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Background: NLR is advantageous in regard to simplicity, low cost, and availability compared to many other previously proposed biomarkers, which makes it promising for diagnostic clinicians. Several studies have reported that the NLR is useful in various clinical situations.Objective: To determine whether NLR obtained from complete blood count (CBC) and with simple calculation can be used to predict mortality in patients with sepsis and septic shock in the ICU in comparison with intensive care unit (ICU) severity scores.Patients and methods: This prospective trial was carried out on 84 ICU cases with severe sepsis, who were admitted to Specialized Medical Hospital ICUs from June 2020 to June 2021.Results: There was statistically significantly higher systolic blood pressure (mmHg), mean arterial pressure, rate pressure product *10^3, EF, INR, RBS, PH, HCO3, L *10^3, platelet count, CRP on admission, ABACHEII score, SOFA score on admission, duration of hospital stay (days), and a statistically significantly lower age (years), diastolic blood pressure (mmHg), heart rate, respiratory rate (RR), GCS, serum creatinine (mg/dl), serum albumin, serum bilirubin, Na, K, total leucocytic count *10^3, N *10^3, in group B NLR >10 vs. group A NLR≤ 10.Conclusion: Neutrophil to lymphocyte ratio is a cheap and rapidly available predictor of sepsis and has shown a significant correlation with other relatively expensive and non-rapidly existing markers of inflammation and sepsis with comparable efficacy with ICU severity scores [SOFA and APACHE II].