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Excitons in monolayer transition metal dichalcogenide are endowed with intrinsic valley-orbit coupling between their center-of-mass motion and valley pseudospin. When trapped in a confinement potential, e.g., generated by strain field, we find that intralayer excitons are valley and orbital angular momentum (OAM) entangled. By tuning trap profile and external magnetic field, one can engineer the exciton states at ground state, and realize a series of valley-OAM entangled states. We further show that the OAM of excitons can be transferred to emitted photons, and these novel exciton states can naturally serve as polarization-OAM locked single photon emitters, which under certain circumstance become polarization-OAM entangled, highly tunable by strain trap and magnetic field. Our proposal demonstrates a novel scheme to generate polarization-OAM locked/entangled photons at nanoscale with high degree of integrability and tunability, pointing to exciting opportunities for quantum information applications., Comment: 10 pages, 5 figures

An accurate identification of poisonous mushrooms and the confirmation of the toxins involved are both of great importance in the treatment of mushroom poisoning incidents. In recent years, cases of mushroom poisoning by Inosperma spp. have been repeatedly reported from tropical Asia. It is urgent to know the real species diversity of Inosperma in this region. In the present study, we proposed two new Inosperma species from tropical Asia, namely I. muscarium and I. hainanense. They were described based on morphology and multilocus phylogeny. Detailed descriptions, color photographs and the discussion with other closely related species of the two new taxa were provided. In addition, a comprehensive muscarine determination of these two new species using ultrahigh performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) approach has been performed. Results showed that these two species were muscarine positive, with a content of 16.03 ± 1.23 g/kg in I. muscarium and a content of 11.87 ± 3.02 g/kg in I. hainanense, much higher than the known species I. virosum. Recovery of muscarine ranged from 93.45% to 97.25%, and the average recovery is 95.56%.

In the past two decades, the concept of microbial resources evolved from the conserved strains in culture collection centers and microbial genome data in databases to functional microbial consortia, strains with superior phenotypes, novel biochemical and signaling systems, highly efficient enzymes, secondary metabolites, and unique genetic traits. Natural and engineered water environments provide diverse ecological niches for microorganisms to evolve and thrive, serving as treasure troves of microbial resources. Compared with that of chemical and energy resources from water, mining of microbial resources is severely underexplored. In this review, we first summarize various approaches (e.g., cultivation, functional metagenomics, and single-cell genomics) that have been employed to mine microbial resources from water, and then discuss their distinctive advantages and limitations. Lastly, we explore future directions on the mining of microbial resources from water. Nanyang Technological University National Research Foundation (NRF) This research / project is supported by the National Research Foundation, Singapore, under its NERC-NRF Joint Grant Call (Award no. NRF-NERC-SEAP-2020-02). This research is also supported by the Accelerating Creativity and Excellence (ACE) grant (Award no. NTUACE2021-01), Nanyang Technological University, Singapore.

Extensive consumption of cobalt in the chemical field such as for battery materials, alloy, pigments, and dyes has aggravated the pollution of cobalt both in food and the environment, and assays for its on-site monitoring are urgently demanded. Herein, we utilized enzyme dependence on metal cofactors to develop terminal transferase (TdT) as a recognition element, achieving a one-pot sensitive and specific assay for detecting cobalt pollution. We engineered a 3'-OH terminus primer to improve the discrimination capacity of TdT for Co

Background Previous studies have revealed that ventrolateral orbital cortex (VLO) may play an important role in the regulation of emotional behavior. However, it is not known what effect VLO damage will have on emotion regulation. Results Data showed that damage of VLO increased the anxiety-like behavior in open field test and elevated plus maze, and decreased the depressive behavior in forced swimming test and learned helplessness test. Besides, the impulsive aggressive behaviors were also increased while the attack latency decreased after VLO lesion. What’s more, damage of VLO decreased depressive behaviors induced by chronic unpredicted mild stress in rats. Conclusions These results suggest that the integrity of VLO plays an important role in emotional regulation, and the damage of VLO may inhibit the development of depression-like behavior.

