Search

Your search keyword '"Shafqat, N."' showing total 127 results
Start Over Author "Shafqat, N."
127 results on '"Shafqat, N."'

1. Design strategies and technology of Elettra 2.0 for a versatile offer to the user community

Author

Karantzoulis, E., Di Mitri, S., Barbo, F., Barletta, W., Bassanese, S., Bracco, R., Brajnik, G., Buonanno, A., Caiazza, D., Carniel, A., Castronovo, D., Cautero, M., Cleva, S., Comisso, M., Cudin, I., Dastan, S., De Monte, R., Diviacco, B., Fabris, A., Fabris, R., Gaio, G., Grulja, S., Gregoratti, L., Gubertini, A., Krecic, S., Lizzit, S., Loda, G., Lonza, M., Manukyan, K., Mazzucco, B., Milani, M., Millo, D., Modica, M., Novinec, L., Pangon, G., Pasotti, C., Passarelli, A., Rumiz, L., Sbarra, S., Scrimali, G., Shafqat, N., Simonetti, G., Svandrlik, M., Tripaldi, F., Veronese, M., Visintini, R., Yousefi, E., and Zaccaria, M.

Published
2024
Full Text
View/download PDF

5. Design strategies and technology of Elettra 2.0 for a versatile offer to the user community

Author

Karantzoulis, E., primary, Di Mitri, S., additional, Barbo, F., additional, Barletta, W., additional, Bassanese, S., additional, Bracco, R., additional, Brajnik, G., additional, Buonanno, A., additional, Caiazza, D., additional, Carniel, A., additional, Castronovo, D., additional, Cautero, M., additional, Cleva, S., additional, Comisso, M., additional, Cudin, I., additional, Dastan, S., additional, De Monte, R., additional, Diviacco, B., additional, Fabris, A., additional, Fabris, R., additional, Gaio, G., additional, Grulja, S., additional, Gregoratti, L., additional, Gubertini, A., additional, Krecic, S., additional, Lizzit, S., additional, Loda, G., additional, Lonza, M., additional, Manukyan, K., additional, Mazzucco, B., additional, Milani, M., additional, Millo, D., additional, Modica, M., additional, Novinec, L., additional, Pangon, G., additional, Pasotti, C., additional, Passarelli, A., additional, Rumiz, L., additional, Sbarra, S., additional, Scrimali, G., additional, Shafqat, N., additional, Simonetti, G., additional, Svandrlik, M., additional, Tripaldi, F., additional, Veronese, M., additional, Visintini, R., additional, Yousefi, E., additional, and Zaccaria, M., additional

Published
2023
Full Text
View/download PDF

6. Effects of Protein Source, Whole Wheat and Butyric Acid on Live Performance, Gut Health and Amino Acid Digestibility in Broiler Chickens

Author

Shafqat N. Qaisrani, Ali I. Hussain, Saima Naveed, Fehmeada Bibi, Chaudhry A. Akram, Talat N. Pasha, Muhammad Asif, Irfan Irshad, and Rana M. Bilal

Subjects
broiler, whole wheat, butyric acid, growth performance, gut health, amino acid digestibility, Microbiology, QR1-502
Abstract

A total of 896 1-day-old straight-run (Ross-308) broilers were used to investigate the interactive effects of protein source (PS), diet structure (DS) and butyric acid (BA) on live performance and carcass characteristics, gut development and its morphology and apparent ileal digestibility (AID) of protein and amino acids (AA). Eight experimental diets comprising 8 replicates with 14 birds each were tested in a 2 × 2 × 2 factorial arrangement with complete randomized design by two levels of BA (0 and 0.1%), two forms of DS (whole vs. ground wheat) and two PS, i.e., soybean meal and canola meal (SBM vs. CM). Throughout the entire experimental period (0 to 35 d), broilers fed SBM-based diets exhibited better (p < 0.05) growth performance (feed intake (FI), body weight gain (BWG) and feed conversion ratio (FCR)), carcass parameters (p < 0.05), gut health (p < 0.05), and nutrient digestibility (p < 0.05) than CM-fed broilers. Dietary whole wheat (WW) positively affected FI (p = 0.001), BWG (p = 0.004) and FCR (p = 0.035) during the overall experimental period. Broilers fed WW had 6, 5, 8, 11 and 10% lower empty relative weights of crop, proventriculus, jejunum, ileum and colon and 25 and 15% heavier gizzard and pancreas, respectively, with longer villus height (p < 0.001), reduced crypt depth (p = 0.031) and longer villus height-to-crypt depth ratio (p < 0.001) than those fed ground-wheat-based diets. Broilers fed WW had greater (p < 0.05) AID of CP and most of the AA. Butyric acid supplementation resulted in improved (p < 0.05) growth performance and digestibility of threonine, valine, leucine, isoleucine, phenylalanine, serine and aspartate. The broilers consuming SBM had 28% lower abdominal fat than those fed CM-based diets. In conclusion, harmful consequences of a less digestible PS can partially be compensated by the inclusion of WW, and supplementation of BA further reduces these detrimental effects.

