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8 results on '"Shagidulin, Murat"'

2. Recombinant Spidroin Microgel as the Base of Cell-Engineered Constructs Mediates Liver Regeneration in Rats

Author

Shagidulin, Murat, primary, Onishchenko, Nina, additional, Grechina, Anastasiia, additional, Nikolskaya, Alla, additional, Krasheninnikov, Mikhail, additional, Lyundup, Aleksey, additional, Volkova, Elena, additional, Mogeiko, Natalia, additional, Venediktov, Artem, additional, Piavchenko, Gennadii, additional, Davydova, Lubov, additional, Ramonova, Alla, additional, Bogush, Vladimir, additional, and Gautier, Sergey, additional

Published
2022
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3. Experimental Correction and Treatment of Chronic Liver Failure Using Implantable Cell-Engineering Constructs of the Auxiliary Liver Based on a Bioactive Heterogeneous Biopolymer Hydrogel.

Author

Shagidulin, Murat, Onishchenko, Nina, Sevastianov, Victor, Krasheninnikov, Mikhail, Lyundup, Aleksey, Nikolskaya, Alla, Kryzhanovskaya, Alena, Voznesenskaia, Sofia, Gorelova, Mariia, Perova, Nadezhda, Kozlov, Igor, Venediktov, Artem, Piavchenko, Gennadii, and Gautier, Sergey

Subjects
HYDROGELS, LIVER failure, BIOACTIVE compounds, BIOPOLYMERS, TISSUE engineering
Abstract

Our study sought approaches for chronic liver failure (CLF) treatment and correction via cell-engineered constructs (CECs). They are built from biopolymer-based, microstructured, and collagen-containing hydrogel (BMCG). We also strove to evaluate the functional activity of BMCG in liver regeneration. Materials and Methods: Allogeneic liver cells (namely, hepatocytes; LC) together with mesenchymal multipotent stem cells of bone marrow origin (MMSC BM; BMSCs) were adhered to our BMCG to compose implanted liver CECs. Thereafter, we investigated a model of CLF in rats receiving the implanted CECs. The CLF had been provoked by long-term exposure to carbon tetrachloride. The study comprised male Wistar rats (n = 120) randomized into 3 groups: Group 1 was a control group with the saline treatment of the hepatic parenchyma (n = 40); Group 2 received BMCG only (n = 40); and Group 3 was loaded with CECs implanted into the parenchyma of their livers (n = 40). August rats (n = 30) made up a donor population for LCs and MMSC BM to develop grafts for animals from Group 3. The study length was 90 days. Results: CECs were shown to affect both biochemical test values and morphological parameters in rats with CLF. Conclusion: We found BMCG-derived CECs to be operational and active, with regenerative potential. Group 3 showed significant evidence of forced liver regeneration that tended to persist until the end of the study (day 90). The phenomenon is reflected by biochemical signs of hepatic functional recovery by day 30 after grafting (compared to Groups 1 and 2), whereas structural features of liver repair (necrosis prevention, missing formation of vacuoles, degenerating LC number decrease, and delay of hepatic fibrotic transformation). Such implantation of BMCG-derived CECs with allogeneic LCs and MMSC BM might represent a proper option to correct and treat CLF, as well as to maintain affected liver function in patients with liver grafting needed. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) 4th meeting: Lessons learned from first clinical trials

Author

Franquesa, Marcella, Hoogduijn, Martin J., Reinders, Marlies E., Eggenhofer, Elke, Engela, Anja U., Mensah, Fane K., Torras, Joan, Pileggi, Antonello, van Kooten, Cees, Mahon, Bernard, Detry, Oliver, Popp, Felix C., Benseler, Volker, Casiraghi, Federica, Johnson, Christian, Ancans, Janis, Fillenberg, Barbara, delaRosa, Olga, Aran, Josep M., Roemeling-vanRhijn, Marieke, Pinxteren, Jef, Perico, Norberto, Gotti, Eliana, Christ, Bruno, Reading, James, Introna, Martino, Deans, Robert, Shagidulin, Murat, Farré, Ramon, Rambaldi, Alessandro, Sanchez-Fueyo, Albert, Obermajer, Natasha, Pulin, Andrey, Dor, Frank J.M.F., Portero-Sanchez, Isabel, Baan, Carla C., Rabelink, Ton J., Remuzzi, Giuseppe, Betjes, Michiel G.H., Dahlke, Marc H., and Grinyó, Josep M.

Subjects
Article
Abstract

The 4th expert meeting of the MiSOT (Mesenchymal Stem Cells in Solid Organ Transplantation) Consortium took place in Barcelona on the 19th and 20th of October 2012. This meeting focused on the translation of pre-clinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells (MSC) as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of MSC and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.

