1. In silico dosimetry for a prostate cancer treatment using 198 Au nanoparticles.
- Author
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Angelocci LV, Sgrignoli SS, de Souza CD, Antunes PCG, Rostelato MECM, and Zeituni CA
- Subjects
- Humans, Male, Computer Simulation, Photons therapeutic use, Brachytherapy methods, Urinary Bladder radiation effects, Urinary Bladder pathology, Electrons therapeutic use, Prostate radiation effects, Prostate pathology, Radiotherapy Planning, Computer-Assisted methods, Rectum radiation effects, Rectum pathology, Prostatic Neoplasms radiotherapy, Gold chemistry, Phantoms, Imaging, Monte Carlo Method, Radiotherapy Dosage, Radiometry methods, Metal Nanoparticles therapeutic use, Metal Nanoparticles chemistry
- Abstract
Objective . To estimate dose rates delivered by using radioactive
198 Au nanoparticles for prostate cancer nanobrachytherapy, identifying contribution by photons and electrons emmited from the source. Approach . Utilizing in silico models, two different anatomical representations were compared: a mathematical model and a unstructured mesh model based on the International Commission on Radiological Protection (ICRP) Publication 145 phantom. Dose rates by activity were calculated to the tumor and nearby healthy tissues, including healthy prostate tissue, urinary bladder wall and rectum, using Monte Carlo code MCNP6.2. Main results . Results indicate that both models provide dose rate estimates within the same order of magnitude, with the mathematical model overestimating doses to the prostate and bladder by approximately 20% compared to the unstructured mesh model. The discrepancies for the tumor and rectum were below 4%. Photons emmited from the source were defined as the primary contributors to dose to other organs, while 97.9% of the dose to the tumor was due to electrons emmited from the source. Significance . Our findings emphasize the importance of model selection in dosimetry, particularly the advantages of using realistic anatomical phantoms for accurate dose calculations. The study demonstrates the feasibility and effectiveness of198 Au nanoparticles in achieving high dose concentrations in tumor regions while minimizing exposure to surrounding healthy tissues. Beta emissions were found to be predominantly responsible for tumor dose delivery, reinforcing the potential of198 Au nanoparticles in localized radiation therapy. We advocate for using realistic body phantoms in further research to enhance reliability in dosimetry for nanobrachytherapy, as the field still lacks dedicated protocols., (© 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)- Published
- 2024
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