raes, Marc, additional, Dupont, Lieven, additional, and Bullens, Dominique M, additional

Published
2023
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23. Can AQUA © questionnaire and FeNO predict atopy in early‐career athletes?

Author

Goossens, Janne, primary, Vandekerckhove, Josefien, additional, Jonckheere, Anne‐Charlotte, additional, Dilissen, Ellen, additional, Seys, Sven F., additional, Vanbelle, Vincent, additional, Aertgeerts, Sven, additional, Stappers, Jeroen, additional, Peers, Koen, additional, Raes, Marc, additional, Verelst, Sophie, additional, Leus, Jasmine, additional, Dupont, Lieven J., additional, and Bullens, Dominique M. A., additional

Published
2023
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27. Peribronchial Inflammation Resulting from Regulatory T Cell Deficiency Damages the Respiratory Epithelium and Disturbs Barrier Function

Author

Jonckheere, Anne-Charlotte, primary, Steelant, Brecht, additional, Seys, Sven F., additional, Cremer, Jonathan, additional, Dilissen, Ellen, additional, Boon, Louis, additional, Liston, Adrian, additional, Schrijvers, Rik, additional, Breynaert, Christine, additional, Vanoirbeek, Jeroen A. J., additional, Ceuppens, Jan L., additional, and Bullens, Dominique M. A., additional

Published
2022
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28. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology

Author

Seys, Sven F., primary, Hellings, Peter W., additional, Alobid, Isam, additional, Backer, Vibeke, additional, Bequignon, Emilie, additional, von Buchwald, Christian, additional, Cavaliere, Carlo, additional, Coste, André, additional, Deneyer, Lauren, additional, Diamant, Zuzana, additional, Eckl-Dorna, Julia, additional, Fokkens, Wytske J., additional, Gane, Simon, additional, Gevaert, Philippe, additional, Holbaek-Haase, Christiane, additional, Holzmeister, Clemens, additional, Hopkins, Claire, additional, Hox, Valérie, additional, Huart, Caroline, additional, Jankowski, Roger, additional, Jorissen, Mark, additional, Kjeldsen, Anette, additional, Knipps, Lisa, additional, Lange, Bibi, additional, van der Lans, Rik, additional, Laulajainen-Hongisto, Anu, additional, Larsen, Kenneth, additional, Liu, David T., additional, Lund, Valerie, additional, Mariën, Gert, additional, Masieri, Simonetta, additional, Mortuaire, Geoffrey, additional, Mullol, Joaquim, additional, Reitsma, Sietze, additional, Rombaux, Philippe, additional, Schneider, Sven, additional, Steinsvik, Andreas, additional, Tomazic, Peter-Valentin, additional, Toppila-Salmi, Sanna K., additional, Van Gerven, Laura, additional, Van Zele, Thibaut, additional, Virkkula, Paula, additional, Wagenmann, Martin, additional, and Bachert, Claus, additional

Published
2022
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30. Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model

Author

Jonckheere, Anne-Charlotte, primary, Seys, Sven F., additional, Steelant, Brecht, additional, Decaesteker, Tatjana, additional, Dekoster, Kaat, additional, Cremer, Jonathan, additional, Dilissen, Ellen, additional, Schols, Dominique, additional, Iwakura, Yoichiro, additional, Vande Velde, Greetje, additional, Breynaert, Christine, additional, Schrijvers, Rik, additional, Vanoirbeek, Jeroen, additional, Ceuppens, Jan L., additional, Dupont, Lieven J., additional, and Bullens, Dominique M. A., additional

Published
2022
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31. Alpine altitude climate treatment for severe and uncontrolled asthma:An EAACI position paper

Author

Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., Akdis, Cezmi A., Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., and Akdis, Cezmi A.

Abstract

Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro-immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.