Foodborne pathogen infection is a key issue of food safety. Herein, we developed a label-free assay for Salmonella enterica (S. enterica) detection based on the G-quadruplex-probing CRISPR-Cas12 system (termed G-CRISPR-Cas), allowing highly sensitive detection of S. enterica and investigation of their colonization in chickens. The introduction of the G-quadruplex probe serving as the substrate of Cas 12a realized a label-free analysis for foodborne pathogens. Due to the amplification process induced by loop-mediated isothermal amplification (LAMP), G-CRISPR-Cas assay can detect S. enterica as low as 20 CFU. Specificity for pathogenic gene detection was guaranteed by the dual recognition process via LAMP primers and Cas 12a-guided RNA binding. The G-CRISPR-Cas assay was applied to explore S. enterica colonization in the intestinal tract and organs of chickens and showed the risk of S. enterica infection outside of the intestinal tract. The G-CRISPR-Cas assay is promising for on-site diagnosis of the infection or contamination of foodborne pathogens outside the laboratories, such as abattoirs and markets.

MicroRNAs (miRNAs) play key roles in biological processes in plants, such as stress resistance, yet can hardly be quantified by an enzyme-involved terminal polymerization process due to their 2'-O-methyl modifications at the 3'-terminal. Herein, we proposed a CRISPR/ Cas14 a-based r olling circle amplification (termed Cas14R) assay, allowing reverse transcription-free and demethylation-free detection of plant miRNAs with single-nucleotide resolution. The employment of target-templated rolling circle amplification circumvents the extension of the unaccessible 2'-O-methyl group at the 3'-terminal. Particularly, the activated Cas14a confers the trans-cleavage activity for identifying target single-stranded DNA sequences without the necessity of the protospacer adjacent motif, generalizing the detection of miRNA sequences and the integration of different isothermal amplification techniques. Ultimately, the Cas14R assay has been applied to profile miR156a to evaluate the ripeness process of banana, indicating its feasibility in analyzing the roles of miRNAs in biological processes of plants.

The halal food market is globally growing along with the increased risk of adulteration. We proposed an amplification-free and mix-to-read CRISPR-Cas12-based nucleic acid analytical strategy allowing rapid identification and analysis of pork components, thus enriching the toolbox for ensuring halal food authenticity. We designed and optimized guide RNA (gRNA) targeting the pork cytochrome b (Cyt b) gene. gRNA allowed specific identification of the target Cyt b gene from pork components followed by activation of Cas12 protein to abundantly cleave single-stranded DNA probes with terminally labeled fluorophore and quencher groups, thus turning on fluorescence. The presence of the pork Cyt b gene thus can be mix-and-read- and only-one-step-detected, which may indicate the risk of halal food adulteration. The method allowed specific discrimination of pork meat from beef, mutton, and chicken and yielded a detection limit of 2.7 ng/μL of total DNA from pork meat. The reliability of the method was tested using the following processed meat products: halal foods beef luncheon meat and spiced beef and non-halal foods sausage and dried pork slices. The CRISPR-Cas12-based nucleic acid test strategy is promising for rapid food authentication.

To expound the relationship between bioleaching behaviors and mineralogical properties of pristine pyrite samples, chemical compositions, semiconductive properties, surface morphologies, and chemical species of synsedimentary pyrite (SSP) and mesothermal pyrite (MTP) were compared, accompanying with bioleaching behaviors analysis by three thermophiles. Mineralogical characterizations showed that both pyrites belonged to p-type semiconductors with an S/Fe ratio higher than 2, and the arsenic content in MTP was as high as 0.6%. The fractured surface of SSP had more kinks and steps, and higher concentrations of S2- and oxides, as compared with that of MTP. Bioleaching results indicated that SSP was leached faster than MTP. The more kinked and stepped structures and the larger contents of S2- and oxides on pyrite surfaces were the dominant reasons for the faster bioleaching kinetics of SSP. The high arsenic content in MTP limiting the cell growth was another cause for its slower leaching.

This study investigated the electrochemical oxidation behaviors of arsenopyrite in sulfuric acid (pH 1) containing various concentrations of ferric ions by cyclic voltammetry, Tafel polarization cu...

Hypertensive kidney injury (Hki) is one of the most common complications of hypertension. Early prevention and treatment of renal injury in patients with hypertension is great significance. The study, which used an integrated ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS) analysis, network pharmacology approach, and plasma metabolomics, aimed to discover the active ingredients and therapeutic mechanisms of Eucommiae folium (Ef) in treating Hki. The chemical components of Ef were analyzed by UPLC-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS), and the "compound-target-disease" network was constructed by screening the closely related drug targets from the drug-target database, then the signaling pathways related to Hki were analyzed. Finally, the enzyme-linked immunosorbent assay (ELISA) and real-time quantitative reverse-transcription polymerase chain reaction were used to test and verify the key targets in the common pathways of metabolomics and network pharmacology. The results indicated that Eucommiae folium might play an excellent role in treating Hki, likely through regulating the vascular endothelial growth factor signaling pathway, hypoxia inducible factor 1 (HIF-1) signaling pathway, and glycerophospholipid metabolism pathway, which were validated by increasing levels of nitric oxide, endothelial nitric oxide synthase and reducing levels of endothelin 1, angiotensin II, renin, cyclic guanosine monophosphate, blood urea nitrogen, and serum creatinine, as well as the reduced gene expression of Ache, Ddah2, Egfr, Lcat, Pla2g2a, Stat3 and Vegfa. The study systematically explored the protective mechanisms of Ef against Hki and also provided the practical treatment strategies of Hki from the Chinese herb.

