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2. Cell Therapy for Parkinson’s Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression

Author

Aron Badin, R., Vadori, M., Vanhove, B., Nerriere‐Daguin, V., Naveilhan, P., Neveu, I., Jan, C., Lévèque, X., Venturi, E., Mermillod, P., Van Camp, N., Dollé, F., Guillermier, M., Denaro, L., Manara, R., Citton, V., Simioni, P., Zampieri, P., D’avella, D., Rubello, D., Fante, F., Boldrin, M., De Benedictis, G.M., Cavicchioli, L., Sgarabotto, D., Plebani, M., Stefani, A.L., Brachet, P., Blancho, G., Soulillou, J.P., Hantraye, P., and Cozzi, E.

Published
2016
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10. Infections and colonizations on admission to a rehabilitation hospital: involved microorganisms and resistance to carbapenems of Klebsiella pneumoniae according to the hospital ward of origin

Author

Dalla Torre, S., Baldovin, T., Marcante, E., Minnicelli, Anil, Bertoncello, C., Cenedese, M., Iaia, V., Sgarabotto, D., Rupolo, G., and Baldo, V.

Subjects
Antimicrobial resistence, colonization, rehabilitation hospital, colonization, Antimicrobial resistence, rehabilitation hospital
Published
2019

13. Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012

Author

Bisoffi, Zeno, Capelli, G, Angheben, A, Giobbia, M, Conforto, M, Franzetti, M, Cattelan, Am, Raise, E, Rovere, P, Mulatti, P, Montarsi, F, Drago, A, Barzon, L, Napoletano, G, Zanella, F, Pozza, F, Russo, F, Rosi, P, Palù, G, Bisoffi, Z, Summer Fever Study Group, Concia, Ercole, Francavilla, E, Marranconi, F, Pellizzer, G, Scotton, P, Sgarabotto, D, Brugnaro, P, Del Bravo, P, Ferretto, R, Masini, G, Mondardini, V, Viviani, F, Piovesan, C, Postiglione, C, Cattai, M, Conti, A, Cusinato, R, Degani, M, Forti, A, Franchin, E, Gion, M, Marcante, R, Modolo, E, Pacenti, M, Rassu, M, Rigoli, R, Scarin, M, and Tonolli, Elisabetta

Subjects
Adult, Male, Veterinary medicine, Aedes albopictus, Adolescent, viruses, Dengue virus, Biology, medicine.disease_cause, West Nile, Dengue fever, Dengue, Young Adult, Culex pipiens, medicine, Animals, Humans, Chikungunya, Horses, Alphavirus infection, Aged, Aged, 80 and over, Travel, Surveillance, Alphavirus Infections, Outbreak, virus diseases, Dengue Virus, Middle Aged, medicine.disease, biology.organism_classification, Virology, Insect Vectors, Infectious Diseases, Culicidae, Italy, Epidemiological Monitoring, Chikungunya Fever, Female, Horse Diseases, Chikungunya virus, West Nile virus, Malaria, West Nile Fever, Research Article
Abstract

Background Since 2010 Veneto region (North-Eastern Italy) planned a special integrated surveillance of summer fevers to promptly identify cases of West Nile Fever (WNF), dengue (DENV) and chikungunya (CHIKV). The objectives of this study were (i) To increase the detection rate of imported CHIKV and DENV cases in travellers from endemic areas and promptly identify potential autochthonous cases.(ii) To detect autochthonous cases of WNF, besides those of West Nile Neuroinvasive Disease (WNND) that were already included in a national surveillance. Methods Human surveillance: a traveler who had returned within the previous 15 days from endemic countries, with fever >38°C, absence of leucocytosis (leukocyte count 38°C for

Published
2013

16. Infezione da Citomegalovirus (CMV) nei trapianti di fegato

Author

Russo, F, Graziotto, A, Sgarabotto, D, Burra, P, Fagiuoli, S, Zanus, G, Fagiuoli, S, Chiaramonte, M, Russo, F, Graziotto, A, Sgarabotto, D, Burra, P, and Zanus, G

Subjects
Citomegalovirus, trapianti di fegato
Published
2001

17. Xenotransplantation of porcine CTLA4-Ig+/+ neural precursors enables recovery of the locomotor activity in parkinsonian primates