Published
2022

32. Erratum: Lacticaseibacillus casei AMBR2 Restores Airway Epithelial Integrity in Chronic Rhinosinusitis With Nasal Polyps (Allergy, Asthma and Immunology Research (2021) 13:4 (560-575) DOI: 10.4168/aair.2021.13.4.560)

Author

Martens, Katleen, de Boeck, Ilke, Jokicevic, Katarina, Kiekens, Filip, Farré, Ricard, Vanderveken, Olivier M., Seys, Sven F., Lebeer, Sarah, Hellings, Peter W., Steelant, Brecht, and Ear, Nose and Throat

Abstract

This erratum is being published to correct the error on page 561 of the article entitled 'Lacticaseibacillus casei AMBR2 Restores Airway Epithelial Integrity in Chronic Rhinosinusitis With Nasal Polyps' by Katleen Martens, Ilke De Boeck, Katarina Jokicevic, Filip Kiekens, Ricard Farré, Olivier M. Vanderveken, Sven F. Seys, Sarah Lebeer, Peter W. Hellings, Brecht Steelant in Allergy Asthma Immunol Res. 2021 Jul;13(4):560-575, https://doi.org/10.4168/aair.2021.13.4.560 as follows. The Disclosure section had missing statement. The authors apologize for any inconvenience that this may have caused. Disclosure There are no financial or other issues that might lead to conflict of interest.

Published
2022

34. Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model

Author

Jonckheere, Anne-Charlotte, primary, Seys, Sven F., additional, Steelant, Brecht, additional, Decaesteker, Tatjana, additional, Dekoster, Kaat, additional, Cremer, Jonathan, additional, Dilissen, Ellen, additional, Schols, Dominique, additional, Iwakura, Yoichiro, additional, Vande Velde, Greetje, additional, Breynaert, Christine, additional, Schrijvers, Rik, additional, Vanoirbeek, Jeroen, additional, Ceuppens, Jan L., additional, Dupont, Lieven J., additional, and Bullens, Dominique M. A., additional

Published
2022
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35. Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Author

Fieten, Karin B., primary, Drijver‐Messelink, Marieke T., additional, Cogo, Annalisa, additional, Charpin, Denis, additional, Sokolowska, Milena, additional, Agache, Ioana, additional, Taborda‐Barata, Luís Manuel, additional, Eguiluz‐Gracia, Ibon, additional, Braunstahl, Gerrit J., additional, Seys, Sven F., additional, van den Berge, Maarten, additional, Bloch, Konrad E., additional, Ulrich, Silvia, additional, Cardoso‐Vigueros, Carlos, additional, Kappen, Jasper H., additional, Brinke, Anneke ten, additional, Koch, Markus, additional, Traidl‐Hoffmann, Claudia, additional, da Mata, Pedro, additional, Prins, David J., additional, Pasmans, Suzanne G. M. A., additional, Bendien, Sarah, additional, Rukhadze, Maia, additional, Shamji, Mohamed H., additional, Couto, Mariana, additional, Oude Elberink, Hanneke, additional, Peroni, Diego G., additional, Piacentini, Giorgio, additional, Weersink, Els J. M., additional, Bonini, Matteo, additional, Rijssenbeek‐Nouwens, Lucia H. M., additional, and Akdis, Cezmi A., additional

Published
2022
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37. Can AQUA© questionnaire and FeNO predict atopy in early‐career athletes?

Author

Goossens, Janne, Vandekerckhove, Josefien, Jonckheere, Anne‐Charlotte, Dilissen, Ellen, Seys, Sven F., Vanbelle, Vincent, Aertgeerts, Sven, Stappers, Jeroen, Peers, Koen, Raes, Marc, Verelst, Sophie, Leus, Jasmine, Dupont, Lieven J., and Bullens, Dominique M. A.