Published
2022
Full Text
View/download PDF

7. Effects of Thermally Oxidized Vegetable Oil on Growth Performance and Carcass Characteristics, Gut Morphology, Nutrients Utilization, Serum Cholesterol and Meat Fatty Acid Profile in Broilers

Author

Ghulam Yaseen, Muhammad A. Sarfraz, Saima Naveed, Farooq Ahmad, Fehmeada Bibi, Irfan Irshad, Muhammad Asif, Talat N. Pasha, and Shafqat N. Qaisrani

Subjects
oxidized vegetable oil, gut morphology, growth performance, fatty acid profile, broilers, Chemical technology, TP1-1185, Chemistry, QD1-999
Abstract

The impacts of dietary levels of oxidized vegetable (sunflower) oil on growth performance, gut morphology, nutrients utilization, serum cholesterol and meat fatty acid profile were evaluated in Ross 308 straight-run (n = 192) day-old broilers. The broilers were arbitrarily distributed among four dietary treatments including; FVO: fresh vegetable oil (1 mEq kg−1), LOO: low oxidized (20 mEq kg−1), MOO: moderately oxidized (40 mEq kg−1), and HOO: highly oxidized vegetable oil (60 mEq kg−1) with 5% inclusion containing six replicates. Results revealed that the broilers consuming MOO and HOO based diets showed reduced (p = 0.05) feed intake, body weight gain and carcass weight accompanied by a poorer feed conversion ratio than those consuming FVO. Villus height, villus height to crypt depth ratio, ileal digestibility of crude protein (p = 0.041), crude fat (p = 0.032) and poly unsaturated fatty acids (p = 0.001) in thigh muscles were decreased, whereas crypt depth (p = 0.001), serum cholesterol levels (p = 0.023) and short chain fatty acids (p = 0.001) were increased (p < 0.001) by increasing dietary oxidation level. In conclusion, MOO and HOO exerted deleterious effects on growth, carcass weight, gut development and nutrients utilization. Low oxidized vegetable oil (20 mEq kg−1), however, with minimum negative effects can be used as a cost effective energy source in poultry diets.

Published
2021
Full Text
View/download PDF

13. Effects of Thermally Oxidized Vegetable Oil on Growth Performance and Carcass Characteristics, Gut Morphology, Nutrients Utilization, Serum Cholesterol and Meat Fatty Acid Profile in Broilers

Author

Yaseen, Ghulam, primary, Sarfraz, Muhammad A., additional, Naveed, Saima, additional, Ahmad, Farooq, additional, Bibi, Fehmeada, additional, Irshad, Irfan, additional, Asif, Muhammad, additional, Pasha, Talat N., additional, and Qaisrani, Shafqat N., additional

Published
2021
Full Text
View/download PDF

14. A Malware Evasion Technique for Auditing Android Anti-Malware Solutions

Author

Mirzax, S., Abbas, H., Shahid, W. B., Shafqat, N., Fugini, M., Iqbal, Z., and Zmuhammad

Subjects
Antivirus Evasion, Antivirus Evasion, Android Security, Malware Analysis, Code Obfuscation, Anti-malware Tools (AMTs), Anti-malware Tools (AMTs), Malware Analysis, Android Security, Code Obfuscation
Published
2021

19. Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD

Author

Shafqat, N, Marschall, HU, Filling, C, Nordling, E, Wu, XQ, Björk, L, Thyberg, J, Mårtensson, E, Salim, S, Jörnvall, H, and Oppermann, U

Abstract

17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the conversion of 17beta-OH (-hydroxy)/17-oxo groups of steroids, and are essential in mammalian hormone physiology. At present, eleven 17beta-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17beta-HSD type 10 (17beta-HSD10) from humans and Drosophila, the latter known to be essential in development. In addition to the known hydroxyacyl-CoA dehydrogenase, and 3alpha-OH and 17beta-OH activities with sex steroids, we here demonstrate novel activities of 17beta-HSD10. Both species variants oxidize the 20beta-OH and 21-OH groups in C21 steroids, and act as 7beta-OH dehydrogenases of ursodeoxycholic or isoursodeoxycholic acid (also known as 7beta-hydroxylithocholic acid or 7beta-hydroxyisolithocholic acid respectively). Additionally, the human orthologue oxidizes the 7alpha-OH of chenodeoxycholic acid (5beta-cholanic acid, 3alpha,7alpha-diol) and cholic acid (5beta-cholanic acid). These novel substrate specificities are explained by homology models based on the orthologous rat crystal structure, showing a wide hydrophobic cleft, capable of accommodating steroids in different orientations. These properties suggest that the human enzyme is involved in glucocorticoid and gestagen catabolism, and participates in bile acid isomerization. Confocal microscopy and electron microscopy studies reveal that the human form is localized to mitochondria, whereas Drosophila 17beta-HSD10 shows a cytosolic localization pattern, possibly due to an N-terminal sequence difference that in human 17beta-HSD10 constitutes a mitochondrial targeting signal, extending into the Rossmann-fold motif.

Published
2016

21. Drift Tube Linac Conditioning of Tank1

Author

Shafqat, N, Ramberger, S, and Toor, W A

Subjects
Accelerators and Storage Rings
Abstract

Tank1 of the Drift Tube Linac (DTL) of the Linac4 has been conditioned at the Linac4 tunnel. The tank was tuned for resonance at 352.2 MHz, and stable operation has been achieved with 725 µs long RF pulses at a repetition rate of 1 Hz. The maximum RF level that has been reached is 810 kW with a pulse width of 600 µs. Since this was the first RF structure exclusively conditioned in the Linac4 tunnel with the operation and control software of Linac4, some related issues and limitations had to be taken into account.

Published
2014

22. Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

Author

Shafqat, N, Muniz, JR, Pilka, E, Papagrigoriou, E, von Delft, F, Oppermann, U, and Yue, W

Abstract

MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation. Mammals encode a liver-specific isoenzyme, MAT1A, that is genetically linked with an inborn metabolic disorder of hypermethioninaemia, as well as a ubiquitously expressed isoenzyme, MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. To understand the molecular mechanism of MAT functions and interactions, we have crystallized the ligand-bound complexes of human MAT1A, MAT2A and MAT2B. The structures of MAT1A and MAT2A in binary complexes with their product SAM allow for a comparison with the Escherichia coli and rat structures. This facilitates the understanding of the different substrate or product conformations, mediated by the neighbouring gating loop, which can be accommodated by the compact active site during catalysis. The structure of MAT2B reveals an SDR (short-chain dehydrogenase/reductase) core with specificity for the NADP/H cofactor, and harbours the SDR catalytic triad (YxxxKS). Extended from the MAT2B core is a second domain with homology with an SDR sub-family that binds nucleotide-sugar substrates, although the equivalent region in MAT2B presents a more open and extended surface which may endow a different ligand/protein-binding capability. Together, the results of the present study provide a framework to assign structural features to the functional and catalytic properties of the human MAT proteins, and facilitate future studies to probe new catalytic and binding functions.