Author

Badin, A.R., Denaro, L., Vadori, M., Boldrin, M., Cavicchioli, Lionel, De Benedictis, G.M., Fante, F., Sgarabotto, D., Jan, Charlie, Daguin, V., Naveilhan, P., Vanhove, B., Blancho, G., Soulillou, J.P., Plat, Martine, Venturi, Eric, Botté, Françoise, Padoan, A., Manara, R., Zampieri, P., D'avella, D., Rubello, D., Gianello, P., Hantraye, P., Cozzi, Elena, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Universita di Padova, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Université Catholique de Louvain = Catholic University of Louvain (UCL), ProdInra, Migration, Università degli Studi di Padova = University of Padua (Unipd), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], XENOGREFFE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], HISTOLOGIE, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, activité leucomotrice
Abstract

331; International audience

Published
2011

19. LONG TERM CLINICAL RECOVERY OF PARKINSON'S DISEASE FOLLOWING TRANSPLANTATION OF CTLA4-IG(+) PORCINE EMBRYONIC NEURONAL CELLS IN NON HUMAN PRIMATE

Author

Badin, Ra, Padoan, A, Vadori, M, Boldrin, M, Cavicchioli, Laura, DE BENEDICTIS, GIULIA MARIA, Fante, F, Seveso, M, Sgarabotto, D, Jan, C, Daguin, V, Naveilhan, P, Neveu, I, Soulillou, Jp, Giannello, P, Vanhove, B, Plat, M, Botte, F, Venturi, E, Denaro, Luca, Manara, R, Zampieri, P, D'Avella, Domenico, Rubello, D, Ancona, Ermanno, Hantraye, P, Cozzi, E., Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Universita di Padova, Consorzio per la Ricerca sul Trapianto di Organi, Partenaires INRAE, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Université Catholique de Louvain = Catholic University of Louvain (UCL), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Azienda Ospedaliera di Padova, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Padova = University of Padua (Unipd), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], XENOGREFFE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], porc transgénique, ComputingMilieux_MISCELLANEOUS
Abstract

Communication orale O-330; International audience

Published
2011

21. Expression of CTLA4-Ig Is Indispensable To Enable Clinical Recovery in Parkinsonian Primate Recipients of Porcine Neural Xenografts

Author

Badin, R.A., Padoan, A., Vadori, M., Boldrin, M., Cavicchioli, Lionel, De Benedictis, G.M., Fante, F., Sgarabotto, D., Jan, Charlie, Daguin, V., Naveilhan, P., Soulillou, J.P., Vanhove, B., Plat, Martine, Venturi, Eric, Botté, Françoise, Denaro, L., Manara, R., Zampieri, P., D'avella, D., Rubello, D., Hantraye, P., Cozzi, Elena, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ura2210, Centre National de la Recherche Scientifique (CNRS), Neurosciences, Universita degli Studi di Padova, Consorzio per la Ricerca sul Trapianto di Organi, Partenaires INRAE, Universita di Padova, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Centre hospitalier universitaire de Nantes (CHU Nantes), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Azienda Ospedaliera di Padova, Università degli Studi di Padova = University of Padua (Unipd), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
XENOGREFFE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

Poster Board #-Session: P89-III Abstract# 1236; International audience

Published
2011
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22. Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey

Author

San-Juan, R., Manuel, O., Hirsch, H. H., Fernandez-Ruiz, M., Lopez-Medrano, F., Comoli, P., Caillard, S., Grossi, P., Aguado, J. M., Alamo-Martinez, J. M., Anaya, F., Anttila, V. -J., Arnol, M., Avolio, Alfonso Wolfango, Baccarani, U., Castello, I. B., Boletis, I., Bonofiglio, R., Bressollette, C., Brockmann, J., Pulido, J. C., Catalan, P., Christiansen, C., Cofan, F., Cordero, E., Leiro, M. C., Dantal, J., D'Armini, A., Delgado, J. F., Strologo, L. D., Raimondo, F. D., Dierickx, D., Eis-Hubinger, A., Kremer, S. F., Faggian, G., Farinas, M. C., Folgueira, M. D., Fontana, I., Franco, A., Furian, L., Garzoni, C., Ghirardo, G., Ginevri, F., Grinyo, J., Gupte, G., Hansson, L., Helantera, I., Herrero, J. I., Hobin, D., Hoffmann, D., Jan, L., Jarque, I., Jespersen, B., Kaczmarek, I., Kevin, P., Koneth, I., Kovac, D., Lacaille, F., Lautenschlager, I., Len, O., Llado, L., Loy, M., Marcos Maeso, M. A., Marianne, L. V., Marsh, J., Meylan, P., Minambres, E., Montejo, M., Mueller, N., Munoz, P., Nadalin, S., Kamar, N., Nicolas, B., Olivier, D., Palomo, J., Pascual, M., Peter, J., Pierre, F., Francisca Portero, M., Provot, F., Boluda, E. R., Regalia, E., Reina, G., Reuter, S., Ricart, J., Garcia, M. R., Rollag, H., Russo, F. P., Sabe, N., Salcedo, M., Santambrogio, L., Seeman, T., Serra, N., Sgarabotto, D., Simonek, J., Thierry, Y., Thomsen, M. K., Tihic, N., Torre-Cisneros, J., Travi, G., Tulissi, P., Moal, V., Veroux, M., Santandreu, A. V., Vizzini, G., Zibar, L., Avolio A. W. (ORCID:0000-0003-2491-7625), San-Juan, R., Manuel, O., Hirsch, H. H., Fernandez-Ruiz, M., Lopez-Medrano, F., Comoli, P., Caillard, S., Grossi, P., Aguado, J. M., Alamo-Martinez, J. M., Anaya, F., Anttila, V. -J., Arnol, M., Avolio, Alfonso Wolfango, Baccarani, U., Castello, I. B., Boletis, I., Bonofiglio, R., Bressollette, C., Brockmann, J., Pulido, J. C., Catalan, P., Christiansen, C., Cofan, F., Cordero, E., Leiro, M. C., Dantal, J., D'Armini, A., Delgado, J. F., Strologo, L. D., Raimondo, F. D., Dierickx, D., Eis-Hubinger, A., Kremer, S. F., Faggian, G., Farinas, M. C., Folgueira, M. D., Fontana, I., Franco, A., Furian, L., Garzoni, C., Ghirardo, G., Ginevri, F., Grinyo, J., Gupte, G., Hansson, L., Helantera, I., Herrero, J. I., Hobin, D., Hoffmann, D., Jan, L., Jarque, I., Jespersen, B., Kaczmarek, I., Kevin, P., Koneth, I., Kovac, D., Lacaille, F., Lautenschlager, I., Len, O., Llado, L., Loy, M., Marcos Maeso, M. A., Marianne, L. V., Marsh, J., Meylan, P., Minambres, E., Montejo, M., Mueller, N., Munoz, P., Nadalin, S., Kamar, N., Nicolas, B., Olivier, D., Palomo, J., Pascual, M., Peter, J., Pierre, F., Francisca Portero, M., Provot, F., Boluda, E. R., Regalia, E., Reina, G., Reuter, S., Ricart, J., Garcia, M. R., Rollag, H., Russo, F. P., Sabe, N., Salcedo, M., Santambrogio, L., Seeman, T., Serra, N., Sgarabotto, D., Simonek, J., Thierry, Y., Thomsen, M. K., Tihic, N., Torre-Cisneros, J., Travi, G., Tulissi, P., Moal, V., Veroux, M., Santandreu, A. V., Vizzini, G., Zibar, L., and Avolio A. W. (ORCID:0000-0003-2491-7625)

Abstract

There is limited clinical evidence on the utility of the monitoring of Epstein-Barr virus (EBV) DNAemia in the pre-emptive management of post-transplant lymphoproliferative disease (PTLD) in solid organ transplant (SOT) recipients. We investigated current preventive measures against EBV-related PTLD through a web-based questionnaire sent to 669 SOT programmes in 35 European countries. This study was performed on behalf of the ESGICH study group from the European Society of Clinical Microbiology and Infectious Diseases. A total of 71 SOT programmes from 15 European countries participated in the study. EBV serostatus of the recipient is routinely obtained in 69/71 centres (97%) and 64 (90%) have access to EBV DNAemia assays. EBV monitoring is routinely used in 85.9% of the programmes and 77.4% reported performing pre-emptive treatment for patients with significant EBV DNAemia levels. Pre-emptive treatment for EBV DNAemia included reduction of immunosuppression in 50.9%, switch to mammalian target of rapamycin inhibitors in 30.9%, and use of rituximab in 14.5% of programmes. Imaging by whole-body 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) is used in 60.9% of centres to rule out PTLD and complemented computer tomography is used in 50%. In 10.9% of centres, FDG-PET is included in the first-line diagnostic workup in patients with high-risk EBV DNAemia. Despite the lack of definitive evidence, EBV load measurements are frequently used in Europe to guide diagnostic workup and pre-emptive reduction of immunosuppression. We need prospective and controlled studies to define the impact of EBV monitoring in reducing the risk of PTLD in SOT recipients.