Subjects
ATOPY, MALE athletes, ATHLETES, GENDER differences (Sociology)
Abstract

Keywords: AQUA questionnaire; athletes; atopy; FeNO EN AQUA questionnaire athletes atopy FeNO 1 5 5 03/30/23 20230301 NES 230301 Allergic sensitization and allergic diseases have been reported to have a high prevalence in athletes.[[1]] Moreover, atopy has been significantly associated with bronchial hyperreactivity and exercise-induced bronchoconstriction in elite athletes.[[3]] Sensitization to allergens is generally determined by a skin prick test (SPT) and/or allergen-specific serum IgE analysis.[5] Recently, the Allergy Questionnaire for Athletes (AQUA©),[6] a screening tool to predict atopy in elite adult athletes, was validated for screening of atopy in young elite athletes.[7] This screening tool may help with the early identification of atopy, which may burden the physical performances, and is especially helpful in young elite athletes.[5] Increased fractional exhaled NO (FeNO) levels are, considered to be an effective, noninvasive tool to assess the presence of eosinophilic airway inflammation and as tool to diagnose childhood asthma.[[8], [10]] This has also been correlated with allergic sensitization.[11] Therefore, we hypothesize that measuring FeNO levels may also be a useful noninvasive method to predict atopy in this population. The AUC of FeNO increased from 0.765 ( I p i < .0001) to 0.814 ( I p i < .0001) if we considered multiple sensitizations (participants with >=2 positive SPTs; Figure 1C), suggesting that FeNO levels might be a useful indicator for multiple sensitizations within atopic athletes. Can AQUA© questionnaire and FeNO predict atopy in early-career athletes? (C) ROC curve indicating the sensitivity and specificity of AQUA© (left) and FeNO (right) to predict atopy and multiple sensitizations (for FeNO). [Extracted from the article]

Published
2023
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40. Tackling nasal symptoms in athletes: Moving towards personalized medicine.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hox, Valérie, Beyaert, Simon, Bullens, Dominique, Couto, Mariana, Langer, Daniel, Hellings, Peter-Willem, Huart, Caroline, Rombaux, Philippe, Seys, Sven F, Surda, Pavol, Walker, Abigail, Steelant, Brecht, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Hox, Valérie, Beyaert, Simon, Bullens, Dominique, Couto, Mariana, Langer, Daniel, Hellings, Peter-Willem, Huart, Caroline, Rombaux, Philippe, Seys, Sven F, Surda, Pavol, Walker, Abigail, and Steelant, Brecht

Abstract

Adequate nasal breathing is indispensable for athletes, and nasal symptoms have been shown to interfere with their subjective feeling of comfortable breathing and quality of life. Nasal symptoms are caused by either structural abnormalities or mucosal pathology. Structural pathologies are managed differently from mucosal disease, and therefore, adequate diagnosis is of utmost importance in athletes in order to choose the correct treatment option for the individual. Literature suggests that nasal symptoms are more prevalent in athletes compared to the general population and certain sports environments might even trigger the development of symptoms. Given the high demands of respiratory function in athletes, insight into triggering factors is of high importance for disease prevention. Also, it has been suggested that athletes are more neglectful to their symptoms and hence remain undertreated, meaning that special attention should be paid to education of athletes and their caregivers. This review aims at giving an overview of nasal physiology in exercise as well as the possible types of nasal pathology. Additionally, diagnostic and treatment options are discussed and we focus on unmet needs for the management and prevention of these symptoms in athletes within the concept of precision medicine.

Published
2021

42. Tackling nasal symptoms in athletes: Moving towards personalized medicine

Author

Hox, Valerie, primary, Beyaert, Simon, additional, Bullens, Dominique, additional, Couto, Mariana, additional, Langer, Daniel, additional, Hellings, Peter‐Willem, additional, Huart, Caroline, additional, Rombaux, Philippe, additional, Seys, Sven F., additional, Surda, Pavol, additional, Walker, Abigail, additional, and Steelant, Brecht, additional

Published
2021
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45. Real‐life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA

Author

Seys, Sven F., primary, De Bont, Shana, additional, Fokkens, Wytske J., additional, Bachert, Claus, additional, Alobid, Isam, additional, Bernal‐Sprekelsen, Manuel, additional, Bjermer, Leif, additional, Callebaut, Ina, additional, Cardell, Lars‐Olaf, additional, Carrie, Sean, additional, Castelnuovo, Paolo, additional, Cathcart, Russell, additional, Constantinidis, Jannis, additional, Cools, Leen, additional, Cornet, Marjolein, additional, Clement, Gregory, additional, Cox, Tony, additional, Delsupehe, Lieve, additional, Correia‐de‐Sousa, Jaime, additional, Deneyer, Lauren, additional, De Vos, Geert, additional, Diamant, Zuzana, additional, Doulaptsi, Maria, additional, Gane, Simon, additional, Gevaert, Philippe, additional, Hopkins, Claire, additional, Hox, Valérie, additional, Hummel, Thomas, additional, Hosemann, Werner, additional, Jacobs, Raf, additional, Jorissen, Mark, additional, Kjeldsen, Anette, additional, Landis, Basile N., additional, Lemmens, Winde, additional, Leunig, Andreas, additional, Lund, Valerie, additional, Mariën, Gert, additional, Mullol, Joaquim, additional, Onerci, Metin, additional, Palkonen, Susanna, additional, Proano, Isabel, additional, Prokopakis, Emmanuel, additional, Ryan, Dermot, additional, Riechelmann, Herbert, additional, Sahlstrand‐Johnson, Pernilla, additional, Salmi‐Toppila, Sanna, additional, Segboer, Christine, additional, Speleman, Kato, additional, Steinsvik, Andreas, additional, Surda, Pavol, additional, Tomazic, Peter‐Valentin, additional, Vanderveken, Olivier, additional, Van Gerven, Laura, additional, Van Zele, Thibaut, additional, Verfaillie, Jan, additional, Verhaeghe, Benedicte, additional, Vierstraete, Kathie, additional, Vlaminck, Stephan, additional, Wagenmann, Martin, additional, Pugin, Benoit, additional, and Hellings, Peter W., additional

Published
2020
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48. Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Seys, Sven F, De Bont, Shana, Fokkens, Wytske J, Bachert, Claus, Alobid, Isam, Bernal-Sprekelsen, Manuel, Bjermer, Leif, Callebaut, Ina, Cardell, Lars-Olaf, Carrie, Sean, Castelnuovo, Paolo, Cathcart, Russell, Constantinidis, Jannis, Cools, Leen, Cornet, Marjolein, Clement, Gregory, Cox, Tony, Delsupehe, Lieve, Correia-de-Sousa, Jaime, Deneyer, Lauren, De Vos, Geert, Diamant, Zuzana, Doulaptsi, Maria, Gane, Simon, Gevaert, Philippe, Hopkins, Claire, Hox, Valérie, Hummel, Thomas, Hosemann, Werner, Jacobs, Raf, Jorissen, Mark, Kjeldsen, Anette, Landis, Basile N, Lemmens, Winde, Leunig, Andreas, Lund, Valerie, Mariën, Gert, Mullol, Joaquim, Onerci, Metin, Palkonen, Susanna, Proano, Isabel, Prokopakis, Emmanuel, Ryan, Dermot, Riechelmann, Herbert, Sahlstrand-Johnson, Pernilla, Salmi-Toppila, Sanna, Segboer, Christine, Speleman, Kato, Steinsvik, Andreas, Surda, Pavol, Tomazic, Peter-Valentin, Vanderveken, Olivier, Van Gerven, Laura, Van Zele, Thibaut, Verfaillie, Jan, Verhaeghe, Benedicte, Vierstraete, Kathie, Vlaminck, Stephan, Wagenmann, Martin, Pugin, Benoit, Hellings, Peter W, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Seys, Sven F, De Bont, Shana, Fokkens, Wytske J, Bachert, Claus, Alobid, Isam, Bernal-Sprekelsen, Manuel, Bjermer, Leif, Callebaut, Ina, Cardell, Lars-Olaf, Carrie, Sean, Castelnuovo, Paolo, Cathcart, Russell, Constantinidis, Jannis, Cools, Leen, Cornet, Marjolein, Clement, Gregory, Cox, Tony, Delsupehe, Lieve, Correia-de-Sousa, Jaime, Deneyer, Lauren, De Vos, Geert, Diamant, Zuzana, Doulaptsi, Maria, Gane, Simon, Gevaert, Philippe, Hopkins, Claire, Hox, Valérie, Hummel, Thomas, Hosemann, Werner, Jacobs, Raf, Jorissen, Mark, Kjeldsen, Anette, Landis, Basile N, Lemmens, Winde, Leunig, Andreas, Lund, Valerie, Mariën, Gert, Mullol, Joaquim, Onerci, Metin, Palkonen, Susanna, Proano, Isabel, Prokopakis, Emmanuel, Ryan, Dermot, Riechelmann, Herbert, Sahlstrand-Johnson, Pernilla, Salmi-Toppila, Sanna, Segboer, Christine, Speleman, Kato, Steinsvik, Andreas, Surda, Pavol, Tomazic, Peter-Valentin, Vanderveken, Olivier, Van Gerven, Laura, Van Zele, Thibaut, Verfaillie, Jan, Verhaeghe, Benedicte, Vierstraete, Kathie, Vlaminck, Stephan, Wagenmann, Martin, Pugin, Benoit, and Hellings, Peter W