Bacillus cereus is a Gram-positive endospore-forming foodborne pathogen that causes lethal food poisoning and significant economic losses, usually through biofilm- and endospore-induced recurrent cross- and postprocessing contamination. Due to the lack of critical inhibitory targets and control strategies, B. cereus biofilm contamination is a problem that urgently needs a solution. In this study, the antibacterial and antibiofilm activities of several natural potential bacterial quorum sensing (QS) interferers, a group of spice-originated monoterpenoids, were screened, and terpinen-4-ol effectively inhibited B. cereus growth and biofilm and spore germination with minimum growth inhibition and 50% biofilm inhibitory concentrations of 8 and 2 μmol/mL, respectively. FESEM/CLSM and phenotypic research illustrated that in addition to a decrease in the number of attached B. cereus cells, (+)-terpinen-4-ol also obviously reduced extracellular matrix synthesis, especially exopolysaccharides, and inhibited the swarming motility and protease activity of B. cereus. (+)-Terpinen-4-ol did not exert a significant effect on AI-2 signals in B. cereus. Accordingly, the B. cereus-produced interspecies QS signals diffusing signal factors (DSFs, C8-C15) and diketopiperazines (DKPs) were detected and identified here, which suppressed B. cereus biofilm formation in a concentration-dependent manner. (+)-Terpinen-4-ol significantly increased the levels of specific DSF and DKP signals in B. cereus and down-regulated the gene expression of some rpfB homologues in transcription level. Moreover, both DKPs and DSFs inhibited swarming motility and protease activity in B. cereus, while just the DSF signals 2-dodecenoic acid and 11-methyl-2-dodecenoic acid inhibited exopolysaccharide synthesis like (+)-terpinen-4-ol. In summary, B. cereus strains were found to produce nine DSF- and six DKP-type QS signaling molecules, which repressed B. cereus biofilm formation. (+)-Terpinen-4-ol was confirmed to be a promising antibacterial and antibiofilm agent against B. cereus upregulating DSFs and DKPs levels, and it could target the critical genes rpfB for DSFs turnover.

Mallocybe is a newly elevated genus of the ectomycorrhizal mushroom family, Inocybaceae, based on Inocybe subg. Mallocybe. Although new species in this genus have constantly been discovered worldwide during the past decades, species native to China is poorly documented. Moreover, as a characteristic feature, members of this genus often have phaseoliform basidiospores and short catenated cheilocystidia. Therefore, this study describes three new Chinese Mallocybe species with elongated cheilocystidia through morphological and molecular analyses. Of the identified species, while M. pallidipes was collected from Populus in northeastern China, M. aurantiodisca was discovered in subtropical evergreen broad-leaved forests dominated by Castanopsis in the Zhejiang Province, and M. longsicystis was discovered under fagaceous forests in tropical and subtropical China. From the multi-gene phylogenetic analysis, four major clades were also elucidated in the genus, of which three new species were grouped with three North American species in a full support clade. Finally, we discussed the systematic position of the new species and the genus's infrageneric phylogeny.

For utilisation of solar energy, the development of form-stable phase change material (PCM) composites with excellent flame retardancy and superior solar–thermal conversion performance is critical. Here, by incorporating dopamine-decorated black phosphorus nanosheets (PDA@BP) into polyethylene glycol-based polyurethane (PEG-PU), novel form-stable PCM composites (PBPCMs) having superior solar–thermal conversion performance and excellent flame retardancy were fabricated. PDA@BP, covalently bonded to PEG-PU, acted as an efficient photothermal filler to capture solar energy and convert it to thermal energy, while PEG-PU absorbed and stored the thermal energy via phase transition. A light irradiation experiment and thermal conductivity test demonstrated that introducing PDA@BP effectively improved the solar–thermal conversion efficiency (up to 88.5%) and thermal conductivity (69.4% increase) of PCM composites. Moreover, by introducing PDA@BP into PBPCMs, the total heat release and heat release rate decreased considerably, while the limiting oxygen index value and char yield increased, demonstrating the considerably enhanced flame retardancy of PCM composites. PBPCMs with superior solar–thermal conversion performance and excellent flame retardancy show considerable potential in the solar–thermal conversion and storage field.