Published
2015

23. Porcine embryonic xenografts transgenic for CTLA4-Ig enable longterm recovery in parkinsonian macaques

Author

Badin, Ra, Padoan, A., Vadori, M., Boldrin, M., Giulia Maria De Benedictis, Fante, F., Sgarabotto, D., Jan, C., Daguin, V., Naveilhan, P., Neveu, I., Soullilou, Jp, Vanhove, B., Plat, M., Botte, F., Venturi, F., LUCA DENARO, Seveso, M., Manara, R., Zampieri, P., Avella, Domenico D., Rubello, D., Ancona, E., Hantraye, P., Cozzi, E., Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ura2210, Centre National de la Recherche Scientifique (CNRS), Universita di Padova, Consorzio per la Ricerca sul Trapianto di Organi, Partenaires INRAE, Azienda Ospedaliera di Padova, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, Università degli Studi di Padova = University of Padua (Unipd), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], XENOGREFFE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], HISTOLOGIE, [INFO] Computer Science [cs], EMBRYON TRANSGENIQUE, MACAQUE, ComputingMilieux_MISCELLANEOUS
Abstract

LB01; International audience

Published
2010

26. Transgenic porcine embryonic xenografts as a treatment for Parkinson's disease in non-human primates

Author

Aron, B.R., Padoan, A., Vadori, M., Boldrin, M., Cavicchioli, Lionel, de Benedictis, G.M., Fante, F., Seveso, M., Sgarabotto, D., Jan, Charlie, Daguin, V., Naveilhan, P., Neveu, I., Soulillou, J.P., Vanhove, B., Plat, Martine, Botté, Françoise, Venturi, Eric, Denaro, L., Manara, R., Zampieri, P., d'Avella, D., Rubello, D., Ancona, E., Hantraye, P., Cozzi, Elena, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ura2210, Centre National de la Recherche Scientifique (CNRS), Universita di Padova, Consortium for Research in Organ Transplantation (CORIT), Azienda Ospedaliera di Padova, Immunointervention dans les allo et xénotransplantations, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)-ITUN, Centre hospitalier universitaire de Nantes (CHU Nantes), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Università degli Studi di Perugia (UNIPG), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Padova = University of Padua (Unipd), Consorzio per la Ricerca sul Trapianto d'Organ = Consortium for Research in Organ Transplantation (CORIT), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Perugia = University of Perugia (UNIPG), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], XENOGREFFE, EMBRYON PORCIN TRANSGENIQUE, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

Communication orale LB IXA O-1; International audience

Published
2009

32. Current preventive strategies and management of Epstein–Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey

Author

San Juan, R, Manuel, O, Hirsch, Hh, Fernández Ruiz, M, López Medrano, F, Comoli, P, Caillard, S, Grossi, P, Aguado, Jm, Álamo Martínez JM, Anaya, F, Anttila, Vj, Arnol, M, Avolio, Aw, Baccarani, U, Castello, Ib, Boletis, I, Bonofiglio, R, Viamigliori, A, Bressollette, C, Brockmann, J, Pulido, Jc, Catalán, P, Christiansen, C, Cofan, F, Cordero, E, Leiro, Mc, Dantal, J, D'Armini, A, Delgado, Jf, Dello Strologo, L, Gesu, B, DI RAIMONDO, Francesco, Dierickx, D, Eis Hübinger, A, Kremer, Sf, Faggian, G, Fariñas, Mc, Folgueira, Md, Fontana, I, Franco, A, Furian, L, Garzoni, C, Ghirardo, G, Ginevri, F, Grinyó, J, Grossi, Pa, Gupte, G, Hansson, L, Helanterä, I, Herrero, Ji, Hobin, D, Hoffmann, D, Jan, L, Jarque, I, Jespersen, B, Kaczmarek, I, Klin, G, Kevin, P, Koneth, I, Kovac, D, Lacaille, F, Lautenschlager, I, Len, O, Lladó, L, Loy, M, Maeso, Ma, Marianne, Lv, Marsh, J, Meylan, P, Miñambres, E, Montejo, M, Mueller, N, Muñoz, P, Nadalin, S, Kamar, N, Nicolas, B, Olivier, D, Palomo, J, Pascual, M, Peter, J, Pierre, F, Portero, Mf, Provot, F, Boluda, Er, Regalia, E, Reina, G, Reuter, S, Ricart, Mj, García, Mr, Rollag, H, Russo, Fp, Sabé, N, Salcedo, M, Santambrogio, L, Seeman, T, Serra, N, Sgarabotto, D, Simonek, J, Thierry, Y, Thomsen, Mk, Tihic, N, Torre Cisneros, J, Travi, G, Tulissi, P, Moal, V, Veroux, Massimiliano, Santandreu, Av, Vizzini, G, Zibar, L., Clinicum, Department of Medicine, Infektiosairauksien yksikkö, Department of Virology, and Medicum