Abstract

BACKGROUND: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. METHODS: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. RESULTS: The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major symptoms. Approximately half of patients reported nasal polyps. 47.3% of all CRS patients were uncontrolled based on evaluation of VAS global rhinosinusitis symptom score compared to 40.9% based on adapted EPOS criteria. The impact of CRS on sleep quality and daily life activities was significantly higher in uncontrolled versus well-controlled patients. Half of patients had a history of FESS (functional endoscopic sinus surgery) and reported lower symptom severity compared to patients without a history of FESS, except for patients with a history of more than 3 procedures. Patients with a history of FESS reported higher VAS levels for impaired smell. CONCLUSION: Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting quality of life. Sinus surgery improves patient-reported outcomes, but not in patients with a history of more than 3 procedures. Mobile technology opens a new era of real-life monitoring, supporting the evolution of care towards precision medicine.

Published
2020

50. ARIA masterclass 2018: From guidelines to real-life implementation

Author

Hellings, Peter W, Seys, Sven F, Marien, Gert, Agache, Ioana, Canonica, Walter, Gevaert, Philippe, Haahtela, Tari, Klimek, Ludger, Mullol, Joaquim, Pfaar, Oliver, Scadding, Glenis, Scadding, Guy, Valiulis, Arunas, Bousquet, Jean, Pugin, Benoit, Al-Muhandis, Nada, Allatt, Sarah, Almeyda, Robert, Armand, Patricia, Markovic, Marina Atanaskovic, Bajoriuniene, Ieva, Banik, Abhijit-Neil, Barbar-Craig, Humera, Barraclough, James, Bedfert, Cecile, Bedrock, Ana, Beel, Mieke, Parra, David Bonilla, Bradatan, Elena, Bras, Michael, Brehmer, Detlef, Brinkman, David, Cardier Suarez, Marisela, Carrasco Llatas, Marina, Chipev, Petar, Cooper, Angela, Corbett, Dennis, Cox, Caroline, Cox, Tony, Decsi, Melinda, Dantsis, Christos, Davies, Danielle, de la Hoz, Belen, Dordal Culla, Maria Teresa, Dworan-Timler, Astrid, Edlinger, Stefan, El Rakhawy, Mohamed, El-Shanawany, Tariq, Elhendi Halawa, Wassim, Fauquert, Jean-Luc, Folliard, Aoife, Frankland, Karen, Gardner, James, Gaskin, Julian, Guiddur, Tamazoust, Hanks, Kerry-Ann, Hanna, Brendan, Heinz, Benjamin, Hettige, Roland, Horisberger, Alice, Hosotte, Maxime, Howe, David, Hox, Valerie, Ifeacho, Sonna, Jain, Anurag, Jaramillo, Mario, Jimenez Morales, Juan Miguel, Kale, Savita, Kamper, Yvonne, Kansal, Gaurav, Kapustova, Lenka, Karamchandani, Dheeraj, Keh, Siew, Kerr, Ute, Khan, Maha, Kosnik, Mitja, Kolar, Matej, Koos, Beate, Kostov, Kosta, Kraxner, Helga, Kvedariene, Violeta, Lawton, Simon, Lefevre, Sebastien, Lentari, Eirini, Lindenberger, Martin, Litschel, Ralph, Lozar, Miha, Lomikovska, Marta, Luckhardt, Clemens, Lukits, Julia, Marchuk, Oksana, Marlair, Caroline, Martens, Katleen, Maria Mateo, Jose, Mc Donald, Stephen, Menaches Guardiola, Maria Isabel, Mohammad, Mohammad, Cosme, Joana Moreno, Morgans, Montio, Morris, Abigail, Mustakov, Tihomir, Nadeem, Shahid, Nagy, Attila, Nemecek, Romina, Nemeth, Barbara, Neukirch, Catherine, Odeh, Ihab, Patiar, Shalini, Pavic, Milena, Peglion, Armony, Pentland, Julie, de Corgnol, Anne Christine Perrot, Petrovicova, Otilia, Piccininni, Krizia, Piont, Valeryi, Popov, Todor, Popovics, Emese, Portejoie, Fabienne, Quirce, Santiago, Ram, Bhaskar, Ramonaite, Agne, Juratli, Abdul Razzak, Rico, Pilar, Ritterhoff, Carsten, Robertson, Alasdair, Fernandes, Rosa Rodrigues, Runge, Sonja, Ryan, Dermot, Sanchez Gutierrez, Rafael, Schatteman, Isabelle, Scheire, Sophie, Schuhmacher-Koval, Aleksandra, Scola Pliego, Esteban, Shukla, Rishi, Siau, Derrick, Siemers, Maaike, Sitkauskiene, Brigita, Slomskis, Tomas, Kosak, Tanja Soklic, Speleman, Kato, Spindler, Thomas, Straetmans, Jos, Striupaitiene, Dina, Sunk, Werner, Tadikonda, Rajendra, Tariq, Muhammad, Terporten, Barbara, Toma, Shamim, Tor, Mirabela, Tsirevelou, Paraskevi, Urban, Matthias, Urbancic, Jure, van der Putten, Lisa, Vasiliu, Vlad-Corneliu, Vesilyk, Nataliia, Vink, Anna-Sophie, Vriess-Uss, Elena, Vu, Kieuhanh, Yaremchuk, Svitlana, Yong, Patrick, Zahoor, Tosief, Zidarn, Mihaela, Ear, Nose and Throat, University Hospitals Leuven [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Transilvania University of Brasov, Istituto Clinico Humanitas [Milan] (IRCCS Milan), Humanitas University [Milan] (Hunimed), Ghent University Hospital, University of Helsinki, Heidelberg University, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), CIBER de Epidemiología y Salud Pública (CIBERESP), Philipps University of Marburg, Royal Brompton and Harefield NHS Foundation Trust, University College of London [London] (UCL), Vilnius University [Vilnius], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), and Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)