Published
2013

24. SDR goes SGC: A structural genomics initiative

Author

Oppermann, U, Kavanagh, K, Guo, K, Ng, S, Lukacik, P, Wu, X, Dubinina, E, Shafqat, N, Bray, J, Marsden, B, Sharma, S, Vedadi, M, von Delft, F, and Sundstrom, M

Published
2006

27. Crystal structure of human GDP-L-fucose synthase with bound NADP

Author

Vollmar, M., primary, Shafqat, N., additional, Rojkova, A., additional, Krojer, T., additional, Bradley, A., additional, Raynor, J.W., additional, Kavanagh, K., additional, von Delft, F., additional, Arrowsmith, C.H., additional, Bountra, C., additional, Edwards, A., additional, Oppermann, U., additional, and Yue, W.W., additional

Published
2013
Full Text
View/download PDF

29. Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form

Author

Vollmar, M., primary, Krojer, T., additional, Shafqat, N., additional, Rojkova, A., additional, Bunkoczi, G., additional, Pike, A., additional, Chaikuat, A., additional, Carpenter, E., additional, Yue, W.W., additional, Kavanagh, K., additional, von Delft, F., additional, Weigelt, J., additional, Arrowsmith, C.H., additional, Bountra, C., additional, Edwards, A., additional, and Oppermann, U., additional

Published
2012
Full Text
View/download PDF

30. Crystal Structure of human epimerase family protein SDR39U1 (isoform2) with NADPH

Author

Vollmar, M., primary, Muniz, J.R.C., additional, Shafqat, N., additional, Picaud, S., additional, Krojer, T., additional, Chaikuad, A., additional, Pike, A.C.W., additional, Yue, W.W., additional, Filippakopoulos, P., additional, Kavanagh, K.L., additional, von Delft, F., additional, Weigelt, J., additional, Arrowsmith, C.H., additional, Bountra, C., additional, Edwards, A., additional, and Oppermann, U., additional

Published
2012
Full Text
View/download PDF

32. Crystal structure of human S-adenosylmethionine synthetase 2, beta subunit

Author

Muniz, J.R.C., primary, Shafqat, N., additional, Pike, A.C.W., additional, Yue, W.W., additional, Vollmar, M., additional, Papagriogriou, V., additional, Roos, A., additional, Gileadi, O., additional, von Delft, F., additional, Kavanagh, K.L., additional, Arrowsmith, C.H., additional, Edwards, A.M., additional, Weigelt, J., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2011
Full Text
View/download PDF

33. Crystal structure of human S-adenosylmethionine synthetase 2, beta subunit in Orthorhombic crystal form

Author

Yue, W.W., primary, Shafqat, N., additional, Muniz, J.R.C., additional, Pike, A.C.W., additional, Chaikuad, A., additional, Allerston, C.K., additional, Gileadi, O., additional, von Delft, F., additional, Kavanagh, K.L., additional, Arrowsmith, C.H., additional, Edwards, A.M., additional, Weigelt, J., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2011
Full Text
View/download PDF

35. Crystal structure of the human MGC45594 gene product in complex with fenoprofen

Author

Shafqat, N., primary, Yue, W.W., additional, Ugochukwu, E., additional, Niesen, F., additional, Vollmar, M., additional, Chaikuad, A., additional, Pike, A.C.W., additional, von Delft, F., additional, Smee, C., additional, Arrowsmith, C., additional, Weigelt, J., additional, Edwards, A., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2010
Full Text
View/download PDF

39. Crystal structure of human acyl-CoA binding domain 4 complexed with stearoyl-CoA

Author

Yue, W.W., primary, Shafqat, N., additional, Ugochukwu, E., additional, Savitsky, P., additional, Johansson, C., additional, Salah, E., additional, Roos, A.K., additional, Chaikuad, A., additional, von Delft, F., additional, Arrowsmith, C., additional, Weigelt, J., additional, Edwards, A., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2009
Full Text
View/download PDF

40. Crystal structure of human magnesium-dependent phosphatase 1 of the haloacid dehalogenase superfamily (MGC5987)

Author

Yue, W.W., primary, Shafqat, N., additional, Pike, A.C.W., additional, Chaikuad, A., additional, Bray, J.E., additional, Pilka, E.W., additional, Burgess-Brown, N., additional, Hapka, E., additional, Filippakopoulos, P., additional, von Delft, F., additional, Arrowsmith, C., additional, Weigelt, J., additional, Edwards, A., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2009
Full Text
View/download PDF