Mercury, as a global toxic pollutant, is easy to be accumulated in aquatic products and poses a great threat to human health. In this work, we proposed a mix-to-read, label-free, and robust assay for detecting mercury pollution in aquatic products by engineering a ratiometric-enhanced G-quadruplex probe. The transformation from the G-quadruplex to a hairpin-like structure allows us to confer a ratiometric and leveraged response to Hg2+, amplifying the signal-to-background ratio for Hg2+ detection. Hg2+ response was further improved by screening parallel- and antiparallel-, single-, and multiple-stranded G-quadruplex structures. Compared to the common aptamer probes, the ratiometric-enhanced G-quadruplex probe increased the sensitivity for Hg2+ detection by 4.7 times. This proposed sensing system allowed a simple and one-tube homogenous detection of Hg2+ at room temperature using a single unlabeled DNA sequence. Its application for Hg2+ detection in fish and shrimp conferred satisfactory recovery rates ranging from 98.5 to 105.9%. The label-free and mix-to-read assay is promising for the onsite detection of mercury pollution and facilitating food safety of aquatic products.

Antibiotic abuse in agricultural products leads to serious food safety issues. To this end, we proposed a mix-and-read and enzyme-free amplified assay for antibiotics based on a dual triple helix-aptamer probe, potentially applicable for on-site monitoring of antibiotic residues. A dual triple helix-aptamer probe can leverage the response toward target molecules without enzyme-based amplification, rendering it sensitive and robust for profiling target molecules. The proposed assay allowed mix-and-read detection of chloramphenicol with a detection limit of 0.18 nM. Besides, it accommodated for specifically resolving chloramphenicol among other antibiotics. Chloramphenicol residual in aquatic products in fish and milk can be precisely determined. Thus, the aptamer probe deems to enrich the toolbox for managing antibiotic use.

Mycotoxins are the most toxic component and pose a major threat to human health. Monitoring mycotoxins in living cells is essential for their toxicology research; however, tools for the live-cell imaging of mycotoxins remain unexplored. Herein, we proposed a conformation-resolved aptamer nanoprobe (cresAptamer), allowing us to image mycotoxins in living cells. cresAptamer endows a dual recognition mechanism: binding-induced detachment from nanocarriers and response of intrinsic G-quadruplex of aptamers. The dual recognition mechanism allows us to resolve conformations of aptamer probes corresponding to nonspecific binding and target binding, thus sufficiently supporting the specific identification of target molecules in a complex matrix. cresAptamer significantly improved the signal-to-background ratio for detecting ochratoxin A (OTA), thus allowing us to sensitively and robustly image ochratoxin A in living cells. cresAptamer would be a facile tool for dynamically investigating the toxicology of mycotoxins at the single-cell level.

Microfluidic paper-based analytical devices (µPADs) take the paper as a base material and integrate nanoscale microchannel on it for multiple detections. Its unique properties like low cost, portability, simple operation, and easy to save make it better than the traditional microfluidic chips. While designed originally for point-of-care medical diagnostics, µPADs have attracted the attention of many researchers in the fields of environmental monitoring, water quality, and food safety. The novelty of this paper is to present a detailed overview of µPADs for clinical applications. Firstly, a brief introduction to production methods, characteristics, and applications of these methods have been given. Secondly, the basic implementation, working principles, and corresponding performance of detection methods of clinical devices have been discussed, which enable the µPADs to detect biomarkers, human cells, bacteria, and viruses in a short time. Lastly, the factors that limit µPADs commercial applications, and their future research directions have also been briefly summarized.

