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3. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex

Author

Makhani, Naila, Lebrun-Frenay, Christine, Siva, Aksel, Shabanova, Veronika, Wassmer, Evangeline, Santoro, Jonathan D., Narula, Sona, Brenton, J. Nicholas, Mar, Soe, Durand-Dubief, Francoise, Zephir, Helene, Mathey, Guillaume, Rojas, Juan I., de Seze, Jerome, Tenembaum, Silvia, Stone, Robert Thompson, Casez, Olivier, Carra-Dallière, Clarisse, Neuteboom, Rinze F., Ahsan, Nusrat, Arroyo, Hugo A., Cabre, Philippe, Gombolay, Grace, Inglese, Matilde, Louapre, Celine, Margoni, Monica, Palavra, Filipe, Pohl, Daniela, Reich, Daniel S., Ruet, Aurélie, Thouvenot, Eric, Timby, Niklas, Tintore, Mar, Uygunoglu, Ugur, Vargas, Wendy, Venkateswaran, Sunita, Verhelst, Helene, Wickstrom, Ronny, Azevedo, Christina J., Kantarci, Orhun, Shapiro, Eugene D., Okuda, Darin T., and Pelletier, Daniel

Published
2024
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4. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies

Author

Faustino, E. Vincent S., Kandil, Sarah B., Leroue, Matthew K., Sochet, Anthony A., Kong, Michele, Cholette, Jill M., Nellis, Marianne E., Pinto, Matthew G., Chegondi, Madhuradhar, Ramirez, Michelle, Schreiber, Hilary, Kerris, Elizabeth W. J., Glau, Christie L., Kolmar, Amanda, Muisyo, Teddy M., Sharathkumar, Anjali, Polikoff, Lee, Silva, Cicero T., Ehrlich, Lauren, Navarro, Oscar M., Spinella, Philip C., Raffini, Leslie, Taylor, Sarah N., McPartland, Tara, Shabanova, Veronika, Faustino, E. Vincent S., Holtz, Laura, McPartland, Tara, Soo, Zi Kai, Kandil, Sarah, Raffini, Leslie, Silva, Cicero, Spinella, Philip, Taylor, Sarah, Shabanova, Veronika, McCullom, Sarah, Silva, Cicero T., Ehrlich, Lauren, Navarro, Oscar M., Barbaro, Ryan, Jaffray, Julie, Warren, Joshua, Sharathkumar, Anjali, Polikoff, Lee, Leroue, Matthew K., Arellano, Venessa Hoppes, Andreaco, Alix, Baig, Natasha, Burke, Ellen, Carpenter, Todd, Dailey, Lanae, Elozory, Allie, Enabulele, Obehi, Furleng, Christiane, Gonzales, Kristen, Gordon, Katie, Gordon, Sharon, Greer, Rachel, Grimsley, Allison, Jones, Rachel, Landis, Michelle, Laurin, Jaime, Lipani, Emily, Maddux, Aline, Mansour, Rachel, Merrow, Mya, Patruccelli, Lexi, Port, Emily, Sauceda, Heidi, Shields, Elizabeth, Sierra, Yamila, Stenson, Erin, Stewart, Christine, Tutman, Jeffrey, Wilson, Patrick, Valenzuela, Ariana, Zorensky, Frances, Glau, Christie L., Arroyo, Teresa, Burnett, Ryan, Bush, Jenny, Dickey, Shawn, Douglas, Rebecca, Edioma, Glory, Famularo, Stephen, Fitzgerald, Julie, Himebauch, Adam, Juste, Nola, Levow, Cindee, McKelvey, Alanah, Sivarupan, Myooran, Slocumb, Taylor, Tizhe, Wandave, Tolkacheva, Katie, Tupil, Krithika, Nguyen, Vu, Scott, Megan, Kolmar, Amanda, Archie-Dilworth, Jessie, Kramer, Michael, Stone, Pamela, Schreiber, Hilary, Privatt, Miranda, Shad, Sadaf, Kong, Michele, Colston, Candice, Kelley, Heather, Murdock, Meghan, Cholette, Jill M., Taillie, Eileen Root, Ramirez, Michelle, Deygoo, Sandra, Groves, Kelley, Hennigan, Claire, McKinstry, Jacklyn, Martinez, Michael, Michos, Rosa, Shah, Ami, Spilios, Maria, Sochet, Anthony A., Babushkin, Tamara, Cree, Hanna, Dallas, Lexie, Nievas, I. Federico F., Teppa, Beatriz, Pinto, Matthew G., Korn, Sarah, Levasseur, Julie, Politano, Serè, Muszynski, Jennifer, Steele, Lisa, Nellis, Marianne E., Chung, Liliko, Cormack, Margaret, Svezhenets, Oleksiy, Muisyo, Teddy M., Allen, Christine, Anderson, Ashley, Huebner, Karl M., Jones, Tracy, Mitchell, Katherine, Taylor, Kaci, Kerris, Elizabeth, Hamilton, Hannah, Spears, Debra, Thomas, Neal, Chegondi, Madhuradhar, Austin, Maureen, Rao, Mahil, Faustino, E. Vincent S., Blalock, Shelby, Ecarma, Michelle, Hayes, Nancy, Kandil, Sarah, Kluko, Matthew, Quinn, Tyler, and Silva, Cicero T.