Subjects
IMPACT, Best practice, MEDLINE, CHILDREN, MECHANISMS, 03 medical and health sciences, 0302 clinical medicine, Belgium, RISK-FACTOR, Mobile technology, MANAGEMENT, Humans, Medicine, In real life, IMMUNOTHERAPY, 030223 otorhinolaryngology, masterclass, ALLERGIC RHINITIS SYMPTOMS, Research data, Asthma therapy, Medical education, Science & Technology, ARIA, allergic rhinitis, PRODUCTIVITY, business.industry, Change management, General Medicine, asthma, MILD, Rhinitis, Allergic, Asthma, 3. Good health, Integrated care, Multimorbidities, Integrated Care Pathways, Otorhinolaryngology, ARIA (Allergic Rhinitis and its Impact on Asthma), [SDV.IMM]Life Sciences [q-bio]/Immunology, Clinical Competence, business, Life Sciences & Biomedicine
Abstract

Over the past 20 years, ARIA (Allergic Rhinitis and its Impact on Asthma) has developed various guidelines for the treatment of allergic rhinitis (AR) and asthma multimorbidity. Over time, the ARIA initiative has evolved to ensure the highest level of bestpractices adoption in real life settings. It has evolved towards Integrated Care Pathways (ICPs) using mobile technology, and has now entered a new phase in which change management is key to provide an active and healthy life to all AR patients. With that in mind, the first ARIA masterclass was held on 12th September 2018 in Brussels, Belgium. The masterclass aimed at informing clinicians about the principles of change management, providing unbiased education on diagnosis and treatments, sharing the most recent research data on AR and multimorbidities, and creating a snowball effect to increase the adoption of best practices around the globe. This report provides an overview of the ARIA masterclass concept, summarizes the key lectures and discussions, and gives an outline of the future key development. ispartof: RHINOLOGY vol:57 issue:5 pages:392-399 ispartof: location:Netherlands status: published

Published
2019
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