The development of organic phase change materials (PCMs) with large energy storage capacity, high thermal conductivity, and satisfactory solar-thermal conversion performance is critical for large-scale solar energy utilization. Here, novel composite PCMs based on poly(ethylene glycol) (PEG), nanofibrillated cellulose (NFC), and graphene were successfully fabricated by impregnating PEG into PEG-grafted NFC/graphene hybrid aerogels (GA/NFC-g-PEG). The GA/NFC-g-PEG with three-dimensional interconnected porous structures well supported the PEG within the nanostructural frameworks and effectively prevented the leakage and diffusion of PEG above its melting point. Grafting of PEG onto NFC was performed to improve the affinity between PEG and NFC/graphene hybrid aerogels, which significantly increased the PEG loading capacity of the CNF-g-PEG/graphene aerogel and prevented the leakage of PEG. Differential scanning calorimetry result showed that the as-prepared composite PCMs possessed extremely high melting enthalpies ranging from 185.5 to 187.4 J/g. The hot stage-digital camera test and thermogravimetric analyses showed that the composite PCMs exhibited excellent form-stability and thermal stability. Moreover, the introduction of graphene significantly increased the thermal conductivity and solar-thermal conversion efficiency of the composite PCMs. In conclusion, the synthesized composite PCMs showed tremendous potential for thermal energy storage applications.

Organic phase change materials (PCMs) have attracted increasing attention in the solar energy utilization field for their large thermal energy storage density, appropriate phase transition temperat...

As a result of molecular phylogenetic analyses and morphological studies, two new species of the genus Pseudosperma, namely P. fulvidiscum and P. singulare were discovered in Wuzhishan Nature Reserve of Hainan Province of China. The two new species are distinct from other known Pseudosperma species in the phylogenetic polygram inferred from a combined nuclear ribosomal internal transcribed spacer region (ITS), the nuclear ribosomal large subunit (nrLSU), and the nuclear second-largest subunit of RNA polymerase II (RPB2) sequence data. Muscarine contents of the two new species were detected using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach. In addition, a new combination was proposed based on phylogenetic evidences.

The male flowers of Eucommia ulmoides Oliv. (MFEU) was a natural product that could alleviate fatigue and accelerate fatigue alleviation. Nonetheless, the active ingredients and underlying pharmacological mechanisms remain unknown. This study aimed to decode the active ingredients and potential action mechanisms of MFEU in the therapy of anti-fatigue using an integrated UPLC-MS analysis, network pharmacology approach, and cell experiments. Characterizations of chemical constituents of MFEU extract were identified by UPLC-Q-TOF-MS. The corresponding drug targets were retrieved from the drug target database and used to construct the "composite-target-pathway" network. The Cytoscape was used to identify potential protein targets of these MFEU components, indicating that 24 anti-fatigue compounds in MFEU regulate 18 anti-fatigue-related targets in 10 signaling pathways. The 16 components of MFEU were verified at the cellular level. The results of cell experiments showed that MFEU extract (0.361 μg/ml), Caffeic acid, Deacetylasperulosidic acid, Naringenin, Acanthoside B, Geniposidic acid, Rutin, and Quercetin could promote testosterone secretion on Leydig cells at 50 μM. The MFEU extract and seven compounds in MFEU might play a role in anti-fatigue by participating in the regulation of testosterone secretion. Finally, the results of PCR analysis showed that MFEU promotes the secretion of testosterone, which is related to CYPIIa1 and 17β-HSD, STAR in the signal pathway of testosterone synthesis. This study provides a basis for further exploring the anti-fatigue mechanism of MFEU, adopting the method of multi-compound and multi-target.

Currently, mushroom poisoning still poses a huge problem to humans' health and life globally. Poisoning incidents caused by

The exploitation of from-stable phase change materials (PCMs) with superior energy storage capacity and excellent solar-thermal conversion performance is crucial for the efficient exploitation of solar energy. Herein, 2D-layered polymerized dopamine-decorated Ti

Paxillin is one of the most important adapters in integrin-mediated adhesions that performs numerous crucial functions relying on its dynamic interactions. Its structural behavior serves different purposes, providing a base for several activities. The various domains of paxillin display different functions in the whole process of cell movements and have a significant role in cell adhesion, migration, signal transmission, and protein-protein interactions. On the other hand, some paxillin-associated proteins provide a unique spatiotemporal mechanism for regulating its dynamic characteristics in the tissue homeostasis and make it a more complex and decisive protein at the focal adhesions. This review briefly describes the structural adaptations and molecular mechanisms of recruitment of paxillin into adhesions, explains paxillin's binding dynamics and impact on adhesion stability and turnover, and reveals a variety of paxillin-associated regulatory mechanisms and how paxillin is embedded into the signaling networks.

