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Your search keyword '"Shafiee-Alavidjeh, Mohammad"' showing total 6 results
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6 results on '"Shafiee-Alavidjeh, Mohammad"'

2. Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-breast-cancer Agent, Synthesis and In Vitro Evaluations

Author

Amanlou, Massoud, primary, Heidari, Zahra, additional, Davar Siadat, Seyed, additional, Reza Aghasadeghi, Mohammad, additional, Ghorbani, Masoud, additional, Esmaeil Sadat Ebrahimi, Seyed, additional, Mehdi Sadat, Seyed, additional, Hajmohammadi, Mehdi, additional, Jabbari Arabzadeh, Ali, additional, Hekmat, Soheila, additional, Alaei-Beirami, Mahmood, additional, Azizi Saraji, Alireza, additional, Fathi Moghaddam, Hadi, additional, Shafiee Alavidjeh, Mohammad, additional, Ali Delbaz, Seyed, additional, Dashtbani-Roozbehani, Abolfazl, additional, and Shafiee Ardestani, Mehdi, additional

Published
2013
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5. Novel and facile methods for the synthesis of DTPA-mono-amide: a new completely revised strategy in radiopharmaceutical chemistry

Author

Ardestani, Mehdi Shafiee, primary, Arabzadeh, Ali Jabbari, additional, Heidari, Zahra, additional, Hosseinzadeh, Amirreza, additional, Ebrahimi, Hamidreza, additional, Hashemi, Elham, additional, Mosayebnia, Mona, additional, Shafiee-Alavidjeh, Mohammad, additional, Alavi, Abbas, additional, Babaei, Mohammad Hossein, additional, Rahmim, Arman, additional, Ebrahimi, Seyed Esmaeil Sadat, additional, and Amanlou, Massoud, additional

Published
2009
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6. Gd(3+)-DTPA-DG: novel nanosized dual anticancer and molecular imaging agent.

Author

Amanlou M, Siadat SD, Ebrahimi SE, Alavi A, Aghasadeghi MR, Ardestani MS, Shanehsaz S, Ghorbani M, Mehravi B, Shafiee Alavidjeh M, Jabbari-Arabzadeh A, and Abbasi M

Subjects
Animals, Antineoplastic Agents pharmacology, Blood Coagulation Tests, Blood Glucose metabolism, Cell Line, Tumor, Cell Survival drug effects, Contrast Media chemical synthesis, Deoxyglucose chemistry, Deoxyglucose pharmacology, Drug Stability, HT29 Cells, Humans, Magnetic Resonance Imaging methods, Mice, Mice, Nude, Rats, Tissue Distribution, Tumor Necrosis Factor-alpha metabolism, Whole Body Imaging methods, Xenograft Model Antitumor Assays, Antineoplastic Agents chemistry, Contrast Media chemistry, Contrast Media pharmacology, Deoxyglucose analogs & derivatives, Gadolinium DTPA chemistry, Gadolinium DTPA pharmacology, Molecular Imaging methods
Abstract

Background: Difficulties in the use, preparation, and cost of radioactively-labeled glycosylated compounds led to this research and development study of a new gadolinium-labeled glucose compound that does not have a radioactive half-life or difficulties in its synthesis and utilization., Methods: Based on the structure of the 2-fluoro-2-deoxy-D-glucose molecule ((18)FDG), a new compound consisting of D-glucose (1.1 nm) conjugated to a well-known chelator, diethylenetriamine penta-acetic acid (DTPA), was synthesized, labeled with Gd(3+), and examined in vitro and in vivo., Results: This novel compound not only demonstrated excellent and less costly imaging capability, but also showed anticancer effects on treated cells. Our results demonstrated that the new Gd(3+)-DTPA-DG compound (GDD, with GDD conjugate aggregation of about 8 nm at 0.02 mg/mL concentration) significantly decreased HT1080 and HT29 tumor cell numbers. Application of GDD to cancer cells also increased levels of tumor necrosis factor alpha, but did not alter blood glucose levels. Interestingly, no toxicological findings were seen in normal human kidney cells., Conclusion: Dual application of GDD for both imaging and treatment of tumor cells could be remarkably advantageous in both the diagnosis and treatment of cancer.

Published
2011
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