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Background: Brunner's gland proliferation can mimic malignancy; the preoperative diagnosis of this lesion is challenging, and it is accidentally identified during imaging. Most of these lesions are identified as gastrointestinal stromal tumour or malignant tumour. The diagnosis of these lesions requires a histopathological examination. Case Presentation: Herein, we present a case of Brunner's gland hyperplasia/hamartoma, which was identified as a gastrointestinal stromal tumour at radiography and as submucosal thickening in endoscopy during the routine workup of anemia. However, histopathological examination revealed it to be a Brunner's gland hyperplasia/hamartoma. Conclusion: A preoperative diagnosis is challenging, so Brunner's gland hyperplasia/hamartoma should be considered as a differential diagnosis. The patient was found to be doing well on follow-up.

Background: This study aimed at classifying meningioma and its variants based on histology, and study its clinicopathological correlation. This analytical study conducted in a tertiary referral centre included clinical presentation, radiological features and histopathological correlation of meningioma. The grading system of meningioma is based on histological features. Difference in subjective assessment can hamper this grading system. A continuous revision of the histopathology of meningiomas and taking into account precise definitions of features such as small cell changes, hypercellularity, sheeting, necrosis, and mitotic count is necessary to improve the accuracy for diagnosis grading of these tumours. Methods: A retrospective and prospective study of meningiomas was carried out in the department of Pathology at a tertiary care hospital over a period of 5 years (July 2011 to June 2016). Clinical presentation, radiological features and histological findings were taken into consideration. Result: Of the 277 cases of lesions of central nervous system, 63 cases were diagnosed as meningioma, the incidence being 22.74%. Most these cases were in the 4th to 6th decade of life (71.42%). The overall male to female ratio was 1: 2.3. The commonest clinical feature was headache (58.73%) followed by limb weakness (33.33%). The most common location was cerebral hemisphere (49.20%). There were 7 cases of spinal meningioma. Most of the meningiomas were hyperdense (60.8%) on CT and iso to hypointense (90%) on MRI.Most of the cases were Grade I meningiomas (88.89%), meningothelial and transitional being the most common histological subtypes. Two of the grade II meningioma cases showed presence of brain invasion. Conclusion: Histopathological examination is an imperative tool for confirmatory diagnosis due to the diverse histological variants. Also, the prognosis of the disease depends on histopathological grading of the lesion.

Choroid plexus papilloma is a rare intracranial neoplasm. These lesions most commonly present in the fourth ventricle in adults and lateral ventricle in children. Herein, we report a case of a 57-year-old male with complaint of backache of few weeks duration. Magnetic resonance imaging revealed an intradural and extramedullary space occupying lesion at D8 level. Histology showed multiple free-floating papillae with a central fibrovascular core. The cells showed immunoreactivity for vimentin, glial fibrillary acidic protein, synaptophysin, S-100 protein, and cytokeratins (CK, CK7).