Published
2024
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10. Parenting Stress and Its Associated Components Prior to an Autism Spectrum Disorder (ASD) Diagnostic Evaluation

Author

Voliovitch, Yair, Leventhal, John M., Fenick, Ada M., Gupta, Abha R., Feinberg, Emily, Hickey, Emily J., Shabanova, Veronika, and Weitzman, Carol

Abstract

Parents of children with autism spectrum disorder (ASD) show increased levels of parenting stress, but only one study has examined this association before a diagnostic evaluation. We conducted a cross-sectional study of parenting stress in 317 low SES parents with children at-risk for ASD before a diagnostic evaluation. Multiple regression modeling evaluated the associations between parenting stress and parent and child factors. Parenting stress was negatively associated with social support and positively associated with active avoidance coping and parental worry. However, parenting stress was not associated with the child's ASD symptom severity or adaptive functioning, except for self-direction. Findings suggest parenting stress among parents of children at risk of ASD should be assessed prior to diagnosis. [This study was conducted in collaboration with the Developmental and Behavioral Pediatrics Research Network (DBPNet).]

Published
2021
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13. Does Maternal Incarceration Impact Infants with Neonatal Abstinence Syndrome?

Author

Drago, Matthew J., Shabanova, Veronika, Hochreiter, Daniela, Grossman, Matthew, and Mercurio, Mark

Subjects
Women prisoners -- Health aspects, Mother and infant -- Health aspects, Prenatal drug exposure -- Complications and side effects, Health care industry
Abstract

Objectives Opioid exposed infants born to incarcerated women represent a vulnerable and understudied subset of infants with neonatal abstinence syndrome (NAS). The impact of maternal incarceration on length of stay (LOS) for infants with NAS is unknown. We hypothesized that infants with NAS born to incarcerated women have longer hospitalizations compared to infants with NAS born to non-incarcerated women. Methods This is a retrospective cohort study of infants with NAS born between 2011 and 2018 at the primary delivery site for Connecticut's only women's prison. Opioid exposed infants were assessed by Finnegan Scores for withdrawal and received morphine as a first line agent and phenobarbital as a second line agent. LOS was compared using Poisson regression. Results Of 206 infants identified, 166 were included in the analysis, with 28 born to incarcerated women and 138 to non-incarcerated women. Incarcerated women were more likely to report prenatal alcohol use, 14.3% vs 2.2% p = 0.016 and benzodiazepine use 21.4% vs 7.3% p = 0.032. Infants of incarcerated women were less likely to be fed breast milk at discharge, 3.6% vs 37% p < 0.001. Adjusted mean LOS was longer among infants born to incarcerated women, 18.5 vs 16.6 days (p = 0.009). Conclusions for Practice Infants with NAS born to incarcerated women in Connecticut had longer LOS, lower rates of being fed breast milk, and different prenatal substance exposures than infants with NAS born to non-incarcerated women. Supporting the maternal-infant dyad until infant discharge may mitigate the potential negative impact of maternal incarceration on the care of infants with NAS., Author(s): Matthew J. Drago [sup.1] [sup.4] , Veronika Shabanova [sup.2] , Daniela Hochreiter [sup.3] , Matthew Grossman [sup.3] , Mark Mercurio [sup.1] Author Affiliations: (1) grid.47100.32, 0000000419368710, Department of Pediatrics, [...]