Published
2013

6. Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

Author

Hoogduijn, Martin Johannes, Rabelink, Ton Johannes, Van Der Laan, Luc J W, Dor, Frank J M F F.J.M.F., Ijzermans, Jan J.N.M., Genever, Paul P.G., Lange, Claudia, Durrbach, Antoine, Houtgraaf, Jaco J.H., Christ, Bruno, Seifert, Martina, Popp, Felix Cristoph, Shagidulin, Murat, Donckier De Donceel, Vincent, Deans, Robert, Ringden, Olle, Perico, Norberto, Remuzzi, Giuseppe, Bartholomew, Amelia, Schlitt, Hans Jürgen ürgen H.J., Weimar, Willem, Baan, Carla C.C., Grohnert, Anja, Dahlke, Marc Hendrik, Crop, Meindert Johannes, Van Rhijn, Marieke, Rowshani, Ajda Tahereh, Eggenhofer, Elke, Renner, Philipp, Reinders, Marlies E J M.E., Hoogduijn, Martin Johannes, Rabelink, Ton Johannes, Van Der Laan, Luc J W, Dor, Frank J M F F.J.M.F., Ijzermans, Jan J.N.M., Genever, Paul P.G., Lange, Claudia, Durrbach, Antoine, Houtgraaf, Jaco J.H., Christ, Bruno, Seifert, Martina, Popp, Felix Cristoph, Shagidulin, Murat, Donckier De Donceel, Vincent, Deans, Robert, Ringden, Olle, Perico, Norberto, Remuzzi, Giuseppe, Bartholomew, Amelia, Schlitt, Hans Jürgen ürgen H.J., Weimar, Willem, Baan, Carla C.C., Grohnert, Anja, Dahlke, Marc Hendrik, Crop, Meindert Johannes, Van Rhijn, Marieke, Rowshani, Ajda Tahereh, Eggenhofer, Elke, Renner, Philipp, and Reinders, Marlies E J M.E.

Abstract

There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation. © 2010 by Lippincott Williams & Wilkins., SCOPUS: sh.j, info:eu-repo/semantics/published

Published
2010

7. Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting

Author

Franquesa, Marcella, primary, Hoogduijn, Martin J., additional, Reinders, Marlies E., additional, Eggenhofer, Elke, additional, Engela, Anja U., additional, Mensah, Fane K., additional, Torras, Joan, additional, Pileggi, Antonello, additional, van Kooten, Cees, additional, Mahon, Bernard, additional, Detry, Oliver, additional, Popp, Felix C., additional, Benseler, Volker, additional, Casiraghi, Federica, additional, Johnson, Christian, additional, Ancans, Janis, additional, Fillenberg, Barbara, additional, delaRosa, Olga, additional, Aran, Josep M., additional, Roemeling-vanRhijn, Marieke, additional, Pinxteren, Jef, additional, Perico, Norberto, additional, Gotti, Eliana, additional, Christ, Bruno, additional, Reading, James, additional, Introna, Martino, additional, Deans, Robert, additional, Shagidulin, Murat, additional, Farré, Ramon, additional, Rambaldi, Alessandro, additional, Sanchez-Fueyo, Albert, additional, Obermajer, Natasha, additional, Pulin, Andrey, additional, Dor, Frank J.M.F., additional, Portero-Sanchez, Isabel, additional, Baan, Carla C., additional, Rabelink, Ton J., additional, Remuzzi, Giuseppe, additional, Betjes, Michiel G.H., additional, Dahlke, Marc H., additional, and Grinyó, Josep M., additional

Published
2013
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8. Advancement of Mesenchymal Stem Cell Therapy in Solid Organ Transplantation (MISOT)

Author

Hoogduijn, Martin J., primary, Popp, Felix C., additional, Grohnert, Anja, additional, Crop, Meindert J., additional, van Rhijn, Marieke, additional, Rowshani, Ajda T., additional, Eggenhofer, Elke, additional, Renner, Philipp, additional, Reinders, Marlies E., additional, Rabelink, Ton J., additional, van der Laan, Luc J. W., additional, Dor, Frank J. M. F., additional, IJzermans, Jan N. M., additional, Genever, Paul G., additional, Lange, Claudia, additional, Durrbach, Antoine, additional, Houtgraaf, Jaco H., additional, Christ, Bruno, additional, Seifert, Martina, additional, Shagidulin, Murat, additional, Donckier, Vincent, additional, Deans, Robert, additional, Ringden, Olle, additional, Perico, Norberto, additional, Remuzzi, Giuseppe, additional, Bartholomew, Amelia, additional, Schlitt, Hans J., additional, Weimar, Willem, additional, Baan, Carla C., additional, and Dahlke, Marc H., additional

Published
2010
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