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Your search keyword '"Shaik, Baji Baba"' showing total 16 results
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16 results on '"Shaik, Baji Baba"'

3. Novel 4,5-dibromo-N-phenyl-1H-pyrrole-2-carboxamide Hybrids as Promising DNA Gyrase Inhibitors: Design, synthesis and antimicrobial evaluation

Author

Merugu, Srinivas Reddy, Mokoena, Sithabile, Obakachi, Vincent A., Shaik, Baji Baba, Kushawaha, Babita, Kushwaha, Narva Deshwar, Ike, Blessing Wisdom, Palkar, Mahesh B., Bonde, Chandrakant G., Ganai, Ab Majeed, Chauhan, Ruchika, Kajee, Afsana, Ghai, Meenu, Kidwai, Saqib, Singh, Ramandeep, and Karpoormath, Rajshekhar

Published
2024
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11. O-Benzoylhydroxylamines: A Versatile Electrophilic Aminating Reagent for Transition Metal-Catalyzed C–N Bond-Forming Reactions

Author

Sachin Balaso Mohite, Milan Bera, Vishal Kumar, Rajshekhar Karpoormath, Shaik Baji Baba, and Arjun S. Kumbhar

Subjects
Nitrogen, Transition Elements, Indicators and Reagents, General Chemistry, Catalysis, Amination
Abstract

Owing to the prevalence of nitrogen-containing compounds in natural products and important pharmaceutical agents, chemists, have actively searched for the development of efficient and selective methodologies allowing for the facile construction of carbon-nitrogen bonds. Over the last decade, transition metal-catalyzed C-N bond construction via electrophilic amination reaction has emerged as an attractive approach for the synthesis of various organic molecules and pharmaceuticals. Particularly, O-benzoylhydroxylamines as an electrophilic aminating agent have proven to be the best and most widely used in both academic and industrial research. In this review, we highlight the key contributions to the recent transition metal-catalyzed C-N bond formation reactions using O-benzoylhydroxylamines as an aminating agent and their relevant mechanistic insights.

Published
2022

16. Recent Literature Review on Coumarin Hybrids as Potential Anticancer Agents.

Author

Shaik BB, Katari NK, Seboletswe P, Gundla R, Kushwaha ND, Kumar V, Singh P, Karpoormath R, and Bala MD

Subjects
Humans, Female, Structure-Activity Relationship, Coumarins chemistry, Molecular Structure, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Anti-Infective Agents pharmacology, Breast Neoplasms drug therapy
Abstract

Cancer is considered one of the leading causes of death globally, especially patients with lung, pancreatic, or brain tumors are most likely to die of cancer, and patients with prostate and breast cancer are at a high risk of noncancer death. As a result, there is ongoing research regarding developing new, safe, and efficient anticancer agents. Coumarin-based naturally occurring compounds possess a broad spectrum of activity in medicinal chemistry, such as anticancer, anti-inflammatory, antimicrobial, antioxidant agents, etc. Many researchers have synthesized coumarinbased novel therapeutic agents via molecular hybridization technique, which offers an excellent opportunity to develop novel compounds with improved biological activities by incorporating two or more pharmacophores. This review aims to shed light on the recent developments of coumarin-based anticancer hybrid derivatives and their Structure-Activity Relationships (SAR). This review serves as a medium that medicinal chemists could utilize to design and synthesize coumarin derivatives with significant pharmacological value as future anticancer agents., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
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