Published
2022
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18. Performance of the 2023 Adult Criteria for the Radiologically Isolated Syndrome in Children and Comparison to the 2009 Criteria (P4-6.007)

Author

Makhani, Naila, primary, Frenay, Christine Lebrun, additional, Siva, Aksel, additional, Shabanova, Veronika, additional, Wassmer, Evangeline, additional, Santoro, Jonathan, additional, Narula, Sona, additional, Brenton, James, additional, Mar, Soe, additional, Dubief, Francoise Durand, additional, Zephir, Helene, additional, Mathey, Guillaume, additional, Rojas, Juan Ignacio, additional, De Seze, Jerome, additional, Tenembaum, Silvia, additional, Thompson-Stone, Robert, additional, Casez, Olivier, additional, Carra-Dalliere, Clarisse, additional, Neuteboom, Rinze F., additional, Ahsan, Nusrat, additional, Arroyo, Hugo, additional, Cabre, Philippe, additional, Gombolay, Grace, additional, Inglese, Matilde, additional, Louapre, Celine, additional, Margoni, Monica, additional, Palavra, Filipe, additional, Pohl, Daniela, additional, Reich, Daniel, additional, Ruet, Aurelie, additional, Thouvenot, Eric, additional, Timby, Niklas, additional, Tintore, Mar, additional, Uygunoglu, Ugur, additional, Vargas, Wendy, additional, Verhelst, Helene, additional, Wickstrom, Ronny, additional, Azevedo, Christina, additional, Kantarci, Orhun, additional, Shapiro, Eugene, additional, Okuda, Darin, additional, and Pelletier, Daniel, additional

Published
2024
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36. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections

Author

Nigrovic, Lise E., Browning, Whitney L., Mitchell, Christine E., Peaper, David R., Feldman, Elana A., Pruitt, Christopher M., Neuman, Mark I., Shah, Samir S., Shabanova, Veronika, Woll, Christopher, Wang, Marie E., Alpern, Elizabeth R., Williams, Derek J., Sartori, Laura, Desai, Sanyukta, Leazer, Rianna C., Marble, Richard D., McCulloh, Russell J., DePorre, Adrienne G., Rooholamini, Sahar N., Lumb, Catherine E., Balamuth, Fran, Shin, Sarah, and Aronson, Paul L.

Published
2019
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37. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence.

Author

Adu-Gyamfi, Raphael, Enos, Juliana, Yeboah, Kwame, Shabanova, Veronika, Hawley, Nicola, Alangea Ogum, Deda, Agyei Nkansah, Adwoa, Paintsil, Elijah, and Torpey, Kwasi

Subjects
HIV-positive teenagers, CLUSTER randomized controlled trials, HIV, MEDICAL screening, MEDICAL personnel, HYPERTENSION
Abstract

Background: Although AIDS-related deaths have reduced with increased access to antiretroviral care, cardiovascular disease-related morbidities among persons living with HIV are rising. Contributing to this is the higher incidence of Hypertension among Persons Living with HIV. The duration of exposure to the virus and antiretroviral drugs plays a vital role in the pathogenesis, putting perinatally infected children and adolescents at higher risk than behaviorally-infected ones, supporting the calls for increased surveillance of Hypertension among them. Despite the availability of guidelines to support this surveillance, the blood pressure (BP) of adolescents living with HIV (ADLHIV) is not checked during clinical visits. This study aims to assess the effect of a theory-based intervention on healthcare workers' adherence to the guidelines for hypertension screening among adolescents. Methods: A multi-facility cluster-randomized study will be conducted. The clusters will be 20 antiretroviral therapy sites in the Greater Accra Region of Ghana with the highest adolescent caseload. Data will be extracted from the folders of adolescents (10–17 years) who received care in these facilities six months before the study. The ART staff of intervention facilities will receive a multicomponent theory of planned behaviour-based intervention. This will include orientation on hypertension risk among ADLHIV, provision of job aids and pediatric sphygmomanometers. Six months after the intervention, the outcome measure will be the change from baseline in the proportion of ADLHIV whose BP was checked during clinical visits. The calculated sample size is 400 folders. Implications of findings: This study will generate evidence on the effectiveness of a multicomponent theory-based intervention for improving the implementation of clinical practice guidelines. Trial registration: PACTR202205641023383. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial

Author

Faustino, E. Vincent S., Raffini, Leslie J., Hanson, Sheila J., Cholette, Jill M., Pinto, Matthew G., Li, Simon, Kandil, Sarah B., Nellis, Marianne E., Shabanova, Veronika, Silva, Cicero T., Tala, Joana A., McPartland, Tara, and Spinella, Philip C.

Published
2021
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41. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents

Author

Miksa, Michael, Taragin, Benjamin, Blickman, Johan G., Taillie, Eileen, Trakas, Erin, Balasco, Alyssa, Herliczek, Thaddeus, Polikoff, Lee A., Dovi, Gina, Napolitano, Massimo, Gertz, Shira, Riordan, Mary Ellen, Zasa, Justin, Brudnicki, Adele R., Eldridge, Peter, Li, Simon, Pinto, Matthew G., Faustino, Edward Vincent S., Silva, Cicero T., Tala, Joana A., and Shabanova, Veronika

Published
2018
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50. High prevalence of low high‐density lipoprotein cholesterol and insulin resistance among children and adolescents living with HIV in Uganda: harbinger for metabolic syndrome?

Author

Kisitu, Grace, Shabanova, Veronika, Naiga, Fairuzi, Nakagwa, Mary, Kekitiinwa, Adeodata R., Elyanu, Peter J., and Paintsil, Elijah

Subjects
*METABOLIC syndrome risk factors, *HIV infections, *HIV-positive persons, *PILOT projects, *HOSPITALS, *OBESITY, *HYPERTENSION, *HOMEOSTASIS, *CONFIDENCE intervals, *AGE distribution, *CROSS-sectional method, *ANTIRETROVIRAL agents, *RISK assessment, *COMPARATIVE studies, *METABOLIC syndrome, *RESEARCH funding, *DESCRIPTIVE statistics, *HIGH density lipoproteins, *HYPERLIPOPROTEINEMIA, *INSULIN resistance, *DISEASE risk factors, *CHILDREN, *ADOLESCENCE
Abstract

Background: Antiretroviral therapy‐associated adverse effects and comorbidities are still pervasive in people living with HIV, especially metabolic syndrome (MetS). We investigated the age‐dependent prevalence of components of MetS and insulin resistance in children and adolescents living with HIV (CALWH). Methods: A cross‐sectional pilot study of CALWH treated at the Baylor Uganda Clinical Centre of Excellence in Kampala, Uganda, May to August 2021. The primary outcome of MetS was defined by both the International Diabetes Federation (IDF) and the Adult Treatment Panel (ATP III) criteria. We estimated the prevalence of MetS and its components for all participants and by the stratification factors. Results: We enrolled 90 children and adolescents, aged 6 to <10 years (n = 30), 10 to <16 years (n = 30), and ≥ 16 to <19 years (n = 30). Fifty‐one percent were females. The estimated prevalence of MetS was 1.11% (1 of 90) using either IDF or ATPIII criteria for all participants, and 3.33% in the oldest age group. Notably, while only one among study participants met the criterion based on having central obesity or blood pressure, over 55% of participants had one or more IDF component, with 47% having low high‐density lipoprotein (HDL) cholesterol. Two participants (6.67%) in the group aged 10 to <16 years met one of the definitions for insulin resistance (IR) using the Homeostatic Model Assessment (HOMA‐IR) index. For every 1‐year increase in age, HOMA‐IR index increased by 0.04 (95% confidence interval: 0.01–0.08; p = 0.02). Conclusions: With increasing survival of CALWH into adulthood, lifetime exposure to ART, the frequency of MetS in this population may rise, increasing the lifetime risk for associated health problems. There is a need to study the natural history of MetS in CALWH to inform preventative and treatment interventions as needed. [ABSTRACT FROM AUTHOR]

Published
2024
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