Moir\'e exciton features tunable Dirac dispersion and spatially dependent optical selection rules. With the long lifetime due to its interlayer nature, it is promising to realize a Bose-Einstein condensation of moir\'e excitons. Here we study the properties of moir\'e exciton condensate within the mean-field theory, with special focus on exciton-exciton interaction effect on the nonlinear Bloch band and Bloch waves of exciton condensate in moir\'e potential. We find the nonlinear dispersion of the moir\'e exciton condensate exhibits complex loop structure induced by exciton-exciton interaction. A nonlinear Dirac cone emerges at $\boldsymbol{\Gamma}$ point of the Bloch band, with a three-fold degenerate nonlinear Dirac point. Each degenerate Bloch wave at nonlinear Dirac point spontaneously breaks $C3$ rotational symmetry of the moir\'e potential, and themselves differ by $C3$ rotations. Since they reside in the light cone, these nontrivial Bloch band structure and broken-symmetry Bloch waves can be experimentally detected by examining light emission from those states. Symmetry breaking of Bloch states implies unusual optical selection rules compared with single exciton case: moir\'e exciton condensate at $\boldsymbol{\Gamma}$ point emits light with all three components of polarization instead of only left or right circular polarization. We further propose that, by applying in-plane electric field on one layer to drive an initially optically dark exciton condensate towards light cone, the light polarization of final states as well as their dependence on field direction serves as the smoking gun for experimental observation., Comment: 7 pages, 6 figures. Comments are welcome

Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumour suppressor and is closely associated with many neuropsychiatric disorders, including major depressive disorders. In addition, HINT1 knockout (KO) mice exhibit anxiolytic-like behaviour, antidepression-like behaviour, and enhanced cognitive performance in several studies. However, it is still unclear whether aging contributes to these changes in the emotion and cognition of HINT1 KO mice. This study examined the role of aging in anxiety-like and depression-like behaviours and cognition behaviours in aged HINT1 KO mice compared with young HINT1 KO mice and their wild-type littermates, along with a number of molecular biological methods. In a battery of behavioural tests, aged wild-type mice showed increased anxiety-like and depression-like behaviours and decreased cognitive performance, along with lower expression levels of glutathione peroxidase, enhanced amount of malondialdehyde, and decreased expression levels of brain-derived neurotrophic factor and tyrosine kinase B in the hippocampus and PFC compared to young wild-type mice. HINT1 KO mice showed reduced anxiety-like and depression-like behaviours and enhanced cognitive performance compared to age-matched wild-type mice. In addition, HINT1 KO mice also showed increased GSH-Px and superoxide dismutase, and decreased malondialdehyde, together with enhanced BDNF and Trk-B expression in the hippocampus and PFC. However, when compared with young HINT1 KO mice, aged HINT1 KO mice did not show increased anxiety-like and depression-like behaviours. And there are no differences in the expression level of superoxide dismutase, malondialdehyde, BDNF, and Trk-B between aged and young HINT1 KO mice. In summary, HINT1 deficiency can counteract age-related emotion and cognition dysfunction.

Conventional polymeric phase change materials (PCMs) exhibit good shape stability, large energy storage density, and satisfactory chemical stability, but they cannot be recycled and self-healed due to their permanent cross-linking structure. Additionally, the high flammability of organic PCMs seriously restricts their applications for thermal energy storage (TES). Therefore, it is urgently required to explore PCM composites exhibiting superior recyclability, good self-healing capability, and excellent flame retardancy simultaneously. Herein, tri-maleimide end-capped cyclotriphosphazene flame retardant (TMCTP) was synthesized via the nucleophilic substitution between 1,3,5,2,4,6-triazatriphosphorine-2,2,4,4,6,6-hexachloride and N-(2-hydroxyethyl)maleimide. Then, novel dynamically cross-linked PCM composites (FPCMs) with superior recyclability, good self-healing capability, and excellent flame retardancy were fabricated by bonding PEG and TMCTP to polymeric skeleton via reversible furan/maleimide Diels-Alder (DA) reaction. TMCTP, which covalently and dynamically binding in the polymeric FPCMs, acted not only as an efficient flame retardant for reducing the flammability of PCM composites but also as dynamic cross-linking skeletons for thermally induced self-healing and recycling. Differential scanning calorimetry (DSC) analysis confirmed the reversible energy storage and release ability of FPCMs. Due to its reversible DA covalent bonds, the introduction of TMCTP endowed the FPCMs with considerably increased self-healing efficiency (up to 93.1%) and recyclability efficiency (94.6%). Moreover, with the introduction of TMCTP into FPCMs, the heat release rate (HRR) and total heat release (THR) significantly decreased, while the char residue and limiting oxygen index (LOI) value increased, confirming that the flame retardancy of FPCMs greatly improved. Hence, the synthesized FPCMs show enormous potential in TES applications.