Subjects
Epstein-Barr Virus Infections, Cross-sectional study, Settore MED/18 - CHIRURGIA GENERALE, medicine.medical_treatment, Medizin, Epstein-Barr virus, Europe, Post-transplant lymphoproliferative disease, Pre-emptive treatment, Survey, Microbiology (medical), Infectious Diseases, medicine.disease_cause, Organ transplantation, Epstein–Barr virus, Surveys and Questionnaires, hemic and lymphatic diseases, Medicine, Tomography, TOR Serine-Threonine Kinases, Immunosuppression, General Medicine, Viral Load, pre-emptive treatment, X-Ray Computed, 3. Good health, Cross-Sectional Studies, Humans, Immunosuppressive Agents, Lymphoproliferative Disorders, Positron-Emission Tomography, Rituximab, Tomography, X-Ray Computed, Viremia, Organ Transplantation, Transplant Recipients, post-transplant lymphoproliferative disease, Viral load, medicine.drug, medicine.medical_specialty, survey, Internal medicine, business.industry, Immunology, 3111 Biomedicine, business, Solid organ transplantation, Serostatus
Abstract

There is limited clinical evidence on the utility of the monitoring of Epstein–Barr virus (EBV) DNAemia in the pre-emptive management of post-transplant lymphoproliferative disease (PTLD) in solid organ transplant (SOT) recipients. We investigated current preventive measures against EBV-related PTLD through a web-based questionnaire sent to 669 SOT programmes in 35 European countries. This study was performed on behalf of the ESGICH study group from the European Society of Clinical Microbiology and Infectious Diseases. A total of 71 SOT programmes from 15 European countries participated in the study. EBV serostatus of the recipient is routinely obtained in 69/71 centres (97%) and 64 (90%) have access to EBV DNAemia assays. EBV monitoring is routinely used in 85.9% of the programmes and 77.4% reported performing pre-emptive treatment for patients with significant EBV DNAemia levels. Pre-emptive treatment for EBV DNAemia included reduction of immunosuppression in 50.9%, switch to mammalian target of rapamycin inhibitors in 30.9%, and use of rituximab in 14.5% of programmes. Imaging by whole-body 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) is used in 60.9% of centres to rule out PTLD and complemented computer tomography is used in 50%. In 10.9% of centres, FDG-PET is included in the first-line diagnostic workup in patients with high-risk EBV DNAemia. Despite the lack of definitive evidence, EBV load measurements are frequently used in Europe to guide diagnostic workup and pre-emptive reduction of immunosuppression. We need prospective and controlled studies to define the impact of EBV monitoring in reducing the risk of PTLD in SOT recipients.

Published
2015
Full Text
View/download PDF

33. Comparison of Cytomegalovirus (CMV) Enzyme-Linked Immunosorbent Spot and CMV Quantiferon Gamma Interferon-Releasing Assays in Assessing Risk of CMV Infection in Kidney Transplant Recipients

Author

Abate, D., primary, Saldan, A., additional, Mengoli, C., additional, Fiscon, M., additional, Silvestre, C., additional, Fallico, L., additional, Peracchi, M., additional, Furian, L., additional, Cusinato, R., additional, Bonfante, L., additional, Rossi, B., additional, Marchini, F., additional, Sgarabotto, D., additional, Rigotti, P., additional, and Palu, G., additional

Published
2014
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35. Caspofungin for post solid organ transplant invasive fungal disease: results of a retrospective observational study