42. Crystal structure of the fourth PDZ domain of PDZ domain-containing protein 1

Author

Yue, W.W., primary, Shafqat, N., additional, Pilka, E.S., additional, Johansson, C., additional, Murray, J.W., additional, Elkins, J., additional, Roos, A., additional, Cooper, C., additional, Phillips, C., additional, Salah, E., additional, von Delft, F., additional, Doyle, D., additional, Edwards, A., additional, Wikstrom, M., additional, Arrowsmith, C., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2009
Full Text
View/download PDF

43. Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1)

Author

Shafqat, N., primary, Kavanagh, K., additional, Pike, A.C.W., additional, Muniz, J.R.C., additional, Pilka, E., additional, Roos, A.K., additional, Picaud, S., additional, Johansson, C., additional, Smee, C., additional, Fedorov, O., additional, Kochan, G., additional, Edwards, A., additional, Arrowsmith, C.H., additional, Weigelt, J., additional, Bountra, C., additional, von Delft, F., additional, and Opperman, U., additional

Published
2009
Full Text
View/download PDF

45. Crystal structure of the human 2-oxoglutarate oxygenase LOC390245

Author

Yue, W.W., primary, Ng, S., additional, Shafqat, N., additional, Ugochukwu, E., additional, McDonough, M., additional, Pike, A.C.W., additional, Filippakopoulos, P., additional, von Delft, F., additional, Arrowsmith, C., additional, Weigelt, J., additional, Edwards, A., additional, Bountra, C., additional, Schofield, C., additional, and Oppermann, U., additional

Published
2009
Full Text
View/download PDF

47. Structure of the PDZ domain of Tax1 (human T-cell leukemia virus type I) binding protein 3

Author

Murray, J.W., primary, Shafqat, N., additional, Yue, W., additional, Pilka, E., additional, Johannsson, C., additional, Salah, E., additional, Cooper, C., additional, Elkins, J.M., additional, Pike, A.C., additional, Roos, A., additional, Filippakopoulos, P., additional, von Delft, F., additional, Wickstroem, M., additional, Bountra, C., additional, Edwards, A.M., additional, Arrowsmith, C.H., additional, and Oppermann, U., additional

Published
2008
Full Text
View/download PDF

48. Crystal structure of the PDZ domain of human rhophilin-2

Author

Pike, A.C.W., primary, Kochan, G., additional, Sun, Z., additional, Shafqat, N., additional, Pilka, E.S., additional, Roos, A., additional, Elkins, J., additional, Burgess-Brown, N., additional, Murray, J.W., additional, von Delft, F., additional, Wikstrom, M., additional, Edwards, A., additional, Arrowsmith, C.H., additional, Bountra, C., additional, and Oppermann, U., additional

Published
2008
Full Text
View/download PDF

49. Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)

Author

Porte, S., primary, Valencia, E., additional, Farres, J., additional, Fita, I., additional, Pike, A.C.W., additional, Shafqat, N., additional, Debreczeni, J., additional, Johansson, C., additional, Haroniti, A., additional, Gileadi, O., additional, Arrowsmith, C.H., additional, Edwards, A., additional, Weigelt, J., additional, Sundstrom, M., additional, von Delft, F., additional, Oppermann, U., additional, and Pares, X., additional

Published
2007
Full Text
View/download PDF

50. RANDOM COINCIDENCE POINT RESULTS FOR WEAKLY INCREASING FUNCTIONS IN PARTIALLY ORDERED METRIC SPACES.

Author

KHAN, A. R., HUSSAIN, N., YASMIN, N., and SHAFQAT, N.

Subjects
PARTIALLY ordered spaces, TOPOLOGICAL spaces, METRIC spaces, GENERALIZED spaces, FIXED point theory
Abstract

The aim of this paper is to establish random coincidence point results for weakly increasing random operators in the setting of ordered metric spaces by using generalized altering distance functions. Our results present random versions and extensions of some well-known results in the current literature. [ABSTRACT FROM AUTHOR]

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results