Author

Winkler, Matteo Maria, Pratschke, J, Schulz, U, Zheng, S, Zhang, Mengzhuo, Li, W, Lu, M, Sgarabotto, D, Sganga, Gabriele, Kaskel, P, Chandwani, S, Ma, L, Petrovic, J, Shivaprakash, M., Sganga, Gabriele (ORCID:0000-0001-5079-0395), Winkler, Matteo Maria, Pratschke, J, Schulz, U, Zheng, S, Zhang, Mengzhuo, Li, W, Lu, M, Sgarabotto, D, Sganga, Gabriele, Kaskel, P, Chandwani, S, Ma, L, Petrovic, J, Shivaprakash, M., and Sganga, Gabriele (ORCID:0000-0001-5079-0395)

Abstract

This study was designed to determine clinical outcomes with caspofungin in patients with proven or probable invasive fungal infection (IFI) after a solid organ transplant (SOT) procedure.

Published
2010

36. Primary breast lymphoma

Author

FABRIZIO VIANELLO, Sgarabotto, D., Stefani, P. M., Radossi, P., Sartori, R., Sartori, D., and Girolami, A.

Subjects
Adult, Aged, 80 and over, Adolescent, Lymphoma, Non-Hodgkin, Breast Neoplasms, Middle Aged, Prognosis, Disease-Free Survival, Survival Rate, Age Distribution, Primary breast lymphoma, Extranodal lymphoma, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Aged, Neoplasm Staging
Abstract

Breast involvement by non-Hodgkin lymphoma is uncommon. Differences between primary and secondary breast lymphoma have been well-defined. However, histopathological features, therapeutic approach and outcome are still debated. We report the clinical and pathological features of 5 cases of malignant lymphoma primarily involving the breast. The literature is extensively reviewed paying particular attention to pathological features, therapeutic approach and survival analysis. All patients were women; the median age was 63.2 yr. The clinical course was indistinguishable from that of breast carcinoma. High-grade lymphoma was found in 4 cases; T cell lineage antigens were expressed in one case. All patients were in stage I or II. Treatment consisted of chemotherapy and/or radiotherapy. The follow-up period ranged from 20 to 54 months (mean, 33.2). All patients are still in complete clinical remission. Analysis of the literature showed that about 80% of cases are high grade lymphoma. In this group, stage I at presentation statistically gives the best survival rate; surgery does not appear to have a role in high-grade lymphoma treatment.

Published
1999

46. Myelodysplastic syndrome and thrombocytosis: a random association?

Author

Tison, T., FABRIZIO VIANELLO, Radossi, P., Girolami, A., Sgarabotto, D., and Dazzi, F.

Subjects
Thrombocytosis, Anabolic Agents, Bone Marrow, Recurrence, Anemia, Refractory, Humans, Female, Middle Aged, Infections, Bone Marrow Diseases
Abstract

We describe a case characterized by the onset of bone marrow hypoplasia. After treatment with steroid and anabolic compounds, it evolved into a myelodysplastic syndrome (MDS) as demonstrated by morphological and karyotypic analysis. Despite the dysplastic nature of the disorder, a unique feature was its association with a high platelet count. The pathogenesis of the thrombocytosis could not be clearly identified. In fact, the course of the disease was complicated by severe infections that, together with therapy, could have played some role in stimulating thrombopoiesis. However, since MDS can precede or follow a chronic myeloproliferative disease, it is also possible that the platelet elevation in our patient could have been sustained by a primitive thrombocyte disorder.

Published
1994

47. LONGTERM CLINICAL RECOVERY IN PARKINSONIAN MONKEY RECIPIENTS OF CTLA4-IG TRANSGENIC PORCINE NEURAL PRECURSORS

Author

badin, Aron R., primary, Padoan, A., additional, Vadori, M., additional, Boldrin, M., additional, Cavicchioli, L., additional, De benedictis, G. M., additional, Fante, F., additional, Seveso, M., additional, Sgarabotto, D., additional, Jan, C., additional, Daguin, V., additional, Naveilhan, P., additional, Neveu, I., additional, Soulillou, J., additional, Vanhove, B., additional, Plat, M., additional, Bottè, F., additional, Eric, V., additional, Denaro, L., additional, Manara, R., additional, Zampieri, P., additional, Dʼavella, D., additional, Rubello, D., additional, Ancona, E., additional, Hantraye, P., additional, and Cozzi, E., additional

Published
2010
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